Mutagenetix > Incidental Mutation

Incidental Mutation 'R2885:Vmn2r91'

261032

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

MMRRC Submission

040473-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R2885 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18305319-18356905 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 18325628 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 82 (Y82F)

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

probably benign
Transcript: ENSMUST00000172359
AA Change: Y82F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: Y82F

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.6%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alpk3	A	G	7: 80,749,940 (GRCm39)	S1453G	probably damaging	Het
Arhgap27	T	C	11: 103,251,669 (GRCm39)		probably null	Het
Casp1	A	T	9: 5,299,851 (GRCm39)	H108L	probably benign	Het
Cerk	A	G	15: 86,027,084 (GRCm39)	F142S	probably damaging	Het
Cmip	A	G	8: 118,111,704 (GRCm39)	N145S	probably benign	Het
Col1a2	G	A	6: 4,518,822 (GRCm39)		probably benign	Het
Cyp4b1	C	T	4: 115,492,849 (GRCm39)	D287N	probably damaging	Het
Dlx2	G	A	2: 71,375,808 (GRCm39)	R172*	probably null	Het
Dnah11	G	A	12: 117,951,162 (GRCm39)	Q1145*	probably null	Het
Dock2	A	T	11: 34,580,593 (GRCm39)	I659N	probably damaging	Het
Dync2h1	G	C	9: 7,102,329 (GRCm39)	F2690L	probably damaging	Het
Fcrl5	A	G	3: 87,364,698 (GRCm39)	Y566C	probably damaging	Het
Ift57	T	C	16: 49,584,114 (GRCm39)	V289A	probably damaging	Het
Lrrc46	G	A	11: 96,925,806 (GRCm39)	R219C	probably damaging	Het
Mapk1	A	G	16: 16,844,309 (GRCm39)	N269S	probably benign	Het
Mrgprb1	A	T	7: 48,097,469 (GRCm39)	Y148N	probably damaging	Het
Mzt2	G	T	16: 15,680,780 (GRCm39)	A3E	unknown	Het
Naif1	C	T	2: 32,344,887 (GRCm39)	P197L	probably benign	Het
Obscn	A	T	11: 58,977,574 (GRCm39)	V1959E	probably damaging	Het
Obscn	T	C	11: 59,022,472 (GRCm39)	R758G	possibly damaging	Het
Phf12	T	C	11: 77,914,595 (GRCm39)	I130T	possibly damaging	Het
Plekhg3	T	C	12: 76,611,735 (GRCm39)	V338A	probably benign	Het
Prl3b1	A	T	13: 27,433,505 (GRCm39)	N220I	probably damaging	Het
Rusc2	A	G	4: 43,415,456 (GRCm39)	Q254R	probably benign	Het
Ryr1	G	T	7: 28,774,223 (GRCm39)	R2404S	probably damaging	Het
Setdb1	A	G	3: 95,247,506 (GRCm39)	I463T	probably benign	Het
Setx	T	G	2: 29,038,637 (GRCm39)	C1707W	probably damaging	Het
Siglec1	A	G	2: 130,914,667 (GRCm39)	F1483S	possibly damaging	Het
Sis	G	A	3: 72,816,506 (GRCm39)	P1515S	probably benign	Het
Sit1	C	T	4: 43,483,314 (GRCm39)	R50H	possibly damaging	Het
Smc6	T	C	12: 11,326,294 (GRCm39)	V97A	probably damaging	Het
Ttc39d	A	G	17: 80,524,144 (GRCm39)	S268G	probably benign	Het
Ube2frt	A	G	12: 36,140,574 (GRCm39)		probably benign	Het
Utrn	A	T	10: 12,615,105 (GRCm39)		probably null	Het
Vmn2r60	T	A	7: 41,790,403 (GRCm39)	D463E	possibly damaging	Het
Zfp709	A	T	8: 72,643,549 (GRCm39)	D325V	probably benign	Het
Znrf3	A	T	11: 5,239,693 (GRCm39)	D58E	probably damaging	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18,325,820 (GRCm39)	missense	probably benign	0.00
IGL01121:Vmn2r91	APN	17	18,356,766 (GRCm39)	missense	possibly damaging	0.94
IGL01464:Vmn2r91	APN	17	18,327,864 (GRCm39)	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18,327,921 (GRCm39)	missense	probably benign
IGL02709:Vmn2r91	APN	17	18,325,711 (GRCm39)	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18,305,539 (GRCm39)	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18,356,348 (GRCm39)	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18,356,884 (GRCm39)	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18,330,373 (GRCm39)	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18,325,712 (GRCm39)	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18,356,705 (GRCm39)	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18,326,405 (GRCm39)	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18,356,142 (GRCm39)	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18,325,691 (GRCm39)	missense	possibly damaging	0.94
R2424:Vmn2r91	UTSW	17	18,356,431 (GRCm39)	nonsense	probably null
R2512:Vmn2r91	UTSW	17	18,356,048 (GRCm39)	missense	probably benign
R2909:Vmn2r91	UTSW	17	18,356,661 (GRCm39)	missense	probably damaging	1.00
R3009:Vmn2r91	UTSW	17	18,325,717 (GRCm39)	missense	probably benign	0.11
R3079:Vmn2r91	UTSW	17	18,355,973 (GRCm39)	splice site	probably null
R3080:Vmn2r91	UTSW	17	18,355,973 (GRCm39)	splice site	probably null
R3434:Vmn2r91	UTSW	17	18,330,370 (GRCm39)	splice site	probably benign
R3723:Vmn2r91	UTSW	17	18,305,540 (GRCm39)	critical splice donor site	probably null
R3829:Vmn2r91	UTSW	17	18,325,759 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18,330,358 (GRCm39)	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18,356,030 (GRCm39)	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18,325,658 (GRCm39)	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18,356,751 (GRCm39)	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18,330,322 (GRCm39)	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18,356,700 (GRCm39)	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18,356,763 (GRCm39)	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18,326,464 (GRCm39)	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18,356,518 (GRCm39)	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18,326,888 (GRCm39)	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18,355,865 (GRCm39)	splice site	probably null
R6450:Vmn2r91	UTSW	17	18,305,527 (GRCm39)	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18,327,807 (GRCm39)	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18,356,271 (GRCm39)	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18,325,880 (GRCm39)	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18,356,424 (GRCm39)	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18,326,429 (GRCm39)	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18,356,838 (GRCm39)	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18,356,060 (GRCm39)	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18,325,693 (GRCm39)	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18,356,080 (GRCm39)	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18,330,311 (GRCm39)	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18,327,887 (GRCm39)	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18,326,762 (GRCm39)	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18,356,625 (GRCm39)	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18,305,323 (GRCm39)	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18,325,636 (GRCm39)	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18,326,296 (GRCm39)	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18,356,122 (GRCm39)	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18,327,905 (GRCm39)	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18,356,819 (GRCm39)	nonsense	probably null
R9555:Vmn2r91	UTSW	17	18,325,792 (GRCm39)	missense	possibly damaging	0.78
R9616:Vmn2r91	UTSW	17	18,356,305 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- ATGTGCTTGCCTAAATCTAACG -3'
(R):5'- AGTGCAGCAGTGAAGTTTCTC -3'

Sequencing Primer
(F):5'- GTGCTTGCCTAAATCTAACGTATTC -3'
(R):5'- GCAGCAGTGAAGTTTCTCTTTTTAC -3'

Posted On

2015-01-23