Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01663:Prmt2'

103251

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prmt2

Ensembl Gene

ENSMUSG00000020230

Gene Name

protein arginine N-methyltransferase 2

Synonyms

Hrmt1l1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01663

Quality Score

Status

Chromosome

Chromosomal Location

76043060-76073699 bp(-) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to T at 76053143 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000097167 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020452] [ENSMUST00000020452] [ENSMUST00000020452] [ENSMUST00000099571] [ENSMUST00000099571] [ENSMUST00000099571] [ENSMUST00000099572] [ENSMUST00000099572] [ENSMUST00000099572] [ENSMUST00000128099] [ENSMUST00000137857] [ENSMUST00000217726]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000020452

SMART Domains

Protein: ENSMUSP00000020452
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000020452

SMART Domains

Protein: ENSMUSP00000020452
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000020452

SMART Domains

Protein: ENSMUSP00000020452
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099571

SMART Domains

Protein: ENSMUSP00000097166
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099571

SMART Domains

Protein: ENSMUSP00000097166
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099571

SMART Domains

Protein: ENSMUSP00000097166
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	122	253	2.5e-8	PFAM
Pfam:PRMT5	123	427	2.4e-13	PFAM
Pfam:Met_10	127	244	5.1e-8	PFAM
Pfam:MTS	134	223	5.7e-11	PFAM
Pfam:Methyltransf_31	147	294	1.5e-8	PFAM
Pfam:Methyltransf_26	150	224	1.2e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099572

SMART Domains

Protein: ENSMUSP00000097167
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	124	253	3.1e-8	PFAM
Pfam:PRMT5	124	451	1.2e-11	PFAM
Pfam:MTS	137	223	3.3e-10	PFAM
Pfam:Methyltransf_31	147	294	1.7e-8	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099572

SMART Domains

Protein: ENSMUSP00000097167
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	124	253	3.1e-8	PFAM
Pfam:PRMT5	124	451	1.2e-11	PFAM
Pfam:MTS	137	223	3.3e-10	PFAM
Pfam:Methyltransf_31	147	294	1.7e-8	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099572

SMART Domains

Protein: ENSMUSP00000097167
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	124	253	3.1e-8	PFAM
Pfam:PRMT5	124	451	1.2e-11	PFAM
Pfam:MTS	137	223	3.3e-10	PFAM
Pfam:Methyltransf_31	147	294	1.7e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000128099

SMART Domains

Protein: ENSMUSP00000137707
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	120	253	1.3e-9	PFAM
Pfam:Met_10	122	235	3.8e-8	PFAM
Pfam:TehB	122	235	6.9e-8	PFAM
Pfam:MTS	133	223	2e-11	PFAM
Pfam:Methyltransf_31	147	243	9.3e-9	PFAM
Pfam:Methyltransf_26	150	224	4.6e-10	PFAM
Pfam:Methyltransf_11	154	238	3.2e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000137857

SMART Domains

Protein: ENSMUSP00000137725
Gene: ENSMUSG00000020230

Domain	Start	End	E-Value	Type
low complexity region	30	43	N/A	INTRINSIC
SH3	45	100	4.22e-15	SMART
Pfam:PrmA	120	253	1.5e-9	PFAM
Pfam:Met_10	129	235	4.2e-7	PFAM
Pfam:MTS	137	223	1.1e-10	PFAM
Pfam:Methyltransf_31	147	243	9.2e-9	PFAM
Pfam:Methyltransf_11	154	237	1.7e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217726

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220116

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	A	G	11: 84,168,628 (GRCm39)	I1085V	possibly damaging	Het
Adamts16	T	C	13: 70,941,260 (GRCm39)	T376A	probably benign	Het
Aifm3	T	A	16: 17,320,650 (GRCm39)		probably null	Het
Ankrd16	A	G	2: 11,783,473 (GRCm39)	E25G	probably damaging	Het
Ano6	T	A	15: 95,865,495 (GRCm39)		probably null	Het
Cdh18	T	C	15: 23,446,077 (GRCm39)	I509T	possibly damaging	Het
Cdon	A	G	9: 35,394,510 (GRCm39)	T919A	possibly damaging	Het
Clca3a2	G	A	3: 144,522,916 (GRCm39)	P148L	probably damaging	Het
Dnph1	G	T	17: 46,809,408 (GRCm39)	R74L	probably benign	Het
Epha6	C	T	16: 59,596,007 (GRCm39)	A895T	probably damaging	Het
Exoc3l4	T	A	12: 111,395,845 (GRCm39)		probably benign	Het
Fbll1	A	G	11: 35,688,648 (GRCm39)	I205T	probably damaging	Het
Frem2	T	A	3: 53,424,434 (GRCm39)	H3001L	probably damaging	Het
Galk2	A	G	2: 125,825,099 (GRCm39)	N432D	probably benign	Het
Gm7535	A	C	17: 18,131,619 (GRCm39)		probably benign	Het
Il10	A	G	1: 130,949,151 (GRCm39)	E104G	probably benign	Het
Il1a	T	C	2: 129,146,637 (GRCm39)	K152R	probably benign	Het
Kdm1b	T	A	13: 47,227,213 (GRCm39)	N568K	probably damaging	Het
Kmt2c	A	C	5: 25,515,668 (GRCm39)	L2725R	probably damaging	Het
Krba1	G	T	6: 48,388,688 (GRCm39)	L527F	probably damaging	Het
Lrp2	A	G	2: 69,259,050 (GRCm39)	S4547P	probably benign	Het
Nin	G	T	12: 70,090,439 (GRCm39)	A992E	possibly damaging	Het
Or11g7	G	A	14: 50,690,607 (GRCm39)	V33M	probably benign	Het
Or5p81	T	A	7: 108,267,098 (GRCm39)	H158Q	probably benign	Het
Pcdhb1	A	G	18: 37,400,186 (GRCm39)	I712M	possibly damaging	Het
Rbm20	T	G	19: 53,829,426 (GRCm39)	V608G	probably damaging	Het
Smarcc2	C	T	10: 128,324,846 (GRCm39)		probably benign	Het
Speer3	A	T	5: 13,843,236 (GRCm39)	R48*	probably null	Het
Tlr1	A	T	5: 65,082,416 (GRCm39)	N720K	possibly damaging	Het
Tnfrsf21	A	T	17: 43,398,702 (GRCm39)	M603L	probably benign	Het
Ttc3	T	A	16: 94,210,590 (GRCm39)		probably null	Het
Usp4	C	A	9: 108,243,079 (GRCm39)	A249E	possibly damaging	Het
Wdr20	T	A	12: 110,759,948 (GRCm39)	V278E	probably damaging	Het

Other mutations in Prmt2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01642:Prmt2	APN	10	76,058,327 (GRCm39)	missense	probably damaging	1.00
IGL02015:Prmt2	APN	10	76,062,089 (GRCm39)	nonsense	probably null
IGL03094:Prmt2	APN	10	76,046,224 (GRCm39)	splice site	probably benign
R0352:Prmt2	UTSW	10	76,044,337 (GRCm39)	missense	possibly damaging	0.89
R0617:Prmt2	UTSW	10	76,044,517 (GRCm39)	intron	probably benign
R0831:Prmt2	UTSW	10	76,043,641 (GRCm39)	unclassified	probably benign
R0885:Prmt2	UTSW	10	76,058,399 (GRCm39)	missense	probably damaging	1.00
R1882:Prmt2	UTSW	10	76,058,302 (GRCm39)	missense	probably benign	0.00
R2022:Prmt2	UTSW	10	76,061,292 (GRCm39)	nonsense	probably null
R2312:Prmt2	UTSW	10	76,062,089 (GRCm39)	nonsense	probably null
R2401:Prmt2	UTSW	10	76,061,249 (GRCm39)	nonsense	probably null
R2408:Prmt2	UTSW	10	76,044,301 (GRCm39)	missense	probably damaging	0.98
R3753:Prmt2	UTSW	10	76,061,137 (GRCm39)	missense	probably benign	0.01
R4707:Prmt2	UTSW	10	76,062,055 (GRCm39)	missense	probably damaging	0.96
R4785:Prmt2	UTSW	10	76,062,055 (GRCm39)	missense	probably damaging	0.96
R4937:Prmt2	UTSW	10	76,056,842 (GRCm39)	missense	probably damaging	1.00
R5072:Prmt2	UTSW	10	76,058,390 (GRCm39)	missense	probably damaging	1.00
R5073:Prmt2	UTSW	10	76,058,390 (GRCm39)	missense	probably damaging	1.00
R5074:Prmt2	UTSW	10	76,058,390 (GRCm39)	missense	probably damaging	1.00
R5851:Prmt2	UTSW	10	76,072,574 (GRCm39)	missense	possibly damaging	0.61
R6084:Prmt2	UTSW	10	76,046,278 (GRCm39)	missense	probably benign	0.23
R6120:Prmt2	UTSW	10	76,045,280 (GRCm39)	missense	possibly damaging	0.51
R6239:Prmt2	UTSW	10	76,058,425 (GRCm39)	nonsense	probably null
R6317:Prmt2	UTSW	10	76,058,351 (GRCm39)	missense	probably benign	0.15
R6659:Prmt2	UTSW	10	76,053,208 (GRCm39)	missense	possibly damaging	0.85
R7174:Prmt2	UTSW	10	76,061,173 (GRCm39)	missense	probably benign	0.00
R7421:Prmt2	UTSW	10	76,056,912 (GRCm39)	missense	probably benign	0.00
R7485:Prmt2	UTSW	10	76,056,838 (GRCm39)	nonsense	probably null
R8326:Prmt2	UTSW	10	76,053,247 (GRCm39)	missense	probably benign	0.00
R9490:Prmt2	UTSW	10	76,053,227 (GRCm39)	missense	probably damaging	0.98
R9620:Prmt2	UTSW	10	76,061,213 (GRCm39)	missense	probably damaging	1.00
R9694:Prmt2	UTSW	10	76,061,213 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21