Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02146:Ces2g'

281771

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ces2g

Ensembl Gene

ENSMUSG00000031877

Gene Name

carboxylesterase 2G

Synonyms

2210023G05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.047) question?

Stock #

IGL02146

Quality Score

Status

Chromosome

Chromosomal Location

105688350-105696169 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 105693576 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 419 (I419T)

Ref Sequence

ENSEMBL: ENSMUSP00000049315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043183]

AlphaFold

E9PV38

Predicted Effect

possibly damaging
Transcript: ENSMUST00000043183
AA Change: I419T

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000049315
Gene: ENSMUSG00000031877
AA Change: I419T

Domain	Start	End	E-Value	Type
Pfam:COesterase	11	539	1.4e-176	PFAM
Pfam:Abhydrolase_3	144	245	4.9e-11	PFAM
Pfam:Peptidase_S9	159	331	8.1e-7	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212330

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	G	9: 57,164,023 (GRCm39)	C784R	possibly damaging	Het
Akp3	A	T	1: 87,054,297 (GRCm39)	D278V	probably benign	Het
Atxn7l1	G	T	12: 33,418,030 (GRCm39)	R730S	probably benign	Het
Bag6	A	G	17: 35,355,191 (GRCm39)	T30A	probably damaging	Het
Blk	G	T	14: 63,611,648 (GRCm39)	P429H	probably damaging	Het
Bmp2k	T	A	5: 97,212,689 (GRCm39)	M524K	unknown	Het
Bst1	T	A	5: 43,983,678 (GRCm39)	H221Q	probably damaging	Het
Cnep1r1	T	C	8: 88,856,326 (GRCm39)	V34A	probably benign	Het
Ctnnbl1	A	G	2: 157,661,414 (GRCm39)	E308G	probably damaging	Het
Cyp20a1	A	T	1: 60,410,410 (GRCm39)	K237I	possibly damaging	Het
Dlg5	T	C	14: 24,252,429 (GRCm39)	T104A	probably damaging	Het
Dnaaf11	C	T	15: 66,361,374 (GRCm39)	W42*	probably null	Het
Dnaaf11	C	A	15: 66,361,375 (GRCm39)	W42L	probably benign	Het
Dnah9	C	T	11: 65,818,526 (GRCm39)	V3271M	probably damaging	Het
Eed	T	A	7: 89,618,803 (GRCm39)	N204Y	possibly damaging	Het
Fat3	A	G	9: 15,910,878 (GRCm39)	V1708A	probably benign	Het
Fcrl6	T	C	1: 172,426,264 (GRCm39)	T178A	probably benign	Het
Galnt4	A	C	10: 98,945,563 (GRCm39)	K429N	possibly damaging	Het
Ints6	T	A	14: 62,996,709 (GRCm39)	T94S	possibly damaging	Het
Iqsec3	A	T	6: 121,360,916 (GRCm39)	S981T	probably damaging	Het
Itga9	T	A	9: 118,663,400 (GRCm39)	S146T	possibly damaging	Het
Itpr3	A	G	17: 27,336,249 (GRCm39)	Y2325C	probably damaging	Het
Kng2	T	A	16: 22,806,582 (GRCm39)	Q539L	probably damaging	Het
Lmtk3	T	A	7: 45,444,371 (GRCm39)		probably benign	Het
Map1a	T	C	2: 121,129,927 (GRCm39)	Y248H	probably damaging	Het
Mroh1	A	G	15: 76,318,879 (GRCm39)		probably benign	Het
Mroh2b	T	C	15: 4,980,776 (GRCm39)		probably null	Het
Myo18b	A	T	5: 112,991,151 (GRCm39)	M942K	probably damaging	Het
Myzap	T	A	9: 71,471,730 (GRCm39)	T94S	probably benign	Het
Nebl	C	A	2: 17,353,679 (GRCm39)	R957S	probably damaging	Het
Nexn	A	T	3: 151,952,885 (GRCm39)	D278E	probably benign	Het
Nlgn1	A	T	3: 25,966,846 (GRCm39)	N222K	probably damaging	Het
Or6c76	T	A	10: 129,612,727 (GRCm39)		probably benign	Het
Or8d1	G	A	9: 38,766,654 (GRCm39)	A99T	probably benign	Het
Osbpl6	A	T	2: 76,380,094 (GRCm39)	R79S	possibly damaging	Het
Phip	T	C	9: 82,763,771 (GRCm39)	I1268M	probably benign	Het
Pkd2	G	T	5: 104,637,157 (GRCm39)	R590L	probably damaging	Het
Reg2	G	A	6: 78,382,568 (GRCm39)		probably benign	Het
Scaf1	A	T	7: 44,662,934 (GRCm39)	D26E	probably damaging	Het
Ska1	A	G	18: 74,329,981 (GRCm39)	I253T	possibly damaging	Het
Slc11a2	T	C	15: 100,299,169 (GRCm39)	N443D	probably damaging	Het
Slc6a12	A	T	6: 121,330,460 (GRCm39)	T155S	probably benign	Het
Slit3	A	G	11: 35,125,675 (GRCm39)	K118R	possibly damaging	Het
Snap23	T	G	2: 120,429,792 (GRCm39)	N212K	probably damaging	Het
Snx13	T	A	12: 35,151,078 (GRCm39)	D346E	probably benign	Het
Sumf1	C	A	6: 108,150,392 (GRCm39)		probably null	Het
Susd2	T	C	10: 75,474,267 (GRCm39)	N479S	possibly damaging	Het
Tiam1	A	G	16: 89,646,569 (GRCm39)	I821T	probably benign	Het
Tll2	C	A	19: 41,086,276 (GRCm39)	V651L	probably benign	Het
Vmn2r1	A	G	3: 64,012,104 (GRCm39)	D655G	probably benign	Het
Vmn2r72	T	C	7: 85,387,170 (GRCm39)	Y798C	probably damaging	Het
Vps13b	A	C	15: 35,646,479 (GRCm39)	I1528L	probably benign	Het
Wdtc1	G	A	4: 133,029,076 (GRCm39)	L337F	probably benign	Het
Zfp128	A	C	7: 12,623,959 (GRCm39)	K109T	possibly damaging	Het

Other mutations in Ces2g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00832:Ces2g	APN	8	105,694,471 (GRCm39)	splice site	probably benign
IGL00901:Ces2g	APN	8	105,691,761 (GRCm39)	missense	probably benign	0.01
IGL02101:Ces2g	APN	8	105,691,769 (GRCm39)	splice site	probably null
IGL02624:Ces2g	APN	8	105,691,380 (GRCm39)	missense	probably damaging	1.00
IGL03091:Ces2g	APN	8	105,691,386 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Ces2g	UTSW	8	105,691,521 (GRCm39)	missense	possibly damaging	0.52
R0025:Ces2g	UTSW	8	105,692,628 (GRCm39)	splice site	probably benign
R0025:Ces2g	UTSW	8	105,692,628 (GRCm39)	splice site	probably benign
R0122:Ces2g	UTSW	8	105,694,932 (GRCm39)	missense	probably damaging	0.96
R0494:Ces2g	UTSW	8	105,693,199 (GRCm39)	missense	probably benign
R1127:Ces2g	UTSW	8	105,694,094 (GRCm39)	splice site	probably null
R1337:Ces2g	UTSW	8	105,690,597 (GRCm39)	missense	possibly damaging	0.63
R1619:Ces2g	UTSW	8	105,693,984 (GRCm39)	missense	probably damaging	1.00
R1813:Ces2g	UTSW	8	105,693,569 (GRCm39)	missense	probably benign	0.32
R2240:Ces2g	UTSW	8	105,689,134 (GRCm39)	missense	probably benign	0.11
R2255:Ces2g	UTSW	8	105,694,046 (GRCm39)	missense	probably damaging	1.00
R2307:Ces2g	UTSW	8	105,695,044 (GRCm39)	missense	probably benign	0.01
R2566:Ces2g	UTSW	8	105,692,621 (GRCm39)	critical splice donor site	probably null
R4026:Ces2g	UTSW	8	105,691,377 (GRCm39)	missense	probably damaging	0.99
R4469:Ces2g	UTSW	8	105,692,602 (GRCm39)	missense	probably benign	0.14
R4631:Ces2g	UTSW	8	105,694,094 (GRCm39)	splice site	probably null
R4859:Ces2g	UTSW	8	105,694,094 (GRCm39)	splice site	probably null
R4900:Ces2g	UTSW	8	105,693,989 (GRCm39)	nonsense	probably null
R4925:Ces2g	UTSW	8	105,691,526 (GRCm39)	missense	probably benign	0.27
R5524:Ces2g	UTSW	8	105,693,527 (GRCm39)	missense	probably benign	0.00
R5556:Ces2g	UTSW	8	105,694,074 (GRCm39)	missense	probably benign	0.14
R6795:Ces2g	UTSW	8	105,694,449 (GRCm39)	missense	probably damaging	0.96
R6988:Ces2g	UTSW	8	105,690,540 (GRCm39)	missense	probably benign
R7653:Ces2g	UTSW	8	105,689,285 (GRCm39)	missense	probably damaging	1.00
R7724:Ces2g	UTSW	8	105,693,484 (GRCm39)	missense	probably benign	0.02
R7740:Ces2g	UTSW	8	105,692,962 (GRCm39)	missense	probably damaging	0.98
R7856:Ces2g	UTSW	8	105,693,014 (GRCm39)	missense	not run
R8123:Ces2g	UTSW	8	105,693,555 (GRCm39)	missense	probably benign	0.06
R8690:Ces2g	UTSW	8	105,693,605 (GRCm39)	missense	probably benign	0.01
R8724:Ces2g	UTSW	8	105,692,955 (GRCm39)	missense	probably benign	0.01
R8732:Ces2g	UTSW	8	105,689,195 (GRCm39)	missense	possibly damaging	0.78
R8825:Ces2g	UTSW	8	105,693,954 (GRCm39)	missense	probably benign	0.13
R9441:Ces2g	UTSW	8	105,690,623 (GRCm39)	missense	possibly damaging	0.52
R9688:Ces2g	UTSW	8	105,691,304 (GRCm39)	missense	probably benign	0.42
Z1177:Ces2g	UTSW	8	105,690,593 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16