Incidental Mutation 'IGL02699:Osm'
ID 304076
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Osm
Ensembl Gene ENSMUSG00000058755
Gene Name oncostatin M
Synonyms OncoM
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02699
Quality Score
Chromosome 11
Chromosomal Location 4186831-4191027 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 4189723 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 169 (V169A)
Ref Sequence ENSEMBL: ENSMUSP00000074708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075221]
AlphaFold P53347
Predicted Effect possibly damaging
Transcript: ENSMUST00000075221
AA Change: V169A

PolyPhen 2 Score 0.454 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000074708
Gene: ENSMUSG00000058755
AA Change: V169A

signal peptide 1 24 N/A INTRINSIC
LIF_OSM 28 183 7.44e-92 SMART
low complexity region 203 214 N/A INTRINSIC
low complexity region 217 245 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131764
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
PHENOTYPE: Homozygous mutant mice display decreased noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adarb1 T C 10: 77,157,853 (GRCm39) D198G probably benign Het
Casq1 T C 1: 172,047,263 (GRCm39) probably benign Het
Cd109 T A 9: 78,579,271 (GRCm39) probably benign Het
Col15a1 T G 4: 47,284,471 (GRCm39) probably benign Het
Ctdp1 T C 18: 80,493,400 (GRCm39) D365G probably benign Het
Daam1 T C 12: 72,035,717 (GRCm39) F971L probably damaging Het
Dalrd3 T A 9: 108,448,088 (GRCm39) probably benign Het
Dnaaf5 T C 5: 139,139,105 (GRCm39) probably benign Het
Efr3b C T 12: 4,033,391 (GRCm39) V139I probably benign Het
Fbxo8 A G 8: 57,043,223 (GRCm39) T236A possibly damaging Het
Ighv1-12 C A 12: 114,579,736 (GRCm39) E29* probably null Het
Il17re A G 6: 113,445,880 (GRCm39) D397G probably damaging Het
Ing5 A G 1: 93,744,164 (GRCm39) N157D possibly damaging Het
Ipo11 T C 13: 107,025,905 (GRCm39) E395G possibly damaging Het
Letm1 T C 5: 33,902,492 (GRCm39) E599G possibly damaging Het
Mansc1 T C 6: 134,587,317 (GRCm39) T287A probably benign Het
Med1 T C 11: 98,070,851 (GRCm39) N131D possibly damaging Het
Or10ak13 G T 4: 118,639,349 (GRCm39) C144* probably null Het
Or13p3 T C 4: 118,567,395 (GRCm39) S264P probably benign Het
Or6c2b T G 10: 128,947,640 (GRCm39) Y218S probably benign Het
Or8k38 A T 2: 86,488,691 (GRCm39) I37N probably benign Het
Phkg2 C T 7: 127,181,722 (GRCm39) A278V probably benign Het
Plod2 T A 9: 92,489,195 (GRCm39) M709K probably damaging Het
Pzp A T 6: 128,464,364 (GRCm39) probably null Het
Ric1 T C 19: 29,499,957 (GRCm39) L12P possibly damaging Het
Skor1 C A 9: 63,047,328 (GRCm39) probably benign Het
Slc39a10 G A 1: 46,857,288 (GRCm39) A696V probably damaging Het
Syncrip A G 9: 88,338,607 (GRCm39) probably benign Het
Tex2 T C 11: 106,459,259 (GRCm39) E57G possibly damaging Het
Tmc1 C T 19: 20,809,714 (GRCm39) probably null Het
Tmem59 T C 4: 107,049,735 (GRCm39) M140T probably benign Het
Ttn T C 2: 76,774,433 (GRCm39) T2158A probably damaging Het
Other mutations in Osm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02007:Osm APN 11 4,189,470 (GRCm39) missense probably damaging 0.99
IGL02477:Osm APN 11 4,189,604 (GRCm39) missense probably damaging 0.99
IGL02478:Osm APN 11 4,189,507 (GRCm39) missense probably damaging 0.96
IGL03328:Osm APN 11 4,188,426 (GRCm39) missense unknown
R0212:Osm UTSW 11 4,188,465 (GRCm39) missense probably benign 0.12
R0667:Osm UTSW 11 4,189,918 (GRCm39) missense possibly damaging 0.53
R2237:Osm UTSW 11 4,188,505 (GRCm39) missense possibly damaging 0.95
R4790:Osm UTSW 11 4,188,435 (GRCm39) missense probably benign 0.01
R6621:Osm UTSW 11 4,189,541 (GRCm39) missense probably benign 0.03
R7148:Osm UTSW 11 4,189,936 (GRCm39) missense probably benign 0.02
R8669:Osm UTSW 11 4,189,665 (GRCm39) missense probably benign 0.04
R8805:Osm UTSW 11 4,189,839 (GRCm39) missense probably benign 0.18
R9205:Osm UTSW 11 4,188,504 (GRCm39) missense possibly damaging 0.95
R9673:Osm UTSW 11 4,189,926 (GRCm39) missense probably benign 0.00
T0975:Osm UTSW 11 4,189,588 (GRCm39) missense probably benign 0.02
Posted On 2015-04-16