Mutagenetix > Incidental Mutation

Incidental Mutation 'R7455:Tex15'

578075

Institutional Source

Beutler Lab

Gene Symbol

Tex15

Ensembl Gene

ENSMUSG00000009628

Gene Name

testis expressed gene 15

Synonyms

2210014E14Rik

MMRRC Submission

045529-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.291) question?

Stock #

R7455 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

34006766-34075610 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 34067025 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 2152 (Y2152H)

Ref Sequence

ENSEMBL: ENSMUSP00000009772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000009772
AA Change: Y2152H

PolyPhen 2 Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: Y2152H

Domain	Start	End	E-Value	Type
low complexity region	262	274	N/A	INTRINSIC
low complexity region	302	313	N/A	INTRINSIC
low complexity region	524	536	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
low complexity region	713	725	N/A	INTRINSIC
low complexity region	946	961	N/A	INTRINSIC
low complexity region	1497	1508	N/A	INTRINSIC
Pfam:TEX15	1572	1788	1.3e-109	PFAM
Pfam:TEX15	1901	2119	1.1e-16	PFAM
low complexity region	2758	2770	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124496

SMART Domains

Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	89	251	1.6e-58	PFAM
low complexity region	536	548	N/A	INTRINSIC
low complexity region	576	587	N/A	INTRINSIC
low complexity region	798	810	N/A	INTRINSIC
low complexity region	939	948	N/A	INTRINSIC
low complexity region	987	999	N/A	INTRINSIC
low complexity region	1220	1235	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124501

SMART Domains

Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	96	251	2.4e-52	PFAM

Meta Mutation Damage Score

0.2146

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

98% (62/63)

MGI Phenotype

PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl1	C	T	7: 76,074,503 (GRCm39)	H646Y	unknown	Het
Ak5	C	T	3: 152,187,209 (GRCm39)	R426H	probably damaging	Het
Akap9	T	C	5: 4,022,792 (GRCm39)	V1207A	probably benign	Het
Asph	A	T	4: 9,531,732 (GRCm39)		probably null	Het
Avpr1a	T	G	10: 122,285,169 (GRCm39)	C154G	probably damaging	Het
Boll	T	C	1: 55,339,262 (GRCm39)	Q283R	probably benign	Het
Cad	C	T	5: 31,231,506 (GRCm39)	P1743S	probably damaging	Het
Ccdc137	T	G	11: 120,350,985 (GRCm39)	M129R	probably damaging	Het
Cdh23	A	G	10: 60,142,003 (GRCm39)	I3028T	possibly damaging	Het
Cep68	T	A	11: 20,180,571 (GRCm39)	I687F	probably damaging	Het
Ces2a	T	A	8: 105,464,154 (GRCm39)	I262N	probably damaging	Het
Cfap44	A	G	16: 44,225,147 (GRCm39)		probably benign	Het
Cfap69	T	G	5: 5,675,873 (GRCm39)	H247P	possibly damaging	Het
Cideb	T	C	14: 55,992,292 (GRCm39)	T134A	probably damaging	Het
Cilp2	A	T	8: 70,333,721 (GRCm39)	D1092E	probably damaging	Het
Cptp	G	A	4: 155,950,957 (GRCm39)	R170C	probably damaging	Het
Cysrt1	A	G	2: 25,129,422 (GRCm39)	L30S	probably benign	Het
Dcc	A	G	18: 71,553,394 (GRCm39)	V754A	probably benign	Het
Entrep2	A	G	7: 64,409,161 (GRCm39)	V411A	probably benign	Het
Fer1l5	A	T	1: 36,428,064 (GRCm39)	T453S	probably benign	Het
Fnbp4	ACCACCTCCACCTCCACCTCC	ACCACCTCCACCTCCACCTCCACCTCC	2: 90,608,159 (GRCm39)		probably benign	Het
Frem2	C	T	3: 53,479,701 (GRCm39)		probably null	Het
Gm13941	A	G	2: 110,925,085 (GRCm39)	F173L	unknown	Het
Greb1l	G	A	18: 10,554,915 (GRCm39)	A1654T	probably damaging	Het
Inpp4b	T	A	8: 82,798,332 (GRCm39)	I840N	probably damaging	Het
Kdm4b	T	A	17: 56,703,657 (GRCm39)	I746N	probably damaging	Het
Lins1	C	A	7: 66,361,692 (GRCm39)	H448N	probably benign	Het
Ly9	A	T	1: 171,421,507 (GRCm39)	Y581*	probably null	Het
Mark1	T	A	1: 184,651,947 (GRCm39)	E186V	probably damaging	Het
Mcph1	T	A	8: 18,681,775 (GRCm39)	V304E	probably benign	Het
Mical3	T	C	6: 120,935,705 (GRCm39)	D1607G	probably damaging	Het
Mup18	A	G	4: 61,592,171 (GRCm39)	V31A	probably benign	Het
Nectin3	A	T	16: 46,317,105 (GRCm39)	C11*	probably null	Het
Nedd1	A	T	10: 92,536,787 (GRCm39)	L172M	probably benign	Het
Nim1k	G	A	13: 120,173,995 (GRCm39)	R300W	probably damaging	Het
Oprm1	T	C	10: 6,780,204 (GRCm39)	F289L	probably damaging	Het
Or4c115	G	T	2: 88,927,434 (GRCm39)	P279Q	probably damaging	Het
Or7g12	A	G	9: 18,900,150 (GRCm39)	I289V	possibly damaging	Het
Or8c8	T	C	9: 38,165,550 (GRCm39)	V276A	probably damaging	Het
Parg	T	C	14: 31,931,432 (GRCm39)	Y351H	probably benign	Het
Phf3	A	C	1: 30,876,239 (GRCm39)	V118G	probably damaging	Het
Pik3c2g	T	C	6: 139,913,643 (GRCm39)	Y1014H	unknown	Het
Pmp22	A	G	11: 63,025,339 (GRCm39)		probably null	Het
Ppfibp1	T	A	6: 146,917,848 (GRCm39)	F501L	probably damaging	Het
Rgl2	G	A	17: 34,151,657 (GRCm39)	A234T	probably benign	Het
Rhpn2	G	A	7: 35,070,669 (GRCm39)		probably null	Het
Ryr3	T	C	2: 112,559,211 (GRCm39)	K3058E	probably damaging	Het
Sbsn	A	T	7: 30,452,602 (GRCm39)	Q539L	possibly damaging	Het
Scgn	G	A	13: 24,150,848 (GRCm39)	R168C	probably benign	Het
Serpinb10	A	G	1: 107,463,832 (GRCm39)	Y38C	probably damaging	Het
Sfmbt2	G	A	2: 10,582,766 (GRCm39)	V709I	probably benign	Het
Slc1a2	A	T	2: 102,566,299 (GRCm39)	M10L	probably benign	Het
Sox6	T	G	7: 115,088,904 (GRCm39)	I653L	probably benign	Het
Tespa1	A	G	10: 130,196,559 (GRCm39)	I166V	probably benign	Het
Tlr9	A	G	9: 106,101,729 (GRCm39)	N340S	probably benign	Het
Tmem198	G	A	1: 75,456,430 (GRCm39)	R28Q	unknown	Het
Tut7	T	C	13: 59,969,871 (GRCm39)	Y8C	probably benign	Het
Vmn2r7	T	C	3: 64,624,014 (GRCm39)	D102G	probably benign	Het
Wdr93	A	G	7: 79,425,267 (GRCm39)	M529V	probably benign	Het
Zfp110	A	G	7: 12,581,984 (GRCm39)	H310R	probably benign	Het
Zfp36l2	A	G	17: 84,494,575 (GRCm39)	S21P	probably damaging	Het
Zfp534	G	A	4: 147,759,212 (GRCm39)	H486Y	probably damaging	Het
Zfp638	G	A	6: 83,907,127 (GRCm39)	V431I	probably damaging	Het

Other mutations in Tex15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00639:Tex15	APN	8	34,065,339 (GRCm39)	missense	probably benign	0.18
IGL00705:Tex15	APN	8	34,071,620 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tex15	APN	8	34,069,034 (GRCm39)	splice site	probably benign
IGL01288:Tex15	APN	8	34,061,412 (GRCm39)	missense	probably benign	0.02
IGL01328:Tex15	APN	8	34,061,424 (GRCm39)	nonsense	probably null
IGL01359:Tex15	APN	8	34,071,926 (GRCm39)	missense	probably damaging	0.99
IGL01603:Tex15	APN	8	34,063,575 (GRCm39)	missense	possibly damaging	0.93
IGL01861:Tex15	APN	8	34,060,717 (GRCm39)	missense	probably damaging	1.00
IGL02052:Tex15	APN	8	34,072,493 (GRCm39)	missense	probably benign	0.28
IGL02560:Tex15	APN	8	34,071,779 (GRCm39)	missense	probably benign	0.00
IGL02677:Tex15	APN	8	34,061,108 (GRCm39)	missense	probably benign	0.03
IGL02739:Tex15	APN	8	34,071,721 (GRCm39)	missense	possibly damaging	0.68
Big_gulp	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
P0005:Tex15	UTSW	8	34,060,896 (GRCm39)	missense	probably benign	0.00
P0037:Tex15	UTSW	8	34,071,608 (GRCm39)	missense	probably benign	0.00
PIT4377001:Tex15	UTSW	8	34,061,129 (GRCm39)	missense	probably damaging	1.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0595:Tex15	UTSW	8	34,062,645 (GRCm39)	missense	probably damaging	1.00
R0646:Tex15	UTSW	8	34,072,354 (GRCm39)	missense	possibly damaging	0.83
R0688:Tex15	UTSW	8	34,063,528 (GRCm39)	missense	probably damaging	1.00
R0842:Tex15	UTSW	8	34,061,575 (GRCm39)	missense	possibly damaging	0.95
R0987:Tex15	UTSW	8	34,066,875 (GRCm39)	missense	probably damaging	1.00
R1084:Tex15	UTSW	8	34,067,032 (GRCm39)	missense	probably benign	0.28
R1183:Tex15	UTSW	8	34,064,893 (GRCm39)	missense	probably benign	0.35
R1186:Tex15	UTSW	8	34,061,661 (GRCm39)	missense	probably benign	0.19
R1378:Tex15	UTSW	8	34,065,244 (GRCm39)	missense	probably damaging	0.99
R1500:Tex15	UTSW	8	34,065,120 (GRCm39)	missense	probably damaging	0.96
R1508:Tex15	UTSW	8	34,066,880 (GRCm39)	missense	probably damaging	1.00
R1597:Tex15	UTSW	8	34,061,511 (GRCm39)	missense	probably damaging	0.96
R1636:Tex15	UTSW	8	34,066,415 (GRCm39)	nonsense	probably null
R1639:Tex15	UTSW	8	34,060,845 (GRCm39)	missense	possibly damaging	0.94
R1809:Tex15	UTSW	8	34,064,262 (GRCm39)	missense	probably benign
R1843:Tex15	UTSW	8	34,066,682 (GRCm39)	missense	probably benign	0.27
R2029:Tex15	UTSW	8	34,061,302 (GRCm39)	missense	probably damaging	0.99
R2228:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2229:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2245:Tex15	UTSW	8	34,061,524 (GRCm39)	missense	possibly damaging	0.77
R2246:Tex15	UTSW	8	34,072,540 (GRCm39)	missense	possibly damaging	0.49
R2880:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2881:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2882:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R3001:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3002:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3020:Tex15	UTSW	8	34,066,698 (GRCm39)	missense	probably damaging	1.00
R3084:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3085:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3701:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3702:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3752:Tex15	UTSW	8	34,061,443 (GRCm39)	missense	probably benign
R4162:Tex15	UTSW	8	34,071,586 (GRCm39)	missense	probably damaging	1.00
R4231:Tex15	UTSW	8	34,062,165 (GRCm39)	missense	probably damaging	0.99
R4589:Tex15	UTSW	8	34,047,401 (GRCm39)	missense	probably damaging	1.00
R4707:Tex15	UTSW	8	34,072,525 (GRCm39)	missense	probably benign	0.00
R4773:Tex15	UTSW	8	34,072,760 (GRCm39)	missense	probably benign	0.42
R4967:Tex15	UTSW	8	34,064,498 (GRCm39)	missense	probably benign	0.34
R5063:Tex15	UTSW	8	34,072,638 (GRCm39)	missense	possibly damaging	0.59
R5121:Tex15	UTSW	8	34,061,794 (GRCm39)	missense	probably damaging	1.00
R5147:Tex15	UTSW	8	34,062,340 (GRCm39)	nonsense	probably null
R5166:Tex15	UTSW	8	34,066,420 (GRCm39)	missense	probably benign	0.07
R5173:Tex15	UTSW	8	34,061,768 (GRCm39)	missense	possibly damaging	0.73
R5439:Tex15	UTSW	8	34,064,199 (GRCm39)	missense	possibly damaging	0.93
R5537:Tex15	UTSW	8	34,061,641 (GRCm39)	missense	probably damaging	1.00
R5580:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R5588:Tex15	UTSW	8	34,067,215 (GRCm39)	missense	probably damaging	1.00
R5696:Tex15	UTSW	8	34,063,220 (GRCm39)	missense	probably benign	0.01
R5734:Tex15	UTSW	8	34,036,364 (GRCm39)	missense	probably benign	0.01
R5756:Tex15	UTSW	8	34,065,861 (GRCm39)	missense	probably benign	0.17
R5823:Tex15	UTSW	8	34,060,962 (GRCm39)	missense	possibly damaging	0.67
R6126:Tex15	UTSW	8	34,063,591 (GRCm39)	missense	probably benign	0.19
R6129:Tex15	UTSW	8	34,064,158 (GRCm39)	missense	possibly damaging	0.90
R6276:Tex15	UTSW	8	34,067,217 (GRCm39)	missense	possibly damaging	0.93
R6374:Tex15	UTSW	8	34,065,940 (GRCm39)	missense	probably damaging	1.00
R6430:Tex15	UTSW	8	34,061,329 (GRCm39)	missense	probably benign	0.01
R6452:Tex15	UTSW	8	34,062,844 (GRCm39)	missense	probably damaging	1.00
R6471:Tex15	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
R6700:Tex15	UTSW	8	34,064,917 (GRCm39)	missense	possibly damaging	0.93
R6918:Tex15	UTSW	8	34,063,212 (GRCm39)	missense	probably benign	0.27
R6958:Tex15	UTSW	8	34,060,899 (GRCm39)	missense	probably benign	0.01
R6970:Tex15	UTSW	8	34,047,456 (GRCm39)	missense	probably benign	0.03
R7059:Tex15	UTSW	8	34,064,758 (GRCm39)	missense	possibly damaging	0.57
R7069:Tex15	UTSW	8	34,060,748 (GRCm39)	missense	probably benign
R7072:Tex15	UTSW	8	34,065,459 (GRCm39)	missense	possibly damaging	0.85
R7212:Tex15	UTSW	8	34,063,023 (GRCm39)	missense	probably damaging	1.00
R7212:Tex15	UTSW	8	34,060,854 (GRCm39)	nonsense	probably null
R7216:Tex15	UTSW	8	34,063,014 (GRCm39)	missense	possibly damaging	0.93
R7219:Tex15	UTSW	8	34,036,268 (GRCm39)	missense	probably benign	0.40
R7313:Tex15	UTSW	8	34,064,845 (GRCm39)	missense	possibly damaging	0.82
R7315:Tex15	UTSW	8	34,071,544 (GRCm39)	missense	probably benign	0.01
R7444:Tex15	UTSW	8	34,066,590 (GRCm39)	missense	possibly damaging	0.92
R7643:Tex15	UTSW	8	34,065,148 (GRCm39)	missense	probably damaging	1.00
R7644:Tex15	UTSW	8	34,064,445 (GRCm39)	missense	probably benign	0.01
R7724:Tex15	UTSW	8	34,036,291 (GRCm39)	missense	possibly damaging	0.60
R7779:Tex15	UTSW	8	34,065,309 (GRCm39)	missense	probably damaging	1.00
R7798:Tex15	UTSW	8	34,071,875 (GRCm39)	missense	possibly damaging	0.69
R7816:Tex15	UTSW	8	34,071,683 (GRCm39)	missense	probably benign	0.14
R7820:Tex15	UTSW	8	34,065,090 (GRCm39)	missense	probably damaging	0.98
R8041:Tex15	UTSW	8	34,065,874 (GRCm39)	missense	probably damaging	1.00
R8150:Tex15	UTSW	8	34,063,534 (GRCm39)	missense	probably benign	0.06
R8152:Tex15	UTSW	8	34,062,921 (GRCm39)	missense	possibly damaging	0.82
R8237:Tex15	UTSW	8	34,067,427 (GRCm39)	missense	possibly damaging	0.72
R8250:Tex15	UTSW	8	34,055,233 (GRCm39)	missense	probably null	0.27
R8264:Tex15	UTSW	8	34,072,390 (GRCm39)	missense	probably benign	0.18
R8279:Tex15	UTSW	8	34,061,765 (GRCm39)	missense	probably damaging	0.96
R8353:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8388:Tex15	UTSW	8	34,065,237 (GRCm39)	missense	probably benign	0.00
R8432:Tex15	UTSW	8	34,066,572 (GRCm39)	missense	probably damaging	0.99
R8453:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8489:Tex15	UTSW	8	34,067,574 (GRCm39)	missense	probably benign	0.02
R8670:Tex15	UTSW	8	34,064,746 (GRCm39)	missense	probably benign	0.19
R8703:Tex15	UTSW	8	34,062,724 (GRCm39)	missense	probably benign	0.00
R8871:Tex15	UTSW	8	34,066,992 (GRCm39)	missense	possibly damaging	0.62
R8945:Tex15	UTSW	8	34,064,724 (GRCm39)	missense	probably benign	0.00
R9104:Tex15	UTSW	8	34,060,950 (GRCm39)	missense	possibly damaging	0.86
R9132:Tex15	UTSW	8	34,067,554 (GRCm39)	missense	possibly damaging	0.84
R9207:Tex15	UTSW	8	34,065,784 (GRCm39)	missense	probably damaging	1.00
R9210:Tex15	UTSW	8	34,064,319 (GRCm39)	missense	possibly damaging	0.91
R9330:Tex15	UTSW	8	34,065,143 (GRCm39)	missense	probably benign	0.01
R9354:Tex15	UTSW	8	34,063,344 (GRCm39)	missense	possibly damaging	0.86
R9365:Tex15	UTSW	8	34,064,564 (GRCm39)	missense	possibly damaging	0.56
R9440:Tex15	UTSW	8	34,072,273 (GRCm39)	missense	possibly damaging	0.90
R9534:Tex15	UTSW	8	34,060,999 (GRCm39)	missense	probably benign	0.45
R9570:Tex15	UTSW	8	34,067,309 (GRCm39)	missense	probably damaging	0.96
R9574:Tex15	UTSW	8	34,064,509 (GRCm39)	missense	probably benign	0.09
R9618:Tex15	UTSW	8	34,062,397 (GRCm39)	missense	probably benign	0.35
R9655:Tex15	UTSW	8	34,066,784 (GRCm39)	nonsense	probably null
R9786:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R9798:Tex15	UTSW	8	34,062,721 (GRCm39)	missense	probably damaging	0.98
RF005:Tex15	UTSW	8	34,066,705 (GRCm39)	missense	probably benign	0.05
X0020:Tex15	UTSW	8	34,066,607 (GRCm39)	missense	probably benign	0.03
X0065:Tex15	UTSW	8	34,065,545 (GRCm39)	nonsense	probably null
Z1088:Tex15	UTSW	8	34,061,343 (GRCm39)	missense	possibly damaging	0.89
Z1088:Tex15	UTSW	8	34,064,898 (GRCm39)	missense	probably benign
Z1088:Tex15	UTSW	8	34,061,838 (GRCm39)	missense	possibly damaging	0.68
Z1176:Tex15	UTSW	8	34,064,754 (GRCm39)	missense	possibly damaging	0.84

Predicted Primers

PCR Primer
(F):5'- CCAGAGATTTCGAGGTATGCTC -3'
(R):5'- TCCAAAATCTTTCTGAGGGACAG -3'

Sequencing Primer
(F):5'- AGAGATTTCGAGGTATGCTCTGGTTC -3'
(R):5'- GAGGGACAGACATTACATTTTTGAG -3'

Posted On

2019-10-07