Incidental Mutation 'IGL01660:Vmn1r21'
ID103121
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r21
Ensembl Gene ENSMUSG00000115343
Gene Namevomeronasal 1 receptor 21
SynonymsV1rc28
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.192) question?
Stock #IGL01660
Quality Score
Status
Chromosome6
Chromosomal Location57842830-57850343 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 57844237 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 74 (I74N)
Ref Sequence ENSEMBL: ENSMUSP00000154295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081186] [ENSMUST00000203310] [ENSMUST00000203488] [ENSMUST00000226191]
Predicted Effect probably damaging
Transcript: ENSMUST00000081186
AA Change: I74N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: I74N

DomainStartEndE-ValueType
Pfam:V1R 28 293 5.9e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203270
Predicted Effect probably damaging
Transcript: ENSMUST00000203310
AA Change: I74N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: I74N

DomainStartEndE-ValueType
Pfam:V1R 27 107 1.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203488
AA Change: I74N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: I74N

DomainStartEndE-ValueType
Pfam:V1R 28 105 2e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226191
AA Change: I74N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik A T 19: 45,940,476 L393H probably damaging Het
Acta2 A G 19: 34,251,791 I66T probably damaging Het
Actl11 T C 9: 107,929,048 V190A probably benign Het
Ankub1 T A 3: 57,690,396 Y51F possibly damaging Het
Ccdc63 G A 5: 122,110,964 S434L possibly damaging Het
Cdan1 T A 2: 120,725,653 I711F possibly damaging Het
Cep170b C A 12: 112,744,160 N1474K probably damaging Het
Cyp2c40 A G 19: 39,786,810 S333P probably damaging Het
Dars A G 1: 128,415,344 probably benign Het
Dock3 T A 9: 107,032,364 probably benign Het
Dsp A G 13: 38,176,495 I359V possibly damaging Het
Fut8 T G 12: 77,450,258 L414* probably null Het
Gja1 A G 10: 56,388,448 Y301C probably damaging Het
Glipr1l1 T C 10: 112,072,279 S161P probably damaging Het
Gpat4 A T 8: 23,175,338 probably null Het
Grhl1 T A 12: 24,608,578 probably null Het
Hectd3 T C 4: 116,996,372 V181A possibly damaging Het
Htr2a T A 14: 74,705,754 I258N probably damaging Het
Hyou1 T A 9: 44,381,117 D83E possibly damaging Het
Myh10 T A 11: 68,785,889 L862Q probably benign Het
Nkx2-2 T C 2: 147,185,913 S36G probably benign Het
Nsun2 T A 13: 69,623,249 V326E probably benign Het
Nuak2 T C 1: 132,331,570 V362A probably benign Het
Nyap2 G A 1: 81,191,927 C133Y probably damaging Het
Oas2 T C 5: 120,741,223 T351A probably benign Het
Olfr1025-ps1 T C 2: 85,918,564 I213T probably benign Het
Olfr279 C T 15: 98,498,195 T241I probably damaging Het
Pde4d A T 13: 109,938,072 I404F probably damaging Het
Pga5 A G 19: 10,675,092 S95P probably damaging Het
Pitpnm2 A T 5: 124,123,194 D947E probably damaging Het
Pla2g10 C T 16: 13,728,086 R28H probably damaging Het
Prlr A G 15: 10,317,590 D84G probably damaging Het
Rbm15b C T 9: 106,885,709 G420D probably damaging Het
Tbcd A G 11: 121,605,327 T1063A probably benign Het
Tmc2 C T 2: 130,260,224 Q770* probably null Het
Tpo T C 12: 30,119,400 probably benign Het
Vim A G 2: 13,574,813 N128D probably damaging Het
Vmn2r52 A C 7: 10,159,180 I677M probably damaging Het
Other mutations in Vmn1r21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Vmn1r21 APN 6 57844064 missense probably benign 0.05
IGL01366:Vmn1r21 APN 6 57843814 missense probably benign 0.01
IGL02864:Vmn1r21 APN 6 57843676 missense probably benign 0.13
IGL02961:Vmn1r21 APN 6 57843989 missense probably benign 0.01
IGL03170:Vmn1r21 APN 6 57843862 missense probably damaging 0.99
PIT4453001:Vmn1r21 UTSW 6 57844322 missense probably benign 0.04
R1800:Vmn1r21 UTSW 6 57843814 missense probably benign 0.01
R1928:Vmn1r21 UTSW 6 57844092 nonsense probably null
R3407:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R5566:Vmn1r21 UTSW 6 57844094 missense probably benign 0.06
R6012:Vmn1r21 UTSW 6 57843906 missense probably damaging 1.00
R6293:Vmn1r21 UTSW 6 57844270 missense probably benign 0.19
R6473:Vmn1r21 UTSW 6 57843598 missense probably damaging 0.99
R7128:Vmn1r21 UTSW 6 57843951 missense probably damaging 0.97
R7489:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R7559:Vmn1r21 UTSW 6 57844242 missense probably damaging 0.99
R8002:Vmn1r21 UTSW 6 57844214 missense probably benign 0.00
R8218:Vmn1r21 UTSW 6 57843925 missense noncoding transcript
Z1176:Vmn1r21 UTSW 6 57843578 missense probably benign 0.01
Posted On2014-01-21