Incidental Mutation 'R3716:Dhrs4'
ID 259933
Institutional Source Beutler Lab
Gene Symbol Dhrs4
Ensembl Gene ENSMUSG00000022210
Gene Name dehydrogenase/reductase 4
Synonyms dehydrogenase/reductase (SDR family) member 4, RRD, D14Ucla2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R3716 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 55716215-55727797 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) G to T at 55716362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000022821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022821] [ENSMUST00000226168] [ENSMUST00000226298] [ENSMUST00000227488]
AlphaFold Q99LB2
Predicted Effect probably null
Transcript: ENSMUST00000022821
AA Change: M1I

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000022821
Gene: ENSMUSG00000022210
AA Change: M1I

DomainStartEndE-ValueType
Pfam:adh_short 34 229 7.8e-54 PFAM
Pfam:KR 35 210 8.4e-14 PFAM
Pfam:adh_short_C2 39 276 7.9e-38 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000226168
AA Change: M1I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000226298
Predicted Effect probably benign
Transcript: ENSMUST00000226902
Predicted Effect probably null
Transcript: ENSMUST00000227488
AA Change: M1I

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227513
Predicted Effect probably benign
Transcript: ENSMUST00000228353
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice exhibit a decreased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. Female mutants exhibit an increased depressive-like response during tail suspension testing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 A T 11: 48,910,363 (GRCm39) L690H probably damaging Het
Abtb3 C T 10: 85,397,392 (GRCm39) H442Y probably damaging Het
Acaa1b A G 9: 118,985,709 (GRCm39) V72A probably benign Het
Actl7a T C 4: 56,744,295 (GRCm39) L274P possibly damaging Het
Ankrd50 T C 3: 38,508,299 (GRCm39) E433G probably damaging Het
Ano6 A G 15: 95,811,260 (GRCm39) D120G probably damaging Het
Bbs10 A G 10: 111,136,995 (GRCm39) K703E probably benign Het
Canx A G 11: 50,195,301 (GRCm39) S256P probably benign Het
Caps2 A G 10: 112,036,637 (GRCm39) H399R probably benign Het
Col6a6 A C 9: 105,659,373 (GRCm39) L524R probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dglucy A T 12: 100,816,375 (GRCm39) N339I probably damaging Het
Disp1 A T 1: 182,869,315 (GRCm39) L1035Q probably damaging Het
Ephb1 T C 9: 102,071,999 (GRCm39) E260G probably damaging Het
Fetub T A 16: 22,754,443 (GRCm39) C217S probably damaging Het
Firrm T C 1: 163,784,457 (GRCm39) I779M probably damaging Het
Frem2 T C 3: 53,479,781 (GRCm39) S1971G probably damaging Het
Gria2 A G 3: 80,648,311 (GRCm39) Y142H possibly damaging Het
Hivep1 C T 13: 42,311,971 (GRCm39) H1404Y probably damaging Het
Il21r A G 7: 125,231,441 (GRCm39) K290E probably damaging Het
Inpp5f C G 7: 128,292,394 (GRCm39) L17V probably damaging Het
Kcnh3 A G 15: 99,130,646 (GRCm39) N421S possibly damaging Het
Krt33a A C 11: 99,904,991 (GRCm39) C172G probably benign Het
Lrp6 A T 6: 134,484,410 (GRCm39) H404Q probably damaging Het
Macf1 T C 4: 123,367,295 (GRCm39) T924A probably benign Het
Mepe C A 5: 104,485,294 (GRCm39) H145N probably benign Het
Mesp2 T G 7: 79,462,542 (GRCm39) L366R possibly damaging Het
Mink1 T A 11: 70,498,587 (GRCm39) L584Q probably damaging Het
Mms19 A G 19: 41,933,174 (GRCm39) V997A probably damaging Het
Mroh7 T C 4: 106,561,407 (GRCm39) E612G probably benign Het
Myo15b G T 11: 115,754,239 (GRCm39) C913F probably benign Het
Nav1 A T 1: 135,378,368 (GRCm39) I1653K probably damaging Het
Neb T C 2: 52,167,482 (GRCm39) E1948G probably damaging Het
Nelfcd T C 2: 174,264,798 (GRCm39) V179A possibly damaging Het
Obscn C T 11: 58,973,487 (GRCm39) C2157Y probably damaging Het
Or8i2 A T 2: 86,852,707 (GRCm39) Y60* probably null Het
Orc1 C T 4: 108,471,656 (GRCm39) A836V probably damaging Het
Pcdhb6 G T 18: 37,469,259 (GRCm39) V43L probably benign Het
Prkcd G T 14: 30,321,669 (GRCm39) D393E probably benign Het
Rb1cc1 G C 1: 6,340,914 (GRCm39) probably null Het
Rp1 T A 1: 4,419,988 (GRCm39) T375S probably benign Het
Slc9c1 A T 16: 45,400,582 (GRCm39) M731L probably benign Het
Sox21 A T 14: 118,472,842 (GRCm39) M69K probably benign Het
Spata18 A T 5: 73,824,193 (GRCm39) probably null Het
Taok1 A G 11: 77,432,636 (GRCm39) F726L probably benign Het
Ttn G A 2: 76,575,558 (GRCm39) P25112S probably damaging Het
Ubac1 C T 2: 25,904,953 (GRCm39) R95H probably damaging Het
Usp32 A G 11: 84,933,389 (GRCm39) Y40H probably damaging Het
Usp37 A T 1: 74,532,145 (GRCm39) S83T possibly damaging Het
Vps13d A G 4: 144,802,296 (GRCm39) I405T probably damaging Het
Other mutations in Dhrs4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01900:Dhrs4 APN 14 55,725,654 (GRCm39) missense probably benign 0.00
R1496:Dhrs4 UTSW 14 55,725,107 (GRCm39) missense probably damaging 0.98
R1962:Dhrs4 UTSW 14 55,725,060 (GRCm39) missense probably damaging 1.00
R6027:Dhrs4 UTSW 14 55,723,580 (GRCm39) missense probably benign 0.00
R7866:Dhrs4 UTSW 14 55,725,092 (GRCm39) missense probably damaging 1.00
R7958:Dhrs4 UTSW 14 55,725,078 (GRCm39) missense probably damaging 1.00
R9347:Dhrs4 UTSW 14 55,727,306 (GRCm39) missense possibly damaging 0.61
R9365:Dhrs4 UTSW 14 55,724,776 (GRCm39) missense probably benign 0.23
R9522:Dhrs4 UTSW 14 55,716,219 (GRCm39) unclassified probably benign
X0021:Dhrs4 UTSW 14 55,724,581 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- TCCCAAATCAGGCAAAGGGG -3'
(R):5'- CAACAGTCCAGGAGTTAAAGAGTAC -3'

Sequencing Primer
(F):5'- TCTGGGAAGTCAGAGCT -3'
(R):5'- AGTACTTGTTTCTGGATGAAGACTC -3'
Posted On 2015-01-23