Incidental Mutation 'R5906:Nisch'
| ID |
460657 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nisch
|
| Ensembl Gene |
ENSMUSG00000021910 |
| Gene Name |
nischarin |
| Synonyms |
1200007D05Rik, edsn, 3202002H23Rik |
| MMRRC Submission |
044103-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5906 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
30892885-30928783 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 30893985 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022469]
[ENSMUST00000036618]
[ENSMUST00000167449]
[ENSMUST00000168206]
[ENSMUST00000169628]
[ENSMUST00000169628]
|
| AlphaFold |
Q80TM9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000022469
AA Change: Q1441L
PolyPhen 2
Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000022469
Gene: ENSMUSG00000021910
AA Change: Q1441L
| Domain | Start | End | E-Value | Type |
|---|
|
PX
|
15 |
119 |
2.17e-26 |
SMART |
|
PDB:4PQ8|A
|
287 |
420 |
9e-8 |
PDB |
|
SCOP:d1h6ta2
|
291 |
421 |
6e-29 |
SMART |
|
Blast:LRR
|
311 |
332 |
5e-6 |
BLAST |
|
Blast:LRR
|
333 |
355 |
6e-6 |
BLAST |
|
Blast:LRR
|
378 |
403 |
5e-7 |
BLAST |
|
Blast:LRR
|
403 |
429 |
6e-7 |
BLAST |
|
low complexity region
|
489 |
501 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
534 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
662 |
695 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1193 |
N/A |
INTRINSIC |
|
low complexity region
|
1491 |
1509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000036618
|
| SMART Domains |
Protein: ENSMUSP00000046199
Gene: ENSMUSG00000042286
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
EGF
|
112 |
149 |
6.65e-2 |
SMART |
|
EGF
|
160 |
194 |
2.28e0 |
SMART |
|
EGF
|
199 |
232 |
1.4e0 |
SMART |
|
EGF
|
236 |
272 |
4.97e-1 |
SMART |
|
EGF
|
276 |
319 |
1.95e1 |
SMART |
|
EGF_like
|
321 |
357 |
5.03e1 |
SMART |
|
low complexity region
|
400 |
413 |
N/A |
INTRINSIC |
|
Blast:FAS1
|
414 |
501 |
2e-52 |
BLAST |
|
FAS1
|
543 |
645 |
1.35e-24 |
SMART |
|
EGF_like
|
780 |
817 |
5.45e1 |
SMART |
|
EGF
|
822 |
861 |
1.08e-1 |
SMART |
|
EGF
|
865 |
904 |
3.15e-3 |
SMART |
|
EGF
|
908 |
947 |
1.3e1 |
SMART |
|
EGF
|
951 |
989 |
1.47e1 |
SMART |
|
FAS1
|
1023 |
1122 |
1.3e-17 |
SMART |
|
FAS1
|
1165 |
1257 |
2.94e0 |
SMART |
|
EGF
|
1332 |
1369 |
1.4e0 |
SMART |
|
EGF
|
1379 |
1413 |
1.88e-1 |
SMART |
|
EGF
|
1420 |
1455 |
6.02e0 |
SMART |
|
EGF
|
1459 |
1497 |
3.82e-2 |
SMART |
|
EGF
|
1501 |
1540 |
2.05e-2 |
SMART |
|
EGF
|
1544 |
1583 |
2.25e1 |
SMART |
|
FAS1
|
1616 |
1712 |
1.61e-22 |
SMART |
|
FAS1
|
1763 |
1868 |
2.12e-17 |
SMART |
|
EGF
|
1970 |
2007 |
1.26e-2 |
SMART |
|
EGF
|
2017 |
2051 |
1.61e0 |
SMART |
|
EGF
|
2059 |
2090 |
2.45e0 |
SMART |
|
EGF
|
2094 |
2131 |
3.46e0 |
SMART |
|
EGF
|
2135 |
2174 |
3.82e-2 |
SMART |
|
LINK
|
2206 |
2301 |
8.55e-49 |
SMART |
|
FAS1
|
2367 |
2462 |
2.06e-6 |
SMART |
|
transmembrane domain
|
2476 |
2498 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159532
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163552
|
| SMART Domains |
Protein: ENSMUSP00000131689
Gene: ENSMUSG00000021910
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
139 |
242 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167449
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168206
AA Change: Q1196L
PolyPhen 2
Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132842
Gene: ENSMUSG00000021910
AA Change: Q1196L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:LRR_8
|
44 |
101 |
3.9e-9 |
PFAM |
|
Pfam:LRR_1
|
45 |
66 |
2.6e-2 |
PFAM |
|
Pfam:LRR_6
|
88 |
109 |
1.1e-2 |
PFAM |
|
Pfam:LRR_4
|
89 |
132 |
6.5e-8 |
PFAM |
|
Pfam:LRR_1
|
90 |
109 |
6.9e-2 |
PFAM |
|
Blast:LRR
|
133 |
158 |
4e-7 |
BLAST |
|
Blast:LRR
|
158 |
184 |
6e-7 |
BLAST |
|
low complexity region
|
244 |
256 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
289 |
N/A |
INTRINSIC |
|
coiled coil region
|
380 |
405 |
N/A |
INTRINSIC |
|
low complexity region
|
417 |
450 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
948 |
N/A |
INTRINSIC |
|
low complexity region
|
1246 |
1264 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168451
|
| SMART Domains |
Protein: ENSMUSP00000132912
Gene: ENSMUSG00000021910
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PX
|
4 |
53 |
5.5e-8 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169628
|
| SMART Domains |
Protein: ENSMUSP00000131465
Gene: ENSMUSG00000021910
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
231 |
249 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169628
|
| SMART Domains |
Protein: ENSMUSP00000131465
Gene: ENSMUSG00000021910
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
231 |
249 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170253
|
| SMART Domains |
Protein: ENSMUSP00000129547
Gene: ENSMUSG00000021910
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1dcea3
|
2 |
86 |
3e-11 |
SMART |
|
Blast:LRR
|
13 |
34 |
1e-5 |
BLAST |
|
Blast:LRR
|
35 |
60 |
1e-7 |
BLAST |
|
Blast:LRR
|
60 |
86 |
2e-8 |
BLAST |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.4%
- 20x: 92.4%
|
| Validation Efficiency |
95% (81/85) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for either a knock-out or hypomorphic allele exhibit hearing loss associated with increased susceptibility to otitis media. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930438A08Rik |
C |
A |
11: 58,182,260 (GRCm39) |
|
probably null |
Het |
| 9130023H24Rik |
G |
A |
7: 127,835,664 (GRCm39) |
P310S |
probably benign |
Het |
| Abcc10 |
G |
T |
17: 46,627,485 (GRCm39) |
H652Q |
probably benign |
Het |
| Actl6b |
A |
G |
5: 137,565,591 (GRCm39) |
I396V |
possibly damaging |
Het |
| Acvr1b |
T |
C |
15: 101,091,772 (GRCm39) |
|
probably benign |
Het |
| Adamts18 |
A |
T |
8: 114,436,251 (GRCm39) |
H989Q |
probably benign |
Het |
| Adamtsl4 |
T |
C |
3: 95,588,094 (GRCm39) |
Y631C |
probably damaging |
Het |
| Angptl3 |
A |
G |
4: 98,925,804 (GRCm39) |
T377A |
probably benign |
Het |
| Ankmy2 |
G |
A |
12: 36,226,632 (GRCm39) |
V109M |
probably damaging |
Het |
| Anpep |
G |
A |
7: 79,483,423 (GRCm39) |
A689V |
probably benign |
Het |
| Brwd1 |
A |
T |
16: 95,859,938 (GRCm39) |
M350K |
probably damaging |
Het |
| Cacna1d |
C |
T |
14: 29,818,917 (GRCm39) |
V1213I |
probably damaging |
Het |
| Capn1 |
A |
G |
19: 6,061,451 (GRCm39) |
F156L |
possibly damaging |
Het |
| Catsperb |
C |
A |
12: 101,476,721 (GRCm39) |
F408L |
probably damaging |
Het |
| Ccdc146 |
A |
T |
5: 21,506,350 (GRCm39) |
L697Q |
possibly damaging |
Het |
| Cdc37l1 |
T |
A |
19: 28,989,386 (GRCm39) |
V281E |
probably benign |
Het |
| Chia1 |
A |
T |
3: 106,039,304 (GRCm39) |
T465S |
probably benign |
Het |
| Cidec |
A |
T |
6: 113,405,282 (GRCm39) |
|
probably null |
Het |
| Clcnkb |
T |
C |
4: 141,139,610 (GRCm39) |
T131A |
probably benign |
Het |
| Clec5a |
T |
A |
6: 40,558,793 (GRCm39) |
M98L |
probably benign |
Het |
| Cnga1 |
A |
T |
5: 72,768,201 (GRCm39) |
F162I |
probably benign |
Het |
| Cyp27b1 |
A |
T |
10: 126,884,267 (GRCm39) |
I40F |
probably damaging |
Het |
| Edrf1 |
A |
G |
7: 133,265,144 (GRCm39) |
S1027G |
probably benign |
Het |
| Entpd1 |
C |
A |
19: 40,727,283 (GRCm39) |
A448E |
probably damaging |
Het |
| Espl1 |
T |
C |
15: 102,205,286 (GRCm39) |
|
probably null |
Het |
| Etfdh |
T |
C |
3: 79,511,422 (GRCm39) |
I520V |
probably damaging |
Het |
| Fchsd1 |
C |
T |
18: 38,092,926 (GRCm39) |
|
probably benign |
Het |
| Gabra4 |
G |
A |
5: 71,781,253 (GRCm39) |
P386L |
probably benign |
Het |
| Gckr |
G |
T |
5: 31,463,922 (GRCm39) |
V281L |
probably damaging |
Het |
| Gfy |
T |
C |
7: 44,827,167 (GRCm39) |
T310A |
probably benign |
Het |
| Gjc2 |
C |
A |
11: 59,067,667 (GRCm39) |
V272L |
probably benign |
Het |
| Gm13441 |
G |
C |
2: 31,777,511 (GRCm39) |
|
silent |
Het |
| H2-DMb2 |
T |
A |
17: 34,367,582 (GRCm39) |
M1K |
probably null |
Het |
| Hipk3 |
T |
C |
2: 104,302,153 (GRCm39) |
Y13C |
probably damaging |
Het |
| Kcnt1 |
A |
T |
2: 25,784,536 (GRCm39) |
|
probably benign |
Het |
| Kcnt1 |
T |
C |
2: 25,788,413 (GRCm39) |
F336S |
probably damaging |
Het |
| Klhdc7b |
A |
G |
15: 89,271,359 (GRCm39) |
D747G |
probably benign |
Het |
| Krt78 |
T |
A |
15: 101,857,030 (GRCm39) |
E359V |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,872,252 (GRCm39) |
D2195G |
probably benign |
Het |
| Matk |
C |
T |
10: 81,096,753 (GRCm39) |
L188F |
probably damaging |
Het |
| Mcoln2 |
T |
C |
3: 145,889,496 (GRCm39) |
I399T |
probably damaging |
Het |
| Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
| Nap1l1 |
A |
T |
10: 111,326,891 (GRCm39) |
K151* |
probably null |
Het |
| Ncbp3 |
T |
A |
11: 72,964,327 (GRCm39) |
S426T |
probably benign |
Het |
| Or4k15b |
T |
C |
14: 50,272,306 (GRCm39) |
T185A |
probably benign |
Het |
| Or5b113 |
T |
C |
19: 13,342,369 (GRCm39) |
C126R |
probably damaging |
Het |
| Or8a1b |
A |
G |
9: 37,623,101 (GRCm39) |
I158T |
probably benign |
Het |
| Or8b8 |
A |
G |
9: 37,809,174 (GRCm39) |
H158R |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,720,854 (GRCm39) |
D17G |
probably damaging |
Het |
| Pkd1 |
G |
A |
17: 24,791,894 (GRCm39) |
V1194M |
probably benign |
Het |
| Pkd1l2 |
A |
T |
8: 117,756,387 (GRCm39) |
I1615N |
probably damaging |
Het |
| Pkd2 |
A |
T |
5: 104,625,045 (GRCm39) |
|
probably null |
Het |
| Pkp4 |
T |
A |
2: 59,135,420 (GRCm39) |
N97K |
possibly damaging |
Het |
| Prrx2 |
C |
T |
2: 30,769,522 (GRCm39) |
R78C |
probably damaging |
Het |
| Pycr1 |
T |
A |
11: 120,532,988 (GRCm39) |
I91F |
probably damaging |
Het |
| Rap1a |
T |
C |
3: 105,645,081 (GRCm39) |
N87S |
possibly damaging |
Het |
| Sbk2 |
T |
G |
7: 4,960,627 (GRCm39) |
Y181S |
probably damaging |
Het |
| Scart1 |
T |
A |
7: 139,808,712 (GRCm39) |
D874E |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,328,843 (GRCm39) |
H1057Q |
possibly damaging |
Het |
| Sfswap |
G |
A |
5: 129,619,107 (GRCm39) |
E486K |
probably benign |
Het |
| Shank3 |
T |
C |
15: 89,433,119 (GRCm39) |
V1213A |
probably damaging |
Het |
| Slfn5 |
T |
A |
11: 82,848,102 (GRCm39) |
I329K |
probably benign |
Het |
| Slit1 |
T |
A |
19: 41,594,813 (GRCm39) |
N1186Y |
probably damaging |
Het |
| Ssbp3 |
A |
G |
4: 106,867,018 (GRCm39) |
|
probably benign |
Het |
| Steap3 |
T |
A |
1: 120,171,731 (GRCm39) |
I125F |
probably damaging |
Het |
| Synpr |
C |
A |
14: 13,608,788 (GRCm38) |
|
probably benign |
Het |
| Tom1 |
T |
C |
8: 75,776,886 (GRCm39) |
L69P |
probably damaging |
Het |
| Traf3ip3 |
T |
A |
1: 192,880,314 (GRCm39) |
D5V |
possibly damaging |
Het |
| Vmn1r29 |
G |
A |
6: 58,284,736 (GRCm39) |
S152N |
probably benign |
Het |
| Vmn1r68 |
T |
C |
7: 10,261,550 (GRCm39) |
I183V |
probably benign |
Het |
| Wdr17 |
C |
G |
8: 55,092,503 (GRCm39) |
V1094L |
probably benign |
Het |
| Wdr95 |
A |
G |
5: 149,487,692 (GRCm39) |
I109V |
possibly damaging |
Het |
| Zfp39 |
T |
C |
11: 58,793,717 (GRCm39) |
D7G |
probably benign |
Het |
| Zfp512 |
A |
T |
5: 31,637,408 (GRCm39) |
Q443L |
probably damaging |
Het |
| Zfp974 |
T |
A |
7: 27,610,230 (GRCm39) |
K498N |
possibly damaging |
Het |
|
| Other mutations in Nisch |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01782:Nisch
|
APN |
14 |
30,898,596 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01934:Nisch
|
APN |
14 |
30,898,696 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02201:Nisch
|
APN |
14 |
30,909,051 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02964:Nisch
|
APN |
14 |
30,902,769 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03340:Nisch
|
APN |
14 |
30,895,101 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0092:Nisch
|
UTSW |
14 |
30,913,410 (GRCm39) |
unclassified |
probably benign |
|
|
R0119:Nisch
|
UTSW |
14 |
30,893,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0196:Nisch
|
UTSW |
14 |
30,925,351 (GRCm39) |
unclassified |
probably benign |
|
|
R0299:Nisch
|
UTSW |
14 |
30,893,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Nisch
|
UTSW |
14 |
30,899,421 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1529:Nisch
|
UTSW |
14 |
30,902,895 (GRCm39) |
unclassified |
probably benign |
|
|
R1643:Nisch
|
UTSW |
14 |
30,895,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Nisch
|
UTSW |
14 |
30,899,228 (GRCm39) |
unclassified |
probably benign |
|
|
R1663:Nisch
|
UTSW |
14 |
30,913,478 (GRCm39) |
unclassified |
probably benign |
|
|
R1676:Nisch
|
UTSW |
14 |
30,902,859 (GRCm39) |
unclassified |
probably benign |
|
|
R1750:Nisch
|
UTSW |
14 |
30,896,839 (GRCm39) |
unclassified |
probably benign |
|
|
R1799:Nisch
|
UTSW |
14 |
30,899,228 (GRCm39) |
unclassified |
probably benign |
|
|
R1824:Nisch
|
UTSW |
14 |
30,898,389 (GRCm39) |
unclassified |
probably benign |
|
|
R1876:Nisch
|
UTSW |
14 |
30,895,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Nisch
|
UTSW |
14 |
30,894,097 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2117:Nisch
|
UTSW |
14 |
30,899,242 (GRCm39) |
unclassified |
probably benign |
|
|
R2276:Nisch
|
UTSW |
14 |
30,898,803 (GRCm39) |
unclassified |
probably benign |
|
|
R2402:Nisch
|
UTSW |
14 |
30,906,971 (GRCm39) |
intron |
probably benign |
|
|
R3703:Nisch
|
UTSW |
14 |
30,898,702 (GRCm39) |
unclassified |
probably benign |
|
|
R3704:Nisch
|
UTSW |
14 |
30,898,702 (GRCm39) |
unclassified |
probably benign |
|
|
R3705:Nisch
|
UTSW |
14 |
30,898,702 (GRCm39) |
unclassified |
probably benign |
|
|
R3897:Nisch
|
UTSW |
14 |
30,912,957 (GRCm39) |
unclassified |
probably benign |
|
|
R4024:Nisch
|
UTSW |
14 |
30,898,776 (GRCm39) |
unclassified |
probably benign |
|
|
R4412:Nisch
|
UTSW |
14 |
30,908,615 (GRCm39) |
intron |
probably benign |
|
|
R4752:Nisch
|
UTSW |
14 |
30,914,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Nisch
|
UTSW |
14 |
30,899,587 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5009:Nisch
|
UTSW |
14 |
30,909,186 (GRCm39) |
unclassified |
probably benign |
|
|
R5043:Nisch
|
UTSW |
14 |
30,898,422 (GRCm39) |
unclassified |
probably benign |
|
|
R5062:Nisch
|
UTSW |
14 |
30,894,397 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5254:Nisch
|
UTSW |
14 |
30,928,524 (GRCm39) |
splice site |
probably null |
|
|
R5754:Nisch
|
UTSW |
14 |
30,913,373 (GRCm39) |
unclassified |
probably benign |
|
|
R5930:Nisch
|
UTSW |
14 |
30,895,102 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6246:Nisch
|
UTSW |
14 |
30,894,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Nisch
|
UTSW |
14 |
30,899,085 (GRCm39) |
unclassified |
probably benign |
|
|
R6260:Nisch
|
UTSW |
14 |
30,899,085 (GRCm39) |
unclassified |
probably benign |
|
|
R6327:Nisch
|
UTSW |
14 |
30,893,444 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6671:Nisch
|
UTSW |
14 |
30,926,420 (GRCm39) |
unclassified |
probably benign |
|
|
R6874:Nisch
|
UTSW |
14 |
30,898,641 (GRCm39) |
unclassified |
probably benign |
|
|
R6887:Nisch
|
UTSW |
14 |
30,907,301 (GRCm39) |
unclassified |
probably benign |
|
|
R7273:Nisch
|
UTSW |
14 |
30,896,364 (GRCm39) |
missense |
unknown |
|
|
R7401:Nisch
|
UTSW |
14 |
30,928,537 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7423:Nisch
|
UTSW |
14 |
30,893,658 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7822:Nisch
|
UTSW |
14 |
30,896,608 (GRCm39) |
unclassified |
probably benign |
|
|
R7870:Nisch
|
UTSW |
14 |
30,894,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7887:Nisch
|
UTSW |
14 |
30,898,652 (GRCm39) |
nonsense |
probably null |
|
|
R8215:Nisch
|
UTSW |
14 |
30,908,658 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8672:Nisch
|
UTSW |
14 |
30,895,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9082:Nisch
|
UTSW |
14 |
30,899,331 (GRCm39) |
missense |
unknown |
|
|
R9134:Nisch
|
UTSW |
14 |
30,896,637 (GRCm39) |
unclassified |
probably benign |
|
|
R9153:Nisch
|
UTSW |
14 |
30,896,782 (GRCm39) |
missense |
unknown |
|
|
R9240:Nisch
|
UTSW |
14 |
30,906,988 (GRCm39) |
missense |
unknown |
|
|
R9652:Nisch
|
UTSW |
14 |
30,893,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9653:Nisch
|
UTSW |
14 |
30,893,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9663:Nisch
|
UTSW |
14 |
30,895,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Nisch
|
UTSW |
14 |
30,895,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Nisch
|
UTSW |
14 |
30,909,041 (GRCm39) |
unclassified |
probably benign |
|
|
Z1177:Nisch
|
UTSW |
14 |
30,899,395 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCGTCTAGCCGGTATCTGTC -3'
(R):5'- ACTCTCATTATGTGGGGCTGC -3'
Sequencing Primer
(F):5'- GGTATCTGTCCCTCTGCGG -3'
(R):5'- TGCACCACAGGCCAGCTC -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation