Incidental Mutation 'IGL02669:Prl3b1'
ID |
302867 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prl3b1
|
Ensembl Gene |
ENSMUSG00000038891 |
Gene Name |
prolactin family 3, subfamily b, member 1 |
Synonyms |
mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
IGL02669
|
Quality Score |
|
Status
|
|
Chromosome |
13 |
Chromosomal Location |
27426413-27433666 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 27429795 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Leucine
at position 78
(M78L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000047680
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035273]
[ENSMUST00000225089]
|
AlphaFold |
P09586 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000035273
AA Change: M78L
PolyPhen 2
Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000047680 Gene: ENSMUSG00000038891 AA Change: M78L
Domain | Start | End | E-Value | Type |
Pfam:Hormone_1
|
18 |
222 |
1e-55 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000225089
AA Change: M78L
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 46 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A930003A15Rik |
T |
A |
16: 19,702,505 (GRCm39) |
|
noncoding transcript |
Het |
Acap1 |
G |
A |
11: 69,785,421 (GRCm39) |
|
probably benign |
Het |
Adam7 |
T |
C |
14: 68,745,343 (GRCm39) |
Y627C |
probably damaging |
Het |
Agrn |
C |
T |
4: 156,259,018 (GRCm39) |
|
probably benign |
Het |
Aoc1l2 |
A |
G |
6: 48,908,407 (GRCm39) |
Y469C |
probably damaging |
Het |
Bace2 |
T |
C |
16: 97,238,093 (GRCm39) |
*515R |
probably null |
Het |
Baiap3 |
C |
T |
17: 25,463,322 (GRCm39) |
V958M |
probably damaging |
Het |
Brms1l |
A |
T |
12: 55,888,401 (GRCm39) |
D63V |
probably damaging |
Het |
Cnksr1 |
A |
T |
4: 133,957,774 (GRCm39) |
I435N |
probably damaging |
Het |
Col14a1 |
G |
A |
15: 55,282,178 (GRCm39) |
G813E |
unknown |
Het |
Cpne6 |
A |
G |
14: 55,751,283 (GRCm39) |
N201S |
probably benign |
Het |
Dnajc12 |
A |
G |
10: 63,233,071 (GRCm39) |
S71G |
probably damaging |
Het |
Dpp3 |
A |
T |
19: 4,973,710 (GRCm39) |
|
probably null |
Het |
E2f3 |
A |
G |
13: 30,100,974 (GRCm39) |
S239P |
probably benign |
Het |
Eif3e |
T |
A |
15: 43,146,088 (GRCm39) |
M1L |
probably benign |
Het |
Erap1 |
A |
G |
13: 74,823,987 (GRCm39) |
T867A |
probably benign |
Het |
Erlin1 |
G |
T |
19: 44,027,658 (GRCm39) |
A260E |
probably damaging |
Het |
Esrp1 |
A |
G |
4: 11,386,324 (GRCm39) |
V38A |
possibly damaging |
Het |
Foxn1 |
T |
C |
11: 78,261,986 (GRCm39) |
R128G |
probably damaging |
Het |
Gnb3 |
A |
G |
6: 124,814,688 (GRCm39) |
L70P |
probably benign |
Het |
Gon4l |
T |
C |
3: 88,802,806 (GRCm39) |
V1139A |
probably damaging |
Het |
Gpt2 |
G |
T |
8: 86,249,908 (GRCm39) |
M463I |
probably benign |
Het |
Gtpbp3 |
C |
A |
8: 71,943,546 (GRCm39) |
A201D |
probably damaging |
Het |
Jaml |
A |
C |
9: 45,015,489 (GRCm39) |
K331T |
possibly damaging |
Het |
Kntc1 |
G |
A |
5: 123,893,727 (GRCm39) |
|
probably benign |
Het |
Ksr2 |
A |
G |
5: 117,693,446 (GRCm39) |
K298R |
probably damaging |
Het |
Mfge8 |
T |
C |
7: 78,795,429 (GRCm39) |
D46G |
probably benign |
Het |
Ncam2 |
T |
A |
16: 81,314,429 (GRCm39) |
N468K |
probably benign |
Het |
Nup88 |
A |
G |
11: 70,847,110 (GRCm39) |
M300T |
probably damaging |
Het |
Or4c118 |
T |
A |
2: 88,974,564 (GRCm39) |
K268* |
probably null |
Het |
Or4k48 |
A |
T |
2: 111,476,236 (GRCm39) |
Y35* |
probably null |
Het |
Or52b4 |
A |
G |
7: 102,184,868 (GRCm39) |
M305V |
probably benign |
Het |
Prdm1 |
A |
T |
10: 44,315,880 (GRCm39) |
M752K |
probably benign |
Het |
Ralgps2 |
T |
C |
1: 156,660,268 (GRCm39) |
E268G |
probably damaging |
Het |
Rgs11 |
G |
A |
17: 26,426,605 (GRCm39) |
V279I |
probably benign |
Het |
Slc4a5 |
A |
G |
6: 83,240,525 (GRCm39) |
D279G |
possibly damaging |
Het |
Tanc1 |
T |
A |
2: 59,630,330 (GRCm39) |
I770K |
probably damaging |
Het |
Tbl2 |
G |
A |
5: 135,181,852 (GRCm39) |
R64H |
probably damaging |
Het |
Tg |
T |
A |
15: 66,620,575 (GRCm39) |
|
probably benign |
Het |
Tmprss13 |
A |
T |
9: 45,243,824 (GRCm39) |
I187F |
probably benign |
Het |
Tubb3 |
T |
C |
8: 124,147,856 (GRCm39) |
L263P |
probably damaging |
Het |
Vmn2r109 |
T |
G |
17: 20,774,518 (GRCm39) |
D279A |
possibly damaging |
Het |
Vps33b |
A |
G |
7: 79,925,786 (GRCm39) |
|
probably benign |
Het |
Yeats2 |
A |
G |
16: 20,005,033 (GRCm39) |
S338G |
probably benign |
Het |
Zfp142 |
T |
C |
1: 74,610,432 (GRCm39) |
Q1121R |
probably benign |
Het |
Zic1 |
G |
T |
9: 91,246,486 (GRCm39) |
H195Q |
possibly damaging |
Het |
|
Other mutations in Prl3b1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02385:Prl3b1
|
APN |
13 |
27,433,366 (GRCm39) |
missense |
possibly damaging |
0.51 |
IGL03035:Prl3b1
|
APN |
13 |
27,433,516 (GRCm39) |
unclassified |
probably benign |
|
IGL03077:Prl3b1
|
APN |
13 |
27,429,759 (GRCm39) |
missense |
probably benign |
0.00 |
Gabby
|
UTSW |
13 |
27,431,928 (GRCm39) |
missense |
probably damaging |
1.00 |
peaches
|
UTSW |
13 |
27,426,473 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
Pits
|
UTSW |
13 |
27,431,957 (GRCm39) |
critical splice donor site |
probably null |
|
R2014_Prl3b1_632
|
UTSW |
13 |
27,431,948 (GRCm39) |
missense |
probably benign |
0.00 |
R0716:Prl3b1
|
UTSW |
13 |
27,427,779 (GRCm39) |
missense |
probably benign |
0.02 |
R0758:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R0773:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R0774:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R0775:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1364:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1366:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1367:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1368:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1530:Prl3b1
|
UTSW |
13 |
27,427,848 (GRCm39) |
missense |
probably benign |
0.00 |
R1884:Prl3b1
|
UTSW |
13 |
27,431,886 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1990:Prl3b1
|
UTSW |
13 |
27,429,775 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1991:Prl3b1
|
UTSW |
13 |
27,431,895 (GRCm39) |
missense |
possibly damaging |
0.60 |
R2014:Prl3b1
|
UTSW |
13 |
27,431,948 (GRCm39) |
missense |
probably benign |
0.00 |
R2885:Prl3b1
|
UTSW |
13 |
27,433,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R4259:Prl3b1
|
UTSW |
13 |
27,427,889 (GRCm39) |
splice site |
probably null |
|
R4580:Prl3b1
|
UTSW |
13 |
27,433,450 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4913:Prl3b1
|
UTSW |
13 |
27,433,460 (GRCm39) |
missense |
probably damaging |
0.99 |
R5897:Prl3b1
|
UTSW |
13 |
27,429,858 (GRCm39) |
missense |
probably benign |
0.08 |
R6235:Prl3b1
|
UTSW |
13 |
27,431,928 (GRCm39) |
missense |
probably damaging |
1.00 |
R6366:Prl3b1
|
UTSW |
13 |
27,427,875 (GRCm39) |
missense |
probably benign |
0.00 |
R6597:Prl3b1
|
UTSW |
13 |
27,431,957 (GRCm39) |
critical splice donor site |
probably null |
|
R7179:Prl3b1
|
UTSW |
13 |
27,427,827 (GRCm39) |
missense |
probably benign |
0.05 |
R7312:Prl3b1
|
UTSW |
13 |
27,426,473 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
X0026:Prl3b1
|
UTSW |
13 |
27,431,906 (GRCm39) |
missense |
probably benign |
0.21 |
Z1177:Prl3b1
|
UTSW |
13 |
27,427,742 (GRCm39) |
missense |
probably benign |
0.23 |
|
Posted On |
2015-04-16 |