Incidental Mutation 'IGL02666:Txndc16'
| ID |
302762 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Txndc16
|
| Ensembl Gene |
ENSMUSG00000021830 |
| Gene Name |
thioredoxin domain containing 16 |
| Synonyms |
5730420B22Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.097)
|
| Stock # |
IGL02666
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
45371905-45457008 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
G to A
at 45448607 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154077
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022377]
[ENSMUST00000123879]
[ENSMUST00000128484]
[ENSMUST00000139526]
[ENSMUST00000143609]
[ENSMUST00000147853]
[ENSMUST00000153383]
[ENSMUST00000226879]
|
| AlphaFold |
Q7TN22 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022377
|
| SMART Domains |
Protein: ENSMUSP00000022377
Gene: ENSMUSG00000021830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
354 |
367 |
N/A |
INTRINSIC |
|
Pfam:Thioredoxin
|
394 |
496 |
1.9e-12 |
PFAM |
|
Pfam:Thioredoxin_6
|
534 |
723 |
2.3e-28 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118407
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123879
|
| SMART Domains |
Protein: ENSMUSP00000123023
Gene: ENSMUSG00000021830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
354 |
367 |
N/A |
INTRINSIC |
|
Pfam:Thioredoxin
|
394 |
496 |
1.9e-12 |
PFAM |
|
Pfam:Thioredoxin_6
|
534 |
723 |
2.3e-28 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128484
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139526
|
| SMART Domains |
Protein: ENSMUSP00000120287
Gene: ENSMUSG00000021830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
354 |
367 |
N/A |
INTRINSIC |
|
Pfam:Thioredoxin
|
394 |
496 |
1e-12 |
PFAM |
|
Pfam:Thioredoxin_6
|
534 |
723 |
7.3e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143609
|
| SMART Domains |
Protein: ENSMUSP00000122128
Gene: ENSMUSG00000021830
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147853
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150648
|
| Predicted Effect |
silent
Transcript: ENSMUST00000153383
|
| Predicted Effect |
silent
Transcript: ENSMUST00000226879
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9230109A22Rik |
T |
C |
15: 25,138,944 (GRCm39) |
|
noncoding transcript |
Het |
| Abca15 |
G |
A |
7: 119,934,431 (GRCm39) |
V136M |
probably damaging |
Het |
| Abhd3 |
A |
G |
18: 10,645,148 (GRCm39) |
I382T |
probably benign |
Het |
| Cux1 |
C |
A |
5: 136,304,169 (GRCm39) |
E1336* |
probably null |
Het |
| Cyb5r3 |
T |
C |
15: 83,044,554 (GRCm39) |
I155V |
probably damaging |
Het |
| Ddx24 |
T |
C |
12: 103,390,314 (GRCm39) |
T226A |
possibly damaging |
Het |
| Dld |
T |
C |
12: 31,382,408 (GRCm39) |
N465S |
probably null |
Het |
| Dnmbp |
A |
G |
19: 43,842,566 (GRCm39) |
|
probably benign |
Het |
| Dock9 |
T |
C |
14: 121,818,111 (GRCm39) |
H1580R |
probably benign |
Het |
| Drd3 |
C |
A |
16: 43,637,319 (GRCm39) |
|
probably benign |
Het |
| Gabrb2 |
G |
T |
11: 42,420,322 (GRCm39) |
|
probably null |
Het |
| Gbp9 |
T |
C |
5: 105,242,141 (GRCm39) |
|
probably null |
Het |
| Inhba |
A |
T |
13: 16,201,664 (GRCm39) |
I409F |
possibly damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,764,564 (GRCm39) |
N1560S |
probably damaging |
Het |
| Itsn1 |
A |
G |
16: 91,617,606 (GRCm39) |
|
probably benign |
Het |
| Kat6b |
T |
C |
14: 21,678,938 (GRCm39) |
F434L |
probably damaging |
Het |
| Klra1 |
A |
G |
6: 130,341,278 (GRCm39) |
C232R |
probably damaging |
Het |
| Krt18 |
T |
A |
15: 101,938,302 (GRCm39) |
I175N |
probably damaging |
Het |
| Lck |
A |
G |
4: 129,450,212 (GRCm39) |
V178A |
probably damaging |
Het |
| Mroh4 |
C |
A |
15: 74,481,624 (GRCm39) |
G737V |
probably benign |
Het |
| Mug2 |
A |
C |
6: 122,058,285 (GRCm39) |
L1282F |
probably damaging |
Het |
| Myo9a |
A |
G |
9: 59,832,187 (GRCm39) |
N2572S |
probably benign |
Het |
| Nup88 |
G |
T |
11: 70,834,695 (GRCm39) |
|
probably benign |
Het |
| Nxph3 |
G |
T |
11: 95,401,834 (GRCm39) |
H193Q |
possibly damaging |
Het |
| Or5b97 |
G |
T |
19: 12,878,221 (GRCm39) |
H308N |
probably benign |
Het |
| Orm2 |
A |
G |
4: 63,283,970 (GRCm39) |
T198A |
possibly damaging |
Het |
| Pom121 |
T |
C |
5: 135,415,686 (GRCm39) |
I397V |
unknown |
Het |
| Prex1 |
C |
A |
2: 166,414,909 (GRCm39) |
E1313D |
probably benign |
Het |
| Prkg2 |
T |
A |
5: 99,145,378 (GRCm39) |
|
probably benign |
Het |
| Prl2a1 |
A |
T |
13: 27,990,310 (GRCm39) |
K86N |
possibly damaging |
Het |
| Ptpro |
G |
A |
6: 137,355,057 (GRCm39) |
S188N |
probably damaging |
Het |
| Ptprz1 |
A |
T |
6: 23,001,209 (GRCm39) |
I1100F |
probably benign |
Het |
| Ryr1 |
C |
A |
7: 28,719,188 (GRCm39) |
M4406I |
unknown |
Het |
| Sdf4 |
T |
A |
4: 156,093,281 (GRCm39) |
Y204* |
probably null |
Het |
| Serinc1 |
A |
T |
10: 57,400,089 (GRCm39) |
|
probably null |
Het |
| Slc39a5 |
C |
T |
10: 128,234,324 (GRCm39) |
R193H |
probably damaging |
Het |
| Smad9 |
A |
G |
3: 54,689,888 (GRCm39) |
K36R |
probably damaging |
Het |
| Spam1 |
T |
A |
6: 24,796,123 (GRCm39) |
L25I |
possibly damaging |
Het |
| Stab2 |
A |
T |
10: 86,686,766 (GRCm39) |
S809R |
possibly damaging |
Het |
| Szt2 |
G |
A |
4: 118,231,252 (GRCm39) |
R35C |
probably damaging |
Het |
| Tcaf2 |
C |
A |
6: 42,606,058 (GRCm39) |
|
probably benign |
Het |
| Tfap2d |
A |
C |
1: 19,174,979 (GRCm39) |
D144A |
probably benign |
Het |
| Tmprss11d |
A |
T |
5: 86,479,052 (GRCm39) |
V117D |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,903,913 (GRCm39) |
D1141G |
probably benign |
Het |
| Traf6 |
A |
T |
2: 101,527,512 (GRCm39) |
T421S |
possibly damaging |
Het |
| Utp25 |
G |
A |
1: 192,789,904 (GRCm39) |
Q752* |
probably null |
Het |
| Vmn1r73 |
C |
A |
7: 11,490,865 (GRCm39) |
P228T |
probably damaging |
Het |
| Vmn2r4 |
A |
G |
3: 64,296,433 (GRCm39) |
I784T |
probably benign |
Het |
| Zfp420 |
A |
G |
7: 29,573,795 (GRCm39) |
D5G |
probably benign |
Het |
|
| Other mutations in Txndc16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00235:Txndc16
|
APN |
14 |
45,399,807 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00427:Txndc16
|
APN |
14 |
45,382,547 (GRCm39) |
splice site |
probably benign |
|
|
IGL02554:Txndc16
|
APN |
14 |
45,409,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02707:Txndc16
|
APN |
14 |
45,399,730 (GRCm39) |
missense |
probably benign |
|
|
IGL03198:Txndc16
|
APN |
14 |
45,388,941 (GRCm39) |
splice site |
probably benign |
|
|
IGL03256:Txndc16
|
APN |
14 |
45,389,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0647:Txndc16
|
UTSW |
14 |
45,402,818 (GRCm39) |
nonsense |
probably null |
|
|
R0647:Txndc16
|
UTSW |
14 |
45,406,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0838:Txndc16
|
UTSW |
14 |
45,402,876 (GRCm39) |
splice site |
probably benign |
|
|
R1035:Txndc16
|
UTSW |
14 |
45,410,020 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1116:Txndc16
|
UTSW |
14 |
45,400,442 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1511:Txndc16
|
UTSW |
14 |
45,389,344 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2114:Txndc16
|
UTSW |
14 |
45,382,484 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2139:Txndc16
|
UTSW |
14 |
45,410,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3784:Txndc16
|
UTSW |
14 |
45,403,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Txndc16
|
UTSW |
14 |
45,388,809 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5215:Txndc16
|
UTSW |
14 |
45,448,597 (GRCm39) |
intron |
probably benign |
|
|
R5620:Txndc16
|
UTSW |
14 |
45,373,335 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5726:Txndc16
|
UTSW |
14 |
45,403,221 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6297:Txndc16
|
UTSW |
14 |
45,389,243 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6603:Txndc16
|
UTSW |
14 |
45,389,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6626:Txndc16
|
UTSW |
14 |
45,398,792 (GRCm39) |
splice site |
probably null |
|
|
R6876:Txndc16
|
UTSW |
14 |
45,400,497 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7102:Txndc16
|
UTSW |
14 |
45,442,839 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7166:Txndc16
|
UTSW |
14 |
45,420,611 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7465:Txndc16
|
UTSW |
14 |
45,402,845 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Txndc16
|
UTSW |
14 |
45,373,324 (GRCm39) |
nonsense |
probably null |
|
|
R7684:Txndc16
|
UTSW |
14 |
45,385,325 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7783:Txndc16
|
UTSW |
14 |
45,382,417 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8316:Txndc16
|
UTSW |
14 |
45,448,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8838:Txndc16
|
UTSW |
14 |
45,378,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Txndc16
|
UTSW |
14 |
45,406,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9169:Txndc16
|
UTSW |
14 |
45,373,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9327:Txndc16
|
UTSW |
14 |
45,379,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9489:Txndc16
|
UTSW |
14 |
45,442,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9500:Txndc16
|
UTSW |
14 |
45,406,798 (GRCm39) |
missense |
probably null |
0.00 |
|
R9605:Txndc16
|
UTSW |
14 |
45,442,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9632:Txndc16
|
UTSW |
14 |
45,400,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9710:Txndc16
|
UTSW |
14 |
45,400,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF013:Txndc16
|
UTSW |
14 |
45,406,795 (GRCm39) |
missense |
probably benign |
0.11 |
|
| Posted On |
2015-04-16 |
Incidental Mutation