Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01413:Or10j2'

278433

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10j2

Ensembl Gene

ENSMUSG00000049605

Gene Name

olfactory receptor family 10 subfamily J member 2

Synonyms

MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL01413

Quality Score

Status

Chromosome

Chromosomal Location

173097714-173098704 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 173098275 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 178 (C178S)

Ref Sequence

ENSEMBL: ENSMUSP00000150427 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]

AlphaFold

A0A140T8J6

Predicted Effect

probably damaging
Transcript: ENSMUST00000059754
AA Change: C178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605
AA Change: C178S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.6e-55	PFAM
Pfam:7tm_1	41	289	5.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000111224

SMART Domains

Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
PTX	20	219	1.93e-94	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000213420
AA Change: C178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaa2	A	T	18: 74,939,015 (GRCm39)		probably benign	Het
Adgrl1	T	A	8: 84,656,486 (GRCm39)	I268N	probably damaging	Het
Asic1	T	A	15: 99,569,998 (GRCm39)	N106K	probably damaging	Het
Ass1	A	G	2: 31,366,934 (GRCm39)	Y11C	probably damaging	Het
Cd44	T	C	2: 102,644,632 (GRCm39)	E448G	probably damaging	Het
Cdca2	A	G	14: 67,915,343 (GRCm39)	S639P	probably damaging	Het
Cfap221	T	A	1: 119,912,801 (GRCm39)	H91L	possibly damaging	Het
Cmtr1	T	C	17: 29,916,956 (GRCm39)	S618P	probably benign	Het
Cnga4	A	T	7: 105,054,169 (GRCm39)	M46L	probably benign	Het
Col4a4	C	T	1: 82,448,969 (GRCm39)	G1207E	unknown	Het
Cracdl	G	A	1: 37,651,387 (GRCm39)	A1160V	possibly damaging	Het
Cthrc1	T	A	15: 38,943,894 (GRCm39)	L58Q	possibly damaging	Het
Cyb561a3	T	A	19: 10,562,610 (GRCm39)	H83Q	probably damaging	Het
Dlgap1	C	A	17: 70,823,069 (GRCm39)	A18E	probably benign	Het
Dnah2	G	A	11: 69,323,790 (GRCm39)	L3707F	probably damaging	Het
Dnai7	A	T	6: 145,120,812 (GRCm39)	M669K	probably damaging	Het
Duox1	A	G	2: 122,151,191 (GRCm39)	N289D	probably benign	Het
Fbrsl1	T	A	5: 110,526,114 (GRCm39)	E443D	probably damaging	Het
Fgfr1	T	A	8: 26,052,239 (GRCm39)	C288*	probably null	Het
Gabbr1	A	G	17: 37,373,598 (GRCm39)	N498S	possibly damaging	Het
Gja10	T	C	4: 32,602,070 (GRCm39)	K105E	probably damaging	Het
Glra4	C	T	X: 135,663,493 (GRCm39)	R352H	probably benign	Het
Gm19402	G	T	10: 77,526,323 (GRCm39)		probably benign	Het
Hadha	T	A	5: 30,346,025 (GRCm39)	M200L	probably benign	Het
Hoxc9	T	A	15: 102,892,432 (GRCm39)	M215K	probably damaging	Het
Huwe1	A	T	X: 150,665,676 (GRCm39)	Q1231L	possibly damaging	Het
Ifi214	T	A	1: 173,356,995 (GRCm39)	N36I	probably damaging	Het
Il17ra	A	G	6: 120,452,542 (GRCm39)	N242D	probably benign	Het
Il1rl1	A	T	1: 40,485,329 (GRCm39)	K260N	possibly damaging	Het
Lhx6	C	A	2: 35,993,528 (GRCm39)	A57S	probably benign	Het
Mdh2	T	A	5: 135,814,879 (GRCm39)	I116N	probably damaging	Het
Met	T	C	6: 17,558,895 (GRCm39)		probably benign	Het
Mgam	A	G	6: 40,638,211 (GRCm39)	D387G	probably damaging	Het
Myo3a	T	C	2: 22,302,411 (GRCm39)	S287P	probably benign	Het
Nol8	T	G	13: 49,813,428 (GRCm39)	N140K	possibly damaging	Het
Nrap	C	A	19: 56,377,823 (GRCm39)	A56S	probably damaging	Het
Nuggc	A	G	14: 65,876,030 (GRCm39)	T548A	probably benign	Het
Or2i1	A	T	17: 37,508,554 (GRCm39)	F102I	possibly damaging	Het
Pcdh11x	A	G	X: 119,309,282 (GRCm39)	T242A	probably benign	Het
Pcdhb8	A	G	18: 37,489,029 (GRCm39)	N236D	probably damaging	Het
Pdzph1	T	C	17: 59,186,147 (GRCm39)	I1215V	possibly damaging	Het
Plekha8	C	T	6: 54,599,261 (GRCm39)	T265I	probably benign	Het
Pou4f2	T	A	8: 79,161,734 (GRCm39)	I290F	probably damaging	Het
Pramel22	A	T	4: 143,381,887 (GRCm39)	F270I	probably benign	Het
Ptpn3	G	A	4: 57,270,156 (GRCm39)	T2I	probably damaging	Het
Rab28	A	T	5: 41,855,790 (GRCm39)	D68E	probably damaging	Het
Rbl1	T	C	2: 156,994,812 (GRCm39)		probably null	Het
Samd4	A	G	14: 47,254,249 (GRCm39)	T137A	probably benign	Het
Serpinb1b	T	G	13: 33,277,842 (GRCm39)	D358E	probably damaging	Het
Serpinb9c	G	A	13: 33,335,787 (GRCm39)	L222F	probably damaging	Het
Slc24a3	A	G	2: 145,482,169 (GRCm39)	D609G	probably damaging	Het
Slc25a40	A	C	5: 8,503,298 (GRCm39)	*338Y	probably null	Het
Spef2	T	A	15: 9,676,376 (GRCm39)	I732L	probably benign	Het
Srrm2	T	C	17: 24,034,999 (GRCm39)		probably benign	Het
Ssxb13	A	G	X: 8,615,692 (GRCm39)	E75G	probably benign	Het
Stmnd1	A	T	13: 46,453,157 (GRCm39)	I278L	probably benign	Het
Strap	C	A	6: 137,722,502 (GRCm39)		probably benign	Het
Supt16	C	T	14: 52,414,489 (GRCm39)	E438K	probably benign	Het
Tcf4	A	C	18: 69,788,090 (GRCm39)	E160D	probably damaging	Het
Themis3	A	G	17: 66,863,092 (GRCm39)	Y289H	probably benign	Het
Tmem87a	T	C	2: 120,216,351 (GRCm39)	T180A	probably benign	Het
Trappc10	A	G	10: 78,033,678 (GRCm39)	V963A	possibly damaging	Het
Trav19	G	T	14: 54,083,072 (GRCm39)	C49F	probably damaging	Het
Trim30c	A	G	7: 104,031,541 (GRCm39)	S425P	possibly damaging	Het
Ubap1	A	T	4: 41,387,333 (GRCm39)	R414S	probably benign	Het
Usp9x	A	G	X: 13,017,579 (GRCm39)	S1696G	probably benign	Het
Vipas39	G	A	12: 87,296,171 (GRCm39)	T274I	probably benign	Het
Vmn1r185	A	T	7: 26,311,046 (GRCm39)	V153E	probably damaging	Het
Vmn2r124	A	G	17: 18,282,827 (GRCm39)	T174A	probably benign	Het
Wdr59	T	A	8: 112,227,706 (GRCm39)	S124C	probably benign	Het
Xirp2	A	T	2: 67,340,270 (GRCm39)	D837V	probably damaging	Het
Zfp185	A	G	X: 72,061,997 (GRCm39)	D403G	possibly damaging	Het
Zfp516	A	T	18: 83,005,795 (GRCm39)	K900*	probably null	Het

Other mutations in Or10j2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01418:Or10j2	APN	1	173,098,275 (GRCm39)	missense	probably damaging	1.00
IGL01930:Or10j2	APN	1	173,098,177 (GRCm39)	missense	probably benign
IGL01963:Or10j2	APN	1	173,097,919 (GRCm39)	missense	probably damaging	0.99
IGL02104:Or10j2	APN	1	173,098,603 (GRCm39)	missense	probably damaging	0.96
IGL02192:Or10j2	APN	1	173,098,417 (GRCm39)	missense	probably damaging	1.00
IGL02256:Or10j2	APN	1	173,098,194 (GRCm39)	missense	probably benign	0.04
IGL02340:Or10j2	APN	1	173,097,972 (GRCm39)	missense	probably benign	0.10
IGL02454:Or10j2	APN	1	173,098,507 (GRCm39)	missense	probably damaging	0.99
IGL02638:Or10j2	APN	1	173,097,898 (GRCm39)	missense	probably benign	0.07
FR4737:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
FR4976:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
R0552:Or10j2	UTSW	1	173,098,372 (GRCm39)	missense	probably benign	0.05
R0621:Or10j2	UTSW	1	173,098,242 (GRCm39)	missense	possibly damaging	0.48
R0735:Or10j2	UTSW	1	173,098,569 (GRCm39)	missense	probably benign	0.05
R1506:Or10j2	UTSW	1	173,098,336 (GRCm39)	missense	probably benign	0.04
R1670:Or10j2	UTSW	1	173,098,467 (GRCm39)	missense	probably damaging	1.00
R2111:Or10j2	UTSW	1	173,097,879 (GRCm39)	missense	probably benign
R2204:Or10j2	UTSW	1	173,097,703 (GRCm39)	splice site	probably null
R4475:Or10j2	UTSW	1	173,098,480 (GRCm39)	missense	probably damaging	0.99
R4909:Or10j2	UTSW	1	173,098,546 (GRCm39)	missense	probably damaging	0.97
R5457:Or10j2	UTSW	1	173,098,141 (GRCm39)	missense	probably benign	0.00
R6124:Or10j2	UTSW	1	173,097,846 (GRCm39)	missense	probably damaging	1.00
R6456:Or10j2	UTSW	1	173,098,105 (GRCm39)	missense	probably damaging	1.00
R7220:Or10j2	UTSW	1	173,097,811 (GRCm39)	missense	possibly damaging	0.56
R7240:Or10j2	UTSW	1	173,098,561 (GRCm39)	missense	probably benign	0.27
R7672:Or10j2	UTSW	1	173,098,440 (GRCm39)	missense	probably benign	0.18
R8073:Or10j2	UTSW	1	173,098,552 (GRCm39)	missense	probably benign	0.42
R8116:Or10j2	UTSW	1	173,098,047 (GRCm39)	missense	possibly damaging	0.88
R8982:Or10j2	UTSW	1	173,098,306 (GRCm39)	missense	probably damaging	1.00
R9038:Or10j2	UTSW	1	173,098,147 (GRCm39)	missense	possibly damaging	0.63
R9668:Or10j2	UTSW	1	173,098,183 (GRCm39)	missense	possibly damaging	0.94
RF032:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF036:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF040:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
X0019:Or10j2	UTSW	1	173,098,124 (GRCm39)	nonsense	probably null

Posted On

2015-04-16