Incidental Mutation 'IGL00870:Or8b37'
| ID |
12856 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or8b37
|
| Ensembl Gene |
ENSMUSG00000095893 |
| Gene Name |
olfactory receptor family 8 subfamily B member 37 |
| Synonyms |
GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
IGL00870
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
37957851-37961433 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 37959036 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 173
(I173F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138035
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077732]
[ENSMUST00000181088]
|
| AlphaFold |
Q7TRE1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077732
AA Change: I173F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: I173F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
306 |
8e-51 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
35 |
300 |
1.5e-6 |
PFAM |
|
Pfam:7tm_1
|
41 |
288 |
5.1e-24 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000181088
AA Change: I173F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: I173F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
33 |
N/A |
INTRINSIC |
|
Pfam:7TM_GPCR_Srsx
|
35 |
300 |
1.5e-6 |
PFAM |
|
Pfam:7tm_1
|
41 |
288 |
4.6e-30 |
PFAM |
|
Pfam:7tm_4
|
138 |
281 |
3.9e-45 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahnak |
T |
A |
19: 8,991,062 (GRCm39) |
D4115E |
probably damaging |
Het |
| Asb5 |
T |
C |
8: 55,036,695 (GRCm39) |
|
probably null |
Het |
| Cpeb3 |
A |
T |
19: 37,031,695 (GRCm39) |
I569N |
probably damaging |
Het |
| Cpsf7 |
T |
C |
19: 10,517,014 (GRCm39) |
|
probably null |
Het |
| Dlat |
A |
G |
9: 50,562,169 (GRCm39) |
L285P |
probably damaging |
Het |
| Dytn |
T |
C |
1: 63,716,272 (GRCm39) |
|
probably benign |
Het |
| Ears2 |
A |
T |
7: 121,654,899 (GRCm39) |
L123Q |
probably damaging |
Het |
| Gad2 |
T |
C |
2: 22,519,983 (GRCm39) |
V212A |
probably benign |
Het |
| Gon4l |
T |
C |
3: 88,764,492 (GRCm39) |
Y358H |
probably damaging |
Het |
| Gys1 |
T |
C |
7: 45,097,437 (GRCm39) |
|
probably null |
Het |
| Hnrnpm |
C |
A |
17: 33,868,876 (GRCm39) |
R517L |
probably damaging |
Het |
| Krtap20-2 |
G |
A |
16: 89,002,875 (GRCm39) |
G25D |
unknown |
Het |
| Lrif1 |
T |
C |
3: 106,641,957 (GRCm39) |
|
probably null |
Het |
| Naip2 |
A |
G |
13: 100,288,568 (GRCm39) |
|
probably benign |
Het |
| Oxct1 |
T |
A |
15: 4,131,300 (GRCm39) |
L396Q |
probably damaging |
Het |
| Pclo |
A |
T |
5: 14,589,997 (GRCm39) |
R766W |
unknown |
Het |
| Pkhd1 |
T |
A |
1: 20,641,614 (GRCm39) |
I275F |
probably damaging |
Het |
| Rxfp3 |
A |
G |
15: 11,036,301 (GRCm39) |
F357S |
probably damaging |
Het |
| Rxfp3 |
A |
G |
15: 11,036,391 (GRCm39) |
V327A |
probably damaging |
Het |
| Serpinb2 |
A |
G |
1: 107,450,800 (GRCm39) |
I181V |
probably damaging |
Het |
| Smad5 |
A |
G |
13: 56,871,480 (GRCm39) |
D25G |
probably benign |
Het |
| Strada |
A |
G |
11: 106,062,083 (GRCm39) |
L82P |
probably damaging |
Het |
| Tek |
T |
A |
4: 94,761,318 (GRCm39) |
Y1079* |
probably null |
Het |
| Tenm3 |
T |
C |
8: 48,870,167 (GRCm39) |
T209A |
probably benign |
Het |
| Tnks1bp1 |
C |
T |
2: 84,892,580 (GRCm39) |
Q836* |
probably null |
Het |
| Toporsl |
T |
C |
4: 52,610,172 (GRCm39) |
S22P |
probably benign |
Het |
| Ttc17 |
T |
C |
2: 94,202,078 (GRCm39) |
|
probably null |
Het |
| Ttc39a |
A |
G |
4: 109,299,542 (GRCm39) |
|
probably benign |
Het |
| Vangl1 |
T |
C |
3: 102,096,756 (GRCm39) |
D60G |
probably damaging |
Het |
| Vmn1r13 |
A |
T |
6: 57,187,098 (GRCm39) |
M86L |
probably benign |
Het |
| Vmn1r220 |
C |
T |
13: 23,368,647 (GRCm39) |
M16I |
probably null |
Het |
|
| Other mutations in Or8b37 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02612:Or8b37
|
APN |
9 |
37,958,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02802:Or8b37
|
UTSW |
9 |
37,959,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0015:Or8b37
|
UTSW |
9 |
37,958,963 (GRCm39) |
nonsense |
probably null |
|
|
R0142:Or8b37
|
UTSW |
9 |
37,959,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0559:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0561:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0715:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0723:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0729:Or8b37
|
UTSW |
9 |
37,959,123 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1350:Or8b37
|
UTSW |
9 |
37,959,111 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1869:Or8b37
|
UTSW |
9 |
37,959,498 (GRCm39) |
splice site |
probably null |
|
|
R3917:Or8b37
|
UTSW |
9 |
37,958,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4131:Or8b37
|
UTSW |
9 |
37,959,170 (GRCm39) |
nonsense |
probably null |
|
|
R4764:Or8b37
|
UTSW |
9 |
37,959,436 (GRCm39) |
missense |
probably benign |
|
|
R5857:Or8b37
|
UTSW |
9 |
37,959,049 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5976:Or8b37
|
UTSW |
9 |
37,958,997 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6329:Or8b37
|
UTSW |
9 |
37,959,121 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7344:Or8b37
|
UTSW |
9 |
37,959,253 (GRCm39) |
missense |
probably benign |
|
|
R8289:Or8b37
|
UTSW |
9 |
37,959,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8485:Or8b37
|
UTSW |
9 |
37,959,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8973:Or8b37
|
UTSW |
9 |
37,958,839 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9026:Or8b37
|
UTSW |
9 |
37,958,885 (GRCm39) |
nonsense |
probably null |
|
|
R9378:Or8b37
|
UTSW |
9 |
37,958,775 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9395:Or8b37
|
UTSW |
9 |
37,959,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9655:Or8b37
|
UTSW |
9 |
37,959,387 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9731:Or8b37
|
UTSW |
9 |
37,958,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF009:Or8b37
|
UTSW |
9 |
37,959,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0052:Or8b37
|
UTSW |
9 |
37,958,995 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1177:Or8b37
|
UTSW |
9 |
37,959,111 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2012-12-06 |
Incidental Mutation