Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01548:Gm8765'

93197

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm8765

Ensembl Gene

ENSMUSG00000094918

Gene Name

predicted gene 8765

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01548

Quality Score

Status

Chromosome

Chromosomal Location

50698312-50703435 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50700378 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 91 (T91A)

Ref Sequence

ENSEMBL: ENSMUSP00000097118 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099518]

AlphaFold

B7ZWJ3

Predicted Effect

probably benign
Transcript: ENSMUST00000099518
AA Change: T91A

PolyPhen 2 Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000097118
Gene: ENSMUSG00000094918
AA Change: T91A

Domain	Start	End	E-Value	Type
low complexity region	69	82	N/A	INTRINSIC
Pfam:FAM75	95	418	1.1e-15	PFAM
SCOP:d1i5pa1	811	874	9e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	T	C	2: 130,814,259	N110D	probably damaging	Het
Acot3	C	T	12: 84,057,089	T224I	probably benign	Het
Adamts18	C	T	8: 113,764,299	G512E	probably damaging	Het
Atp4b	A	G	8: 13,389,679	I181T	probably damaging	Het
Bcl11a	A	G	11: 24,163,346	I230V	probably benign	Het
Cenpj	C	A	14: 56,532,319	V1138L	probably benign	Het
Cep78	A	G	19: 15,981,200		probably benign	Het
Clec2j	T	A	6: 128,655,978		noncoding transcript	Het
Col5a3	T	C	9: 20,803,000		probably benign	Het
Cpne6	A	T	14: 55,512,726	T105S	probably damaging	Het
Csmd1	A	T	8: 16,288,646	Y482*	probably null	Het
Ctrl	C	A	8: 105,933,258		probably benign	Het
Dhcr24	T	A	4: 106,573,871	C252*	probably null	Het
Dnah17	G	A	11: 118,098,612	P1261S	probably benign	Het
Dnaic2	T	C	11: 114,752,942	L466P	probably damaging	Het
Dync2h1	A	T	9: 7,071,922	F3036Y	probably damaging	Het
Eef1akmt2	A	C	7: 132,831,405	S191A	probably damaging	Het
Fam205c	T	C	4: 42,868,564	E353G	probably benign	Het
Fat4	G	A	3: 39,009,257	C4454Y	probably damaging	Het
Fat4	T	C	3: 38,887,758	S267P	probably damaging	Het
Frrs1	T	C	3: 116,885,185	C219R	probably damaging	Het
Gabra6	T	A	11: 42,317,023	Q207L	probably damaging	Het
Gm19668	A	T	10: 77,798,408	C242*	probably null	Het
Gm2840	G	A	5: 96,174,277		noncoding transcript	Het
Gm6614	A	G	6: 141,992,512	I227T	possibly damaging	Het
Gmcl1p1	G	A	X: 3,078,226	G423S	probably benign	Het
Golim4	C	T	3: 75,908,125		probably null	Het
Gucy1b1	G	T	3: 82,034,862	T530K	probably damaging	Het
Hacl1	A	T	14: 31,640,596	D31E	possibly damaging	Het
Hectd4	A	G	5: 121,364,660	T4276A	possibly damaging	Het
Henmt1	T	C	3: 108,942,779	I26T	probably damaging	Het
Hspa1l	G	A	17: 34,978,391	A469T	probably damaging	Het
Htra3	T	A	5: 35,664,076		probably null	Het
Lrrc28	C	A	7: 67,628,294		probably null	Het
Mfhas1	T	C	8: 35,590,459	L696P	probably damaging	Het
Mios	A	G	6: 8,234,252	K808E	possibly damaging	Het
Mtnr1b	A	G	9: 15,863,200	Y188H	probably damaging	Het
Myom1	A	G	17: 71,101,220		probably benign	Het
Naca	A	T	10: 128,040,904		probably benign	Het
Nckap1l	T	A	15: 103,462,720	V213D	probably benign	Het
Ndufa6	C	T	15: 82,354,081	V50M	possibly damaging	Het
Olfr1000	A	G	2: 85,608,761	W50R	probably benign	Het
Olfr1055	T	A	2: 86,347,733	Y11F	possibly damaging	Het
Olfr1260	T	A	2: 89,978,539	F254I	possibly damaging	Het
Olfr1465	A	G	19: 13,313,986	F100L	possibly damaging	Het
Olfr923	A	G	9: 38,828,350	T220A	probably benign	Het
Osbpl1a	T	C	18: 12,763,575	Y311C	probably damaging	Het
Parp11	A	C	6: 127,491,599	Y204S	probably damaging	Het
Pla2g4a	A	G	1: 149,932,656		probably null	Het
Plec	T	C	15: 76,189,258	R519G	probably benign	Het
Ppp2r5c	T	A	12: 110,567,827	Y375N	probably benign	Het
Prss35	C	A	9: 86,755,274	S32R	probably benign	Het
Prss57	C	T	10: 79,785,747		probably benign	Het
Ptprc	A	C	1: 138,099,481		probably null	Het
Rims1	A	G	1: 22,538,602	C188R	probably damaging	Het
Ripk4	G	T	16: 97,751,496	Y144*	probably null	Het
Rpgrip1	A	T	14: 52,126,271		probably benign	Het
Rps6ka4	A	G	19: 6,832,323	V378A	probably benign	Het
Rtf1	A	G	2: 119,712,108	K298E	probably benign	Het
Sdk1	T	C	5: 142,085,765	F1237L	possibly damaging	Het
Slc40a1	T	C	1: 45,909,492	K543E	probably benign	Het
Sorcs3	A	T	19: 48,794,168	I1041F	possibly damaging	Het
Taok3	T	C	5: 117,272,197	M818T	probably benign	Het
Tas2r119	T	A	15: 32,177,977	F230I	probably damaging	Het
Tbc1d8	T	C	1: 39,381,304	D716G	probably damaging	Het
Tfg	A	G	16: 56,701,102	S58P	probably damaging	Het
Thnsl1	A	G	2: 21,213,132	I45V	probably damaging	Het
Tle1	A	G	4: 72,170,718	L96P	probably damaging	Het
Tmem260	A	C	14: 48,480,325	S276R	possibly damaging	Het
Utp20	A	G	10: 88,764,781	S24P	probably damaging	Het
Vcam1	T	C	3: 116,115,951	I576V	probably benign	Het
Vmn1r27	G	T	6: 58,215,553	N105K	probably benign	Het
Vmn2r12	A	C	5: 109,093,027	Y73*	probably null	Het
Vmn2r86	T	C	10: 130,446,282	I822V	probably benign	Het
Wdr6	C	T	9: 108,574,897	V596I	possibly damaging	Het
Zfp946	A	T	17: 22,454,662	K132N	possibly damaging	Het

Other mutations in Gm8765

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02452:Gm8765	APN	13	50703077	missense	probably damaging	0.99
IGL02610:Gm8765	APN	13	50701712	missense	possibly damaging	0.91
IGL03171:Gm8765	APN	13	50702352	missense	probably benign	0.23
IGL03369:Gm8765	APN	13	50703164	missense	possibly damaging	0.74
PIT4382001:Gm8765	UTSW	13	50700971	missense	probably damaging	0.99
R0346:Gm8765	UTSW	13	50703310	missense	probably benign	0.12
R1015:Gm8765	UTSW	13	50701628	missense	possibly damaging	0.92
R1054:Gm8765	UTSW	13	50702396	missense	probably benign	0.01
R1102:Gm8765	UTSW	13	50703082	missense	probably benign	0.00
R1519:Gm8765	UTSW	13	50700407	critical splice donor site	probably null
R1628:Gm8765	UTSW	13	50702288	missense	probably benign	0.25
R1754:Gm8765	UTSW	13	50701087	missense	probably damaging	0.98
R4212:Gm8765	UTSW	13	50700352	missense	possibly damaging	0.94
R4672:Gm8765	UTSW	13	50703172	missense	probably benign
R4780:Gm8765	UTSW	13	50701080	missense	probably damaging	0.97
R4794:Gm8765	UTSW	13	50703239	missense	probably benign	0.07
R5171:Gm8765	UTSW	13	50700378	missense	possibly damaging	0.85
R6240:Gm8765	UTSW	13	50701417	missense	probably damaging	0.97
R6366:Gm8765	UTSW	13	50701936	missense	probably benign	0.01
R6421:Gm8765	UTSW	13	50701951	missense	probably benign	0.35
R6644:Gm8765	UTSW	13	50702035	missense	possibly damaging	0.54
R6678:Gm8765	UTSW	13	50701910	missense	probably benign	0.14
R6788:Gm8765	UTSW	13	50703095	missense	probably damaging	0.99
R7030:Gm8765	UTSW	13	50702983	missense	possibly damaging	0.52
R7513:Gm8765	UTSW	13	50702873	missense	probably benign	0.01
R7681:Gm8765	UTSW	13	50702254	missense	possibly damaging	0.70
R7753:Gm8765	UTSW	13	50701781	missense	probably damaging	1.00
R7794:Gm8765	UTSW	13	50702308	missense	probably damaging	0.98
R7994:Gm8765	UTSW	13	50702864	missense	probably benign	0.04
R8021:Gm8765	UTSW	13	50701094	missense	possibly damaging	0.50
R8858:Gm8765	UTSW	13	50701387	missense	probably benign	0.07
R9027:Gm8765	UTSW	13	50702971	nonsense	probably null
R9037:Gm8765	UTSW	13	50702908	missense	probably benign	0.09
R9047:Gm8765	UTSW	13	50702092	nonsense	probably null
R9065:Gm8765	UTSW	13	50702240	missense	probably benign	0.01
R9476:Gm8765	UTSW	13	50702113	missense	possibly damaging	0.70
R9495:Gm8765	UTSW	13	50701429	missense	possibly damaging	0.82
R9510:Gm8765	UTSW	13	50702113	missense	possibly damaging	0.70
Z1177:Gm8765	UTSW	13	50702144	missense	probably damaging	1.00

Posted On

2013-12-09