Incidental Mutation 'IGL00157:Serpinb9b'
ID 1035
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serpinb9b
Ensembl Gene ENSMUSG00000021403
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms 1600019A21Rik, Spi10, ovalbumin, SPI-CI, R86
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00157
Quality Score
Status
Chromosome 13
Chromosomal Location 33027416-33041884 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33035625 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 178 (E178D)
Ref Sequence ENSEMBL: ENSMUSP00000006392 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006392]
AlphaFold Q9DAV6
Predicted Effect probably benign
Transcript: ENSMUST00000006392
AA Change: E178D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000006392
Gene: ENSMUSG00000021403
AA Change: E178D

DomainStartEndE-ValueType
SERPIN 13 377 7.86e-164 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221946
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 A G 7: 44,253,451 V331A possibly damaging Het
Casr C A 16: 36,495,810 V633F probably damaging Het
Cblb T G 16: 52,183,307 V716G probably benign Het
Cbln2 C T 18: 86,716,384 Q156* probably null Het
Cnn1 G T 9: 22,099,397 L14F possibly damaging Het
D830013O20Rik T C 12: 73,364,247 noncoding transcript Het
Drd1 A G 13: 54,053,878 S99P probably damaging Het
Fam35a A G 14: 34,268,625 V108A probably benign Het
Fat1 T C 8: 44,951,670 V486A possibly damaging Het
Galnt7 T C 8: 57,540,039 N416S probably damaging Het
Gm10735 T C 13: 113,041,484 probably benign Het
Gm8909 A T 17: 36,165,354 probably null Het
Jag2 T C 12: 112,912,718 T790A probably benign Het
Klhdc1 T A 12: 69,242,008 Y31N possibly damaging Het
Lama1 A T 17: 67,815,928 M2769L probably benign Het
Mms19 A G 19: 41,945,457 probably null Het
Msrb2 C A 2: 19,394,341 P172T probably damaging Het
Olfr228 T C 2: 86,483,218 S175G probably benign Het
Olfr955 A G 9: 39,470,243 V161A probably benign Het
Pcdhb9 T A 18: 37,403,279 D775E possibly damaging Het
Pkhd1 T C 1: 20,566,874 probably null Het
Preb A T 5: 30,955,964 D375E probably damaging Het
Prkdc T C 16: 15,697,226 I1010T probably damaging Het
Rbp2 A G 9: 98,498,897 probably null Het
Sept9 A G 11: 117,352,184 T66A probably damaging Het
Tg A G 15: 66,847,166 Y258C probably damaging Het
Tmprss7 T C 16: 45,663,368 R548G probably benign Het
Uba7 G A 9: 107,979,111 A536T probably benign Het
Vmn2r114 G A 17: 23,291,665 P614S probably damaging Het
Xpc A G 6: 91,492,264 probably benign Het
Yrdc T C 4: 124,853,961 S86P probably damaging Het
Zbed6 G T 1: 133,657,376 A741D probably damaging Het
Other mutations in Serpinb9b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00518:Serpinb9b APN 13 33039570 missense probably benign 0.17
IGL01939:Serpinb9b APN 13 33039665 missense probably damaging 0.99
IGL02472:Serpinb9b APN 13 33039970 utr 3 prime probably benign
IGL02632:Serpinb9b APN 13 33039823 missense probably benign 0.01
R0255:Serpinb9b UTSW 13 33038020 missense probably benign
R0667:Serpinb9b UTSW 13 33032926 nonsense probably null
R0699:Serpinb9b UTSW 13 33033566 missense probably benign 0.00
R0703:Serpinb9b UTSW 13 33032981 missense probably benign 0.29
R1605:Serpinb9b UTSW 13 33038129 critical splice donor site probably null
R1623:Serpinb9b UTSW 13 33029565 missense possibly damaging 0.61
R1815:Serpinb9b UTSW 13 33039904 missense probably damaging 1.00
R1920:Serpinb9b UTSW 13 33039548 critical splice acceptor site probably null
R1987:Serpinb9b UTSW 13 33029559 missense probably benign 0.07
R1988:Serpinb9b UTSW 13 33029559 missense probably benign 0.07
R3035:Serpinb9b UTSW 13 33029546 missense possibly damaging 0.81
R3683:Serpinb9b UTSW 13 33029598 missense probably damaging 0.98
R3758:Serpinb9b UTSW 13 33035588 missense probably damaging 1.00
R4677:Serpinb9b UTSW 13 33039823 missense probably damaging 0.97
R5412:Serpinb9b UTSW 13 33029513 missense probably benign 0.00
R5481:Serpinb9b UTSW 13 33038093 missense possibly damaging 0.93
R5672:Serpinb9b UTSW 13 33039599 missense probably benign 0.01
R5957:Serpinb9b UTSW 13 33039848 missense possibly damaging 0.81
R6797:Serpinb9b UTSW 13 33029484 missense possibly damaging 0.60
R7586:Serpinb9b UTSW 13 33039760 missense probably damaging 1.00
R8115:Serpinb9b UTSW 13 33035548 missense probably null 0.94
R8309:Serpinb9b UTSW 13 33039571 missense probably damaging 1.00
R8529:Serpinb9b UTSW 13 33039560 missense probably benign 0.04
R8802:Serpinb9b UTSW 13 33029604 missense probably benign
R8810:Serpinb9b UTSW 13 33029469 missense possibly damaging 0.83
R9020:Serpinb9b UTSW 13 33039904 missense probably damaging 1.00
R9310:Serpinb9b UTSW 13 33035540 missense probably benign
R9424:Serpinb9b UTSW 13 33029561 missense probably damaging 0.99
X0019:Serpinb9b UTSW 13 33035531 nonsense probably null
Posted On 2011-07-12