Incidental Mutation 'IGL03119:Naa25'
ID 409900
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Naa25
Ensembl Gene ENSMUSG00000042719
Gene Name N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms C330023M02Rik, 4833422K13Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03119
Quality Score
Status
Chromosome 5
Chromosomal Location 121535977-121580612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 121573041 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 720 (V720E)
Ref Sequence ENSEMBL: ENSMUSP00000038977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042163] [ENSMUST00000151458] [ENSMUST00000153758] [ENSMUST00000173895]
AlphaFold Q8BWZ3
Predicted Effect probably null
Transcript: ENSMUST00000042163
AA Change: V720E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038977
Gene: ENSMUSG00000042719
AA Change: V720E

DomainStartEndE-ValueType
low complexity region 35 45 N/A INTRINSIC
Pfam:NatB_MDM20 263 658 1.6e-121 PFAM
low complexity region 672 683 N/A INTRINSIC
low complexity region 687 700 N/A INTRINSIC
low complexity region 721 734 N/A INTRINSIC
low complexity region 915 935 N/A INTRINSIC
low complexity region 958 971 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151458
SMART Domains Protein: ENSMUSP00000120970
Gene: ENSMUSG00000042719

DomainStartEndE-ValueType
SCOP:d1a17__ 21 94 1e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000153758
SMART Domains Protein: ENSMUSP00000122522
Gene: ENSMUSG00000029616

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
SCOP:d1g7ea_ 35 55 3e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172908
SMART Domains Protein: ENSMUSP00000134345
Gene: ENSMUSG00000042719

DomainStartEndE-ValueType
low complexity region 5 25 N/A INTRINSIC
low complexity region 48 61 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000173895
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,764,887 (GRCm39) T626A probably benign Het
Adcy1 C T 11: 7,059,051 (GRCm39) T319I probably damaging Het
Adgrv1 A G 13: 81,530,492 (GRCm39) S5861P probably damaging Het
Adgrv1 A C 13: 81,581,819 (GRCm39) C4742G probably benign Het
Arid5b A T 10: 68,079,057 (GRCm39) D93E probably damaging Het
Atp6v1h A G 1: 5,165,892 (GRCm39) T121A probably benign Het
Atxn7 C T 14: 14,100,734 (GRCm38) L807F probably damaging Het
Cep104 A C 4: 154,066,181 (GRCm39) K126N probably damaging Het
Dcaf6 T C 1: 165,167,545 (GRCm39) E708G probably damaging Het
Dst A G 1: 34,200,143 (GRCm39) Y107C probably damaging Het
E2f3 A G 13: 30,169,348 (GRCm39) S102P probably benign Het
Eif3e A C 15: 43,129,000 (GRCm39) S207A probably benign Het
Etl4 A G 2: 20,718,198 (GRCm39) Y313C probably damaging Het
Fyttd1 T C 16: 32,721,065 (GRCm39) V121A probably benign Het
Gstk1 T C 6: 42,226,833 (GRCm39) S200P probably damaging Het
Ifrd1 A T 12: 40,262,333 (GRCm39) F244L probably null Het
Ints7 T C 1: 191,342,477 (GRCm39) V491A probably damaging Het
Kcnd2 G T 6: 21,216,508 (GRCm39) E71* probably null Het
Ltbp3 A T 19: 5,807,471 (GRCm39) Q1123L probably damaging Het
Myo5a A G 9: 75,081,297 (GRCm39) T961A probably benign Het
Or52ab4 A G 7: 102,987,929 (GRCm39) I223V probably damaging Het
Or5b121 T C 19: 13,507,799 (GRCm39) I298T probably benign Het
Pcdhb15 C A 18: 37,608,067 (GRCm39) T433N probably damaging Het
Peli1 T C 11: 21,090,560 (GRCm39) probably benign Het
Ptbp1 T C 10: 79,695,458 (GRCm39) V209A probably damaging Het
Ranbp2 A G 10: 58,287,825 (GRCm39) Y31C probably damaging Het
Smg1 G A 7: 117,794,336 (GRCm39) probably benign Het
Stat2 A G 10: 128,119,386 (GRCm39) M457V probably benign Het
Trpm6 G T 19: 18,815,381 (GRCm39) E1156* probably null Het
Usp53 T A 3: 122,755,064 (GRCm39) R130S possibly damaging Het
Vwa5b1 A G 4: 138,333,852 (GRCm39) S193P probably benign Het
Xrn2 A G 2: 146,884,792 (GRCm39) I626V probably damaging Het
Zfp574 G A 7: 24,779,898 (GRCm39) A307T probably benign Het
Other mutations in Naa25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02025:Naa25 APN 5 121,577,928 (GRCm39) missense probably damaging 1.00
IGL02142:Naa25 APN 5 121,564,825 (GRCm39) missense possibly damaging 0.52
IGL02541:Naa25 APN 5 121,562,594 (GRCm39) missense possibly damaging 0.92
IGL02747:Naa25 APN 5 121,552,668 (GRCm39) splice site probably benign
IGL03074:Naa25 APN 5 121,546,400 (GRCm39) critical splice donor site probably null
IGL03218:Naa25 APN 5 121,564,133 (GRCm39) missense probably damaging 1.00
R0003:Naa25 UTSW 5 121,545,247 (GRCm39) intron probably benign
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0399:Naa25 UTSW 5 121,573,553 (GRCm39) missense probably benign 0.00
R0973:Naa25 UTSW 5 121,576,779 (GRCm39) splice site probably benign
R1418:Naa25 UTSW 5 121,561,797 (GRCm39) missense probably damaging 1.00
R1582:Naa25 UTSW 5 121,572,892 (GRCm39) missense probably benign
R1793:Naa25 UTSW 5 121,558,656 (GRCm39) missense probably damaging 1.00
R1793:Naa25 UTSW 5 121,555,478 (GRCm39) missense possibly damaging 0.82
R1863:Naa25 UTSW 5 121,573,611 (GRCm39) missense probably benign 0.00
R3160:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3162:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3721:Naa25 UTSW 5 121,569,619 (GRCm39) missense probably benign
R3864:Naa25 UTSW 5 121,547,260 (GRCm39) missense probably damaging 0.96
R4852:Naa25 UTSW 5 121,568,755 (GRCm39) missense probably damaging 1.00
R5077:Naa25 UTSW 5 121,562,639 (GRCm39) missense probably benign 0.02
R5602:Naa25 UTSW 5 121,558,558 (GRCm39) missense probably benign 0.30
R5855:Naa25 UTSW 5 121,561,755 (GRCm39) missense possibly damaging 0.94
R6464:Naa25 UTSW 5 121,556,024 (GRCm39) missense probably damaging 1.00
R6734:Naa25 UTSW 5 121,576,888 (GRCm39) missense possibly damaging 0.65
R6750:Naa25 UTSW 5 121,546,372 (GRCm39) missense probably damaging 1.00
R6767:Naa25 UTSW 5 121,577,928 (GRCm39) missense probably damaging 1.00
R6856:Naa25 UTSW 5 121,576,867 (GRCm39) missense probably damaging 1.00
R7145:Naa25 UTSW 5 121,555,552 (GRCm39) critical splice donor site probably null
R7631:Naa25 UTSW 5 121,576,791 (GRCm39) missense possibly damaging 0.92
R7701:Naa25 UTSW 5 121,564,042 (GRCm39) missense probably benign
R7800:Naa25 UTSW 5 121,562,594 (GRCm39) missense possibly damaging 0.92
R7804:Naa25 UTSW 5 121,562,652 (GRCm39) missense probably benign 0.00
R7822:Naa25 UTSW 5 121,545,276 (GRCm39) missense probably damaging 1.00
R8707:Naa25 UTSW 5 121,552,875 (GRCm39) missense probably damaging 1.00
R8944:Naa25 UTSW 5 121,552,573 (GRCm39) missense probably benign 0.34
R9486:Naa25 UTSW 5 121,577,958 (GRCm39) missense probably damaging 1.00
X0004:Naa25 UTSW 5 121,551,144 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02