Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02690:Eif3f'

303694

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif3f

Ensembl Gene

ENSMUSG00000031029

Gene Name

eukaryotic translation initiation factor 3, subunit F

Synonyms

Eif3s5, 0610037M02Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.965) question?

Stock #

IGL02690

Quality Score

Status

Chromosome

Chromosomal Location

108533622-108541149 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108533925 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 96 (V96A)

Ref Sequence

ENSEMBL: ENSMUSP00000033342 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033342] [ENSMUST00000055745]

AlphaFold

Q9DCH4

Predicted Effect

probably damaging
Transcript: ENSMUST00000033342
AA Change: V96A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000033342
Gene: ENSMUSG00000031029
AA Change: V96A

Domain	Start	End	E-Value	Type
low complexity region	2	93	N/A	INTRINSIC
JAB_MPN	95	225	3.11e-42	SMART
Pfam:MitMem_reg	247	359	7e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000055745

SMART Domains

Protein: ENSMUSP00000050252
Gene: ENSMUSG00000049709

Domain	Start	End	E-Value	Type
PYRIN	9	88	4.13e-18	SMART
low complexity region	126	137	N/A	INTRINSIC
AAA	161	302	1.07e-2	SMART
low complexity region	576	597	N/A	INTRINSIC
low complexity region	646	659	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153596

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre1	T	C	17: 57,787,921 (GRCm39)	V896A	probably damaging	Het
Ahnak	C	A	19: 8,989,948 (GRCm39)	S3744*	probably null	Het
Aldh7a1	A	G	18: 56,661,427 (GRCm39)		probably benign	Het
Ankk1	T	A	9: 49,333,200 (GRCm39)	I95F	probably damaging	Het
Borcs8	C	A	8: 70,617,738 (GRCm39)	A32D	probably damaging	Het
Ccn3	A	G	15: 54,611,198 (GRCm39)	Y111C	probably damaging	Het
Cdh1	T	A	8: 107,384,516 (GRCm39)	I328N	probably damaging	Het
Cebpz	C	T	17: 79,229,986 (GRCm39)	D856N	probably damaging	Het
Clip2	T	A	5: 134,539,013 (GRCm39)		probably benign	Het
Dock7	C	A	4: 98,857,872 (GRCm39)	V1451F	possibly damaging	Het
Edem3	T	G	1: 151,680,550 (GRCm39)	C558W	probably damaging	Het
Gen1	A	G	12: 11,291,576 (GRCm39)	S738P	probably damaging	Het
Ipo8	A	T	6: 148,678,861 (GRCm39)	S912R	probably benign	Het
Kcp	G	T	6: 29,484,998 (GRCm39)		probably benign	Het
Larp7-ps	T	A	4: 92,079,248 (GRCm39)	D191V	probably damaging	Het
Lrrfip1	A	G	1: 90,981,383 (GRCm39)	T2A	probably damaging	Het
Lyst	A	G	13: 13,815,710 (GRCm39)	E1198G	possibly damaging	Het
Maml1	A	G	11: 50,149,457 (GRCm39)	L761P	probably damaging	Het
Mon2	T	A	10: 122,845,532 (GRCm39)	E1392V	possibly damaging	Het
Nol12	A	G	15: 78,821,374 (GRCm39)	E78G	probably damaging	Het
Or13c7b	G	A	4: 43,821,190 (GRCm39)	T57M	possibly damaging	Het
Or5k17	G	A	16: 58,746,214 (GRCm39)	T240I	possibly damaging	Het
Rag2	A	T	2: 101,459,839 (GRCm39)	I50L	probably benign	Het
Rasgrf2	T	C	13: 92,167,273 (GRCm39)	N267D	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Rsc1a1	A	T	4: 141,412,612 (GRCm39)	V100D	probably damaging	Het
Rtp1	T	C	16: 23,250,132 (GRCm39)	Y166H	probably damaging	Het
Scly	A	T	1: 91,233,047 (GRCm39)	T109S	probably benign	Het
Scn8a	A	T	15: 100,868,135 (GRCm39)	S327C	probably damaging	Het
Sgsm1	T	C	5: 113,434,633 (GRCm39)		probably benign	Het
Slc4a9	A	G	18: 36,665,040 (GRCm39)	Y463C	probably damaging	Het
Speer1j	C	T	5: 11,555,228 (GRCm39)	Q66*	probably null	Het
Sptan1	A	G	2: 29,888,195 (GRCm39)	M936V	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tbx20	T	A	9: 24,685,033 (GRCm39)	N37Y	probably benign	Het
Tent4a	T	A	13: 69,658,744 (GRCm39)	M364L	probably benign	Het
Tex14	C	T	11: 87,377,100 (GRCm39)	T148I	probably benign	Het
Ubxn7	A	G	16: 32,200,423 (GRCm39)	E371G	probably benign	Het
Ugt2b35	T	C	5: 87,149,096 (GRCm39)	F116L	probably benign	Het
Vmn2r111	C	T	17: 22,778,023 (GRCm39)		probably null	Het
Vmn2r26	T	C	6: 124,003,091 (GRCm39)	L167P	probably benign	Het
Vps13b	T	C	15: 35,917,288 (GRCm39)	W3711R	probably damaging	Het
Wdr5	A	T	2: 27,424,840 (GRCm39)	T326S	probably benign	Het

Other mutations in Eif3f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02821:Eif3f	APN	7	108,533,882 (GRCm39)	unclassified	probably benign
IGL02821:Eif3f	APN	7	108,533,881 (GRCm39)	unclassified	probably benign
R0010:Eif3f	UTSW	7	108,540,212 (GRCm39)	missense	possibly damaging	0.93
R1054:Eif3f	UTSW	7	108,537,024 (GRCm39)	critical splice donor site	probably null
R1886:Eif3f	UTSW	7	108,539,958 (GRCm39)	missense	probably benign	0.08
R2877:Eif3f	UTSW	7	108,534,019 (GRCm39)	splice site	probably null
R3700:Eif3f	UTSW	7	108,539,482 (GRCm39)	missense	probably benign	0.23
R3882:Eif3f	UTSW	7	108,540,162 (GRCm39)	missense	possibly damaging	0.88
R4471:Eif3f	UTSW	7	108,540,153 (GRCm39)	missense	possibly damaging	0.79
R4472:Eif3f	UTSW	7	108,540,153 (GRCm39)	missense	possibly damaging	0.79
R4817:Eif3f	UTSW	7	108,536,982 (GRCm39)	missense	probably damaging	0.99
R4953:Eif3f	UTSW	7	108,533,847 (GRCm39)	unclassified	probably benign
R5744:Eif3f	UTSW	7	108,537,624 (GRCm39)	missense	probably damaging	0.99
R7162:Eif3f	UTSW	7	108,539,938 (GRCm39)	missense	probably benign	0.02
R7235:Eif3f	UTSW	7	108,537,295 (GRCm39)	missense	possibly damaging	0.78
R7445:Eif3f	UTSW	7	108,533,865 (GRCm39)	missense	unknown
R9077:Eif3f	UTSW	7	108,539,425 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16