Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02342:Tasor'

289145

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tasor

Ensembl Gene

ENSMUSG00000040651

Gene Name

transcription activation suppressor

Synonyms

D14Abb1e, Fam208a, 4933409E02Rik, MommeD6

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02342

Quality Score

Status

Chromosome

Chromosomal Location

27150791-27205512 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 27198624 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 1319 (S1319T)

Ref Sequence

ENSEMBL: ENSMUSP00000022450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022450] [ENSMUST00000223689]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000022450
AA Change: S1319T

PolyPhen 2 Score 0.832 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000022450
Gene: ENSMUSG00000040651
AA Change: S1319T

Domain	Start	End	E-Value	Type
low complexity region	20	27	N/A	INTRINSIC
low complexity region	42	61	N/A	INTRINSIC
low complexity region	74	88	N/A	INTRINSIC
Pfam:DUF3715	153	314	1.5e-55	PFAM
low complexity region	442	457	N/A	INTRINSIC
low complexity region	1087	1102	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000223689

Predicted Effect

probably benign
Transcript: ENSMUST00000225139

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for ENU mutations are not viable past gastrulation. [provided by MGI curators]

Allele List at MGI

All alleles(26) : Gene trapped(26)

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	C	A	10: 43,050,997 (GRCm39)	P97Q	probably damaging	Het
Abcb10	A	T	8: 124,688,773 (GRCm39)	V501E	probably damaging	Het
Acsf3	T	C	8: 123,544,237 (GRCm39)	Y572H	probably benign	Het
Adamts3	A	T	5: 89,839,332 (GRCm39)		probably null	Het
Alox8	A	G	11: 69,077,053 (GRCm39)	L480P	probably damaging	Het
Arhgap35	G	A	7: 16,296,305 (GRCm39)	T920I	probably benign	Het
Brca2	C	A	5: 150,466,289 (GRCm39)	L2018M	possibly damaging	Het
Brdt	C	A	5: 107,490,069 (GRCm39)	H45N	probably damaging	Het
C1s2	A	G	6: 124,609,075 (GRCm39)	F155L	probably damaging	Het
Ccser2	A	G	14: 36,640,562 (GRCm39)		probably benign	Het
Cd8a	T	A	6: 71,350,723 (GRCm39)	C63S	probably damaging	Het
Clk2	A	T	3: 89,082,998 (GRCm39)	T424S	probably benign	Het
Cntn1	A	G	15: 92,143,898 (GRCm39)	E287G	probably benign	Het
Cobl	A	C	11: 12,203,672 (GRCm39)	V928G	possibly damaging	Het
Col12a1	A	G	9: 79,557,178 (GRCm39)		probably null	Het
Crnkl1	A	T	2: 145,766,633 (GRCm39)		probably null	Het
Defb26	T	C	2: 152,350,121 (GRCm39)	N53S	possibly damaging	Het
Duox1	A	T	2: 122,177,793 (GRCm39)	T1526S	probably damaging	Het
Dync2h1	A	G	9: 7,142,246 (GRCm39)	L1233P	probably damaging	Het
Eif5a2	A	G	3: 28,847,910 (GRCm39)	E116G	possibly damaging	Het
Garin1b	A	G	6: 29,323,829 (GRCm39)	T185A	possibly damaging	Het
Gdap2	G	A	3: 100,085,632 (GRCm39)	A185T	probably damaging	Het
Grm8	T	C	6: 27,363,803 (GRCm39)	R571G	probably benign	Het
Hjv	G	A	3: 96,435,488 (GRCm39)	D249N	possibly damaging	Het
Hsp90b1	T	C	10: 86,531,603 (GRCm39)		probably null	Het
Ift70a1	G	T	2: 75,810,976 (GRCm39)	T369K	probably benign	Het
Ighv1-75	T	G	12: 115,797,878 (GRCm39)		probably benign	Het
Ikzf1	A	G	11: 11,650,216 (GRCm39)		probably benign	Het
Itprid2	A	G	2: 79,490,629 (GRCm39)	N943S	probably benign	Het
Kdm4d	A	G	9: 14,374,860 (GRCm39)	W333R	probably damaging	Het
Lama3	A	T	18: 12,624,533 (GRCm39)	N1426I	probably damaging	Het
Lmbrd1	A	G	1: 24,743,959 (GRCm39)	Y119C	probably damaging	Het
Mctp1	A	G	13: 77,172,976 (GRCm39)	Y884C	probably damaging	Het
Naip6	G	T	13: 100,439,748 (GRCm39)	P340T	possibly damaging	Het
Nfkbib	G	T	7: 28,461,528 (GRCm39)	H70N	probably damaging	Het
Nol4	A	T	18: 22,903,926 (GRCm39)		probably benign	Het
Obscn	C	T	11: 58,891,914 (GRCm39)	A6873T	probably benign	Het
Or2ag1	A	G	7: 106,313,232 (GRCm39)	S219P	probably benign	Het
Or51b4	T	A	7: 103,530,587 (GRCm39)	I288F	probably benign	Het
Or6x1	T	A	9: 40,098,823 (GRCm39)	N137K	probably benign	Het
Paqr6	A	G	3: 88,273,491 (GRCm39)	Y136C	probably damaging	Het
Pcdh18	T	A	3: 49,710,493 (GRCm39)	D274V	probably damaging	Het
Phip	A	G	9: 82,768,745 (GRCm39)	Y1196H	probably damaging	Het
Prc1	T	C	7: 79,959,190 (GRCm39)	L345S	probably damaging	Het
Smpdl3a	A	G	10: 57,685,276 (GRCm39)		probably benign	Het
Tac1	G	T	6: 7,559,119 (GRCm39)		probably null	Het
Tg	A	G	15: 66,636,140 (GRCm39)	T576A	probably benign	Het
Thbs2	A	T	17: 14,896,578 (GRCm39)	D770E	probably damaging	Het
Tmem117	T	C	15: 94,909,331 (GRCm39)	V248A	possibly damaging	Het
Trpm8	T	C	1: 88,255,972 (GRCm39)	I209T	possibly damaging	Het
Wrap53	A	G	11: 69,454,417 (GRCm39)	F244L	probably damaging	Het
Wrap73	A	T	4: 154,233,237 (GRCm39)	Q137L	probably benign	Het
Zfhx4	A	T	3: 5,467,434 (GRCm39)	T2531S	probably benign	Het

Other mutations in Tasor

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00093:Tasor	APN	14	27,170,163 (GRCm39)	missense	probably damaging	1.00
IGL00467:Tasor	APN	14	27,170,121 (GRCm39)	missense	probably benign	0.02
IGL01071:Tasor	APN	14	27,164,579 (GRCm39)	critical splice donor site	probably null
IGL01351:Tasor	APN	14	27,186,258 (GRCm39)	missense	probably benign	0.02
IGL01375:Tasor	APN	14	27,162,120 (GRCm39)	missense	probably damaging	1.00
IGL01509:Tasor	APN	14	27,181,731 (GRCm39)	splice site	probably benign
IGL03105:Tasor	APN	14	27,164,509 (GRCm39)	missense	probably damaging	0.98
IGL03131:Tasor	APN	14	27,183,136 (GRCm39)	nonsense	probably null
IGL03248:Tasor	APN	14	27,198,649 (GRCm39)	missense	probably damaging	1.00
IGL03383:Tasor	APN	14	27,163,918 (GRCm39)	missense	possibly damaging	0.93
balsam	UTSW	14	27,183,107 (GRCm39)	missense	probably benign	0.01
santa_rosa	UTSW	14	27,198,658 (GRCm39)	splice site	probably null
D4043:Tasor	UTSW	14	27,193,949 (GRCm39)	missense	probably benign	0.07
R0147:Tasor	UTSW	14	27,193,725 (GRCm39)	missense	probably benign	0.23
R0512:Tasor	UTSW	14	27,168,363 (GRCm39)	missense	probably damaging	1.00
R0589:Tasor	UTSW	14	27,183,107 (GRCm39)	missense	probably benign	0.01
R0609:Tasor	UTSW	14	27,183,707 (GRCm39)	missense	probably benign	0.09
R0798:Tasor	UTSW	14	27,198,593 (GRCm39)	missense	probably damaging	1.00
R1107:Tasor	UTSW	14	27,201,680 (GRCm39)	nonsense	probably null
R1205:Tasor	UTSW	14	27,183,275 (GRCm39)	missense	probably damaging	1.00
R1376:Tasor	UTSW	14	27,151,338 (GRCm39)	missense	probably benign	0.00
R1376:Tasor	UTSW	14	27,151,338 (GRCm39)	missense	probably benign	0.00
R1441:Tasor	UTSW	14	27,186,217 (GRCm39)	nonsense	probably null
R1493:Tasor	UTSW	14	27,171,926 (GRCm39)	missense	probably damaging	1.00
R1527:Tasor	UTSW	14	27,202,050 (GRCm39)	critical splice donor site	probably null
R1729:Tasor	UTSW	14	27,201,590 (GRCm39)	missense	probably damaging	1.00
R1752:Tasor	UTSW	14	27,193,885 (GRCm39)	nonsense	probably null
R1960:Tasor	UTSW	14	27,201,746 (GRCm39)	missense	possibly damaging	0.95
R1960:Tasor	UTSW	14	27,160,621 (GRCm39)	missense	probably damaging	1.00
R1965:Tasor	UTSW	14	27,164,511 (GRCm39)	missense	probably damaging	1.00
R2074:Tasor	UTSW	14	27,183,170 (GRCm39)	missense	probably benign	0.03
R2107:Tasor	UTSW	14	27,183,744 (GRCm39)	critical splice donor site	probably null
R2130:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2130:Tasor	UTSW	14	27,168,345 (GRCm39)	missense	probably damaging	1.00
R2131:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2133:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2140:Tasor	UTSW	14	27,201,992 (GRCm39)	missense	probably damaging	1.00
R2184:Tasor	UTSW	14	27,188,141 (GRCm39)	missense	possibly damaging	0.83
R2279:Tasor	UTSW	14	27,164,452 (GRCm39)	missense	probably damaging	1.00
R3979:Tasor	UTSW	14	27,199,087 (GRCm39)	missense	possibly damaging	0.95
R4113:Tasor	UTSW	14	27,181,918 (GRCm39)	nonsense	probably null
R4434:Tasor	UTSW	14	27,171,818 (GRCm39)	critical splice donor site	probably null
R4562:Tasor	UTSW	14	27,188,265 (GRCm39)	missense	possibly damaging	0.67
R4568:Tasor	UTSW	14	27,198,658 (GRCm39)	splice site	probably null
R4754:Tasor	UTSW	14	27,183,052 (GRCm39)	missense	probably benign
R4980:Tasor	UTSW	14	27,183,382 (GRCm39)	missense	probably benign	0.39
R4993:Tasor	UTSW	14	27,151,071 (GRCm39)	missense	possibly damaging	0.88
R5200:Tasor	UTSW	14	27,151,183 (GRCm39)	missense	probably benign	0.41
R5316:Tasor	UTSW	14	27,193,992 (GRCm39)	missense	possibly damaging	0.52
R5599:Tasor	UTSW	14	27,201,886 (GRCm39)	missense	probably benign	0.01
R5678:Tasor	UTSW	14	27,151,080 (GRCm39)	small insertion	probably benign
R5680:Tasor	UTSW	14	27,151,080 (GRCm39)	small insertion	probably benign
R5887:Tasor	UTSW	14	27,188,254 (GRCm39)	nonsense	probably null
R6181:Tasor	UTSW	14	27,194,235 (GRCm39)	missense	probably benign	0.01
R6556:Tasor	UTSW	14	27,151,215 (GRCm39)	missense	probably benign
R6603:Tasor	UTSW	14	27,168,343 (GRCm39)	missense	probably damaging	1.00
R6829:Tasor	UTSW	14	27,164,438 (GRCm39)	missense	possibly damaging	0.90
R6864:Tasor	UTSW	14	27,183,115 (GRCm39)	missense	probably damaging	0.96
R6919:Tasor	UTSW	14	27,171,758 (GRCm39)	nonsense	probably null
R7046:Tasor	UTSW	14	27,194,392 (GRCm39)	missense	probably damaging	1.00
R7057:Tasor	UTSW	14	27,183,608 (GRCm39)	missense	probably damaging	0.97
R7064:Tasor	UTSW	14	27,194,288 (GRCm39)	missense	probably benign	0.09
R7290:Tasor	UTSW	14	27,160,610 (GRCm39)	missense	probably damaging	1.00
R7303:Tasor	UTSW	14	27,193,809 (GRCm39)	missense	probably damaging	1.00
R7439:Tasor	UTSW	14	27,193,602 (GRCm39)	missense	probably damaging	1.00
R7524:Tasor	UTSW	14	27,188,160 (GRCm39)	missense	probably damaging	0.99
R7580:Tasor	UTSW	14	27,188,243 (GRCm39)	missense	probably benign	0.29
R7726:Tasor	UTSW	14	27,169,454 (GRCm39)	missense	probably damaging	0.99
R7771:Tasor	UTSW	14	27,189,516 (GRCm39)	missense	probably damaging	1.00
R7782:Tasor	UTSW	14	27,193,901 (GRCm39)	missense	probably benign	0.07
R7795:Tasor	UTSW	14	27,203,340 (GRCm39)	missense
R7835:Tasor	UTSW	14	27,198,600 (GRCm39)	missense	probably damaging	1.00
R7954:Tasor	UTSW	14	27,169,481 (GRCm39)	critical splice donor site	probably null
R7981:Tasor	UTSW	14	27,168,373 (GRCm39)	missense	possibly damaging	0.49
R8101:Tasor	UTSW	14	27,164,438 (GRCm39)	missense	possibly damaging	0.90
R8160:Tasor	UTSW	14	27,171,913 (GRCm39)	missense	probably damaging	1.00
R8307:Tasor	UTSW	14	27,193,622 (GRCm39)	missense	probably damaging	1.00
R8913:Tasor	UTSW	14	27,188,145 (GRCm39)	missense	probably damaging	1.00
R9070:Tasor	UTSW	14	27,194,484 (GRCm39)	missense	probably benign	0.14
R9219:Tasor	UTSW	14	27,186,344 (GRCm39)	missense	possibly damaging	0.50
R9420:Tasor	UTSW	14	27,163,927 (GRCm39)	missense	probably damaging	0.99
R9513:Tasor	UTSW	14	27,186,271 (GRCm39)	nonsense	probably null
R9562:Tasor	UTSW	14	27,201,766 (GRCm39)	critical splice donor site	probably null
R9565:Tasor	UTSW	14	27,201,766 (GRCm39)	critical splice donor site	probably null
R9627:Tasor	UTSW	14	27,194,123 (GRCm39)	missense	probably benign
X0002:Tasor	UTSW	14	27,194,063 (GRCm39)	missense	possibly damaging	0.90
Z1176:Tasor	UTSW	14	27,199,105 (GRCm39)	missense	probably damaging	1.00
Z1176:Tasor	UTSW	14	27,151,165 (GRCm39)	missense	probably damaging	0.97
Z1177:Tasor	UTSW	14	27,170,207 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16