Incidental Mutation 'IGL02246:Olfr577'
ID 286205
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr577
Ensembl Gene ENSMUSG00000043354
Gene Name olfactory receptor 577
Synonyms MOR7-2, GA_x6K02T2PBJ9-5685322-5684384
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # IGL02246
Quality Score
Status
Chromosome 7
Chromosomal Location 102971180-102975943 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102973744 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 83 (T83A)
Ref Sequence ENSEMBL: ENSMUSP00000150712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051505] [ENSMUST00000185326] [ENSMUST00000214080] [ENSMUST00000215237]
AlphaFold Q8VH11
Predicted Effect possibly damaging
Transcript: ENSMUST00000051505
AA Change: T83A

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000059586
Gene: ENSMUSG00000043354
AA Change: T83A

DomainStartEndE-ValueType
Pfam:7tm_4 34 312 3.3e-140 PFAM
Pfam:7TM_GPCR_Srsx 38 310 1.2e-6 PFAM
Pfam:7tm_1 44 295 7.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185326
SMART Domains Protein: ENSMUSP00000142459
Gene: ENSMUSG00000073962

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 300 9.7e-12 PFAM
Pfam:7tm_1 41 291 1.8e-29 PFAM
Pfam:7tm_4 140 284 2.6e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214080
AA Change: T83A

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215237
AA Change: T83A

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik G T 4: 123,860,862 D190Y probably damaging Het
Acat1 G A 9: 53,584,866 L324F probably benign Het
Ago2 T C 15: 73,108,418 H743R probably damaging Het
Ahnak A T 19: 9,008,268 L2305F probably damaging Het
Ankhd1 T A 18: 36,656,726 H2438Q probably damaging Het
Atm G T 9: 53,527,185 Q162K probably benign Het
Bpifa6 A T 2: 153,989,276 E254V probably damaging Het
Carns1 T A 19: 4,166,432 N584Y possibly damaging Het
Cmklr1 T C 5: 113,614,400 N180S probably benign Het
Col6a5 G A 9: 105,911,107 R1565* probably null Het
Fbxo43 T A 15: 36,162,696 I122L probably benign Het
Fibp A G 19: 5,463,236 Y193C probably damaging Het
Gm10923 A G 15: 85,116,931 probably benign Het
Il12rb2 A G 6: 67,308,956 probably null Het
Jakmip2 T C 18: 43,567,158 E445G possibly damaging Het
Krcc1 G A 6: 71,284,421 D146N probably benign Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Map2k5 A T 9: 63,377,129 D43E probably benign Het
Nup155 A G 15: 8,143,002 K824R probably benign Het
Olfr1394 T C 11: 49,160,094 S27P probably benign Het
Phkg1 G A 5: 129,864,638 R324W probably damaging Het
Plcd1 G A 9: 119,072,609 L616F probably benign Het
Rnf141 A T 7: 110,825,287 S122T probably benign Het
Tap1 G A 17: 34,193,989 V593M probably benign Het
Ticrr T C 7: 79,675,328 L534P probably damaging Het
Ubr4 G T 4: 139,459,103 E640D possibly damaging Het
Vmn1r169 A C 7: 23,577,236 I18L probably benign Het
Other mutations in Olfr577
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03111:Olfr577 APN 7 102973531 missense probably damaging 1.00
R1529:Olfr577 UTSW 7 102973879 missense probably damaging 1.00
R1753:Olfr577 UTSW 7 102973056 missense probably benign
R3005:Olfr577 UTSW 7 102973258 missense possibly damaging 0.56
R4457:Olfr577 UTSW 7 102973527 missense probably damaging 1.00
R4675:Olfr577 UTSW 7 102973806 missense probably damaging 0.99
R4808:Olfr577 UTSW 7 102973911 missense probably damaging 0.99
R4891:Olfr577 UTSW 7 102973552 missense probably benign 0.12
R4917:Olfr577 UTSW 7 102973407 missense possibly damaging 0.93
R4918:Olfr577 UTSW 7 102973407 missense possibly damaging 0.93
R5328:Olfr577 UTSW 7 102973968 missense possibly damaging 0.46
R6375:Olfr577 UTSW 7 102973753 missense probably damaging 1.00
R6683:Olfr577 UTSW 7 102973713 missense probably benign 0.05
R6958:Olfr577 UTSW 7 102973884 missense possibly damaging 0.67
R7022:Olfr577 UTSW 7 102973968 missense possibly damaging 0.46
R7429:Olfr577 UTSW 7 102973762 missense probably damaging 1.00
R7430:Olfr577 UTSW 7 102973762 missense probably damaging 1.00
R7490:Olfr577 UTSW 7 102973810 missense probably damaging 1.00
R7808:Olfr577 UTSW 7 102973110 missense possibly damaging 0.56
R8169:Olfr577 UTSW 7 102973338 missense probably damaging 0.99
R8544:Olfr577 UTSW 7 102973731 missense probably damaging 1.00
R9027:Olfr577 UTSW 7 102973353 missense probably damaging 1.00
R9265:Olfr577 UTSW 7 102973905 nonsense probably null
X0027:Olfr577 UTSW 7 102973686 missense probably benign 0.05
Z1176:Olfr577 UTSW 7 102973309 missense not run
Z1177:Olfr577 UTSW 7 102973309 missense not run
Posted On 2015-04-16