Incidental Mutation 'IGL01660:Pga5'
ID103127
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pga5
Ensembl Gene ENSMUSG00000024738
Gene Namepepsinogen 5, group I
Synonyms1110035E17Rik, Pepf, pepsinogen A5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL01660
Quality Score
Status
Chromosome19
Chromosomal Location10668956-10678071 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 10675092 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 95 (S95P)
Ref Sequence ENSEMBL: ENSMUSP00000025647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025647]
Predicted Effect probably damaging
Transcript: ENSMUST00000025647
AA Change: S95P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025647
Gene: ENSMUSG00000024738
AA Change: S95P

DomainStartEndE-ValueType
Pfam:A1_Propeptide 16 44 1.1e-13 PFAM
Pfam:Asp 73 386 1.1e-112 PFAM
Pfam:TAXi_N 74 229 7.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225016
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225135
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik A T 19: 45,940,476 L393H probably damaging Het
Acta2 A G 19: 34,251,791 I66T probably damaging Het
Actl11 T C 9: 107,929,048 V190A probably benign Het
Ankub1 T A 3: 57,690,396 Y51F possibly damaging Het
Ccdc63 G A 5: 122,110,964 S434L possibly damaging Het
Cdan1 T A 2: 120,725,653 I711F possibly damaging Het
Cep170b C A 12: 112,744,160 N1474K probably damaging Het
Cyp2c40 A G 19: 39,786,810 S333P probably damaging Het
Dars A G 1: 128,415,344 probably benign Het
Dock3 T A 9: 107,032,364 probably benign Het
Dsp A G 13: 38,176,495 I359V possibly damaging Het
Fut8 T G 12: 77,450,258 L414* probably null Het
Gja1 A G 10: 56,388,448 Y301C probably damaging Het
Glipr1l1 T C 10: 112,072,279 S161P probably damaging Het
Gpat4 A T 8: 23,175,338 probably null Het
Grhl1 T A 12: 24,608,578 probably null Het
Hectd3 T C 4: 116,996,372 V181A possibly damaging Het
Htr2a T A 14: 74,705,754 I258N probably damaging Het
Hyou1 T A 9: 44,381,117 D83E possibly damaging Het
Myh10 T A 11: 68,785,889 L862Q probably benign Het
Nkx2-2 T C 2: 147,185,913 S36G probably benign Het
Nsun2 T A 13: 69,623,249 V326E probably benign Het
Nuak2 T C 1: 132,331,570 V362A probably benign Het
Nyap2 G A 1: 81,191,927 C133Y probably damaging Het
Oas2 T C 5: 120,741,223 T351A probably benign Het
Olfr1025-ps1 T C 2: 85,918,564 I213T probably benign Het
Olfr279 C T 15: 98,498,195 T241I probably damaging Het
Pde4d A T 13: 109,938,072 I404F probably damaging Het
Pitpnm2 A T 5: 124,123,194 D947E probably damaging Het
Pla2g10 C T 16: 13,728,086 R28H probably damaging Het
Prlr A G 15: 10,317,590 D84G probably damaging Het
Rbm15b C T 9: 106,885,709 G420D probably damaging Het
Tbcd A G 11: 121,605,327 T1063A probably benign Het
Tmc2 C T 2: 130,260,224 Q770* probably null Het
Tpo T C 12: 30,119,400 probably benign Het
Vim A G 2: 13,574,813 N128D probably damaging Het
Vmn1r21 A T 6: 57,844,237 I74N probably damaging Het
Vmn2r52 A C 7: 10,159,180 I677M probably damaging Het
Other mutations in Pga5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02037:Pga5 APN 19 10676701 missense probably benign 0.01
IGL02069:Pga5 APN 19 10669399 missense possibly damaging 0.76
IGL02197:Pga5 APN 19 10671913 splice site probably benign
IGL02871:Pga5 APN 19 10671780 splice site probably benign
R0238:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0238:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0239:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0239:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R1573:Pga5 UTSW 19 10673837 missense probably benign 0.13
R1941:Pga5 UTSW 19 10669456 splice site probably null
R4354:Pga5 UTSW 19 10674826 critical splice donor site probably null
R4568:Pga5 UTSW 19 10671852 missense probably damaging 1.00
R5119:Pga5 UTSW 19 10676689 missense probably benign 0.00
R5738:Pga5 UTSW 19 10669660 missense probably benign 0.05
R5864:Pga5 UTSW 19 10675149 missense probably damaging 1.00
R6176:Pga5 UTSW 19 10671785 splice site probably null
R6270:Pga5 UTSW 19 10674861 missense probably benign
R6990:Pga5 UTSW 19 10669415 missense probably benign 0.03
R8056:Pga5 UTSW 19 10676797 splice site probably benign
R8348:Pga5 UTSW 19 10671809 missense probably damaging 1.00
R8448:Pga5 UTSW 19 10671809 missense probably damaging 1.00
R8510:Pga5 UTSW 19 10677944 missense possibly damaging 0.73
Z1176:Pga5 UTSW 19 10669159 missense probably damaging 1.00
Posted On2014-01-21