Incidental Mutation 'R0010:Zfp608'
| ID |
32518 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp608
|
| Ensembl Gene |
ENSMUSG00000052713 |
| Gene Name |
zinc finger protein 608 |
| Synonyms |
4932417D18Rik |
| MMRRC Submission |
038305-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.899)
|
| Stock # |
R0010 (G1)
|
| Quality Score |
172 |
|
Status
|
Validated
(trace)
|
| Chromosome |
18 |
| Chromosomal Location |
55021120-55125627 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 55028286 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000068192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064763]
|
| AlphaFold |
Q56A10 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064763
|
| SMART Domains |
Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
51 |
61 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
214 |
234 |
N/A |
INTRINSIC |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
309 |
326 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
459 |
471 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
552 |
577 |
1.86e0 |
SMART |
|
low complexity region
|
624 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
706 |
718 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
773 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
833 |
846 |
N/A |
INTRINSIC |
|
low complexity region
|
934 |
956 |
N/A |
INTRINSIC |
|
coiled coil region
|
1028 |
1054 |
N/A |
INTRINSIC |
|
low complexity region
|
1182 |
1193 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1439 |
1450 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1486 |
1502 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.9%
|
| Validation Efficiency |
100% (89/89) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrf3 |
T |
C |
5: 30,410,607 (GRCm39) |
|
probably benign |
Het |
| Ahrr |
G |
A |
13: 74,431,143 (GRCm39) |
|
probably benign |
Het |
| Aoc1l3 |
A |
T |
6: 48,965,840 (GRCm39) |
H616L |
probably damaging |
Het |
| Bbs7 |
T |
C |
3: 36,661,866 (GRCm39) |
|
probably null |
Het |
| Cacna1h |
T |
C |
17: 25,599,818 (GRCm39) |
K1566E |
probably damaging |
Het |
| Ccdc73 |
C |
T |
2: 104,811,332 (GRCm39) |
|
probably benign |
Het |
| Cd74 |
A |
T |
18: 60,942,143 (GRCm39) |
H124L |
probably benign |
Het |
| Cd74 |
A |
T |
18: 60,936,968 (GRCm39) |
|
probably benign |
Het |
| Cdk5rap2 |
T |
C |
4: 70,161,696 (GRCm39) |
E270G |
probably benign |
Het |
| Ces2a |
G |
A |
8: 105,468,028 (GRCm39) |
D520N |
probably benign |
Het |
| Cldnd1 |
T |
A |
16: 58,551,622 (GRCm39) |
|
probably benign |
Het |
| Cox17 |
T |
A |
16: 38,167,532 (GRCm39) |
C24S |
possibly damaging |
Het |
| Cyp2b9 |
T |
A |
7: 25,886,178 (GRCm39) |
|
probably benign |
Het |
| Dennd4a |
T |
C |
9: 64,803,997 (GRCm39) |
L1112P |
probably benign |
Het |
| Dennd4c |
T |
C |
4: 86,699,814 (GRCm39) |
S222P |
probably damaging |
Het |
| Dhx37 |
T |
A |
5: 125,508,680 (GRCm39) |
Q85L |
probably benign |
Het |
| Egfem1 |
G |
T |
3: 29,637,068 (GRCm39) |
C192F |
probably damaging |
Het |
| Eif3f |
A |
T |
7: 108,540,212 (GRCm39) |
N336Y |
possibly damaging |
Het |
| Evc2 |
T |
A |
5: 37,574,793 (GRCm39) |
L1016Q |
probably damaging |
Het |
| Fam114a2 |
G |
T |
11: 57,404,982 (GRCm39) |
T40N |
probably damaging |
Het |
| Fam135b |
T |
C |
15: 71,493,881 (GRCm39) |
K16R |
probably damaging |
Het |
| Fcho1 |
A |
G |
8: 72,162,643 (GRCm39) |
Y725H |
probably damaging |
Het |
| Frem1 |
T |
C |
4: 82,918,335 (GRCm39) |
I536V |
probably benign |
Het |
| Galnt2l |
G |
A |
8: 122,997,337 (GRCm39) |
|
probably benign |
Het |
| Ginm1 |
T |
C |
10: 7,651,138 (GRCm39) |
|
probably benign |
Het |
| Glrb |
A |
T |
3: 80,767,622 (GRCm39) |
|
probably benign |
Het |
| Glt6d1 |
C |
A |
2: 25,684,739 (GRCm39) |
|
probably null |
Het |
| Gm10320 |
T |
C |
13: 98,626,054 (GRCm39) |
Y110C |
probably damaging |
Het |
| Gm3985 |
A |
T |
8: 33,432,484 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5422 |
A |
G |
10: 31,125,750 (GRCm39) |
|
noncoding transcript |
Het |
| Igkv6-29 |
A |
T |
6: 70,115,754 (GRCm39) |
|
probably benign |
Het |
| Inpp5d |
G |
A |
1: 87,625,268 (GRCm39) |
|
probably null |
Het |
| Itpr3 |
T |
G |
17: 27,339,951 (GRCm39) |
V2610G |
probably damaging |
Het |
| Kmt5c |
T |
A |
7: 4,749,207 (GRCm39) |
M88K |
probably benign |
Het |
| Lrp12 |
C |
T |
15: 39,741,672 (GRCm39) |
A367T |
probably damaging |
Het |
| Ltbp1 |
A |
G |
17: 75,670,386 (GRCm39) |
T1476A |
probably damaging |
Het |
| Mcoln2 |
C |
T |
3: 145,889,316 (GRCm39) |
T374M |
probably damaging |
Het |
| Milr1 |
T |
G |
11: 106,657,829 (GRCm39) |
*209G |
probably null |
Het |
| Mitf |
A |
G |
6: 97,784,242 (GRCm39) |
K33R |
probably benign |
Het |
| Mon2 |
A |
C |
10: 122,868,599 (GRCm39) |
S485A |
probably damaging |
Het |
| Mpdu1 |
C |
T |
11: 69,549,667 (GRCm39) |
G47R |
probably damaging |
Het |
| Ms4a4d |
A |
G |
19: 11,532,190 (GRCm39) |
N112S |
probably damaging |
Het |
| Mybpc3 |
G |
A |
2: 90,965,178 (GRCm39) |
W1082* |
probably null |
Het |
| Myl3 |
A |
C |
9: 110,596,997 (GRCm39) |
D119A |
probably damaging |
Het |
| Naa15 |
A |
T |
3: 51,343,634 (GRCm39) |
|
probably null |
Het |
| Nav3 |
A |
G |
10: 109,659,087 (GRCm39) |
|
probably benign |
Het |
| Nek7 |
T |
A |
1: 138,471,942 (GRCm39) |
Q66L |
possibly damaging |
Het |
| Nktr |
G |
A |
9: 121,570,232 (GRCm39) |
|
probably benign |
Het |
| Nlgn1 |
G |
T |
3: 25,490,006 (GRCm39) |
|
probably benign |
Het |
| Npr1 |
T |
C |
3: 90,362,139 (GRCm39) |
E1002G |
probably damaging |
Het |
| Nup133 |
A |
T |
8: 124,631,318 (GRCm39) |
I1072N |
probably damaging |
Het |
| Oc90 |
C |
T |
15: 65,748,397 (GRCm39) |
C371Y |
probably damaging |
Het |
| Or5ak24 |
A |
T |
2: 85,260,239 (GRCm39) |
D311E |
probably benign |
Het |
| Or7g20 |
A |
T |
9: 18,946,618 (GRCm39) |
L66F |
probably damaging |
Het |
| Or8b42 |
A |
T |
9: 38,342,216 (GRCm39) |
I213F |
possibly damaging |
Het |
| Pradc1 |
A |
T |
6: 85,424,213 (GRCm39) |
N44K |
probably damaging |
Het |
| Pradc1 |
T |
C |
6: 85,424,602 (GRCm39) |
D116G |
probably damaging |
Het |
| Ptprk |
G |
A |
10: 28,461,965 (GRCm39) |
C91Y |
probably damaging |
Het |
| Pus7 |
T |
C |
5: 23,952,843 (GRCm39) |
I491V |
probably benign |
Het |
| Rock1 |
T |
A |
18: 10,084,380 (GRCm39) |
D951V |
probably damaging |
Het |
| Scgb2b26 |
T |
A |
7: 33,643,774 (GRCm39) |
E55D |
probably damaging |
Het |
| Scn8a |
T |
C |
15: 100,911,454 (GRCm39) |
V958A |
probably damaging |
Het |
| Sec14l1 |
T |
C |
11: 117,034,596 (GRCm39) |
|
probably benign |
Het |
| Sec24c |
A |
G |
14: 20,739,329 (GRCm39) |
|
probably benign |
Het |
| Sema6b |
C |
T |
17: 56,431,105 (GRCm39) |
E853K |
probably benign |
Het |
| Sgk1 |
G |
A |
10: 21,873,337 (GRCm39) |
|
probably null |
Het |
| Shprh |
C |
T |
10: 11,027,675 (GRCm39) |
T94I |
probably benign |
Het |
| Slc16a3 |
T |
C |
11: 120,847,531 (GRCm39) |
S240P |
probably benign |
Het |
| Slc5a8 |
T |
C |
10: 88,722,452 (GRCm39) |
V95A |
probably benign |
Het |
| Smg1 |
A |
T |
7: 117,771,082 (GRCm39) |
|
probably benign |
Het |
| Spta1 |
G |
A |
1: 174,045,509 (GRCm39) |
V1556I |
probably benign |
Het |
| Trappc14 |
T |
C |
5: 138,258,555 (GRCm39) |
|
probably null |
Het |
| Trappc4 |
G |
A |
9: 44,316,528 (GRCm39) |
|
probably benign |
Het |
| Tubgcp6 |
A |
G |
15: 88,987,386 (GRCm39) |
S1188P |
probably benign |
Het |
| Txlna |
T |
G |
4: 129,522,879 (GRCm39) |
D487A |
probably benign |
Het |
| Ube2d2b |
T |
C |
5: 107,978,502 (GRCm39) |
F51S |
possibly damaging |
Het |
| Vmn2r6 |
G |
A |
3: 64,466,966 (GRCm39) |
Q178* |
probably null |
Het |
| Wdfy3 |
T |
C |
5: 101,996,215 (GRCm39) |
T3234A |
probably damaging |
Het |
| Ylpm1 |
C |
A |
12: 85,075,800 (GRCm39) |
Q384K |
probably damaging |
Het |
| Zbtb41 |
T |
G |
1: 139,351,268 (GRCm39) |
V127G |
probably damaging |
Het |
| Zfp605 |
T |
A |
5: 110,275,400 (GRCm39) |
C173S |
probably benign |
Het |
| Zhx2 |
T |
C |
15: 57,684,670 (GRCm39) |
V13A |
possibly damaging |
Het |
|
| Other mutations in Zfp608 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Zfp608
|
APN |
18 |
55,121,405 (GRCm39) |
missense |
probably benign |
|
|
IGL00920:Zfp608
|
APN |
18 |
55,022,903 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01088:Zfp608
|
APN |
18 |
55,031,159 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01447:Zfp608
|
APN |
18 |
55,032,083 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01534:Zfp608
|
APN |
18 |
55,032,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01547:Zfp608
|
APN |
18 |
55,027,521 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01933:Zfp608
|
APN |
18 |
55,120,871 (GRCm39) |
missense |
probably benign |
|
|
IGL01998:Zfp608
|
APN |
18 |
55,024,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02167:Zfp608
|
APN |
18 |
55,121,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02266:Zfp608
|
APN |
18 |
55,030,653 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02335:Zfp608
|
APN |
18 |
55,030,509 (GRCm39) |
nonsense |
probably null |
|
|
IGL02455:Zfp608
|
APN |
18 |
55,032,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02612:Zfp608
|
APN |
18 |
55,031,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02900:Zfp608
|
APN |
18 |
55,079,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4243001:Zfp608
|
UTSW |
18 |
55,031,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4519001:Zfp608
|
UTSW |
18 |
55,079,783 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0005:Zfp608
|
UTSW |
18 |
55,028,592 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0010:Zfp608
|
UTSW |
18 |
55,028,286 (GRCm39) |
splice site |
probably benign |
|
|
R0064:Zfp608
|
UTSW |
18 |
55,031,888 (GRCm39) |
missense |
probably benign |
|
|
R0401:Zfp608
|
UTSW |
18 |
55,032,066 (GRCm39) |
missense |
probably benign |
|
|
R0722:Zfp608
|
UTSW |
18 |
55,033,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1351:Zfp608
|
UTSW |
18 |
55,031,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1512:Zfp608
|
UTSW |
18 |
55,079,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1554:Zfp608
|
UTSW |
18 |
55,031,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1622:Zfp608
|
UTSW |
18 |
55,121,366 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1669:Zfp608
|
UTSW |
18 |
55,120,811 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1690:Zfp608
|
UTSW |
18 |
55,120,706 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1721:Zfp608
|
UTSW |
18 |
55,032,321 (GRCm39) |
missense |
probably benign |
|
|
R1826:Zfp608
|
UTSW |
18 |
55,031,648 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1864:Zfp608
|
UTSW |
18 |
55,030,983 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1952:Zfp608
|
UTSW |
18 |
55,030,851 (GRCm39) |
nonsense |
probably null |
|
|
R2049:Zfp608
|
UTSW |
18 |
55,028,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Zfp608
|
UTSW |
18 |
55,121,386 (GRCm39) |
missense |
probably benign |
|
|
R2168:Zfp608
|
UTSW |
18 |
55,031,125 (GRCm39) |
nonsense |
probably null |
|
|
R2218:Zfp608
|
UTSW |
18 |
55,120,756 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2283:Zfp608
|
UTSW |
18 |
55,121,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2399:Zfp608
|
UTSW |
18 |
55,030,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Zfp608
|
UTSW |
18 |
55,121,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2961:Zfp608
|
UTSW |
18 |
55,031,544 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R4074:Zfp608
|
UTSW |
18 |
55,031,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4076:Zfp608
|
UTSW |
18 |
55,031,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4206:Zfp608
|
UTSW |
18 |
55,121,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4756:Zfp608
|
UTSW |
18 |
55,027,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Zfp608
|
UTSW |
18 |
55,121,372 (GRCm39) |
missense |
probably benign |
|
|
R4820:Zfp608
|
UTSW |
18 |
55,120,756 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4825:Zfp608
|
UTSW |
18 |
55,031,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4912:Zfp608
|
UTSW |
18 |
55,079,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Zfp608
|
UTSW |
18 |
55,022,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Zfp608
|
UTSW |
18 |
55,024,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5192:Zfp608
|
UTSW |
18 |
55,031,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5557:Zfp608
|
UTSW |
18 |
55,120,942 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5624:Zfp608
|
UTSW |
18 |
55,031,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5818:Zfp608
|
UTSW |
18 |
55,028,468 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5840:Zfp608
|
UTSW |
18 |
55,031,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5992:Zfp608
|
UTSW |
18 |
55,032,320 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6106:Zfp608
|
UTSW |
18 |
55,120,944 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6174:Zfp608
|
UTSW |
18 |
55,121,616 (GRCm39) |
start gained |
probably benign |
|
|
R6181:Zfp608
|
UTSW |
18 |
55,028,700 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6517:Zfp608
|
UTSW |
18 |
55,032,150 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6567:Zfp608
|
UTSW |
18 |
55,030,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6668:Zfp608
|
UTSW |
18 |
55,031,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6920:Zfp608
|
UTSW |
18 |
55,121,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Zfp608
|
UTSW |
18 |
55,121,069 (GRCm39) |
missense |
probably benign |
|
|
R7074:Zfp608
|
UTSW |
18 |
55,030,454 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7087:Zfp608
|
UTSW |
18 |
55,032,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7391:Zfp608
|
UTSW |
18 |
55,030,619 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7600:Zfp608
|
UTSW |
18 |
55,121,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7723:Zfp608
|
UTSW |
18 |
55,030,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Zfp608
|
UTSW |
18 |
55,032,618 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8236:Zfp608
|
UTSW |
18 |
55,032,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Zfp608
|
UTSW |
18 |
55,030,821 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8732:Zfp608
|
UTSW |
18 |
55,121,072 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8781:Zfp608
|
UTSW |
18 |
55,031,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Zfp608
|
UTSW |
18 |
55,032,194 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8940:Zfp608
|
UTSW |
18 |
55,033,301 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9051:Zfp608
|
UTSW |
18 |
55,032,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Zfp608
|
UTSW |
18 |
55,032,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9092:Zfp608
|
UTSW |
18 |
55,031,648 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9236:Zfp608
|
UTSW |
18 |
55,032,354 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9270:Zfp608
|
UTSW |
18 |
55,032,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9283:Zfp608
|
UTSW |
18 |
55,030,913 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9288:Zfp608
|
UTSW |
18 |
55,033,341 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9463:Zfp608
|
UTSW |
18 |
55,030,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTAGAGCCCAAGGACTCTTGAC -3'
(R):5'- AAAGAGGGCAAGCGTCCTGATTC -3'
Sequencing Primer
(F):5'- AGCCCAAGGACTCTTGACATTTC -3'
(R):5'- GTCCTGATTCCCAGTCGGTG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation