Incidental Mutation 'R2038:Or10d1'
ID 225316
Institutional Source Beutler Lab
Gene Symbol Or10d1
Ensembl Gene ENSMUSG00000059366
Gene Name olfactory receptor family 10 subfamily D member 1
Synonyms MOR224-3, GA_x6K02T2PVTD-33270211-33269276, Olfr959
MMRRC Submission 040045-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R2038 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39483618-39484553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39484283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 91 (S91P)
Ref Sequence ENSEMBL: ENSMUSP00000150349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079178] [ENSMUST00000215194] [ENSMUST00000216298]
AlphaFold Q9EQ86
Predicted Effect probably damaging
Transcript: ENSMUST00000079178
AA Change: S91P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078176
Gene: ENSMUSG00000059366
AA Change: S91P

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 4.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 33 251 1.2e-7 PFAM
Pfam:7tm_1 39 286 2.7e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215194
AA Change: S91P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216298
AA Change: S91P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik T C 8: 125,389,762 (GRCm39) Y54C probably damaging Het
Adgrf4 A T 17: 42,978,754 (GRCm39) H196Q probably damaging Het
Astn1 T G 1: 158,484,690 (GRCm39) S918A probably benign Het
Cd79a A T 7: 24,598,782 (GRCm39) K110N probably benign Het
Cdc34b C T 11: 94,633,114 (GRCm39) Q105* probably null Het
Cdh23 T C 10: 60,148,366 (GRCm39) D2667G probably damaging Het
Clpx G A 9: 65,224,775 (GRCm39) G168R probably damaging Het
Col8a2 T C 4: 126,205,108 (GRCm39) probably benign Het
Ddx27 G A 2: 166,875,675 (GRCm39) E669K probably damaging Het
Dnah8 A T 17: 30,977,255 (GRCm39) I2898F probably damaging Het
Dus2 T C 8: 106,775,294 (GRCm39) Y274H probably damaging Het
Dync2h1 A G 9: 6,967,226 (GRCm39) S4073P probably damaging Het
Dynlrb2 G A 8: 117,241,549 (GRCm39) R31Q possibly damaging Het
Esyt1 C T 10: 128,347,820 (GRCm39) V957I probably benign Het
Fhdc1 A T 3: 84,351,868 (GRCm39) L1119Q probably benign Het
H2-T10 T C 17: 36,430,317 (GRCm39) K212E probably benign Het
H60b A T 10: 22,162,114 (GRCm39) N113I probably benign Het
Hace1 A C 10: 45,576,721 (GRCm39) K798Q probably benign Het
Hdac7 C T 15: 97,696,151 (GRCm39) R631H probably damaging Het
Kat7 T A 11: 95,190,928 (GRCm39) I153F probably benign Het
Lman1 T C 18: 66,131,681 (GRCm39) T101A probably benign Het
Mapk8 A T 14: 33,110,893 (GRCm39) C245* probably null Het
Mfhas1 T A 8: 36,058,431 (GRCm39) W969R probably damaging Het
Mlxipl A T 5: 135,135,853 (GRCm39) D26V probably damaging Het
Msh5 A G 17: 35,265,016 (GRCm39) V53A probably benign Het
Msl2 C A 9: 100,979,183 (GRCm39) A519D probably damaging Het
Nbeal1 A G 1: 60,245,503 (GRCm39) S176G probably benign Het
Ninl T A 2: 150,817,763 (GRCm39) K134* probably null Het
Or1e25 T A 11: 73,494,239 (GRCm39) Y278N probably damaging Het
Or4a68 C A 2: 89,269,689 (GRCm39) M311I probably benign Het
Pabpn1 T G 14: 55,134,609 (GRCm39) I250S probably damaging Het
Ppp4r4 G A 12: 103,542,539 (GRCm39) probably null Het
Rad51ap2 T C 12: 11,507,025 (GRCm39) S316P possibly damaging Het
Scn7a C A 2: 66,567,780 (GRCm39) W271C probably damaging Het
Set T C 2: 29,960,212 (GRCm39) S182P probably benign Het
Sez6l T C 5: 112,620,618 (GRCm39) T321A possibly damaging Het
Sfpq A T 4: 126,915,295 (GRCm39) H29L unknown Het
Slc33a1 A G 3: 63,855,577 (GRCm39) L356P probably damaging Het
Sptbn1 C G 11: 30,109,293 (GRCm39) probably null Het
Srrd C T 5: 112,486,316 (GRCm39) G179D probably benign Het
Taf4b T C 18: 14,940,456 (GRCm39) S312P probably damaging Het
Tgfbrap1 A T 1: 43,093,794 (GRCm39) L566* probably null Het
Tln2 T A 9: 67,304,935 (GRCm39) M1L probably benign Het
Ttc27 T C 17: 75,163,497 (GRCm39) F702L probably benign Het
Vmn2r54 C T 7: 12,363,637 (GRCm39) G419R possibly damaging Het
Vps13b A G 15: 35,884,887 (GRCm39) S3187G probably damaging Het
Vps13d C A 4: 144,907,685 (GRCm39) probably null Het
Vps35l T C 7: 118,411,097 (GRCm39) F677L probably damaging Het
Zfp568 A T 7: 29,688,507 (GRCm39) E23V probably null Het
Other mutations in Or10d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Or10d1 APN 9 39,483,877 (GRCm39) missense probably damaging 0.97
R0122:Or10d1 UTSW 9 39,484,020 (GRCm39) missense probably damaging 1.00
R0483:Or10d1 UTSW 9 39,484,139 (GRCm39) missense probably damaging 1.00
R1843:Or10d1 UTSW 9 39,484,031 (GRCm39) missense possibly damaging 0.74
R3838:Or10d1 UTSW 9 39,484,267 (GRCm39) missense probably benign
R4801:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4802:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4839:Or10d1 UTSW 9 39,484,441 (GRCm39) missense probably benign
R4967:Or10d1 UTSW 9 39,484,054 (GRCm39) missense probably damaging 1.00
R6128:Or10d1 UTSW 9 39,484,549 (GRCm39) missense probably benign 0.00
R6196:Or10d1 UTSW 9 39,483,776 (GRCm39) missense possibly damaging 0.75
R6551:Or10d1 UTSW 9 39,483,856 (GRCm39) missense probably benign 0.00
R7757:Or10d1 UTSW 9 39,483,761 (GRCm39) missense probably benign 0.02
R7892:Or10d1 UTSW 9 39,483,845 (GRCm39) missense possibly damaging 0.96
R8674:Or10d1 UTSW 9 39,484,249 (GRCm39) missense probably damaging 1.00
R8693:Or10d1 UTSW 9 39,483,800 (GRCm39) missense probably damaging 1.00
R8958:Or10d1 UTSW 9 39,484,091 (GRCm39) missense probably benign 0.00
R9101:Or10d1 UTSW 9 39,483,805 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAAGTAGCCTGAATGCAGCC -3'
(R):5'- CTGGAAACTATGCTCTTTGTCCTG -3'

Sequencing Primer
(F):5'- AGTAGCGTAATGGGTAGC -3'
(R):5'- GTCTTTCTACATCTTCACTCTGATGG -3'
Posted On 2014-08-25