Incidental Mutation 'R6468:Vmn2r74'
| ID |
516426 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| MMRRC Submission |
044601-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
R6468 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85610599 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 31
(D31G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166355
AA Change: D31G
PolyPhen 2
Score 0.342 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: D31G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.9%
|
| Validation Efficiency |
97% (57/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl5 |
A |
G |
10: 80,177,747 (GRCm39) |
V305A |
possibly damaging |
Het |
| Adgrl4 |
A |
G |
3: 151,198,012 (GRCm39) |
T91A |
probably benign |
Het |
| Ano6 |
A |
G |
15: 95,865,595 (GRCm39) |
I860V |
probably benign |
Het |
| B3galnt1 |
A |
G |
3: 69,482,866 (GRCm39) |
S132P |
probably damaging |
Het |
| Bltp1 |
T |
C |
3: 37,062,592 (GRCm39) |
I3368T |
probably damaging |
Het |
| Btbd10 |
A |
T |
7: 112,946,266 (GRCm39) |
V33E |
probably benign |
Het |
| Cacna1g |
A |
T |
11: 94,330,548 (GRCm39) |
V989D |
probably damaging |
Het |
| Celsr3 |
A |
G |
9: 108,712,989 (GRCm39) |
D1807G |
probably benign |
Het |
| Chd6 |
A |
G |
2: 160,854,987 (GRCm39) |
M807T |
probably damaging |
Het |
| Cpxm2 |
T |
C |
7: 131,672,589 (GRCm39) |
D320G |
probably damaging |
Het |
| Cryzl1 |
A |
C |
16: 91,489,413 (GRCm39) |
|
probably null |
Het |
| Dcbld2 |
A |
T |
16: 58,253,736 (GRCm39) |
K158* |
probably null |
Het |
| Depdc5 |
A |
G |
5: 33,069,575 (GRCm39) |
N437S |
probably benign |
Het |
| Dock7 |
G |
A |
4: 98,855,464 (GRCm39) |
S1496L |
probably benign |
Het |
| Eea1 |
T |
G |
10: 95,864,274 (GRCm39) |
I931R |
probably benign |
Het |
| Eif2ak4 |
C |
A |
2: 118,266,722 (GRCm39) |
L714I |
probably damaging |
Het |
| Enpep |
A |
G |
3: 129,125,509 (GRCm39) |
|
probably null |
Het |
| Fam83b |
T |
A |
9: 76,409,413 (GRCm39) |
K238* |
probably null |
Het |
| Fam83f |
A |
G |
15: 80,576,312 (GRCm39) |
Y321C |
possibly damaging |
Het |
| Fanci |
A |
G |
7: 79,067,687 (GRCm39) |
I42V |
probably benign |
Het |
| Flg2 |
A |
T |
3: 93,121,728 (GRCm39) |
R1299S |
unknown |
Het |
| Gak |
G |
T |
5: 108,771,202 (GRCm39) |
C102* |
probably null |
Het |
| Gcnt7 |
A |
G |
2: 172,295,993 (GRCm39) |
L277P |
probably damaging |
Het |
| Gucy2d |
A |
G |
7: 98,099,168 (GRCm39) |
E329G |
probably benign |
Het |
| Hacd1 |
T |
C |
2: 14,040,755 (GRCm39) |
I167V |
probably damaging |
Het |
| Hdlbp |
T |
A |
1: 93,345,389 (GRCm39) |
D662V |
possibly damaging |
Het |
| Hspa4 |
A |
T |
11: 53,155,883 (GRCm39) |
V674E |
probably benign |
Het |
| Hunk |
A |
G |
16: 90,290,320 (GRCm39) |
Q442R |
possibly damaging |
Het |
| Lce1j |
A |
T |
3: 92,696,729 (GRCm39) |
C16* |
probably null |
Het |
| Lrat |
A |
T |
3: 82,810,799 (GRCm39) |
M74K |
probably damaging |
Het |
| Lrig2 |
G |
A |
3: 104,374,509 (GRCm39) |
R191C |
probably damaging |
Het |
| Lrrc37a |
A |
C |
11: 103,351,666 (GRCm39) |
F2558L |
unknown |
Het |
| Mctp1 |
T |
A |
13: 76,879,930 (GRCm39) |
|
probably null |
Het |
| Mecom |
T |
A |
3: 30,194,535 (GRCm39) |
|
probably benign |
Het |
| Mgst1 |
A |
G |
6: 138,118,585 (GRCm39) |
|
probably null |
Het |
| Ms4a15 |
T |
G |
19: 10,970,534 (GRCm39) |
E3A |
probably benign |
Het |
| Myo1d |
T |
C |
11: 80,448,300 (GRCm39) |
I942V |
probably benign |
Het |
| Neu2 |
A |
G |
1: 87,524,600 (GRCm39) |
Y195C |
probably damaging |
Het |
| Nipa1 |
A |
T |
7: 55,669,252 (GRCm39) |
V22E |
probably benign |
Het |
| Or4n4b |
A |
T |
14: 50,535,924 (GRCm39) |
L281I |
probably benign |
Het |
| Or6c35 |
T |
C |
10: 129,169,580 (GRCm39) |
S277P |
possibly damaging |
Het |
| Or8k25 |
T |
A |
2: 86,244,381 (GRCm39) |
N5I |
probably damaging |
Het |
| Pik3r4 |
A |
G |
9: 105,562,389 (GRCm39) |
T1223A |
possibly damaging |
Het |
| Ppl |
T |
C |
16: 4,910,305 (GRCm39) |
D811G |
probably damaging |
Het |
| Prep |
T |
A |
10: 44,991,203 (GRCm39) |
Y290N |
probably damaging |
Het |
| Ptk6 |
A |
T |
2: 180,840,895 (GRCm39) |
H215Q |
probably benign |
Het |
| Rad50 |
A |
G |
11: 53,582,971 (GRCm39) |
I474T |
possibly damaging |
Het |
| Rnf213 |
T |
A |
11: 119,343,513 (GRCm39) |
V3626E |
possibly damaging |
Het |
| Scn4a |
C |
T |
11: 106,236,502 (GRCm39) |
V253M |
probably damaging |
Het |
| Snta1 |
T |
A |
2: 154,219,069 (GRCm39) |
D422V |
probably damaging |
Het |
| Spata31h1 |
G |
T |
10: 82,131,150 (GRCm39) |
T620K |
probably benign |
Het |
| Stk38 |
A |
G |
17: 29,203,086 (GRCm39) |
L160P |
probably benign |
Het |
| Tapbp |
T |
C |
17: 34,145,072 (GRCm39) |
F323S |
probably damaging |
Het |
| Uggt1 |
C |
T |
1: 36,212,531 (GRCm39) |
R937Q |
probably benign |
Het |
| Vash2 |
G |
A |
1: 190,710,484 (GRCm39) |
P57L |
probably damaging |
Het |
| Vmn1r4 |
G |
A |
6: 56,933,852 (GRCm39) |
V119I |
probably benign |
Het |
| Zfp114 |
T |
C |
7: 23,877,206 (GRCm39) |
V16A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGCCAGAAGACACATGGTATC -3'
(R):5'- AGTATTAAATAGTGGCACCTGGATG -3'
Sequencing Primer
(F):5'- GGTATCATGATCTACATTCCAGCATC -3'
(R):5'- GGATGGTTTCACAAAATGTTAATGC -3'
|
| Posted On |
2018-05-21 |
Incidental Mutation