Mutagenetix > Incidental Mutations

Incidental Mutation 'R0109:Pard3'

17820

Institutional Source

Beutler Lab

Gene Symbol

Pard3

Ensembl Gene

ENSMUSG00000025812

Gene Name

par-3 family cell polarity regulator

Synonyms

ASIP, PAR-3, Pard3a, Par3, D8Ertd580e

MMRRC Submission

038395-MU

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R0109 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

127063893-127612286 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 127398666 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 712 (R712C)

Ref Sequence

ENSEMBL: ENSMUSP00000124319 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026921] [ENSMUST00000079777] [ENSMUST00000108752] [ENSMUST00000159537] [ENSMUST00000160272] [ENSMUST00000160581] [ENSMUST00000160717] [ENSMUST00000160766] [ENSMUST00000161355] [ENSMUST00000162176] [ENSMUST00000162309] [ENSMUST00000162907] [ENSMUST00000162456] [ENSMUST00000162531] [ENSMUST00000162602] [ENSMUST00000162536]

Predicted Effect

probably damaging
Transcript: ENSMUST00000026921
AA Change: R712C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000026921
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1.1e-72	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	3e-10	PDB
low complexity region	863	875	N/A	INTRINSIC
low complexity region	892	902	N/A	INTRINSIC
low complexity region	921	950	N/A	INTRINSIC
low complexity region	965	1005	N/A	INTRINSIC
low complexity region	1162	1200	N/A	INTRINSIC
low complexity region	1264	1281	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000079777
AA Change: R577C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078710
Gene: ENSMUSG00000025812
AA Change: R577C

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART
low complexity region	636	646	N/A	INTRINSIC
PDB:4DC2\|Z	675	702	2e-10	PDB
low complexity region	743	755	N/A	INTRINSIC
low complexity region	772	782	N/A	INTRINSIC
low complexity region	801	830	N/A	INTRINSIC
low complexity region	845	885	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108752
AA Change: R577C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104383
Gene: ENSMUSG00000025812
AA Change: R577C

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000159537
AA Change: R655C

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000124934
Gene: ENSMUSG00000025812
AA Change: R655C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	6.7e-73	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	542	627	9.87e-14	SMART
low complexity region	717	727	N/A	INTRINSIC
PDB:4DC2\|Z	756	783	2e-10	PDB
low complexity region	823	835	N/A	INTRINSIC
low complexity region	852	862	N/A	INTRINSIC
low complexity region	881	910	N/A	INTRINSIC
low complexity region	925	943	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000160272
AA Change: R712C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000125453
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1.7e-60	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	4e-10	PDB
low complexity region	878	890	N/A	INTRINSIC
low complexity region	907	917	N/A	INTRINSIC
low complexity region	936	965	N/A	INTRINSIC
low complexity region	980	1020	N/A	INTRINSIC
low complexity region	1177	1215	N/A	INTRINSIC
low complexity region	1279	1296	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000160581
AA Change: R702C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000124141
Gene: ENSMUSG00000025812
AA Change: R702C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	4	149	7.1e-73	PFAM
low complexity region	237	249	N/A	INTRINSIC
PDZ	285	364	2.34e-6	SMART
low complexity region	434	443	N/A	INTRINSIC
PDZ	472	551	4.1e-20	SMART
PDZ	589	674	9.87e-14	SMART
low complexity region	764	774	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
low complexity region	870	880	N/A	INTRINSIC
low complexity region	899	928	N/A	INTRINSIC
low complexity region	943	983	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160593

Predicted Effect

probably damaging
Transcript: ENSMUST00000160717
AA Change: R577C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125612
Gene: ENSMUSG00000025812
AA Change: R577C

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000160766
AA Change: R655C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124533
Gene: ENSMUSG00000025812
AA Change: R655C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1e-72	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	542	627	9.87e-14	SMART
low complexity region	714	724	N/A	INTRINSIC
low complexity region	791	803	N/A	INTRINSIC
low complexity region	820	830	N/A	INTRINSIC
low complexity region	849	878	N/A	INTRINSIC
low complexity region	893	933	N/A	INTRINSIC
low complexity region	1090	1128	N/A	INTRINSIC
low complexity region	1192	1209	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000161277
AA Change: R630C

SMART Domains

Protein: ENSMUSP00000124789
Gene: ENSMUSG00000025812
AA Change: R630C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	3	122	9.6e-37	PFAM
PDZ	214	293	2.34e-6	SMART
low complexity region	363	372	N/A	INTRINSIC
PDZ	401	480	4.1e-20	SMART
PDZ	518	603	9.87e-14	SMART
low complexity region	693	703	N/A	INTRINSIC
PDB:4DC2\|Z	732	759	2e-10	PDB
low complexity region	799	811	N/A	INTRINSIC
low complexity region	828	838	N/A	INTRINSIC
low complexity region	857	886	N/A	INTRINSIC
low complexity region	901	919	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000161355
AA Change: R712C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125064
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	7.2e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
low complexity region	847	859	N/A	INTRINSIC
low complexity region	876	886	N/A	INTRINSIC
low complexity region	905	934	N/A	INTRINSIC
low complexity region	949	989	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162176

SMART Domains

Protein: ENSMUSP00000123944
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
PDZ	1	83	4.11e-2	SMART
low complexity region	153	162	N/A	INTRINSIC
PDZ	191	270	4.1e-20	SMART
PDZ	321	406	9.87e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162309
AA Change: R712C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124282
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	6.2e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	4e-10	PDB
low complexity region	877	889	N/A	INTRINSIC
low complexity region	906	916	N/A	INTRINSIC
low complexity region	935	964	N/A	INTRINSIC
low complexity region	979	1019	N/A	INTRINSIC
low complexity region	1176	1214	N/A	INTRINSIC
low complexity region	1278	1295	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162907
AA Change: R712C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124319
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	4.6e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162456
AA Change: R577C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124162
Gene: ENSMUSG00000025812
AA Change: R577C

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART
low complexity region	636	646	N/A	INTRINSIC
PDB:4DC2\|Z	675	702	2e-10	PDB
low complexity region	743	755	N/A	INTRINSIC
low complexity region	772	782	N/A	INTRINSIC
low complexity region	801	830	N/A	INTRINSIC
low complexity region	845	885	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162531
AA Change: R699C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000125610
Gene: ENSMUSG00000025812
AA Change: R699C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	8.4e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	586	671	9.87e-14	SMART
low complexity region	761	771	N/A	INTRINSIC
low complexity region	838	850	N/A	INTRINSIC
low complexity region	867	877	N/A	INTRINSIC
low complexity region	896	925	N/A	INTRINSIC
low complexity region	940	980	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162602
AA Change: R712C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125450
Gene: ENSMUSG00000025812
AA Change: R712C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	7.6e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	774	784	N/A	INTRINSIC
PDB:4DC2\|Z	813	840	2e-10	PDB
low complexity region	881	893	N/A	INTRINSIC
low complexity region	910	920	N/A	INTRINSIC
low complexity region	939	968	N/A	INTRINSIC
low complexity region	983	1023	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162536
AA Change: R668C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125212
Gene: ENSMUSG00000025812
AA Change: R668C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1e-72	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	555	640	9.87e-14	SMART
low complexity region	727	737	N/A	INTRINSIC
PDB:4DC2\|Z	766	793	3e-10	PDB
low complexity region	833	845	N/A	INTRINSIC
low complexity region	862	872	N/A	INTRINSIC
low complexity region	891	920	N/A	INTRINSIC
low complexity region	935	975	N/A	INTRINSIC
low complexity region	1132	1170	N/A	INTRINSIC
low complexity region	1234	1251	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000162665
AA Change: R731C

SMART Domains

Protein: ENSMUSP00000124718
Gene: ENSMUSG00000025812
AA Change: R731C

Domain	Start	End	E-Value	Type
Pfam:DUF3534	21	166	1.4e-60	PFAM
low complexity region	254	266	N/A	INTRINSIC
PDZ	302	381	2.34e-6	SMART
low complexity region	451	460	N/A	INTRINSIC
PDZ	489	568	4.1e-20	SMART
PDZ	619	704	9.87e-14	SMART
low complexity region	791	801	N/A	INTRINSIC
low complexity region	868	880	N/A	INTRINSIC
low complexity region	897	907	N/A	INTRINSIC
low complexity region	926	955	N/A	INTRINSIC
low complexity region	970	1010	N/A	INTRINSIC
low complexity region	1167	1205	N/A	INTRINSIC
low complexity region	1269	1286	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000162727
AA Change: R83C

SMART Domains

Protein: ENSMUSP00000124359
Gene: ENSMUSG00000025812
AA Change: R83C

Domain	Start	End	E-Value	Type
Blast:PDZ	2	56	8e-30	BLAST
PDB:2KOH\|A	2	61	4e-35	PDB
SCOP:d1qaua_	4	55	3e-4	SMART

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 90.6%
3x: 88.5%
10x: 83.8%
20x: 77.5%

Validation Efficiency

90% (95/106)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	C	A	6: 121,659,303	H710Q	probably benign	Het
Abca14	A	T	7: 120,318,762	K1496*	probably null	Het
Anapc1	C	A	2: 128,634,693	R1335L	probably damaging	Het
Arhgef10l	A	T	4: 140,578,294	S203T	probably benign	Het
Astn1	C	T	1: 158,664,104	T41I	possibly damaging	Het
Atrnl1	T	A	19: 57,755,517	Y1184N	possibly damaging	Het
Avil	A	G	10: 127,013,644	N603S	probably benign	Het
Brca1	T	C	11: 101,531,090	D149G	possibly damaging	Het
Car14	C	A	3: 95,899,451	A234S	probably benign	Het
Cep164	A	C	9: 45,771,587	L935R	probably damaging	Het
Cps1	T	C	1: 67,229,418	V1435A	possibly damaging	Het
Csmd2	T	G	4: 128,544,743	S3038R	probably benign	Het
Cyp2j6	A	T	4: 96,518,157	I459N	probably damaging	Het
Cyth1	T	C	11: 118,182,306	E242G	probably damaging	Het
Dclk3	T	G	9: 111,467,670	L94R	possibly damaging	Het
Disp2	T	C	2: 118,791,816	S1010P	probably damaging	Het
Dlec1	G	A	9: 119,105,824	R145H	probably damaging	Het
Dsg3	T	C	18: 20,540,134	V954A	probably damaging	Het
Dync2h1	T	A	9: 7,111,487	D309V	probably damaging	Het
Fam13b	A	G	18: 34,451,308	I601T	probably benign	Het
Fgd5	T	A	6: 91,988,235	M325K	possibly damaging	Het
Frmpd1	A	T	4: 45,279,340	E688D	probably benign	Het
Gabrb1	C	T	5: 72,121,946		probably benign	Het
Gm10130	A	T	2: 150,323,841		probably benign	Het
Gm6590	A	T	6: 130,484,906		noncoding transcript	Het
Gse1	T	A	8: 120,567,785	S284T	probably damaging	Het
Ipo13	C	T	4: 117,905,016	R387Q	possibly damaging	Het
Kctd16	A	G	18: 40,259,151	E264G	probably benign	Het
Krt73	A	T	15: 101,796,395	L352*	probably null	Het
Mapk15	A	T	15: 75,996,077	K153*	probably null	Het
Mcemp1	C	A	8: 3,667,055	Y65*	probably null	Het
Mcoln2	C	G	3: 146,175,718	R210G	probably damaging	Het
Miox	G	A	15: 89,335,581	V91I	probably benign	Het
Myh7b	A	G	2: 155,611,674	E6G	possibly damaging	Het
Ncapg	A	G	5: 45,693,748		probably null	Het
Nfyb	G	A	10: 82,755,002	A65V	possibly damaging	Het
Olfr1241	A	G	2: 89,482,803	F111L	probably benign	Het
Olfr1442	C	A	19: 12,674,860	F218L	probably benign	Het
Olfr646	T	C	7: 104,106,605	S109P	probably damaging	Het
Osbp2	A	C	11: 3,711,791	S754A	probably benign	Het
Parp9	T	C	16: 35,948,341	I64T	probably damaging	Het
Pcm1	T	A	8: 41,257,937	H81Q	possibly damaging	Het
Pcnt	G	A	10: 76,389,196	P1825S	probably benign	Het
Pfkfb4	T	C	9: 108,998,889	V43A	probably benign	Het
Pgap1	A	T	1: 54,494,825	V643E	probably damaging	Het
Pip5k1a	T	C	3: 95,065,442	T433A	probably benign	Het
Pip5k1b	T	A	19: 24,379,047	M176L	probably benign	Het
Polg2	T	C	11: 106,777,132		probably benign	Het
Pomp	T	A	5: 147,875,513	H136Q	probably benign	Het
Ppfia4	A	T	1: 134,324,217		probably null	Het
Prdx2	G	A	8: 84,970,251	G4S	probably benign	Het
Rbm28	C	T	6: 29,160,105	G70D	probably benign	Het
Rdh10	T	A	1: 16,106,265	I83N	probably damaging	Het
Rin3	A	G	12: 102,313,081	I50V	possibly damaging	Het
Rnf122	T	C	8: 31,124,849		probably benign	Het
Sik2	A	G	9: 50,899,475	M447T	possibly damaging	Het
Sla2	A	G	2: 156,883,587		probably null	Het
Slc51a	T	A	16: 32,477,607	I192L	probably benign	Het
Sorcs1	T	C	19: 50,378,891		probably benign	Het
Spata16	T	A	3: 26,913,267	F389I	probably damaging	Het
Srebf1	G	A	11: 60,201,804	A793V	probably benign	Het
Tbc1d9b	T	C	11: 50,158,434	V736A	probably benign	Het
Tbx15	C	A	3: 99,351,866	T351N	possibly damaging	Het
Tep1	A	G	14: 50,851,916		probably null	Het
Tmed11	T	A	5: 108,777,412	D178V	probably damaging	Het
Traf7	A	G	17: 24,513,926	F110L	probably benign	Het
Ubqlnl	C	T	7: 104,150,192	V33M	probably damaging	Het
Vcan	A	T	13: 89,678,073		probably null	Het
Vmn1r194	A	G	13: 22,245,047	Y278C	probably damaging	Het
Vmn1r46	T	C	6: 89,977,062	F298L	probably benign	Het
Vps13b	A	G	15: 35,572,119	T961A	probably benign	Het
Wdr48	G	A	9: 119,918,568		probably benign	Het
Wwp1	G	A	4: 19,641,725		probably benign	Het
Zfp217	C	T	2: 170,115,462	A539T	probably benign	Het
Zfp839	G	A	12: 110,860,874	E400K	possibly damaging	Het

Other mutations in Pard3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Pard3	APN	8	127359818	splice site	probably benign
IGL00484:Pard3	APN	8	127371846	missense	probably benign	0.05
IGL00674:Pard3	APN	8	127388678	missense	probably damaging	1.00
IGL01471:Pard3	APN	8	127378246	missense	probably benign	0.01
IGL01505:Pard3	APN	8	127324063	missense	probably damaging	1.00
IGL02252:Pard3	APN	8	127398756	missense	probably benign	0.09
IGL02511:Pard3	APN	8	127161320	splice site	probably benign
IGL02838:Pard3	APN	8	127426647	missense	probably damaging	0.99
IGL02948:Pard3	APN	8	127306494	missense	probably benign	0.00
IGL02987:Pard3	APN	8	127389491	missense	probably damaging	0.98
IGL03037:Pard3	APN	8	127306494	missense	probably benign	0.00
IGL03084:Pard3	APN	8	127593092	missense	probably damaging	0.96
BB001:Pard3	UTSW	8	127410750	missense	probably benign
BB011:Pard3	UTSW	8	127410750	missense	probably benign
R0025:Pard3	UTSW	8	127161308	missense	probably damaging	1.00
R0025:Pard3	UTSW	8	127161308	missense	probably damaging	1.00
R0029:Pard3	UTSW	8	127426758	splice site	probably benign
R0309:Pard3	UTSW	8	127376897	splice site	probably benign
R0415:Pard3	UTSW	8	127610566	missense	probably damaging	1.00
R0507:Pard3	UTSW	8	127371486	splice site	probably benign
R1055:Pard3	UTSW	8	127378280	missense	probably benign	0.34
R1305:Pard3	UTSW	8	127306410	missense	possibly damaging	0.62
R1619:Pard3	UTSW	8	127380502	missense	probably benign	0.02
R1855:Pard3	UTSW	8	127447812	splice site	probably null
R2001:Pard3	UTSW	8	127064347	splice site	probably null
R2060:Pard3	UTSW	8	127398604	missense	probably benign	0.05
R2064:Pard3	UTSW	8	127610611	missense	probably damaging	1.00
R2113:Pard3	UTSW	8	127388537	missense	probably damaging	1.00
R2136:Pard3	UTSW	8	127376885	critical splice donor site	probably null
R2224:Pard3	UTSW	8	127359776	missense	probably damaging	1.00
R2252:Pard3	UTSW	8	127610599	missense	probably damaging	1.00
R3870:Pard3	UTSW	8	127409686	missense	probably damaging	1.00
R4154:Pard3	UTSW	8	127474396	missense	probably damaging	1.00
R4212:Pard3	UTSW	8	127610458	missense	probably benign	0.43
R4243:Pard3	UTSW	8	127371647	missense	probably benign	0.09
R4523:Pard3	UTSW	8	127398627	missense	probably benign	0.08
R4857:Pard3	UTSW	8	127324054	missense	probably damaging	0.98
R4876:Pard3	UTSW	8	127561469	intron	probably benign
R4877:Pard3	UTSW	8	127388537	missense	probably damaging	1.00
R5197:Pard3	UTSW	8	127073290	splice site	probably null
R5215:Pard3	UTSW	8	127378264	missense	probably damaging	1.00
R5279:Pard3	UTSW	8	127460386	critical splice donor site	probably null
R5349:Pard3	UTSW	8	127415743	missense	probably damaging	1.00
R5479:Pard3	UTSW	8	127370355	missense	probably damaging	1.00
R5514:Pard3	UTSW	8	127426605	missense	probably damaging	1.00
R5681:Pard3	UTSW	8	127389433	missense	possibly damaging	0.81
R5934:Pard3	UTSW	8	127389338	missense	probably damaging	1.00
R6034:Pard3	UTSW	8	127064327	utr 5 prime	probably benign
R6034:Pard3	UTSW	8	127064327	utr 5 prime	probably benign
R6187:Pard3	UTSW	8	127073273	missense	probably benign	0.00
R6382:Pard3	UTSW	8	127376783	missense	probably damaging	1.00
R6774:Pard3	UTSW	8	127410747	missense	probably damaging	0.98
R7130:Pard3	UTSW	8	127415683	missense	probably damaging	1.00
R7267:Pard3	UTSW	8	127371575	missense	probably damaging	0.97
R7358:Pard3	UTSW	8	127593092	missense	probably damaging	0.98
R7528:Pard3	UTSW	8	127603165	missense	probably damaging	1.00
R7537:Pard3	UTSW	8	127610582	missense	probably damaging	1.00
R7679:Pard3	UTSW	8	127371846	missense	probably benign	0.05
R7924:Pard3	UTSW	8	127410750	missense	probably benign
R8076:Pard3	UTSW	8	127415596	missense	probably damaging	1.00
R8258:Pard3	UTSW	8	127371540	nonsense	probably null
R8259:Pard3	UTSW	8	127371540	nonsense	probably null
R8345:Pard3	UTSW	8	127324068	missense	probably damaging	1.00
R8421:Pard3	UTSW	8	127140408	intron	probably benign
R8500:Pard3	UTSW	8	127460303	missense	probably damaging	1.00

Posted On

2013-03-25