Incidental Mutation 'R2161:Or5b108'
ID 235182
Institutional Source Beutler Lab
Gene Symbol Or5b108
Ensembl Gene ENSMUSG00000094721
Gene Name olfactory receptor family 5 subfamily B member 108
Synonyms GA_x6K02T2RE5P-3517488-3518411, Olfr1462, MOR202-13
MMRRC Submission 040164-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2161 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13168033-13168956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13168673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 214 (I214K)
Ref Sequence ENSEMBL: ENSMUSP00000147174 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076832] [ENSMUST00000208533]
AlphaFold Q8VFW3
Predicted Effect probably damaging
Transcript: ENSMUST00000076832
AA Change: I214K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076107
Gene: ENSMUSG00000094721
AA Change: I214K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-51 PFAM
Pfam:7tm_1 39 288 6e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208533
AA Change: I214K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 A G 15: 11,215,821 (GRCm39) M281V probably damaging Het
Ap1g1 A T 8: 110,570,986 (GRCm39) D423V probably damaging Het
Arel1 A G 12: 84,968,030 (GRCm39) probably null Het
Arhgap33 T C 7: 30,228,075 (GRCm39) probably null Het
Arhgef18 T G 8: 3,489,575 (GRCm39) Y302* probably null Het
Blm T C 7: 80,131,118 (GRCm39) probably null Het
Cep295 T G 9: 15,264,354 (GRCm39) E97D probably damaging Het
Cep295nl T C 11: 118,223,335 (GRCm39) D503G possibly damaging Het
Chchd2 G T 5: 129,912,989 (GRCm39) A29E probably damaging Het
Cic A G 7: 24,987,559 (GRCm39) probably null Het
Cmtr1 C T 17: 29,921,147 (GRCm39) L798F probably benign Het
Col11a2 C A 17: 34,283,771 (GRCm39) probably benign Het
Crispld2 A G 8: 120,742,078 (GRCm39) Y142C probably damaging Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Dsp G A 13: 38,380,427 (GRCm39) D1792N probably damaging Het
Esp4 C A 17: 40,913,284 (GRCm39) N50K probably benign Het
Fbxo21 T C 5: 118,133,451 (GRCm39) S404P probably damaging Het
Ggnbp2 A G 11: 84,725,259 (GRCm39) F639L probably benign Het
Golph3l G A 3: 95,524,436 (GRCm39) G229D probably damaging Het
Hlx G T 1: 184,459,838 (GRCm39) S433R probably benign Het
Kdm2b T A 5: 123,018,762 (GRCm39) S233C probably damaging Het
Krt14 C T 11: 100,097,939 (GRCm39) G115R unknown Het
Ldb3 A G 14: 34,289,353 (GRCm39) probably null Het
Lrp1 T A 10: 127,391,607 (GRCm39) E2937D probably damaging Het
Mark2 G C 19: 7,260,112 (GRCm39) S111C probably damaging Het
Naa20 T A 2: 145,753,715 (GRCm39) probably null Het
Ndufa8 A T 2: 35,926,527 (GRCm39) W170R probably damaging Het
Nlrp2 A T 7: 5,328,041 (GRCm39) L671I probably damaging Het
Or52e19b T A 7: 103,032,407 (GRCm39) R267S probably benign Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Ptpro A G 6: 137,426,885 (GRCm39) D280G probably benign Het
Reps1 A G 10: 17,972,031 (GRCm39) E361G probably damaging Het
Rgs6 A G 12: 83,138,578 (GRCm39) E304G probably damaging Het
Siglece T C 7: 43,308,793 (GRCm39) T187A probably benign Het
Slc5a10 C T 11: 61,610,760 (GRCm39) G5R probably null Het
Sohlh1 A G 2: 25,734,648 (GRCm39) I215T probably benign Het
Stag1 T A 9: 100,771,648 (GRCm39) V691D probably damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Tmed8 A G 12: 87,221,031 (GRCm39) V185A probably damaging Het
Trim71 A G 9: 114,341,840 (GRCm39) F814S probably damaging Het
Trmt9b T C 8: 36,972,804 (GRCm39) C85R probably damaging Het
Tsnax A T 8: 125,742,428 (GRCm39) K52N probably damaging Het
Tubgcp3 T C 8: 12,682,292 (GRCm39) T676A probably benign Het
Other mutations in Or5b108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01114:Or5b108 APN 19 13,168,598 (GRCm39) missense possibly damaging 0.60
IGL01999:Or5b108 APN 19 13,168,924 (GRCm39) missense probably damaging 0.99
IGL02326:Or5b108 APN 19 13,168,779 (GRCm39) nonsense probably null
IGL03381:Or5b108 APN 19 13,168,769 (GRCm39) missense probably damaging 0.98
R1184:Or5b108 UTSW 19 13,168,739 (GRCm39) missense probably damaging 0.99
R1434:Or5b108 UTSW 19 13,168,662 (GRCm39) missense probably benign 0.19
R2399:Or5b108 UTSW 19 13,168,709 (GRCm39) missense probably benign 0.02
R4583:Or5b108 UTSW 19 13,168,062 (GRCm39) missense probably damaging 1.00
R5937:Or5b108 UTSW 19 13,168,675 (GRCm39) missense probably damaging 1.00
R7164:Or5b108 UTSW 19 13,168,270 (GRCm39) missense probably benign 0.00
R7270:Or5b108 UTSW 19 13,168,768 (GRCm39) missense possibly damaging 0.90
R7645:Or5b108 UTSW 19 13,168,937 (GRCm39) missense probably benign 0.01
R7649:Or5b108 UTSW 19 13,168,136 (GRCm39) missense possibly damaging 0.94
R9713:Or5b108 UTSW 19 13,168,727 (GRCm39) missense probably benign 0.15
R9742:Or5b108 UTSW 19 13,168,769 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAAGCCCCTACATTATGCCAC -3'
(R):5'- TGTCAGTGTCCATGGAGTGAC -3'

Sequencing Primer
(F):5'- CTGAATGCTTCCATCTATACAGTGG -3'
(R):5'- ACTGGAGGTTGGCTGCAAGTAC -3'
Posted On 2014-10-01