Incidental Mutation 'IGL03263:Polr3c'
ID414984
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Polr3c
Ensembl Gene ENSMUSG00000028099
Gene Namepolymerase (RNA) III (DNA directed) polypeptide C
Synonyms4933407E01Rik, RPC62, RPC3
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.960) question?
Stock #IGL03263
Quality Score
Status
Chromosome3
Chromosomal Location96711490-96727628 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to T at 96714251 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122435 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029741] [ENSMUST00000154679]
Predicted Effect probably benign
Transcript: ENSMUST00000029741
SMART Domains Protein: ENSMUSP00000029741
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:HTH_9 7 68 9.4e-26 PFAM
Pfam:RNA_pol_Rpc82 146 344 7.6e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128918
SMART Domains Protein: ENSMUSP00000119236
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:RNA_pol_Rpc82 20 180 5.9e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137009
Predicted Effect probably benign
Transcript: ENSMUST00000154679
SMART Domains Protein: ENSMUSP00000122435
Gene: ENSMUSG00000028099

DomainStartEndE-ValueType
Pfam:HTH_9 7 68 1.6e-26 PFAM
Pfam:RNA_pol_Rpc82 146 344 7.6e-46 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik T A 5: 138,564,237 I81F probably damaging Het
Acacb C T 5: 114,213,693 H1164Y probably damaging Het
Adamts5 A T 16: 85,869,942 V554E probably damaging Het
Asns G A 6: 7,689,404 R33C probably benign Het
BC051076 T G 5: 87,964,118 noncoding transcript Het
Bcas3 C T 11: 85,822,122 probably benign Het
Bpifb1 A G 2: 154,215,306 M395V probably benign Het
Cdcp1 C A 9: 123,180,087 V509L probably benign Het
Cdhr2 A G 13: 54,718,113 T277A possibly damaging Het
Ces1d C A 8: 93,169,718 probably null Het
Clca4a T A 3: 144,966,431 E250V probably damaging Het
Cplx4 T C 18: 65,967,488 D79G probably benign Het
Dcaf11 A G 14: 55,565,492 D246G probably damaging Het
Dnah2 A T 11: 69,529,381 probably null Het
Dock3 A T 9: 106,930,131 probably benign Het
Fam170a T C 18: 50,280,521 probably benign Het
Fgfr2 T A 7: 130,180,419 M423L probably benign Het
Gabra2 A G 5: 70,973,493 F331L probably damaging Het
Galnt18 C T 7: 111,520,114 R400Q probably damaging Het
Gm884 A G 11: 103,613,699 V2481A possibly damaging Het
H2-M11 A T 17: 36,548,913 Q266L probably damaging Het
Igf2bp1 A T 11: 95,966,673 V502D probably damaging Het
Ik A G 18: 36,748,646 N111S probably damaging Het
Intu T A 3: 40,672,597 Y269* probably null Het
Krt82 T C 15: 101,541,872 Y463C probably benign Het
Lrig1 A G 6: 94,611,647 M507T probably benign Het
Mag T G 7: 30,899,528 probably null Het
Map7 T A 10: 20,245,322 Y121* probably null Het
March6 A G 15: 31,486,362 I349T probably benign Het
Mas1 A G 17: 12,841,564 V324A possibly damaging Het
Nckap1l T C 15: 103,464,405 W259R probably damaging Het
Nhsl1 T A 10: 18,498,079 Y164* probably null Het
Olfr678 T A 7: 105,070,002 H178Q probably damaging Het
Olfr885 A T 9: 38,061,713 Y131F probably damaging Het
Pcdhb2 A G 18: 37,296,006 D344G probably damaging Het
Pclo T C 5: 14,681,810 V3442A unknown Het
Ppp2r2d C T 7: 138,872,922 R11* probably null Het
Ptgfr T A 3: 151,835,863 M3L probably benign Het
Rfx6 A G 10: 51,725,807 S741G probably benign Het
Rif1 T C 2: 52,090,261 V490A probably damaging Het
Samd7 T A 3: 30,762,153 H349Q probably damaging Het
Sh3pxd2a T C 19: 47,314,043 N199S probably damaging Het
Spef2 T A 15: 9,667,219 K794N possibly damaging Het
Spta1 C T 1: 174,213,918 A1316V probably damaging Het
Vwa7 A G 17: 35,021,599 E410G probably benign Het
Washc2 T A 6: 116,238,123 probably benign Het
Wdr72 A C 9: 74,157,429 Y581S probably damaging Het
Zdhhc17 T C 10: 110,961,016 D298G probably damaging Het
Other mutations in Polr3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Polr3c APN 3 96713520 missense probably damaging 1.00
IGL01904:Polr3c APN 3 96716665 critical splice donor site probably null
IGL01964:Polr3c APN 3 96711975 unclassified probably benign
IGL02640:Polr3c APN 3 96716686 missense probably damaging 0.98
IGL02955:Polr3c APN 3 96714312 missense probably damaging 1.00
IGL03129:Polr3c APN 3 96719454 splice site probably benign
R0503:Polr3c UTSW 3 96713636 splice site probably null
R0800:Polr3c UTSW 3 96719311 missense probably damaging 0.99
R0881:Polr3c UTSW 3 96723847 missense probably damaging 0.99
R1763:Polr3c UTSW 3 96713595 missense probably damaging 1.00
R1931:Polr3c UTSW 3 96719298 missense probably damaging 1.00
R1932:Polr3c UTSW 3 96719298 missense probably damaging 1.00
R1994:Polr3c UTSW 3 96714373 splice site probably null
R3771:Polr3c UTSW 3 96725854 missense probably damaging 1.00
R4116:Polr3c UTSW 3 96715244 missense probably damaging 1.00
R4614:Polr3c UTSW 3 96716471 missense probably benign 0.00
R4732:Polr3c UTSW 3 96723661 missense probably damaging 1.00
R4733:Polr3c UTSW 3 96723661 missense probably damaging 1.00
R5057:Polr3c UTSW 3 96712057 missense probably damaging 0.98
R5058:Polr3c UTSW 3 96723517 missense probably benign 0.01
R5756:Polr3c UTSW 3 96714134 missense probably damaging 1.00
R6005:Polr3c UTSW 3 96719468 missense possibly damaging 0.96
R6009:Polr3c UTSW 3 96713614 missense probably damaging 1.00
R6580:Polr3c UTSW 3 96727343 splice site probably null
R7003:Polr3c UTSW 3 96723638 missense possibly damaging 0.94
Posted On2016-08-02