Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01552:Ino80d'

90619

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ino80d

Ensembl Gene

ENSMUSG00000040865

Gene Name

INO80 complex subunit D

Synonyms

A430093A21Rik

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01552

Quality Score

Status

Chromosome

Chromosomal Location

62958418-63114667 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 63057977 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127378 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097718] [ENSMUST00000133236] [ENSMUST00000137511] [ENSMUST00000153992] [ENSMUST00000165066] [ENSMUST00000172416]

Predicted Effect

probably benign
Transcript: ENSMUST00000097718

SMART Domains

Protein: ENSMUSP00000095325
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
low complexity region	91	101	N/A	INTRINSIC
low complexity region	153	158	N/A	INTRINSIC
low complexity region	249	260	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
Pfam:zf-C3Hc3H	336	402	1.2e-22	PFAM
low complexity region	414	459	N/A	INTRINSIC
low complexity region	535	549	N/A	INTRINSIC
low complexity region	647	666	N/A	INTRINSIC
low complexity region	706	722	N/A	INTRINSIC
low complexity region	802	821	N/A	INTRINSIC
low complexity region	890	911	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000133236

SMART Domains

Protein: ENSMUSP00000123430
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
low complexity region	91	101	N/A	INTRINSIC
low complexity region	153	158	N/A	INTRINSIC
low complexity region	249	260	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
Pfam:zf-C3Hc3H	337	401	4.3e-20	PFAM
low complexity region	414	459	N/A	INTRINSIC
low complexity region	535	549	N/A	INTRINSIC
low complexity region	647	666	N/A	INTRINSIC
low complexity region	706	722	N/A	INTRINSIC
low complexity region	802	821	N/A	INTRINSIC
low complexity region	890	911	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000137511

SMART Domains

Protein: ENSMUSP00000119118
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
low complexity region	91	101	N/A	INTRINSIC
low complexity region	153	158	N/A	INTRINSIC
low complexity region	249	260	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
Pfam:zf-C3Hc3H	336	402	4.3e-23	PFAM
low complexity region	414	438	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000153992

SMART Domains

Protein: ENSMUSP00000115332
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
low complexity region	91	101	N/A	INTRINSIC
low complexity region	153	158	N/A	INTRINSIC
low complexity region	249	260	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
Pfam:zf-C3Hc3H	336	402	4.3e-23	PFAM
low complexity region	414	431	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000165066

SMART Domains

Protein: ENSMUSP00000130864
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
Pfam:zf-C3Hc3H	18	79	5.9e-21	PFAM
low complexity region	196	206	N/A	INTRINSIC
low complexity region	258	263	N/A	INTRINSIC
low complexity region	354	365	N/A	INTRINSIC
low complexity region	419	430	N/A	INTRINSIC
Pfam:zf-C3Hc3H	442	506	7e-21	PFAM
low complexity region	519	564	N/A	INTRINSIC
low complexity region	640	654	N/A	INTRINSIC
low complexity region	752	771	N/A	INTRINSIC
low complexity region	811	827	N/A	INTRINSIC
low complexity region	907	926	N/A	INTRINSIC
low complexity region	995	1016	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172416

SMART Domains

Protein: ENSMUSP00000127378
Gene: ENSMUSG00000040865

Domain	Start	End	E-Value	Type
low complexity region	91	101	N/A	INTRINSIC
low complexity region	153	158	N/A	INTRINSIC
low complexity region	249	260	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
Pfam:zf-C3Hc3H	336	402	1.2e-22	PFAM
low complexity region	414	459	N/A	INTRINSIC
low complexity region	535	549	N/A	INTRINSIC
low complexity region	647	666	N/A	INTRINSIC
low complexity region	706	722	N/A	INTRINSIC
low complexity region	802	821	N/A	INTRINSIC
low complexity region	890	911	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188100

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417C22Rik	A	G	3: 108,481,312	W252R	possibly damaging	Het
Arl8a	T	C	1: 135,152,868		probably null	Het
Bivm	A	G	1: 44,126,773	N128D	probably benign	Het
Chil3	C	A	3: 106,148,848	G330V	probably damaging	Het
Dscaml1	A	G	9: 45,447,908	H155R	probably damaging	Het
Etl4	T	A	2: 20,778,189	V687D	probably damaging	Het
Fbxw10	A	T	11: 62,857,684		probably null	Het
Gfpt2	G	T	11: 49,805,005	E21*	probably null	Het
Gm10197	C	T	19: 53,371,691	V26I	possibly damaging	Het
Gm4788	A	G	1: 139,739,302	Y412H	probably damaging	Het
Gm6614	T	C	6: 141,987,706	K451R	possibly damaging	Het
Golim4	T	C	3: 75,956,195	E35G	probably damaging	Het
Igdcc4	A	G	9: 65,122,502		probably benign	Het
Ipo13	A	G	4: 117,900,964	M734T	probably benign	Het
Klk1b27	C	T	7: 44,054,615	L61F	probably damaging	Het
Lamtor5	T	C	3: 107,279,008	V31A	probably benign	Het
Lrp1	A	T	10: 127,588,510	L769*	probably null	Het
Nipsnap1	A	T	11: 4,889,124	S135C	probably damaging	Het
Olfr1277	C	A	2: 111,269,912	G152C	probably damaging	Het
Pparg	A	T	6: 115,490,122	H452L	probably benign	Het
Rab34	C	T	11: 78,191,438	A202V	probably damaging	Het
Ryr3	T	A	2: 112,825,883	T1923S	possibly damaging	Het
Sall4	A	G	2: 168,756,123	S266P	probably damaging	Het
Sh2d4b	T	C	14: 40,860,648	Q195R	probably benign	Het
Sik2	C	A	9: 50,917,522		probably benign	Het
Slc25a36	A	G	9: 97,079,233	V111A	probably benign	Het
Sptbn5	A	T	2: 120,054,422		probably benign	Het
Tac2	G	A	10: 127,726,101	E25K	possibly damaging	Het
Tnc	A	G	4: 63,970,408	V1807A	probably damaging	Het
Top3b	T	C	16: 16,887,823		probably benign	Het
Zfp827	A	G	8: 79,076,191	E464G	probably damaging	Het

Other mutations in Ino80d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00813:Ino80d	APN	1	63093303	missense	probably damaging	1.00
IGL01960:Ino80d	APN	1	63058147	missense	probably damaging	0.98
IGL02374:Ino80d	APN	1	63086061	missense	possibly damaging	0.63
IGL03201:Ino80d	APN	1	63058308	missense	probably damaging	1.00
IGL03248:Ino80d	APN	1	63068182	critical splice donor site	probably null
Creepy	UTSW	1	63079047	missense	possibly damaging	0.88
Friable	UTSW	1	63062126	missense	probably damaging	1.00
Herpes	UTSW	1	63065834	missense	probably damaging	1.00
PIT4696001:Ino80d	UTSW	1	63085986	missense	probably benign
R0153:Ino80d	UTSW	1	63058318	missense	probably damaging	0.97
R0371:Ino80d	UTSW	1	63057956	utr 3 prime	probably benign
R0416:Ino80d	UTSW	1	63086276	missense	possibly damaging	0.93
R1738:Ino80d	UTSW	1	63093465	missense	probably damaging	1.00
R2341:Ino80d	UTSW	1	63065826	missense	possibly damaging	0.75
R2351:Ino80d	UTSW	1	63085835	missense	probably benign	0.00
R2870:Ino80d	UTSW	1	63061039	critical splice donor site	probably null
R2870:Ino80d	UTSW	1	63061039	critical splice donor site	probably null
R3814:Ino80d	UTSW	1	63074424	missense	probably benign	0.05
R3828:Ino80d	UTSW	1	63062078	missense	possibly damaging	0.94
R3947:Ino80d	UTSW	1	63074503	missense	probably benign	0.16
R3949:Ino80d	UTSW	1	63074503	missense	probably benign	0.16
R5180:Ino80d	UTSW	1	63086329	start gained	probably benign
R5301:Ino80d	UTSW	1	63074419	missense	probably benign
R5338:Ino80d	UTSW	1	63058939	missense	probably benign	0.34
R5634:Ino80d	UTSW	1	63062283	intron	probably benign
R5716:Ino80d	UTSW	1	63058697	missense	probably benign	0.01
R5841:Ino80d	UTSW	1	63058840	missense	probably damaging	1.00
R6219:Ino80d	UTSW	1	63079047	missense	possibly damaging	0.88
R6222:Ino80d	UTSW	1	63058525	missense	probably damaging	0.99
R6283:Ino80d	UTSW	1	63062126	missense	probably damaging	1.00
R6720:Ino80d	UTSW	1	63058610	missense	probably damaging	1.00
R6835:Ino80d	UTSW	1	63074326	missense	probably benign
R6897:Ino80d	UTSW	1	63065834	missense	probably damaging	1.00
R7162:Ino80d	UTSW	1	63065735	missense	probably damaging	1.00
R7403:Ino80d	UTSW	1	63062219	missense	possibly damaging	0.52
R7644:Ino80d	UTSW	1	63058771	missense	probably benign	0.18
R7816:Ino80d	UTSW	1	63086397	missense	probably damaging	1.00
R8054:Ino80d	UTSW	1	63058678	missense	possibly damaging	0.62

Posted On

2013-12-09