Incidental Mutation 'IGL01921:Prss21'
ID 180116
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss21
Ensembl Gene ENSMUSG00000024116
Gene Name serine protease 21
Synonyms TESP5, mT4, 1700023E12Rik, testisin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL01921
Quality Score
Status
Chromosome 17
Chromosomal Location 24087046-24092087 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24091414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 217 (M217K)
Ref Sequence ENSEMBL: ENSMUSP00000024928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024928]
AlphaFold Q9JHJ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000024928
AA Change: M217K

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000024928
Gene: ENSMUSG00000024116
AA Change: M217K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Tryp_SPc 54 291 1.18e-94 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased spermfertilization capability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l C A 8: 44,078,548 (GRCm39) V559L probably damaging Het
Agtpbp1 T C 13: 59,660,297 (GRCm39) T310A possibly damaging Het
Ccdc102a T C 8: 95,640,019 (GRCm39) T92A probably damaging Het
Ciao1 C T 2: 127,084,755 (GRCm39) V328I probably benign Het
Col12a1 T A 9: 79,557,299 (GRCm39) Q1943L possibly damaging Het
Diaph1 T C 18: 37,989,261 (GRCm39) D898G possibly damaging Het
Dio3 A T 12: 110,245,789 (GRCm39) T42S possibly damaging Het
Dnah8 T A 17: 30,955,115 (GRCm39) I2048N probably benign Het
Egr2 T A 10: 67,376,208 (GRCm39) probably null Het
Epc2 T A 2: 49,422,209 (GRCm39) Y368N probably damaging Het
Furin A G 7: 80,045,702 (GRCm39) probably benign Het
Gga1 T C 15: 78,777,995 (GRCm39) M620T possibly damaging Het
Gm21976 T A 13: 98,441,829 (GRCm39) Y45* probably null Het
Gpn1 T C 5: 31,656,612 (GRCm39) V105A probably damaging Het
Hoxb8 A T 11: 96,175,181 (GRCm39) N206I probably damaging Het
Kif15 T A 9: 122,808,569 (GRCm39) L67Q probably damaging Het
Krt40 T A 11: 99,433,989 (GRCm39) probably benign Het
Mat1a T C 14: 40,836,292 (GRCm39) probably benign Het
Mkrn1 T C 6: 39,382,847 (GRCm39) D99G possibly damaging Het
Plxnb2 T C 15: 89,048,474 (GRCm39) Y645C possibly damaging Het
Ppp1r13b A G 12: 111,799,671 (GRCm39) V702A probably benign Het
Ppp4r4 G T 12: 103,542,569 (GRCm39) M1I probably null Het
R3hcc1l A G 19: 42,552,220 (GRCm39) S406G possibly damaging Het
Rfesd T C 13: 76,156,385 (GRCm39) E7G probably benign Het
Ripk4 T C 16: 97,544,565 (GRCm39) E694G possibly damaging Het
Rlf T C 4: 121,003,943 (GRCm39) D1679G probably damaging Het
Ryr2 C T 13: 11,569,436 (GRCm39) C4956Y possibly damaging Het
Scart1 G T 7: 139,808,632 (GRCm39) E848* probably null Het
Uri1 T A 7: 37,681,072 (GRCm39) K111* probably null Het
Usf1 A G 1: 171,244,424 (GRCm39) E108G possibly damaging Het
Vmn1r71 C A 7: 10,482,199 (GRCm39) R163L probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r86 T C 10: 130,291,610 (GRCm39) T52A probably benign Het
Washc5 A T 15: 59,213,958 (GRCm39) probably null Het
Zfp583 T C 7: 6,328,569 (GRCm39) T7A possibly damaging Het
Zim1 T G 7: 6,685,184 (GRCm39) probably benign Het
Other mutations in Prss21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03151:Prss21 APN 17 24,088,376 (GRCm39) missense probably damaging 0.98
R1136:Prss21 UTSW 17 24,091,968 (GRCm39) missense probably damaging 1.00
R2299:Prss21 UTSW 17 24,088,563 (GRCm39) missense probably benign 0.18
R3615:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R3616:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R4589:Prss21 UTSW 17 24,091,796 (GRCm39) missense possibly damaging 0.96
R5691:Prss21 UTSW 17 24,087,759 (GRCm39) splice site probably null
R6946:Prss21 UTSW 17 24,087,138 (GRCm39) missense possibly damaging 0.92
R7835:Prss21 UTSW 17 24,088,425 (GRCm39) missense possibly damaging 0.57
R8243:Prss21 UTSW 17 24,088,376 (GRCm39) missense probably damaging 0.98
R8421:Prss21 UTSW 17 24,088,342 (GRCm39) missense possibly damaging 0.92
Posted On 2014-05-07