Incidental Mutation 'R0376:Tcp11l1'
ID 30730
Institutional Source Beutler Lab
Gene Symbol Tcp11l1
Ensembl Gene ENSMUSG00000027175
Gene Name t-complex 11 like 1
Synonyms C130096D04Rik
MMRRC Submission 038582-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0376 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 104497587-104542525 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 104527850 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000106747 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028597] [ENSMUST00000111118]
AlphaFold Q8BTG3
Predicted Effect probably benign
Transcript: ENSMUST00000028597
SMART Domains Protein: ENSMUSP00000028597
Gene: ENSMUSG00000027175

DomainStartEndE-ValueType
low complexity region 12 30 N/A INTRINSIC
Pfam:Tcp11 78 502 3.9e-105 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111118
SMART Domains Protein: ENSMUSP00000106747
Gene: ENSMUSG00000027175

DomainStartEndE-ValueType
low complexity region 12 30 N/A INTRINSIC
Pfam:Tcp11 77 505 5.2e-134 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126310
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129792
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137428
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.0%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6a T C 12: 113,508,310 (GRCm39) Y228H probably damaging Het
Als2 A G 1: 59,254,724 (GRCm39) F211S probably benign Het
Ankrd12 T A 17: 66,360,004 (GRCm39) Q11L probably damaging Het
Anxa5 T C 3: 36,514,637 (GRCm39) R115G probably damaging Het
Arhgap10 T C 8: 78,177,453 (GRCm39) probably benign Het
Atp2a3 T A 11: 72,873,528 (GRCm39) D782E probably damaging Het
Bcr G T 10: 74,981,159 (GRCm39) L659F probably damaging Het
Cacna1b A G 2: 24,549,015 (GRCm39) probably benign Het
Camp C T 9: 109,677,467 (GRCm39) C122Y probably damaging Het
Cimip1 G A 2: 173,370,120 (GRCm39) E132K probably benign Het
Col12a1 A T 9: 79,600,776 (GRCm39) S769R probably benign Het
Cyp2j6 T A 4: 96,414,260 (GRCm39) K335I probably damaging Het
Cyp3a11 A C 5: 145,799,262 (GRCm39) Y308* probably null Het
Flnb G A 14: 7,946,014 (GRCm38) probably null Het
Frmd4a G T 2: 4,577,198 (GRCm39) M351I probably damaging Het
Gabrg2 C T 11: 41,807,142 (GRCm39) S365N possibly damaging Het
Ggn T C 7: 28,872,447 (GRCm39) V609A possibly damaging Het
H60c T C 10: 3,210,435 (GRCm39) probably benign Het
Hexd T A 11: 121,108,991 (GRCm39) probably benign Het
Igsf9b A G 9: 27,245,878 (GRCm39) T1282A probably benign Het
Ikzf4 T C 10: 128,468,625 (GRCm39) N618S probably benign Het
Ints14 A G 9: 64,891,272 (GRCm39) K418E probably damaging Het
Iqgap1 T C 7: 80,373,627 (GRCm39) E1454G probably benign Het
Kif13b T C 14: 64,994,853 (GRCm39) probably benign Het
Krt71 A C 15: 101,646,505 (GRCm39) F328C probably damaging Het
Lama2 T C 10: 26,891,542 (GRCm39) T2524A possibly damaging Het
Mfn2 C T 4: 147,969,983 (GRCm39) V363I probably benign Het
Mkln1 A T 6: 31,454,953 (GRCm39) D496V probably benign Het
Or2q1 A T 6: 42,795,226 (GRCm39) M274L probably benign Het
Patj T A 4: 98,457,224 (GRCm39) I1242N probably damaging Het
Pcnx1 C T 12: 82,021,353 (GRCm39) probably benign Het
Plcb2 T C 2: 118,547,721 (GRCm39) E502G probably damaging Het
Plppr4 G T 3: 117,116,740 (GRCm39) H314Q probably benign Het
Prkcsh A G 9: 21,921,547 (GRCm39) probably benign Het
Prr14 C T 7: 127,075,815 (GRCm39) H181Y probably benign Het
Pus3 A T 9: 35,477,718 (GRCm39) M317L possibly damaging Het
Pwwp2a T A 11: 43,595,499 (GRCm39) D221E probably benign Het
Rbm15 T C 3: 107,238,254 (GRCm39) S715G probably benign Het
Rbm28 A G 6: 29,158,927 (GRCm39) probably benign Het
Rhobtb2 A T 14: 70,034,184 (GRCm39) V347E probably benign Het
Rimbp2 C T 5: 128,880,925 (GRCm39) R161Q probably damaging Het
Scgb1b27 C T 7: 33,721,322 (GRCm39) T70I possibly damaging Het
Slc40a1 T C 1: 45,951,651 (GRCm39) probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spaca9 A G 2: 28,583,672 (GRCm39) V104A probably benign Het
Spag7 T C 11: 70,560,016 (GRCm39) probably benign Het
Sugp1 A G 8: 70,505,288 (GRCm39) D85G probably damaging Het
Sun1 A G 5: 139,212,454 (GRCm39) probably benign Het
Tead3 A C 17: 28,560,339 (GRCm39) D88E probably damaging Het
Tecpr1 A T 5: 144,144,294 (GRCm39) V636E possibly damaging Het
Tldc2 T C 2: 156,937,225 (GRCm39) W147R probably damaging Het
Tmem161b A G 13: 84,440,502 (GRCm39) T125A probably benign Het
Trrap A G 5: 144,753,149 (GRCm39) M1825V probably benign Het
Ttbk2 A G 2: 120,608,062 (GRCm39) F186L probably damaging Het
U2surp C T 9: 95,366,496 (GRCm39) V470I probably benign Het
Zc3h7a T C 16: 10,974,066 (GRCm39) M240V probably benign Het
Zc3hc1 G C 6: 30,372,789 (GRCm39) S351W probably damaging Het
Zfp366 T C 13: 99,370,759 (GRCm39) M493T probably benign Het
Zfp93 C T 7: 23,975,286 (GRCm39) P424S probably damaging Het
Other mutations in Tcp11l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Tcp11l1 APN 2 104,536,831 (GRCm39) missense probably benign
IGL01999:Tcp11l1 APN 2 104,528,914 (GRCm39) missense possibly damaging 0.61
IGL02792:Tcp11l1 APN 2 104,512,165 (GRCm39) missense probably benign 0.19
R0683:Tcp11l1 UTSW 2 104,512,237 (GRCm39) missense possibly damaging 0.90
R0828:Tcp11l1 UTSW 2 104,530,181 (GRCm39) splice site probably benign
R2091:Tcp11l1 UTSW 2 104,514,484 (GRCm39) missense possibly damaging 0.77
R2095:Tcp11l1 UTSW 2 104,512,185 (GRCm39) missense probably damaging 1.00
R3750:Tcp11l1 UTSW 2 104,528,887 (GRCm39) missense probably damaging 1.00
R4456:Tcp11l1 UTSW 2 104,514,567 (GRCm39) missense probably damaging 1.00
R4926:Tcp11l1 UTSW 2 104,512,130 (GRCm39) missense probably benign 0.01
R5184:Tcp11l1 UTSW 2 104,530,289 (GRCm39) missense probably damaging 1.00
R5461:Tcp11l1 UTSW 2 104,518,856 (GRCm39) missense probably benign 0.00
R6979:Tcp11l1 UTSW 2 104,536,784 (GRCm39) missense probably benign
R7387:Tcp11l1 UTSW 2 104,530,275 (GRCm39) missense possibly damaging 0.92
R7443:Tcp11l1 UTSW 2 104,514,480 (GRCm39) missense probably benign 0.01
R7872:Tcp11l1 UTSW 2 104,536,837 (GRCm39) missense probably benign 0.25
R7940:Tcp11l1 UTSW 2 104,528,993 (GRCm39) missense probably damaging 1.00
R8399:Tcp11l1 UTSW 2 104,515,720 (GRCm39) missense probably benign 0.09
R8431:Tcp11l1 UTSW 2 104,530,314 (GRCm39) missense probably damaging 0.96
R8445:Tcp11l1 UTSW 2 104,512,278 (GRCm39) missense probably benign 0.02
R8810:Tcp11l1 UTSW 2 104,518,763 (GRCm39) missense probably benign 0.00
R8988:Tcp11l1 UTSW 2 104,536,853 (GRCm39) missense probably damaging 1.00
R9057:Tcp11l1 UTSW 2 104,528,026 (GRCm39) missense probably damaging 1.00
R9109:Tcp11l1 UTSW 2 104,528,897 (GRCm39) missense possibly damaging 0.67
R9298:Tcp11l1 UTSW 2 104,528,897 (GRCm39) missense possibly damaging 0.67
V8831:Tcp11l1 UTSW 2 104,515,829 (GRCm39) missense probably benign
Predicted Primers
Posted On 2013-04-24