Mutagenetix > Incidental Mutation

Incidental Mutation 'R4611:Zfp423'

344725

Institutional Source

Beutler Lab

Gene Symbol

Zfp423

Ensembl Gene

ENSMUSG00000045333

Gene Name

zinc finger protein 423

Synonyms

Roaz, Zfp104, Ebfaz, ataxia1

MMRRC Submission

041822-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.838) question?

Stock #

R4611 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

88388438-88686223 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 88414709 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 1182 (G1182D)

Ref Sequence

ENSEMBL: ENSMUSP00000052379 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052250] [ENSMUST00000109655] [ENSMUST00000165770]

AlphaFold

Q80TS5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000052250
AA Change: G1182D

PolyPhen 2 Score 0.898 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052379
Gene: ENSMUSG00000045333
AA Change: G1182D

Domain	Start	End	E-Value	Type
low complexity region	39	51	N/A	INTRINSIC
ZnF_C2H2	54	75	5.07e0	SMART
low complexity region	107	123	N/A	INTRINSIC
ZnF_C2H2	125	147	1.28e-3	SMART
ZnF_C2H2	153	175	1.64e-1	SMART
ZnF_C2H2	181	203	2.05e-2	SMART
ZnF_C2H2	209	231	3.21e-4	SMART
ZnF_C2H2	250	273	5.42e-2	SMART
ZnF_C2H2	282	305	1.76e-1	SMART
ZnF_C2H2	310	332	8.67e-1	SMART
low complexity region	350	364	N/A	INTRINSIC
ZnF_C2H2	396	420	1.16e-1	SMART
ZnF_C2H2	428	451	3.52e-1	SMART
ZnF_C2H2	467	490	7.9e-4	SMART
low complexity region	492	503	N/A	INTRINSIC
ZnF_C2H2	504	527	2.53e-2	SMART
ZnF_C2H2	550	575	3.99e0	SMART
low complexity region	591	602	N/A	INTRINSIC
ZnF_C2H2	619	641	3.16e-3	SMART
ZnF_C2H2	649	671	5.81e-2	SMART
ZnF_C2H2	679	702	4.87e-4	SMART
ZnF_C2H2	707	730	7.26e-3	SMART
ZnF_C2H2	737	760	4.79e-3	SMART
ZnF_C2H2	768	790	1.36e-2	SMART
ZnF_C2H2	794	817	4.72e-2	SMART
ZnF_C2H2	873	896	4.12e0	SMART
ZnF_C2H2	917	939	5.59e-4	SMART
ZnF_C2H2	946	968	6.42e-4	SMART
ZnF_C2H2	975	997	4.94e0	SMART
ZnF_C2H2	1007	1029	4.99e1	SMART
Pfam:zf-C2H2_6	1050	1068	1.6e-1	PFAM
ZnF_C2H2	1107	1130	1.12e-3	SMART
ZnF_C2H2	1155	1177	1.45e-2	SMART
ZnF_C2H2	1185	1207	5.72e-1	SMART
ZnF_C2H2	1216	1239	1.18e-2	SMART
ZnF_C2H2	1246	1269	4.05e-1	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109655
AA Change: G1203D

PolyPhen 2 Score 0.835 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000105282
Gene: ENSMUSG00000045333
AA Change: G1203D

Domain	Start	End	E-Value	Type
low complexity region	60	72	N/A	INTRINSIC
ZnF_C2H2	75	96	5.07e0	SMART
low complexity region	128	144	N/A	INTRINSIC
ZnF_C2H2	146	168	1.28e-3	SMART
ZnF_C2H2	174	196	1.64e-1	SMART
ZnF_C2H2	202	224	2.05e-2	SMART
ZnF_C2H2	230	252	3.21e-4	SMART
ZnF_C2H2	271	294	5.42e-2	SMART
ZnF_C2H2	303	326	1.76e-1	SMART
ZnF_C2H2	331	353	8.67e-1	SMART
low complexity region	371	385	N/A	INTRINSIC
ZnF_C2H2	417	441	1.16e-1	SMART
ZnF_C2H2	449	472	3.52e-1	SMART
ZnF_C2H2	488	511	7.9e-4	SMART
low complexity region	513	524	N/A	INTRINSIC
ZnF_C2H2	525	548	2.53e-2	SMART
ZnF_C2H2	571	596	3.99e0	SMART
low complexity region	612	623	N/A	INTRINSIC
ZnF_C2H2	640	662	3.16e-3	SMART
ZnF_C2H2	670	692	5.81e-2	SMART
ZnF_C2H2	700	723	4.87e-4	SMART
ZnF_C2H2	728	751	7.26e-3	SMART
ZnF_C2H2	758	781	4.79e-3	SMART
ZnF_C2H2	789	811	1.36e-2	SMART
ZnF_C2H2	815	838	4.72e-2	SMART
ZnF_C2H2	894	917	4.12e0	SMART
ZnF_C2H2	938	960	5.59e-4	SMART
ZnF_C2H2	967	989	6.42e-4	SMART
ZnF_C2H2	996	1018	4.94e0	SMART
ZnF_C2H2	1028	1050	4.99e1	SMART
ZnF_C2H2	1128	1151	1.12e-3	SMART
ZnF_C2H2	1176	1198	1.45e-2	SMART
ZnF_C2H2	1206	1228	5.72e-1	SMART
ZnF_C2H2	1237	1260	1.18e-2	SMART
ZnF_C2H2	1267	1290	4.05e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000165770
AA Change: G1078D

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000129724
Gene: ENSMUSG00000045333
AA Change: G1078D

Domain	Start	End	E-Value	Type
low complexity region	3	19	N/A	INTRINSIC
ZnF_C2H2	21	43	1.28e-3	SMART
ZnF_C2H2	49	71	1.64e-1	SMART
ZnF_C2H2	77	99	2.05e-2	SMART
ZnF_C2H2	105	127	3.21e-4	SMART
ZnF_C2H2	146	169	5.42e-2	SMART
ZnF_C2H2	178	201	1.76e-1	SMART
ZnF_C2H2	206	228	8.67e-1	SMART
low complexity region	246	260	N/A	INTRINSIC
ZnF_C2H2	292	316	1.16e-1	SMART
ZnF_C2H2	324	347	3.52e-1	SMART
ZnF_C2H2	363	386	7.9e-4	SMART
low complexity region	388	399	N/A	INTRINSIC
ZnF_C2H2	400	423	2.53e-2	SMART
ZnF_C2H2	446	471	3.99e0	SMART
low complexity region	487	498	N/A	INTRINSIC
ZnF_C2H2	515	537	3.16e-3	SMART
ZnF_C2H2	545	567	5.81e-2	SMART
ZnF_C2H2	575	598	4.87e-4	SMART
ZnF_C2H2	603	626	7.26e-3	SMART
ZnF_C2H2	633	656	4.79e-3	SMART
ZnF_C2H2	664	686	1.36e-2	SMART
ZnF_C2H2	690	713	4.72e-2	SMART
ZnF_C2H2	769	792	4.12e0	SMART
ZnF_C2H2	813	835	5.59e-4	SMART
ZnF_C2H2	842	864	6.42e-4	SMART
ZnF_C2H2	871	893	4.94e0	SMART
ZnF_C2H2	903	925	4.99e1	SMART
Pfam:zf-C2H2_6	946	964	2.5e-1	PFAM
ZnF_C2H2	1003	1026	1.12e-3	SMART
ZnF_C2H2	1051	1073	1.45e-2	SMART
ZnF_C2H2	1081	1103	5.72e-1	SMART
ZnF_C2H2	1112	1135	1.18e-2	SMART
ZnF_C2H2	1142	1165	4.05e-1	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mutations in this gene lead to postnatal lethality, abnormal gait, ataxia, reduced body size, loss of the corpus callosum, reduction of the hippocampus, olfactory bulb defects, and variable malformation of the cerebellum, including vermis agenesis, due to reduced proliferation of neural precursors. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	G	A	5: 109,885,259 (GRCm39)	R200C	probably benign	Het
Ak7	G	A	12: 105,679,834 (GRCm39)	V123M	probably benign	Het
Aoc1l1	A	T	6: 48,952,090 (GRCm39)	Q5L	probably benign	Het
Apc	T	C	18: 34,451,618 (GRCm39)	L2804P	probably damaging	Het
Apob	C	A	12: 8,061,331 (GRCm39)	A3271E	probably damaging	Het
Asl	G	T	5: 130,047,157 (GRCm39)	A147E	probably damaging	Het
Atp1a1	A	G	3: 101,494,259 (GRCm39)	V447A	probably benign	Het
AY358078	T	A	14: 52,063,532 (GRCm39)	C393S	possibly damaging	Het
Bcl11b	T	C	12: 107,882,789 (GRCm39)	K509E	probably damaging	Het
Btnl1	T	C	17: 34,598,699 (GRCm39)	I105T	probably damaging	Het
Btnl10	A	G	11: 58,811,183 (GRCm39)	T169A	probably damaging	Het
C8b	T	C	4: 104,647,841 (GRCm39)	I278T	probably damaging	Het
Ccdc66	T	C	14: 27,222,377 (GRCm39)	N122S	probably damaging	Het
Cd8b1	T	C	6: 71,309,459 (GRCm39)	V181A	probably benign	Het
Cdan1	A	T	2: 120,561,201 (GRCm39)	V189D	probably damaging	Het
Celf2	G	T	2: 6,590,831 (GRCm39)	N279K	possibly damaging	Het
Cfap52	T	C	11: 67,817,247 (GRCm39)	N549D	probably damaging	Het
Cmklr1	C	T	5: 113,752,930 (GRCm39)	V24M	probably benign	Het
Cntnap4	G	T	8: 113,500,371 (GRCm39)		probably null	Het
Col27a1	G	A	4: 63,211,743 (GRCm39)	G91R	probably damaging	Het
Col5a3	A	G	9: 20,726,192 (GRCm39)		probably benign	Het
Dcc	C	T	18: 71,682,069 (GRCm39)		probably null	Het
Deaf1	T	A	7: 140,890,884 (GRCm39)	T433S	possibly damaging	Het
Dnah8	T	A	17: 30,903,211 (GRCm39)	L950H	probably damaging	Het
Dnajc7	A	T	11: 100,481,803 (GRCm39)	Y228*	probably null	Het
Eno1b	T	C	18: 48,180,770 (GRCm39)	V316A	probably damaging	Het
Exoc4	T	C	6: 33,415,340 (GRCm39)	M404T	possibly damaging	Het
Fignl1	A	T	11: 11,751,268 (GRCm39)	C596S	probably benign	Het
Fn1	A	C	1: 71,663,337 (GRCm39)	Y1050*	probably null	Het
Frem2	A	G	3: 53,455,228 (GRCm39)	L2116S	possibly damaging	Het
Gba2	T	A	4: 43,568,092 (GRCm39)	S732C	probably damaging	Het
Gcnt4	C	A	13: 97,082,990 (GRCm39)	S95R	probably benign	Het
Gpr37	A	G	6: 25,669,623 (GRCm39)	V407A	probably benign	Het
Gria2	A	T	3: 80,599,799 (GRCm39)	M695K	probably damaging	Het
Hoxa9	T	C	6: 52,202,690 (GRCm39)	K132R	probably damaging	Het
Ifi213	T	A	1: 173,417,480 (GRCm39)	T311S	possibly damaging	Het
Itgb2	T	A	10: 77,385,884 (GRCm39)	N282K	probably damaging	Het
Kcnh8	A	T	17: 52,909,864 (GRCm39)	Q11L	probably benign	Het
Klk14	T	C	7: 43,343,781 (GRCm39)	C163R	probably damaging	Het
Klk1b3	T	A	7: 43,850,689 (GRCm39)	W74R	possibly damaging	Het
Krtap13-1	G	T	16: 88,526,142 (GRCm39)	C122F	possibly damaging	Het
Luzp2	T	C	7: 54,713,104 (GRCm39)		probably null	Het
Mbtps1	A	T	8: 120,262,086 (GRCm39)	D354E	probably damaging	Het
Mcpt9	C	T	14: 56,266,049 (GRCm39)	V60M	probably damaging	Het
Mical3	C	A	6: 120,911,799 (GRCm39)	E1083*	probably null	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Mtor	T	A	4: 148,570,576 (GRCm39)	V1211E	probably benign	Het
Myb	T	A	10: 21,021,223 (GRCm39)	D402V	probably damaging	Het
Ncor2	G	A	5: 125,107,923 (GRCm39)	T1593I	probably damaging	Het
Ndst3	A	G	3: 123,465,198 (GRCm39)	I258T	probably benign	Het
Npy6r	C	A	18: 44,409,468 (GRCm39)	H296Q	probably damaging	Het
Olfml2b	T	A	1: 170,472,516 (GRCm39)	L9H	probably damaging	Het
Or10a3n	A	G	7: 108,493,324 (GRCm39)	C97R	probably damaging	Het
Or1a1b	A	T	11: 74,097,361 (GRCm39)	V227D	possibly damaging	Het
Or2w2	A	T	13: 21,757,744 (GRCm39)	V294D	probably damaging	Het
Or4k15	C	A	14: 50,364,530 (GRCm39)	N165K	probably benign	Het
Or5b119	C	T	19: 13,457,376 (GRCm39)	C62Y	probably damaging	Het
Or5b94	T	A	19: 12,652,318 (GRCm39)	Y250N	probably damaging	Het
Or6c207	G	A	10: 129,104,274 (GRCm39)	A306V	probably benign	Het
Or8b8	T	A	9: 37,809,622 (GRCm39)	S307R	probably benign	Het
Ovgp1	T	C	3: 105,893,883 (GRCm39)		probably benign	Het
Parg	G	A	14: 31,996,821 (GRCm39)	R304Q	probably damaging	Het
Pdf	T	G	8: 107,775,167 (GRCm39)	S22R	probably benign	Het
Phlpp2	A	T	8: 110,603,515 (GRCm39)	R60S	possibly damaging	Het
Piwil2	C	T	14: 70,639,646 (GRCm39)	E401K	probably benign	Het
Pla2g4e	T	G	2: 120,016,863 (GRCm39)	H226P	possibly damaging	Het
Polr3a	T	C	14: 24,502,576 (GRCm39)		probably null	Het
Ppp3cb	T	C	14: 20,570,714 (GRCm39)	N339S	possibly damaging	Het
Ptch2	G	A	4: 116,967,575 (GRCm39)	D748N	probably benign	Het
Rai14	A	C	15: 10,592,224 (GRCm39)	Y224D	probably damaging	Het
Rft1	A	G	14: 30,411,747 (GRCm39)	I432V	probably damaging	Het
Rictor	C	T	15: 6,816,625 (GRCm39)	A1299V	possibly damaging	Het
Sall2	A	G	14: 52,551,210 (GRCm39)	C662R	probably damaging	Het
Scn4b	A	G	9: 45,061,737 (GRCm39)	N208D	probably damaging	Het
Sdhb	G	A	4: 140,700,226 (GRCm39)	G109R	probably damaging	Het
Sec16a	A	G	2: 26,331,817 (GRCm39)	V66A	probably benign	Het
Sema4g	A	G	19: 44,990,051 (GRCm39)	Y710C	probably damaging	Het
Serpinb12	T	A	1: 106,876,883 (GRCm39)	D66E	probably benign	Het
Shc4	T	A	2: 125,497,602 (GRCm39)	D369V	probably benign	Het
Siglech	T	C	7: 55,421,441 (GRCm39)	L285P	probably damaging	Het
Skint6	A	G	4: 112,931,273 (GRCm39)	M506T	probably benign	Het
Slco1a6	C	A	6: 142,047,378 (GRCm39)	C404F	probably benign	Het
Slfn14	T	A	11: 83,174,140 (GRCm39)	K284*	probably null	Het
Sox14	A	G	9: 99,757,715 (GRCm39)	I8T	probably damaging	Het
Srpk3	A	G	X: 72,818,547 (GRCm39)	H79R	possibly damaging	Het
Tdpoz3	A	T	3: 93,734,330 (GRCm39)	H335L	probably damaging	Het
Tdrd5	T	A	1: 156,111,944 (GRCm39)	T479S	probably benign	Het
Tnik	T	C	3: 28,596,249 (GRCm39)		probably null	Het
Tnpo2	T	C	8: 85,780,432 (GRCm39)	S720P	probably benign	Het
Tpst1	A	G	5: 130,130,547 (GRCm39)	K6E	probably damaging	Het
Trank1	T	A	9: 111,191,329 (GRCm39)	I446N	probably damaging	Het
Trmt44	A	T	5: 35,732,351 (GRCm39)	D13E	probably benign	Het
Ubr4	T	A	4: 139,126,890 (GRCm39)	V471E	possibly damaging	Het
Ubtd1	A	G	19: 42,022,030 (GRCm39)	T101A	probably benign	Het
Ugt3a1	A	T	15: 9,306,486 (GRCm39)	K212*	probably null	Het
Zbtb7c	C	T	18: 76,269,918 (GRCm39)	A2V	possibly damaging	Het
Zfp618	G	A	4: 63,051,216 (GRCm39)	V666M	probably damaging	Het
Zmat1	A	T	X: 133,873,694 (GRCm39)	S566T	probably damaging	Homo
Zscan20	T	C	4: 128,481,899 (GRCm39)	T588A	probably benign	Het
Zscan25	G	A	5: 145,227,926 (GRCm39)	R530H	probably damaging	Het

Other mutations in Zfp423

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01325:Zfp423	APN	8	88,508,239 (GRCm39)	splice site	probably null
IGL01359:Zfp423	APN	8	88,507,290 (GRCm39)	missense	probably damaging	1.00
IGL01780:Zfp423	APN	8	88,508,136 (GRCm39)	missense	probably damaging	1.00
IGL02250:Zfp423	APN	8	88,509,883 (GRCm39)	missense	probably damaging	1.00
IGL02301:Zfp423	APN	8	88,508,202 (GRCm39)	missense	probably damaging	1.00
IGL02320:Zfp423	APN	8	88,508,230 (GRCm39)	missense	probably damaging	1.00
IGL02804:Zfp423	APN	8	88,509,285 (GRCm39)	missense	probably benign	0.02
IGL03090:Zfp423	APN	8	88,508,071 (GRCm39)	missense	probably damaging	1.00
IGL03198:Zfp423	APN	8	88,508,304 (GRCm39)	missense	possibly damaging	0.73
IGL03383:Zfp423	APN	8	88,586,080 (GRCm39)	nonsense	probably null
swell	UTSW	8	88,413,187 (GRCm39)	splice site	probably null
Temptation	UTSW	8	88,508,381 (GRCm39)	missense	probably benign	0.25
trials	UTSW	8	88,507,341 (GRCm39)	missense	probably damaging	1.00
R0110:Zfp423	UTSW	8	88,508,887 (GRCm39)	missense	possibly damaging	0.60
R0142:Zfp423	UTSW	8	88,506,968 (GRCm39)	nonsense	probably null
R0256:Zfp423	UTSW	8	88,500,262 (GRCm39)	nonsense	probably null
R0538:Zfp423	UTSW	8	88,508,713 (GRCm39)	missense	probably damaging	0.99
R0542:Zfp423	UTSW	8	88,507,237 (GRCm39)	missense	probably damaging	1.00
R0614:Zfp423	UTSW	8	88,508,742 (GRCm39)	missense	probably damaging	1.00
R1179:Zfp423	UTSW	8	88,414,700 (GRCm39)	missense	probably damaging	0.97
R1417:Zfp423	UTSW	8	88,500,284 (GRCm39)	splice site	probably null
R1429:Zfp423	UTSW	8	88,413,070 (GRCm39)	missense	probably damaging	0.99
R1570:Zfp423	UTSW	8	88,509,186 (GRCm39)	missense	probably benign	0.37
R2013:Zfp423	UTSW	8	88,509,025 (GRCm39)	missense	probably benign	0.43
R2043:Zfp423	UTSW	8	88,509,246 (GRCm39)	missense	probably damaging	1.00
R2064:Zfp423	UTSW	8	88,507,986 (GRCm39)	missense	probably benign	0.04
R2108:Zfp423	UTSW	8	88,507,806 (GRCm39)	missense	possibly damaging	0.73
R2358:Zfp423	UTSW	8	88,507,179 (GRCm39)	missense	possibly damaging	0.56
R3177:Zfp423	UTSW	8	88,508,959 (GRCm39)	missense	probably damaging	1.00
R3277:Zfp423	UTSW	8	88,508,959 (GRCm39)	missense	probably damaging	1.00
R3738:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R3739:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R3773:Zfp423	UTSW	8	88,507,140 (GRCm39)	missense	probably benign	0.03
R4034:Zfp423	UTSW	8	88,507,972 (GRCm39)	missense	probably damaging	1.00
R4425:Zfp423	UTSW	8	88,509,601 (GRCm39)	missense	probably damaging	1.00
R4700:Zfp423	UTSW	8	88,508,338 (GRCm39)	splice site	probably null
R4753:Zfp423	UTSW	8	88,508,074 (GRCm39)	missense	probably benign	0.00
R4818:Zfp423	UTSW	8	88,631,128 (GRCm39)	missense	probably benign	0.00
R5026:Zfp423	UTSW	8	88,507,302 (GRCm39)	missense	probably damaging	1.00
R5190:Zfp423	UTSW	8	88,509,091 (GRCm39)	missense	probably damaging	1.00
R5243:Zfp423	UTSW	8	88,500,275 (GRCm39)	missense	probably benign	0.03
R5284:Zfp423	UTSW	8	88,508,305 (GRCm39)	missense	possibly damaging	0.73
R5586:Zfp423	UTSW	8	88,585,968 (GRCm39)	missense	possibly damaging	0.93
R5601:Zfp423	UTSW	8	88,508,637 (GRCm39)	missense	probably damaging	1.00
R5671:Zfp423	UTSW	8	88,508,955 (GRCm39)	missense	probably damaging	0.99
R5717:Zfp423	UTSW	8	88,413,187 (GRCm39)	splice site	probably null
R5801:Zfp423	UTSW	8	88,585,990 (GRCm39)	missense	probably damaging	0.99
R5917:Zfp423	UTSW	8	88,508,860 (GRCm39)	nonsense	probably null
R5985:Zfp423	UTSW	8	88,508,774 (GRCm39)	missense	possibly damaging	0.83
R6111:Zfp423	UTSW	8	88,509,315 (GRCm39)	missense	probably damaging	0.99
R6306:Zfp423	UTSW	8	88,508,662 (GRCm39)	missense	possibly damaging	0.64
R6770:Zfp423	UTSW	8	88,508,445 (GRCm39)	missense	probably damaging	0.99
R6970:Zfp423	UTSW	8	88,530,407 (GRCm39)	missense	probably benign	0.00
R7029:Zfp423	UTSW	8	88,414,694 (GRCm39)	missense	probably damaging	0.99
R7060:Zfp423	UTSW	8	88,509,507 (GRCm39)	missense	probably damaging	1.00
R7074:Zfp423	UTSW	8	88,509,060 (GRCm39)	missense	probably benign	0.00
R7121:Zfp423	UTSW	8	88,507,489 (GRCm39)	missense	probably damaging	1.00
R7242:Zfp423	UTSW	8	88,631,155 (GRCm39)	missense	probably benign	0.07
R7359:Zfp423	UTSW	8	88,508,871 (GRCm39)	missense	possibly damaging	0.52
R7426:Zfp423	UTSW	8	88,507,341 (GRCm39)	missense	probably damaging	1.00
R7540:Zfp423	UTSW	8	88,414,695 (GRCm39)	missense	possibly damaging	0.95
R7640:Zfp423	UTSW	8	88,507,905 (GRCm39)	missense	probably damaging	1.00
R7767:Zfp423	UTSW	8	88,507,512 (GRCm39)	missense	probably damaging	1.00
R7938:Zfp423	UTSW	8	88,622,304 (GRCm39)	missense	unknown
R7986:Zfp423	UTSW	8	88,506,978 (GRCm39)	missense	probably benign	0.04
R8347:Zfp423	UTSW	8	88,509,784 (GRCm39)	missense	probably damaging	0.99
R8356:Zfp423	UTSW	8	88,509,910 (GRCm39)	missense	probably damaging	1.00
R8676:Zfp423	UTSW	8	88,509,338 (GRCm39)	missense	probably benign	0.04
R8710:Zfp423	UTSW	8	88,507,549 (GRCm39)	missense	possibly damaging	0.74
R8794:Zfp423	UTSW	8	88,507,857 (GRCm39)	missense	probably damaging	1.00
R8832:Zfp423	UTSW	8	88,507,827 (GRCm39)	missense	probably damaging	0.98
R9018:Zfp423	UTSW	8	88,508,381 (GRCm39)	missense	probably benign	0.25
R9182:Zfp423	UTSW	8	88,508,742 (GRCm39)	missense	probably damaging	0.99
R9309:Zfp423	UTSW	8	88,509,688 (GRCm39)	missense	probably damaging	0.99
R9312:Zfp423	UTSW	8	88,508,569 (GRCm39)	missense	probably damaging	1.00
R9453:Zfp423	UTSW	8	88,508,251 (GRCm39)	missense	probably damaging	1.00
R9469:Zfp423	UTSW	8	88,509,519 (GRCm39)	missense	probably damaging	0.99
R9480:Zfp423	UTSW	8	88,631,115 (GRCm39)	critical splice donor site	probably null
R9483:Zfp423	UTSW	8	88,507,725 (GRCm39)	missense	possibly damaging	0.90
R9510:Zfp423	UTSW	8	88,510,041 (GRCm39)	missense	possibly damaging	0.94
R9521:Zfp423	UTSW	8	88,509,033 (GRCm39)	missense	probably damaging	1.00
R9606:Zfp423	UTSW	8	88,414,595 (GRCm39)	missense	probably damaging	0.99
R9789:Zfp423	UTSW	8	88,506,877 (GRCm39)	missense	probably benign	0.03
Z1176:Zfp423	UTSW	8	88,586,048 (GRCm39)	missense	possibly damaging	0.49
Z1177:Zfp423	UTSW	8	88,507,553 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTCCAGCTGTGATACAGGGC -3'
(R):5'- TTAGGCTGTCCAGAGCAGAG -3'

Sequencing Primer
(F):5'- TGTGATACAGGGCAGGCTC -3'
(R):5'- AGCTGCGACTCACGTCTGTAG -3'

Posted On

2015-09-25