Mutagenetix > Incidental Mutation

Incidental Mutation 'R3080:Vmn2r91'

265398

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

MMRRC Submission

040570-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R3080 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18305319-18356905 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 18355973 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

probably null
Transcript: ENSMUST00000172359

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 94.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amer3	T	G	1: 34,627,503 (GRCm39)	L581V	probably benign	Het
Anks4b	A	T	7: 119,781,146 (GRCm39)	D59V	probably damaging	Het
Cdc42bpb	A	G	12: 111,262,252 (GRCm39)	I75T	probably damaging	Het
Ces1c	A	C	8: 93,846,975 (GRCm39)	L93R	probably damaging	Het
Ciao2b	G	C	8: 105,368,259 (GRCm39)	R22G	possibly damaging	Het
Clca4a	T	A	3: 144,669,551 (GRCm39)	K333N	probably damaging	Het
Copa	G	T	1: 171,940,716 (GRCm39)	D710Y	probably damaging	Het
Cyp3a25	T	A	5: 145,935,341 (GRCm39)	I92F	probably benign	Het
Dcx	T	A	X: 142,706,266 (GRCm39)	D175V	probably damaging	Het
Fam76b	G	A	9: 13,744,458 (GRCm39)	G185D	probably benign	Het
Fastkd5	T	C	2: 130,457,373 (GRCm39)	M406V	possibly damaging	Het
Fbn2	G	A	18: 58,282,122 (GRCm39)	S298L	probably damaging	Het
Gak	T	C	5: 108,761,468 (GRCm39)	K188E	possibly damaging	Het
Gemin2	G	A	12: 59,071,877 (GRCm39)	C230Y	probably damaging	Het
Gm5150	A	C	3: 16,045,085 (GRCm39)	S47A	possibly damaging	Het
H3c2	A	G	13: 23,936,481 (GRCm39)	H40R	possibly damaging	Het
Herc3	A	T	6: 58,833,631 (GRCm39)		probably null	Het
Ighv5-6	T	A	12: 113,589,237 (GRCm39)	D81V	probably damaging	Het
Igkv13-54-1	A	G	6: 69,594,454 (GRCm39)		probably null	Het
Itgad	T	C	7: 127,784,959 (GRCm39)	I288T	possibly damaging	Het
Krt1	C	T	15: 101,754,622 (GRCm39)	G543S	unknown	Het
Ltbp3	GTA	GTATA	19: 5,806,916 (GRCm39)		probably null	Het
Map4k2	G	A	19: 6,403,218 (GRCm39)	E774K	probably damaging	Het
Mbtps1	A	G	8: 120,257,944 (GRCm39)	V431A	probably benign	Het
Mbtps1	T	C	8: 120,265,602 (GRCm39)	D315G	probably damaging	Het
Nebl	A	G	2: 17,381,462 (GRCm39)	V738A	possibly damaging	Het
Npr3	G	C	15: 11,905,235 (GRCm39)	T164R	probably benign	Het
Or14j4	T	C	17: 37,921,169 (GRCm39)	T158A	probably benign	Het
Or6d14	T	G	6: 116,534,178 (GRCm39)	V264G	probably damaging	Het
Pcdhb3	T	G	18: 37,434,535 (GRCm39)	L167R	probably damaging	Het
Pcdhb8	A	T	18: 37,489,219 (GRCm39)	E299V	probably damaging	Het
Shcbp1l	A	G	1: 153,311,783 (GRCm39)	E312G	possibly damaging	Het
Shroom3	G	T	5: 93,090,945 (GRCm39)	V1151F	probably damaging	Het
Slc1a2	T	G	2: 102,578,901 (GRCm39)	L272R	probably damaging	Het
Slc35a5	A	T	16: 44,964,758 (GRCm39)	S152T	probably benign	Het
Tas2r136	C	A	6: 132,754,972 (GRCm39)	V52L	probably damaging	Het
Tbr1	C	T	2: 61,637,635 (GRCm39)	Q65*	probably null	Het
Tro	G	A	X: 149,438,198 (GRCm39)	T153I	probably benign	Het
Vmn1r222	A	G	13: 23,416,631 (GRCm39)	M194T	possibly damaging	Het
Vmn2r1	A	G	3: 63,997,205 (GRCm39)	D287G	probably damaging	Het
Zfp35	T	A	18: 24,136,367 (GRCm39)	I237N	probably damaging	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18,325,820 (GRCm39)	missense	probably benign	0.00
IGL01121:Vmn2r91	APN	17	18,356,766 (GRCm39)	missense	possibly damaging	0.94
IGL01464:Vmn2r91	APN	17	18,327,864 (GRCm39)	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18,327,921 (GRCm39)	missense	probably benign
IGL02709:Vmn2r91	APN	17	18,325,711 (GRCm39)	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18,305,539 (GRCm39)	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18,356,348 (GRCm39)	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18,356,884 (GRCm39)	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18,330,373 (GRCm39)	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18,325,712 (GRCm39)	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18,356,705 (GRCm39)	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18,326,405 (GRCm39)	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18,356,142 (GRCm39)	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18,325,691 (GRCm39)	missense	possibly damaging	0.94
R2424:Vmn2r91	UTSW	17	18,356,431 (GRCm39)	nonsense	probably null
R2512:Vmn2r91	UTSW	17	18,356,048 (GRCm39)	missense	probably benign
R2885:Vmn2r91	UTSW	17	18,325,628 (GRCm39)	missense	probably benign	0.00
R2909:Vmn2r91	UTSW	17	18,356,661 (GRCm39)	missense	probably damaging	1.00
R3009:Vmn2r91	UTSW	17	18,325,717 (GRCm39)	missense	probably benign	0.11
R3079:Vmn2r91	UTSW	17	18,355,973 (GRCm39)	splice site	probably null
R3434:Vmn2r91	UTSW	17	18,330,370 (GRCm39)	splice site	probably benign
R3723:Vmn2r91	UTSW	17	18,305,540 (GRCm39)	critical splice donor site	probably null
R3829:Vmn2r91	UTSW	17	18,325,759 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18,330,358 (GRCm39)	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18,356,030 (GRCm39)	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18,325,658 (GRCm39)	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18,356,751 (GRCm39)	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18,330,322 (GRCm39)	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18,356,700 (GRCm39)	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18,356,763 (GRCm39)	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18,326,464 (GRCm39)	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18,356,518 (GRCm39)	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18,326,888 (GRCm39)	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18,355,865 (GRCm39)	splice site	probably null
R6450:Vmn2r91	UTSW	17	18,305,527 (GRCm39)	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18,327,807 (GRCm39)	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18,356,271 (GRCm39)	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18,325,880 (GRCm39)	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18,356,424 (GRCm39)	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18,326,429 (GRCm39)	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18,356,838 (GRCm39)	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18,356,060 (GRCm39)	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18,325,693 (GRCm39)	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18,356,080 (GRCm39)	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18,330,311 (GRCm39)	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18,327,887 (GRCm39)	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18,326,762 (GRCm39)	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18,356,625 (GRCm39)	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18,305,323 (GRCm39)	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18,325,636 (GRCm39)	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18,326,296 (GRCm39)	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18,356,122 (GRCm39)	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18,327,905 (GRCm39)	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18,356,819 (GRCm39)	nonsense	probably null
R9555:Vmn2r91	UTSW	17	18,325,792 (GRCm39)	missense	possibly damaging	0.78
R9616:Vmn2r91	UTSW	17	18,356,305 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- GCAAACGTGTGTGCTGGTAAG -3'
(R):5'- GTCTCTGTGTTTCACAAATATGCC -3'

Sequencing Primer
(F):5'- CAAGAAATATGTAAGGATCAAGGTGC -3'
(R):5'- TGCCAATAACAAAGACAGTGAGTGC -3'

Posted On

2015-02-05