Incidental Mutation 'IGL00913:Olfr1351'
ID28318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1351
Ensembl Gene ENSMUSG00000063216
Gene Nameolfactory receptor 1351
SynonymsMOR139-4, GA_x6K02T2QGN0-2794907-2793948
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.205) question?
Stock #IGL00913
Quality Score
Status
Chromosome10
Chromosomal Location79012472-79019645 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 79018251 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 310 (T310A)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]
Predicted Effect probably benign
Transcript: ENSMUST00000080730
AA Change: T310A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: T310A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203906
AA Change: T310A
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: T310A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216030
AA Change: T310A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 A G 17: 42,666,902 S517P possibly damaging Het
Arl4c T C 1: 88,701,384 D94G probably damaging Het
Bag5 T C 12: 111,711,332 E19G probably damaging Het
Carf T A 1: 60,147,955 D537E probably benign Het
Cd177 C A 7: 24,756,195 D301Y probably damaging Het
Csmd1 C T 8: 16,071,287 V1799I probably benign Het
Cyp4x1 T A 4: 115,112,863 I356F probably benign Het
Elmsan1 T A 12: 84,172,858 I441L probably benign Het
F5 A T 1: 164,204,896 H1804L probably damaging Het
Fras1 G T 5: 96,695,076 G1718C probably damaging Het
Ganc T C 2: 120,439,452 probably benign Het
Gm9992 A T 17: 7,369,739 V130D probably damaging Het
Hs3st5 A G 10: 36,832,850 D127G probably damaging Het
Inpp5a A G 7: 139,516,721 D154G probably benign Het
Kif16b T A 2: 142,704,007 R1134* probably null Het
Lrrc66 C T 5: 73,608,156 A515T possibly damaging Het
Map3k10 C T 7: 27,663,215 probably benign Het
Mrpl12 G A 11: 120,485,376 D71N possibly damaging Het
Nfix A T 8: 84,726,477 V316E probably damaging Het
Nop2 A G 6: 125,139,821 Y346C probably damaging Het
Nrbp1 A G 5: 31,251,059 E513G possibly damaging Het
Ogfrl1 T C 1: 23,370,090 I352V probably benign Het
Olfr912 T A 9: 38,581,376 V33E probably damaging Het
Oxr1 G A 15: 41,820,143 V15I possibly damaging Het
Pik3r6 T G 11: 68,551,321 F697C probably damaging Het
Ptk2 A G 15: 73,295,389 probably benign Het
Rnft2 G A 5: 118,201,215 T380M probably damaging Het
Scel A G 14: 103,581,809 N346S probably benign Het
Sema4a T A 3: 88,449,810 T153S probably damaging Het
Serinc2 A T 4: 130,264,408 L82Q possibly damaging Het
Sin3a A G 9: 57,098,118 T392A probably benign Het
Slc25a38 T A 9: 120,120,307 Y108* probably null Het
Tmc8 G A 11: 117,786,504 G317R probably damaging Het
Trpc3 A G 3: 36,640,639 V722A possibly damaging Het
Other mutations in Olfr1351
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01833:Olfr1351 APN 10 79017936 missense probably benign
IGL02141:Olfr1351 APN 10 79017721 missense probably damaging 1.00
IGL02178:Olfr1351 APN 10 79017720 missense possibly damaging 0.59
R1070:Olfr1351 UTSW 10 79017850 missense probably damaging 0.99
R1631:Olfr1351 UTSW 10 79017405 missense probably benign 0.00
R1646:Olfr1351 UTSW 10 79017506 nonsense probably null
R1781:Olfr1351 UTSW 10 79017325 start codon destroyed probably null 0.89
R2358:Olfr1351 UTSW 10 79018188 missense probably damaging 1.00
R3161:Olfr1351 UTSW 10 79017604 missense probably benign
R3162:Olfr1351 UTSW 10 79017604 missense probably benign
R3162:Olfr1351 UTSW 10 79017604 missense probably benign
R5874:Olfr1351 UTSW 10 79017357 missense possibly damaging 0.95
R6382:Olfr1351 UTSW 10 79017517 missense probably damaging 1.00
R7108:Olfr1351 UTSW 10 79017649 nonsense probably null
R7567:Olfr1351 UTSW 10 79017545 missense probably benign 0.04
R7568:Olfr1351 UTSW 10 79017507 missense probably benign
Posted On2013-04-17