Incidental Mutation 'IGL01552:Lamtor5'
ID90605
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lamtor5
Ensembl Gene ENSMUSG00000087260
Gene Namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01552
Quality Score
Status
Chromosome3
Chromosomal Location107278858-107284082 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 107279008 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 31 (V31A)
Ref Sequence ENSEMBL: ENSMUSP00000129012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000145735] [ENSMUST00000199317]
Predicted Effect probably benign
Transcript: ENSMUST00000145735
AA Change: V31A

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000129012
Gene: ENSMUSG00000087260
AA Change: V31A

DomainStartEndE-ValueType
Pfam:LAMTOR5 55 142 2e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000199317
SMART Domains Protein: ENSMUSP00000143494
Gene: ENSMUSG00000087260

DomainStartEndE-ValueType
Pfam:LAMTOR5 1 88 2.1e-37 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5330417C22Rik A G 3: 108,481,312 W252R possibly damaging Het
Arl8a T C 1: 135,152,868 probably null Het
Bivm A G 1: 44,126,773 N128D probably benign Het
Chil3 C A 3: 106,148,848 G330V probably damaging Het
Dscaml1 A G 9: 45,447,908 H155R probably damaging Het
Etl4 T A 2: 20,778,189 V687D probably damaging Het
Fbxw10 A T 11: 62,857,684 probably null Het
Gfpt2 G T 11: 49,805,005 E21* probably null Het
Gm10197 C T 19: 53,371,691 V26I possibly damaging Het
Gm4788 A G 1: 139,739,302 Y412H probably damaging Het
Gm6614 T C 6: 141,987,706 K451R possibly damaging Het
Golim4 T C 3: 75,956,195 E35G probably damaging Het
Igdcc4 A G 9: 65,122,502 probably benign Het
Ino80d A G 1: 63,057,977 probably benign Het
Ipo13 A G 4: 117,900,964 M734T probably benign Het
Klk1b27 C T 7: 44,054,615 L61F probably damaging Het
Lrp1 A T 10: 127,588,510 L769* probably null Het
Nipsnap1 A T 11: 4,889,124 S135C probably damaging Het
Olfr1277 C A 2: 111,269,912 G152C probably damaging Het
Pparg A T 6: 115,490,122 H452L probably benign Het
Rab34 C T 11: 78,191,438 A202V probably damaging Het
Ryr3 T A 2: 112,825,883 T1923S possibly damaging Het
Sall4 A G 2: 168,756,123 S266P probably damaging Het
Sh2d4b T C 14: 40,860,648 Q195R probably benign Het
Sik2 C A 9: 50,917,522 probably benign Het
Slc25a36 A G 9: 97,079,233 V111A probably benign Het
Sptbn5 A T 2: 120,054,422 probably benign Het
Tac2 G A 10: 127,726,101 E25K possibly damaging Het
Tnc A G 4: 63,970,408 V1807A probably damaging Het
Top3b T C 16: 16,887,823 probably benign Het
Zfp827 A G 8: 79,076,191 E464G probably damaging Het
Other mutations in Lamtor5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0419:Lamtor5 UTSW 3 107281911 missense probably damaging 0.96
R4246:Lamtor5 UTSW 3 107279038 missense probably benign
R5433:Lamtor5 UTSW 3 107282007 missense probably benign 0.09
R7246:Lamtor5 UTSW 3 107282020 missense probably damaging 1.00
Posted On2013-12-09