Incidental Mutation 'R0034:Zfp949'
ID15306
Institutional Source Beutler Lab
Gene Symbol Zfp949
Ensembl Gene ENSMUSG00000032425
Gene Namezinc finger protein 949
Synonyms4930422I07Rik
MMRRC Submission 038328-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #R0034 (G1)
Quality Score
Status Validated
Chromosome9
Chromosomal Location88548020-88571061 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to T at 88567640 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160652] [ENSMUST00000161458] [ENSMUST00000162827]
Predicted Effect probably benign
Transcript: ENSMUST00000160652
Predicted Effect probably benign
Transcript: ENSMUST00000161458
SMART Domains Protein: ENSMUSP00000125017
Gene: ENSMUSG00000032425

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
ZnF_C2H2 268 290 5.99e1 SMART
ZnF_C2H2 296 318 5.5e-3 SMART
ZnF_C2H2 324 346 6.42e-4 SMART
ZnF_C2H2 352 374 2.91e-2 SMART
ZnF_C2H2 380 402 4.11e-2 SMART
ZnF_C2H2 408 430 3.63e-3 SMART
ZnF_C2H2 436 458 5.67e-5 SMART
ZnF_C2H2 464 486 7.9e-4 SMART
ZnF_C2H2 492 514 2.43e-4 SMART
ZnF_C2H2 520 542 2.95e-3 SMART
ZnF_C2H2 548 570 1.03e-2 SMART
ZnF_C2H2 576 598 1.4e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162827
SMART Domains Protein: ENSMUSP00000125325
Gene: ENSMUSG00000032425

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
ZnF_C2H2 268 290 5.99e1 SMART
ZnF_C2H2 296 318 5.5e-3 SMART
ZnF_C2H2 324 346 6.42e-4 SMART
ZnF_C2H2 352 374 2.91e-2 SMART
ZnF_C2H2 380 402 4.11e-2 SMART
ZnF_C2H2 408 430 3.63e-3 SMART
ZnF_C2H2 436 458 5.67e-5 SMART
ZnF_C2H2 464 486 7.9e-4 SMART
ZnF_C2H2 492 514 2.43e-4 SMART
ZnF_C2H2 520 542 2.95e-3 SMART
ZnF_C2H2 548 570 1.03e-2 SMART
ZnF_C2H2 576 598 1.4e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162985
SMART Domains Protein: ENSMUSP00000124007
Gene: ENSMUSG00000032425

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 76.6%
  • 3x: 64.3%
  • 10x: 35.1%
  • 20x: 16.8%
Validation Efficiency 87% (59/68)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis with defects in growth, development, cell proliferation, apoptosis and turning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402H24Rik T C 2: 130,736,572 H664R probably damaging Het
Asns G A 6: 7,676,299 P419L probably damaging Het
Cep152 C T 2: 125,583,893 A851T probably benign Het
Chrna7 T G 7: 63,148,606 K109N possibly damaging Het
Farp1 A G 14: 121,255,429 H481R probably benign Het
Kif9 G A 9: 110,519,611 C738Y probably benign Het
Klf12 A G 14: 99,987,429 probably null Het
Ltbp1 T A 17: 75,047,568 probably benign Het
Map2k4 A G 11: 65,719,611 probably benign Het
Nat8f5 C A 6: 85,817,886 A31S probably benign Het
Plb1 G T 5: 32,273,113 G138V probably benign Het
Plcz1 A T 6: 140,020,448 probably benign Het
Poln A C 5: 34,115,418 V398G possibly damaging Het
Ppp2r2c A G 5: 36,927,539 I115V probably benign Het
Rapgef1 C A 2: 29,724,768 probably benign Het
Rbm43 A T 2: 51,925,710 D166E probably benign Het
Sgk3 T C 1: 9,885,677 V301A probably damaging Het
Trap1 A T 16: 4,069,030 probably benign Het
Trim14 A G 4: 46,523,627 L137P probably damaging Het
Tsku T C 7: 98,352,663 T154A possibly damaging Het
Usp50 T C 2: 126,777,975 E139G possibly damaging Het
Zscan20 T C 4: 128,585,662 N1012S probably damaging Het
Other mutations in Zfp949
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03201:Zfp949 APN 9 88568664 missense probably benign 0.23
R0462:Zfp949 UTSW 9 88568734 missense possibly damaging 0.63
R1457:Zfp949 UTSW 9 88569838 missense probably damaging 1.00
R1574:Zfp949 UTSW 9 88569777 nonsense probably null
R1574:Zfp949 UTSW 9 88569777 nonsense probably null
R1878:Zfp949 UTSW 9 88569303 missense probably damaging 0.99
R1917:Zfp949 UTSW 9 88570062 missense probably damaging 0.98
R4488:Zfp949 UTSW 9 88570089 missense probably damaging 0.98
R4839:Zfp949 UTSW 9 88569994 missense probably damaging 0.97
R5309:Zfp949 UTSW 9 88567183 missense possibly damaging 0.92
R5312:Zfp949 UTSW 9 88567183 missense possibly damaging 0.92
R5461:Zfp949 UTSW 9 88569484 missense probably benign 0.00
R6530:Zfp949 UTSW 9 88567287 critical splice donor site probably null
R6844:Zfp949 UTSW 9 88569411 missense possibly damaging 0.91
R7749:Zfp949 UTSW 9 88569870 missense probably damaging 1.00
R7937:Zfp949 UTSW 9 88569270 missense probably damaging 1.00
R8150:Zfp949 UTSW 9 88570000 missense probably benign
R8290:Zfp949 UTSW 9 88569240 missense probably damaging 0.98
R8349:Zfp949 UTSW 9 88567249 missense possibly damaging 0.84
Posted On2012-12-17