Incidental Mutation 'IGL01924:Or51ag1'
ID 180229
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or51ag1
Ensembl Gene ENSMUSG00000045584
Gene Name olfactory receptor family 51 subfamily AG member 1
Synonyms GA_x6K02T2PBJ9-6221839-6220892, Olfr610, MOR9-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL01924
Quality Score
Chromosome 7
Chromosomal Location 103155204-103156151 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103156003 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 50 (I50T)
Ref Sequence ENSEMBL: ENSMUSP00000150921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063109] [ENSMUST00000217627]
AlphaFold E9Q598
Predicted Effect possibly damaging
Transcript: ENSMUST00000063109
AA Change: I50T

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000052577
Gene: ENSMUSG00000045584
AA Change: I50T

Pfam:7tm_4 33 313 3.5e-106 PFAM
Pfam:7TM_GPCR_Srsx 37 310 1.9e-10 PFAM
Pfam:7tm_1 43 295 1.4e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213422
Predicted Effect possibly damaging
Transcript: ENSMUST00000217627
AA Change: I50T

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb C T 5: 114,362,047 (GRCm39) probably benign Het
Adamts13 A G 2: 26,886,595 (GRCm39) E938G possibly damaging Het
Aox1 C T 1: 58,326,902 (GRCm39) T167I possibly damaging Het
Apba3 G T 10: 81,108,907 (GRCm39) A557S probably benign Het
Atad2b T C 12: 5,084,093 (GRCm39) L1382P probably damaging Het
Atrn C T 2: 130,777,485 (GRCm39) T178I probably damaging Het
B4galnt1 A G 10: 127,002,630 (GRCm39) S88G probably benign Het
Baz2b T C 2: 59,765,615 (GRCm39) K887E probably damaging Het
Castor2 T C 5: 134,164,441 (GRCm39) F134S probably benign Het
Ccdc162 A C 10: 41,445,883 (GRCm39) F430V probably damaging Het
Cdc42bpb T A 12: 111,283,887 (GRCm39) probably benign Het
Cfhr4 G A 1: 139,666,944 (GRCm39) L444F probably damaging Het
Chit1 A G 1: 134,077,148 (GRCm39) D317G probably benign Het
Chrnb1 A T 11: 69,685,845 (GRCm39) probably benign Het
Cobl G T 11: 12,204,596 (GRCm39) T620K probably benign Het
Creld1 T C 6: 113,460,921 (GRCm39) F20L probably benign Het
Csmd2 A T 4: 128,453,740 (GRCm39) D3475V unknown Het
Cyp3a57 A G 5: 145,309,439 (GRCm39) D259G probably benign Het
Dbnl A G 11: 5,747,142 (GRCm39) Y224C probably damaging Het
Det1 A T 7: 78,493,571 (GRCm39) C144* probably null Het
Fbxo47 G T 11: 97,746,986 (GRCm39) A360D probably damaging Het
Frrs1 G A 3: 116,678,888 (GRCm39) G237R probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Gria2 T C 3: 80,617,638 (GRCm39) T372A probably benign Het
Hmcn2 A T 2: 31,288,929 (GRCm39) Q2246L probably benign Het
Ide T C 19: 37,249,563 (GRCm39) M930V unknown Het
Kdm5a T C 6: 120,371,216 (GRCm39) probably null Het
Khnyn A G 14: 56,132,426 (GRCm39) T625A probably benign Het
Lrrtm1 T C 6: 77,221,169 (GRCm39) F209L possibly damaging Het
Med13 C A 11: 86,199,522 (GRCm39) probably benign Het
Myom2 A G 8: 15,119,685 (GRCm39) E147G probably benign Het
Myrip T A 9: 120,217,330 (GRCm39) V88D probably damaging Het
Nbeal2 T C 9: 110,460,482 (GRCm39) H1784R probably benign Het
Nlrp4e T A 7: 23,020,255 (GRCm39) C247* probably null Het
Nup54 G A 5: 92,572,294 (GRCm39) P252L probably benign Het
Otoa C A 7: 120,705,191 (GRCm39) N244K probably damaging Het
Pbrm1 G A 14: 30,804,561 (GRCm39) R960H probably damaging Het
Ptcd3 A T 6: 71,875,411 (GRCm39) N190K probably damaging Het
Rhobtb1 T A 10: 69,106,134 (GRCm39) L233H probably damaging Het
Sec24c T A 14: 20,739,757 (GRCm39) F545I probably damaging Het
Slc6a15 T C 10: 103,240,686 (GRCm39) probably null Het
Slitrk1 G A 14: 109,148,671 (GRCm39) A680V probably benign Het
Smpd1 C T 7: 105,204,655 (GRCm39) S178L probably benign Het
Spindoc A G 19: 7,360,042 (GRCm39) L42P probably damaging Het
Tenm4 A G 7: 96,544,419 (GRCm39) E2145G probably damaging Het
Tmem144 G T 3: 79,746,501 (GRCm39) A18E probably damaging Het
Tmem213 A T 6: 38,086,373 (GRCm39) S10C possibly damaging Het
Trav6-3 A T 14: 53,667,800 (GRCm39) I102L probably benign Het
Trip11 T G 12: 101,853,143 (GRCm39) N483T possibly damaging Het
Unc13b C T 4: 43,239,385 (GRCm39) R1056* probably null Het
Wdr27 T G 17: 15,137,488 (GRCm39) K433N probably damaging Het
Wls C A 3: 159,607,080 (GRCm39) S189* probably null Het
Yeats2 A G 16: 20,024,917 (GRCm39) N706D probably damaging Het
Zbp1 A G 2: 173,054,047 (GRCm39) V158A probably benign Het
Zfp595 G T 13: 67,465,847 (GRCm39) H139N possibly damaging Het
Other mutations in Or51ag1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02179:Or51ag1 APN 7 103,155,934 (GRCm39) missense probably damaging 1.00
IGL02303:Or51ag1 APN 7 103,155,295 (GRCm39) missense probably benign 0.05
IGL02507:Or51ag1 APN 7 103,155,925 (GRCm39) nonsense probably null
IGL02562:Or51ag1 APN 7 103,155,423 (GRCm39) nonsense probably null
IGL02806:Or51ag1 APN 7 103,155,210 (GRCm39) missense probably benign 0.10
R0743:Or51ag1 UTSW 7 103,156,069 (GRCm39) nonsense probably null
R0884:Or51ag1 UTSW 7 103,156,069 (GRCm39) nonsense probably null
R1673:Or51ag1 UTSW 7 103,155,896 (GRCm39) missense probably damaging 0.99
R1752:Or51ag1 UTSW 7 103,155,765 (GRCm39) missense probably benign 0.02
R1800:Or51ag1 UTSW 7 103,155,248 (GRCm39) missense possibly damaging 0.89
R2043:Or51ag1 UTSW 7 103,156,150 (GRCm39) start codon destroyed probably null 0.98
R2254:Or51ag1 UTSW 7 103,155,271 (GRCm39) missense probably damaging 1.00
R2566:Or51ag1 UTSW 7 103,155,367 (GRCm39) missense probably benign 0.08
R4433:Or51ag1 UTSW 7 103,155,346 (GRCm39) missense probably benign 0.04
R5206:Or51ag1 UTSW 7 103,155,309 (GRCm39) nonsense probably null
R5470:Or51ag1 UTSW 7 103,155,716 (GRCm39) missense probably benign 0.00
R6020:Or51ag1 UTSW 7 103,156,006 (GRCm39) missense probably benign
R6848:Or51ag1 UTSW 7 103,155,664 (GRCm39) missense possibly damaging 0.50
R7222:Or51ag1 UTSW 7 103,155,664 (GRCm39) missense possibly damaging 0.50
R7832:Or51ag1 UTSW 7 103,155,586 (GRCm39) missense probably damaging 1.00
R7837:Or51ag1 UTSW 7 103,156,052 (GRCm39) missense possibly damaging 0.80
R7893:Or51ag1 UTSW 7 103,155,817 (GRCm39) missense possibly damaging 0.86
R9293:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9335:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9567:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9615:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
R9653:Or51ag1 UTSW 7 103,155,727 (GRCm39) missense probably benign 0.00
Posted On 2014-05-07