Mutagenetix > Incidental Mutation

Incidental Mutation 'R6970:Zfp423'

542190

Institutional Source

Beutler Lab

Gene Symbol

Zfp423

Ensembl Gene

ENSMUSG00000045333

Gene Name

zinc finger protein 423

Synonyms

Roaz, Zfp104, Ebfaz, ataxia1

MMRRC Submission

045080-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.838) question?

Stock #

R6970 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

88388438-88686223 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88530407 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 13 (V13A)

Ref Sequence

ENSEMBL: ENSMUSP00000134103 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052250] [ENSMUST00000109655] [ENSMUST00000165770] [ENSMUST00000174249] [ENSMUST00000174764]

AlphaFold

Q80TS5

Predicted Effect

probably benign
Transcript: ENSMUST00000052250

SMART Domains

Protein: ENSMUSP00000052379
Gene: ENSMUSG00000045333

Domain	Start	End	E-Value	Type
low complexity region	39	51	N/A	INTRINSIC
ZnF_C2H2	54	75	5.07e0	SMART
low complexity region	107	123	N/A	INTRINSIC
ZnF_C2H2	125	147	1.28e-3	SMART
ZnF_C2H2	153	175	1.64e-1	SMART
ZnF_C2H2	181	203	2.05e-2	SMART
ZnF_C2H2	209	231	3.21e-4	SMART
ZnF_C2H2	250	273	5.42e-2	SMART
ZnF_C2H2	282	305	1.76e-1	SMART
ZnF_C2H2	310	332	8.67e-1	SMART
low complexity region	350	364	N/A	INTRINSIC
ZnF_C2H2	396	420	1.16e-1	SMART
ZnF_C2H2	428	451	3.52e-1	SMART
ZnF_C2H2	467	490	7.9e-4	SMART
low complexity region	492	503	N/A	INTRINSIC
ZnF_C2H2	504	527	2.53e-2	SMART
ZnF_C2H2	550	575	3.99e0	SMART
low complexity region	591	602	N/A	INTRINSIC
ZnF_C2H2	619	641	3.16e-3	SMART
ZnF_C2H2	649	671	5.81e-2	SMART
ZnF_C2H2	679	702	4.87e-4	SMART
ZnF_C2H2	707	730	7.26e-3	SMART
ZnF_C2H2	737	760	4.79e-3	SMART
ZnF_C2H2	768	790	1.36e-2	SMART
ZnF_C2H2	794	817	4.72e-2	SMART
ZnF_C2H2	873	896	4.12e0	SMART
ZnF_C2H2	917	939	5.59e-4	SMART
ZnF_C2H2	946	968	6.42e-4	SMART
ZnF_C2H2	975	997	4.94e0	SMART
ZnF_C2H2	1007	1029	4.99e1	SMART
Pfam:zf-C2H2_6	1050	1068	1.6e-1	PFAM
ZnF_C2H2	1107	1130	1.12e-3	SMART
ZnF_C2H2	1155	1177	1.45e-2	SMART
ZnF_C2H2	1185	1207	5.72e-1	SMART
ZnF_C2H2	1216	1239	1.18e-2	SMART
ZnF_C2H2	1246	1269	4.05e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109655

SMART Domains

Protein: ENSMUSP00000105282
Gene: ENSMUSG00000045333

Domain	Start	End	E-Value	Type
low complexity region	60	72	N/A	INTRINSIC
ZnF_C2H2	75	96	5.07e0	SMART
low complexity region	128	144	N/A	INTRINSIC
ZnF_C2H2	146	168	1.28e-3	SMART
ZnF_C2H2	174	196	1.64e-1	SMART
ZnF_C2H2	202	224	2.05e-2	SMART
ZnF_C2H2	230	252	3.21e-4	SMART
ZnF_C2H2	271	294	5.42e-2	SMART
ZnF_C2H2	303	326	1.76e-1	SMART
ZnF_C2H2	331	353	8.67e-1	SMART
low complexity region	371	385	N/A	INTRINSIC
ZnF_C2H2	417	441	1.16e-1	SMART
ZnF_C2H2	449	472	3.52e-1	SMART
ZnF_C2H2	488	511	7.9e-4	SMART
low complexity region	513	524	N/A	INTRINSIC
ZnF_C2H2	525	548	2.53e-2	SMART
ZnF_C2H2	571	596	3.99e0	SMART
low complexity region	612	623	N/A	INTRINSIC
ZnF_C2H2	640	662	3.16e-3	SMART
ZnF_C2H2	670	692	5.81e-2	SMART
ZnF_C2H2	700	723	4.87e-4	SMART
ZnF_C2H2	728	751	7.26e-3	SMART
ZnF_C2H2	758	781	4.79e-3	SMART
ZnF_C2H2	789	811	1.36e-2	SMART
ZnF_C2H2	815	838	4.72e-2	SMART
ZnF_C2H2	894	917	4.12e0	SMART
ZnF_C2H2	938	960	5.59e-4	SMART
ZnF_C2H2	967	989	6.42e-4	SMART
ZnF_C2H2	996	1018	4.94e0	SMART
ZnF_C2H2	1028	1050	4.99e1	SMART
ZnF_C2H2	1128	1151	1.12e-3	SMART
ZnF_C2H2	1176	1198	1.45e-2	SMART
ZnF_C2H2	1206	1228	5.72e-1	SMART
ZnF_C2H2	1237	1260	1.18e-2	SMART
ZnF_C2H2	1267	1290	4.05e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000165770

SMART Domains

Protein: ENSMUSP00000129724
Gene: ENSMUSG00000045333

Domain	Start	End	E-Value	Type
low complexity region	3	19	N/A	INTRINSIC
ZnF_C2H2	21	43	1.28e-3	SMART
ZnF_C2H2	49	71	1.64e-1	SMART
ZnF_C2H2	77	99	2.05e-2	SMART
ZnF_C2H2	105	127	3.21e-4	SMART
ZnF_C2H2	146	169	5.42e-2	SMART
ZnF_C2H2	178	201	1.76e-1	SMART
ZnF_C2H2	206	228	8.67e-1	SMART
low complexity region	246	260	N/A	INTRINSIC
ZnF_C2H2	292	316	1.16e-1	SMART
ZnF_C2H2	324	347	3.52e-1	SMART
ZnF_C2H2	363	386	7.9e-4	SMART
low complexity region	388	399	N/A	INTRINSIC
ZnF_C2H2	400	423	2.53e-2	SMART
ZnF_C2H2	446	471	3.99e0	SMART
low complexity region	487	498	N/A	INTRINSIC
ZnF_C2H2	515	537	3.16e-3	SMART
ZnF_C2H2	545	567	5.81e-2	SMART
ZnF_C2H2	575	598	4.87e-4	SMART
ZnF_C2H2	603	626	7.26e-3	SMART
ZnF_C2H2	633	656	4.79e-3	SMART
ZnF_C2H2	664	686	1.36e-2	SMART
ZnF_C2H2	690	713	4.72e-2	SMART
ZnF_C2H2	769	792	4.12e0	SMART
ZnF_C2H2	813	835	5.59e-4	SMART
ZnF_C2H2	842	864	6.42e-4	SMART
ZnF_C2H2	871	893	4.94e0	SMART
ZnF_C2H2	903	925	4.99e1	SMART
Pfam:zf-C2H2_6	946	964	2.5e-1	PFAM
ZnF_C2H2	1003	1026	1.12e-3	SMART
ZnF_C2H2	1051	1073	1.45e-2	SMART
ZnF_C2H2	1081	1103	5.72e-1	SMART
ZnF_C2H2	1112	1135	1.18e-2	SMART
ZnF_C2H2	1142	1165	4.05e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174249
AA Change: V13A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000134103
Gene: ENSMUSG00000045333
AA Change: V13A

Domain	Start	End	E-Value	Type
low complexity region	60	76	N/A	INTRINSIC
ZnF_C2H2	78	100	1.28e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174764

SMART Domains

Protein: ENSMUSP00000134575
Gene: ENSMUSG00000045333

Domain	Start	End	E-Value	Type
low complexity region	63	75	N/A	INTRINSIC
ZnF_C2H2	78	99	5.07e0	SMART
low complexity region	131	147	N/A	INTRINSIC
ZnF_C2H2	149	171	1.28e-3	SMART
ZnF_C2H2	177	199	1.64e-1	SMART
ZnF_C2H2	205	227	2.05e-2	SMART
Pfam:zf-C2H2_6	232	244	2.5e-1	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	T	C	7: 131,036,044 (GRCm39)	Y285H	possibly damaging	Het
Adam17	A	G	12: 21,395,669 (GRCm39)	S285P	probably benign	Het
Adcy10	A	G	1: 165,384,485 (GRCm39)	N1082S	probably benign	Het
Ahdc1	T	A	4: 132,789,656 (GRCm39)	L299Q	possibly damaging	Het
Ambra1	T	A	2: 91,602,945 (GRCm39)		probably benign	Het
Arfgef1	T	C	1: 10,223,903 (GRCm39)	Q1465R	probably damaging	Het
Arfgef1	G	T	1: 10,223,904 (GRCm39)	Q1465K	probably damaging	Het
Atp8a1	A	G	5: 67,895,805 (GRCm39)	V543A	probably damaging	Het
BC034090	T	A	1: 155,117,185 (GRCm39)	D311V	probably damaging	Het
Blnk	G	T	19: 40,950,821 (GRCm39)	P110Q	probably damaging	Het
Cc2d2a	A	G	5: 43,875,927 (GRCm39)	E968G	probably damaging	Het
Ccdc14	A	T	16: 34,529,903 (GRCm39)	E394V	probably damaging	Het
Ccdc162	A	T	10: 41,491,954 (GRCm39)	H1086Q	probably benign	Het
Ccdc85b	T	A	19: 5,507,248 (GRCm39)	I60F	probably damaging	Het
Ceacam20	T	A	7: 19,723,902 (GRCm39)	L562Q	probably damaging	Het
Cntrl	T	C	2: 35,008,149 (GRCm39)	F188L	probably benign	Het
Cplane1	T	C	15: 8,217,032 (GRCm39)	V750A	probably benign	Het
Dclk1	A	T	3: 55,374,022 (GRCm39)		probably benign	Het
Ddx20	A	T	3: 105,587,674 (GRCm39)	L434H	probably damaging	Het
Ddx51	G	A	5: 110,804,728 (GRCm39)	V547M	probably damaging	Het
Dnah11	T	A	12: 118,072,679 (GRCm39)	Q1472L	probably benign	Het
Dnajb13	T	C	7: 100,156,629 (GRCm39)	E149G	probably damaging	Het
Efcab3	A	G	11: 104,667,182 (GRCm39)	E1422G	probably benign	Het
Eif1ad8	G	T	12: 87,563,388 (GRCm39)		probably benign	Het
Fat4	A	G	3: 39,035,924 (GRCm39)	N3192S	probably damaging	Het
Fat4	A	T	3: 39,050,120 (GRCm39)	D3994V	probably damaging	Het
Fcgr1	C	A	3: 96,191,936 (GRCm39)		probably null	Het
Gm12185	G	A	11: 48,798,739 (GRCm39)	R585*	probably null	Het
Gm32687	A	G	10: 81,715,304 (GRCm39)	H232R	probably benign	Het
Gm5431	G	T	11: 48,779,317 (GRCm39)	A535D	probably damaging	Het
Jarid2	C	T	13: 45,056,461 (GRCm39)	P556S	probably damaging	Het
Map3k4	C	A	17: 12,467,803 (GRCm39)	G1077V	probably damaging	Het
Mast4	C	T	13: 102,941,155 (GRCm39)	V301I	probably damaging	Het
Mlxip	A	G	5: 123,583,735 (GRCm39)	T433A	possibly damaging	Het
Ms4a20	A	G	19: 11,089,678 (GRCm39)		probably null	Het
Mus81	G	T	19: 5,535,554 (GRCm39)	H199Q	probably benign	Het
Mylk3	G	A	8: 86,085,892 (GRCm39)	T54M	probably damaging	Het
Nalcn	A	G	14: 123,551,506 (GRCm39)	F1034L	possibly damaging	Het
Nfatc1	A	C	18: 80,710,228 (GRCm39)	S513A	probably benign	Het
Ninj2	A	G	6: 120,175,092 (GRCm39)	I88V	possibly damaging	Het
Nomo1	C	T	7: 45,695,391 (GRCm39)	P277L	probably damaging	Het
Nup214	C	T	2: 31,941,810 (GRCm39)	S571L	probably damaging	Het
Or10g9b	T	A	9: 39,918,009 (GRCm39)	M79L	probably benign	Het
Or5b3	T	A	19: 13,388,792 (GRCm39)	N286K	probably damaging	Het
Or9a7	T	C	6: 40,521,590 (GRCm39)	S108G	probably benign	Het
Pcdh15	C	T	10: 74,338,519 (GRCm39)	P1005S	probably damaging	Het
Pkhd1l1	G	A	15: 44,375,070 (GRCm39)	A942T	possibly damaging	Het
Plagl1	T	C	10: 13,000,860 (GRCm39)	C34R	probably damaging	Het
Plekha2	T	C	8: 25,549,280 (GRCm39)	Q168R	probably benign	Het
Plekha6	G	A	1: 133,191,556 (GRCm39)	A146T	probably benign	Het
Plekhm3	T	G	1: 64,931,912 (GRCm39)	K564T	possibly damaging	Het
Plpp2	A	G	10: 79,366,380 (GRCm39)	V26A	possibly damaging	Het
Prdm10	T	G	9: 31,241,119 (GRCm39)	Y302*	probably null	Het
Prdm8	A	G	5: 98,332,471 (GRCm39)	E124G	probably damaging	Het
Prg4	T	G	1: 150,331,657 (GRCm39)		probably benign	Het
Qser1	A	G	2: 104,618,475 (GRCm39)	V779A	probably benign	Het
Rbm39	G	A	2: 156,009,504 (GRCm39)	R123C	probably damaging	Het
Ric1	C	T	19: 29,565,172 (GRCm39)	P640S	probably damaging	Het
Rpl14	G	A	9: 120,403,293 (GRCm39)		probably benign	Het
Rsl1d1	T	A	16: 11,011,558 (GRCm39)	D382V	probably benign	Het
Rubcn	G	T	16: 32,688,514 (GRCm39)		probably benign	Het
Sec16a	G	A	2: 26,320,498 (GRCm39)	R1361C	probably damaging	Het
Slc26a11	T	G	11: 119,247,798 (GRCm39)	V41G	probably damaging	Het
Slc41a2	A	G	10: 83,151,960 (GRCm39)	F172L	possibly damaging	Het
Slc4a4	A	C	5: 89,327,690 (GRCm39)	Y674S	probably damaging	Het
Spata31e3	A	T	13: 50,401,007 (GRCm39)	Y440N	possibly damaging	Het
Strc	A	C	2: 121,208,495 (GRCm39)	M292R	probably benign	Het
Syde2	A	G	3: 145,694,381 (GRCm39)	T210A	probably benign	Het
Tcf7l2	C	A	19: 55,743,480 (GRCm39)	A97E	probably benign	Het
Tenm3	C	T	8: 48,689,474 (GRCm39)	D2038N	probably damaging	Het
Tepsin	G	A	11: 119,986,190 (GRCm39)	T168M	probably damaging	Het
Tex15	A	T	8: 34,047,456 (GRCm39)	M178L	probably benign	Het
Tgfbr2	T	C	9: 115,939,119 (GRCm39)	N236S	probably damaging	Het
Tnrc18	A	G	5: 142,713,744 (GRCm39)	V2531A	probably damaging	Het
Ttn	T	G	2: 76,725,767 (GRCm39)		probably benign	Het
Tubgcp3	G	T	8: 12,687,000 (GRCm39)	D630E	probably damaging	Het
Ubr4	G	A	4: 139,133,839 (GRCm39)	W745*	probably null	Het
Vmn2r115	G	A	17: 23,564,989 (GRCm39)	G292D	probably benign	Het
Vmn2r38	T	A	7: 9,078,340 (GRCm39)	K681*	probably null	Het
Xrcc6	A	G	15: 81,915,375 (GRCm39)	K98E	probably benign	Het
Zfp512b	A	G	2: 181,228,141 (GRCm39)	I5T	possibly damaging	Het
Zmynd8	C	T	2: 165,717,670 (GRCm39)	E14K	probably damaging	Het

Other mutations in Zfp423

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01325:Zfp423	APN	8	88,508,239 (GRCm39)	splice site	probably null
IGL01359:Zfp423	APN	8	88,507,290 (GRCm39)	missense	probably damaging	1.00
IGL01780:Zfp423	APN	8	88,508,136 (GRCm39)	missense	probably damaging	1.00
IGL02250:Zfp423	APN	8	88,509,883 (GRCm39)	missense	probably damaging	1.00
IGL02301:Zfp423	APN	8	88,508,202 (GRCm39)	missense	probably damaging	1.00
IGL02320:Zfp423	APN	8	88,508,230 (GRCm39)	missense	probably damaging	1.00
IGL02804:Zfp423	APN	8	88,509,285 (GRCm39)	missense	probably benign	0.02
IGL03090:Zfp423	APN	8	88,508,071 (GRCm39)	missense	probably damaging	1.00
IGL03198:Zfp423	APN	8	88,508,304 (GRCm39)	missense	possibly damaging	0.73
IGL03383:Zfp423	APN	8	88,586,080 (GRCm39)	nonsense	probably null
swell	UTSW	8	88,413,187 (GRCm39)	splice site	probably null
Temptation	UTSW	8	88,508,381 (GRCm39)	missense	probably benign	0.25
trials	UTSW	8	88,507,341 (GRCm39)	missense	probably damaging	1.00
R0110:Zfp423	UTSW	8	88,508,887 (GRCm39)	missense	possibly damaging	0.60
R0142:Zfp423	UTSW	8	88,506,968 (GRCm39)	nonsense	probably null
R0256:Zfp423	UTSW	8	88,500,262 (GRCm39)	nonsense	probably null
R0538:Zfp423	UTSW	8	88,508,713 (GRCm39)	missense	probably damaging	0.99
R0542:Zfp423	UTSW	8	88,507,237 (GRCm39)	missense	probably damaging	1.00
R0614:Zfp423	UTSW	8	88,508,742 (GRCm39)	missense	probably damaging	1.00
R1179:Zfp423	UTSW	8	88,414,700 (GRCm39)	missense	probably damaging	0.97
R1417:Zfp423	UTSW	8	88,500,284 (GRCm39)	splice site	probably null
R1429:Zfp423	UTSW	8	88,413,070 (GRCm39)	missense	probably damaging	0.99
R1570:Zfp423	UTSW	8	88,509,186 (GRCm39)	missense	probably benign	0.37
R2013:Zfp423	UTSW	8	88,509,025 (GRCm39)	missense	probably benign	0.43
R2043:Zfp423	UTSW	8	88,509,246 (GRCm39)	missense	probably damaging	1.00
R2064:Zfp423	UTSW	8	88,507,986 (GRCm39)	missense	probably benign	0.04
R2108:Zfp423	UTSW	8	88,507,806 (GRCm39)	missense	possibly damaging	0.73
R2358:Zfp423	UTSW	8	88,507,179 (GRCm39)	missense	possibly damaging	0.56
R3177:Zfp423	UTSW	8	88,508,959 (GRCm39)	missense	probably damaging	1.00
R3277:Zfp423	UTSW	8	88,508,959 (GRCm39)	missense	probably damaging	1.00
R3738:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R3739:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R3773:Zfp423	UTSW	8	88,507,140 (GRCm39)	missense	probably benign	0.03
R4034:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R4425:Zfp423	UTSW	8	88,509,601 (GRCm39)	missense	probably damaging	1.00
R4611:Zfp423	UTSW	8	88,414,709 (GRCm39)	missense	possibly damaging	0.90
R4700:Zfp423	UTSW	8	88,508,338 (GRCm39)	splice site	probably null
R4753:Zfp423	UTSW	8	88,508,074 (GRCm39)	missense	probably benign	0.00
R4818:Zfp423	UTSW	8	88,631,128 (GRCm39)	missense	probably benign	0.00
R5026:Zfp423	UTSW	8	88,507,302 (GRCm39)	missense	probably damaging	1.00
R5190:Zfp423	UTSW	8	88,509,091 (GRCm39)	missense	probably damaging	1.00
R5243:Zfp423	UTSW	8	88,500,275 (GRCm39)	missense	probably benign	0.03
R5284:Zfp423	UTSW	8	88,508,305 (GRCm39)	missense	possibly damaging	0.73
R5586:Zfp423	UTSW	8	88,585,968 (GRCm39)	missense	possibly damaging	0.93
R5601:Zfp423	UTSW	8	88,508,637 (GRCm39)	missense	probably damaging	1.00
R5671:Zfp423	UTSW	8	88,508,955 (GRCm39)	missense	probably damaging	0.99
R5717:Zfp423	UTSW	8	88,413,187 (GRCm39)	splice site	probably null
R5801:Zfp423	UTSW	8	88,585,990 (GRCm39)	missense	probably damaging	0.99
R5917:Zfp423	UTSW	8	88,508,860 (GRCm39)	nonsense	probably null
R5985:Zfp423	UTSW	8	88,508,774 (GRCm39)	missense	possibly damaging	0.83
R6111:Zfp423	UTSW	8	88,509,315 (GRCm39)	missense	probably damaging	0.99
R6306:Zfp423	UTSW	8	88,508,662 (GRCm39)	missense	possibly damaging	0.64
R6770:Zfp423	UTSW	8	88,508,445 (GRCm39)	missense	probably damaging	0.99
R7029:Zfp423	UTSW	8	88,414,694 (GRCm39)	missense	probably damaging	0.99
R7060:Zfp423	UTSW	8	88,509,507 (GRCm39)	missense	probably damaging	1.00
R7074:Zfp423	UTSW	8	88,509,060 (GRCm39)	missense	probably benign	0.00
R7121:Zfp423	UTSW	8	88,507,489 (GRCm39)	missense	probably damaging	1.00
R7242:Zfp423	UTSW	8	88,631,155 (GRCm39)	missense	probably benign	0.07
R7359:Zfp423	UTSW	8	88,508,871 (GRCm39)	missense	possibly damaging	0.52
R7426:Zfp423	UTSW	8	88,507,341 (GRCm39)	missense	probably damaging	1.00
R7540:Zfp423	UTSW	8	88,414,695 (GRCm39)	missense	possibly damaging	0.95
R7640:Zfp423	UTSW	8	88,507,905 (GRCm39)	missense	probably damaging	1.00
R7767:Zfp423	UTSW	8	88,507,512 (GRCm39)	missense	probably damaging	1.00
R7938:Zfp423	UTSW	8	88,622,304 (GRCm39)	missense	unknown
R7986:Zfp423	UTSW	8	88,506,978 (GRCm39)	missense	probably benign	0.04
R8347:Zfp423	UTSW	8	88,509,784 (GRCm39)	missense	probably damaging	0.99
R8356:Zfp423	UTSW	8	88,509,910 (GRCm39)	missense	probably damaging	1.00
R8676:Zfp423	UTSW	8	88,509,338 (GRCm39)	missense	probably benign	0.04
R8710:Zfp423	UTSW	8	88,507,549 (GRCm39)	missense	possibly damaging	0.74
R8794:Zfp423	UTSW	8	88,507,857 (GRCm39)	missense	probably damaging	1.00
R8832:Zfp423	UTSW	8	88,507,827 (GRCm39)	missense	probably damaging	0.98
R9018:Zfp423	UTSW	8	88,508,381 (GRCm39)	missense	probably benign	0.25
R9182:Zfp423	UTSW	8	88,508,742 (GRCm39)	missense	probably damaging	0.99
R9309:Zfp423	UTSW	8	88,509,688 (GRCm39)	missense	probably damaging	0.99
R9312:Zfp423	UTSW	8	88,508,569 (GRCm39)	missense	probably damaging	1.00
R9453:Zfp423	UTSW	8	88,508,251 (GRCm39)	missense	probably damaging	1.00
R9469:Zfp423	UTSW	8	88,509,519 (GRCm39)	missense	probably damaging	0.99
R9480:Zfp423	UTSW	8	88,631,115 (GRCm39)	critical splice donor site	probably null
R9483:Zfp423	UTSW	8	88,507,725 (GRCm39)	missense	possibly damaging	0.90
R9510:Zfp423	UTSW	8	88,510,041 (GRCm39)	missense	possibly damaging	0.94
R9521:Zfp423	UTSW	8	88,509,033 (GRCm39)	missense	probably damaging	1.00
R9606:Zfp423	UTSW	8	88,414,595 (GRCm39)	missense	probably damaging	0.99
R9789:Zfp423	UTSW	8	88,506,877 (GRCm39)	missense	probably benign	0.03
Z1176:Zfp423	UTSW	8	88,586,048 (GRCm39)	missense	possibly damaging	0.49
Z1177:Zfp423	UTSW	8	88,507,553 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AATTGCCGAACCGAAGTTTG -3'
(R):5'- GCCATTAGCTTCCCTTGGTG -3'

Sequencing Primer
(F):5'- ACCGAAGTTTGCCATCTCGGTAG -3'
(R):5'- CTTGGTGATCCCCGGCTTG -3'

Posted On

2018-11-28