Mutagenetix > Incidental Mutation

Incidental Mutation 'R1147:Vmn2r33'

102487

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r33

Ensembl Gene

ENSMUSG00000096691

Gene Name

vomeronasal 2, receptor 33

Synonyms

MMRRC Submission

039220-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R1147 (G1)

Quality Score

124

Status

Not validated

Chromosome

Chromosomal Location

7553966-7569785 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 7557144 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 519 (E519K)

Ref Sequence

ENSEMBL: ENSMUSP00000129960 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165921]

AlphaFold

K7N705

Predicted Effect

probably benign
Transcript: ENSMUST00000165921
AA Change: E519K

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000129960
Gene: ENSMUSG00000096691
AA Change: E519K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	4.2e-34	PFAM
Pfam:NCD3G	512	565	4.1e-19	PFAM
Pfam:7tm_3	598	833	3.1e-55	PFAM

Coding Region Coverage

1x: 99.4%
3x: 97.7%
10x: 89.5%
20x: 66.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam20	T	C	8: 41,248,655 (GRCm39)	I255T	possibly damaging	Het
Aknad1	T	A	3: 108,659,857 (GRCm39)	N290K	possibly damaging	Het
Ano8	C	A	8: 71,934,661 (GRCm39)	V447F	probably damaging	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
Ash1l	A	T	3: 88,892,194 (GRCm39)	M1358L	possibly damaging	Het
Ccdc110	A	G	8: 46,397,121 (GRCm39)	K837E	possibly damaging	Het
Cd19	T	A	7: 126,010,217 (GRCm39)	D384V	possibly damaging	Het
Ces1f	C	T	8: 93,984,909 (GRCm39)	V473I	possibly damaging	Het
Chd6	C	T	2: 160,832,191 (GRCm39)	E994K	probably damaging	Het
Col5a2	G	T	1: 45,415,931 (GRCm39)	N1405K	probably damaging	Het
Dnah7b	A	G	1: 46,379,426 (GRCm39)	D3720G	probably damaging	Het
Dsel	T	C	1: 111,789,939 (GRCm39)	T199A	possibly damaging	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Flacc1	A	T	1: 58,708,622 (GRCm39)	Y215N	probably damaging	Het
Hrg	G	T	16: 22,779,754 (GRCm39)	C344F	probably damaging	Het
Htt	T	C	5: 35,008,596 (GRCm39)	Y1462H	probably damaging	Het
Kcnh2	T	A	5: 24,529,385 (GRCm39)	I784F	probably damaging	Het
Kifc3	T	C	8: 95,864,546 (GRCm39)	T55A	probably damaging	Het
Kirrel1	C	T	3: 86,996,458 (GRCm39)	M380I	probably null	Het
Oog3	A	G	4: 143,884,982 (GRCm39)	F318S	possibly damaging	Het
Or2a20	A	T	6: 43,194,146 (GRCm39)	T100S	probably damaging	Het
Or52w1	G	A	7: 105,018,484 (GRCm39)	R308Q	probably benign	Het
Pde5a	C	T	3: 122,587,962 (GRCm39)	T376M	probably damaging	Het
Pkhd1l1	A	G	15: 44,400,837 (GRCm39)	I2204V	probably null	Het
Ppp1r13l	A	G	7: 19,109,772 (GRCm39)	D731G	probably damaging	Het
Ptk6	C	T	2: 180,837,590 (GRCm39)	G443D	probably benign	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Ptprs	T	C	17: 56,730,504 (GRCm39)	D749G	probably damaging	Het
Ralgapa1	A	T	12: 55,749,265 (GRCm39)	D1212E	probably damaging	Het
Rsad1	T	C	11: 94,434,966 (GRCm39)	Y290C	probably damaging	Het
Sfi1	CCTCTC	CCTCTCTC	11: 3,127,419 (GRCm39)		probably benign	Het
Slc6a11	T	A	6: 114,221,831 (GRCm39)	I507N	possibly damaging	Het
Sp140l1	C	G	1: 85,077,226 (GRCm39)	K113N	probably benign	Het
Sybu	A	T	15: 44,609,651 (GRCm39)	F78I	probably damaging	Het
Tox	A	T	4: 6,823,055 (GRCm39)	N87K	possibly damaging	Het
Trrap	G	A	5: 144,741,576 (GRCm39)	G1308R	probably damaging	Het
Trub2	A	G	2: 29,677,644 (GRCm39)		probably benign	Het
Vmn2r114	A	T	17: 23,530,037 (GRCm39)	H123Q	probably benign	Het
Vmn2r15	T	A	5: 109,441,072 (GRCm39)	Y262F	probably damaging	Het
Zfp106	A	T	2: 120,351,017 (GRCm39)	C1545S	probably damaging	Het

Other mutations in Vmn2r33

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01893:Vmn2r33	APN	7	7,566,776 (GRCm39)	missense	probably benign
R1147:Vmn2r33	UTSW	7	7,557,144 (GRCm39)	missense	probably benign	0.16
R3966:Vmn2r33	UTSW	7	7,557,168 (GRCm39)	missense	probably benign	0.00
R4408:Vmn2r33	UTSW	7	7,554,229 (GRCm39)	missense	probably damaging	1.00
R6571:Vmn2r33	UTSW	7	7,566,668 (GRCm39)	missense	probably benign	0.00
R6783:Vmn2r33	UTSW	7	7,566,797 (GRCm39)	missense	probably benign
R7180:Vmn2r33	UTSW	7	7,566,896 (GRCm39)	missense	probably benign	0.00
R7984:Vmn2r33	UTSW	7	7,566,862 (GRCm39)	missense	probably benign	0.01
R8202:Vmn2r33	UTSW	7	7,557,153 (GRCm39)	missense	possibly damaging	0.87
R8894:Vmn2r33	UTSW	7	7,566,809 (GRCm39)	missense	probably benign	0.00
R8954:Vmn2r33	UTSW	7	7,554,655 (GRCm39)	missense	probably benign	0.02
R8995:Vmn2r33	UTSW	7	7,554,192 (GRCm39)	missense	probably damaging	1.00
R9027:Vmn2r33	UTSW	7	7,554,168 (GRCm39)	missense	probably damaging	1.00
R9564:Vmn2r33	UTSW	7	7,557,081 (GRCm39)	missense	probably benign	0.06
R9608:Vmn2r33	UTSW	7	7,557,153 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

Posted On

2014-01-15