Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03131:Ifi209'

410309

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi209

Ensembl Gene

ENSMUSG00000043263

Gene Name

interferon activated gene 209

Synonyms

Ifix, Pyhin-1, Pyhin1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.126) question?

Stock #

IGL03131

Quality Score

Status

Chromosome

Chromosomal Location

173458483-173475494 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 173468800 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 210 (T210I)

Ref Sequence

ENSEMBL: ENSMUSP00000142161 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056071] [ENSMUST00000193727]

AlphaFold

Q8BV49

Predicted Effect

probably benign
Transcript: ENSMUST00000056071
AA Change: T210I

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000061900
Gene: ENSMUSG00000043263
AA Change: T210I

Domain	Start	End	E-Value	Type
PYRIN	6	83	3.54e-17	SMART
low complexity region	152	169	N/A	INTRINSIC
Pfam:HIN	231	396	4.2e-75	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000193727
AA Change: T210I

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000142161
Gene: ENSMUSG00000043263
AA Change: T210I

Domain	Start	End	E-Value	Type
PYRIN	6	83	1.7e-21	SMART
low complexity region	152	169	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200598

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	A	C	3: 121,473,251 (GRCm39)	R135S	unknown	Het
A1bg	T	C	15: 60,791,605 (GRCm39)	Y277C	probably damaging	Het
Abca12	A	T	1: 71,385,861 (GRCm39)	F252L	probably benign	Het
Abcd3	A	T	3: 121,575,640 (GRCm39)		probably benign	Het
Acvr2b	C	A	9: 119,260,350 (GRCm39)	F364L	possibly damaging	Het
Adamts12	T	C	15: 11,345,650 (GRCm39)	C1564R	probably damaging	Het
Agap3	A	G	5: 24,682,130 (GRCm39)	T392A	probably benign	Het
Ano1	A	G	7: 144,157,322 (GRCm39)	F767L	possibly damaging	Het
Atg10	C	A	13: 91,085,412 (GRCm39)	R179I	probably null	Het
Bsph1	A	T	7: 13,207,012 (GRCm39)	K129N	probably damaging	Het
Calml4	A	G	9: 62,782,765 (GRCm39)	D77G	probably benign	Het
Cc2d1a	T	A	8: 84,870,056 (GRCm39)	K153M	probably damaging	Het
Col4a2	G	A	8: 11,475,979 (GRCm39)	V672I	probably benign	Het
Crnkl1	T	C	2: 145,774,178 (GRCm39)	K95R	probably benign	Het
Crtap	T	C	9: 114,209,072 (GRCm39)	D324G	possibly damaging	Het
Csmd1	C	T	8: 16,138,231 (GRCm39)	G1607E	probably damaging	Het
Dcbld2	T	G	16: 58,272,051 (GRCm39)	I369R	probably benign	Het
Dmc1	T	A	15: 79,452,892 (GRCm39)	I246L	probably benign	Het
Dock1	G	T	7: 134,475,912 (GRCm39)	V896L	possibly damaging	Het
Eftud2	G	A	11: 102,761,009 (GRCm39)	T112M	probably damaging	Het
F5	A	T	1: 163,989,388 (GRCm39)	I97F	possibly damaging	Het
Fasn	C	T	11: 120,701,550 (GRCm39)	V1939M	possibly damaging	Het
Gpatch2l	T	C	12: 86,328,285 (GRCm39)	V414A	probably benign	Het
Gpd2	T	C	2: 57,228,855 (GRCm39)		probably benign	Het
Gria4	T	G	9: 4,432,876 (GRCm39)	N769T	probably damaging	Het
Gtf3c2	A	T	5: 31,314,964 (GRCm39)	F885I	probably damaging	Het
Kmt2c	A	G	5: 25,520,359 (GRCm39)	V1917A	probably benign	Het
Mad1l1	G	A	5: 140,293,458 (GRCm39)	A120V	probably benign	Het
Mef2c	T	C	13: 83,810,494 (GRCm39)	I382T	probably damaging	Het
Ms4a14	A	T	19: 11,285,056 (GRCm39)	L171I	probably benign	Het
Myf6	T	A	10: 107,330,132 (GRCm39)	Q145L	probably damaging	Het
Myh3	G	A	11: 66,981,935 (GRCm39)		probably benign	Het
Nbas	A	G	12: 13,329,417 (GRCm39)	I121V	probably benign	Het
Ncoa2	A	T	1: 13,247,398 (GRCm39)	S342T	probably damaging	Het
Nlrp1b	C	T	11: 71,052,741 (GRCm39)	D896N	possibly damaging	Het
Prss41	A	G	17: 24,061,498 (GRCm39)	Y98H	probably benign	Het
Ptpn13	A	T	5: 103,665,425 (GRCm39)	T450S	probably benign	Het
Rab39	G	A	9: 53,597,861 (GRCm39)	R135C	probably damaging	Het
Radil	A	G	5: 142,481,097 (GRCm39)	V570A	probably damaging	Het
Sbno1	C	T	5: 124,526,668 (GRCm39)	R949Q	probably damaging	Het
Sec61a2	T	A	2: 5,887,689 (GRCm39)	K98*	probably null	Het
Serbp1	T	A	6: 67,258,807 (GRCm39)		probably null	Het
Serpinb3c	G	T	1: 107,199,457 (GRCm39)	Q355K	probably benign	Het
Slc34a3	T	G	2: 25,121,246 (GRCm39)	D307A	probably benign	Het
Smarcad1	T	A	6: 65,051,937 (GRCm39)	S357T	probably damaging	Het
Spag17	G	A	3: 99,918,075 (GRCm39)	D353N	possibly damaging	Het
Spdl1	T	A	11: 34,721,592 (GRCm39)	Q39L	possibly damaging	Het
Syne2	A	C	12: 76,104,264 (GRCm39)	Q5485P	probably damaging	Het
Synj1	C	A	16: 90,785,056 (GRCm39)	V227F	probably damaging	Het
Syt12	T	C	19: 4,506,882 (GRCm39)	T88A	probably benign	Het
Tasor	C	T	14: 27,183,136 (GRCm39)	Q532*	probably null	Het
Tlr12	A	G	4: 128,509,670 (GRCm39)	F860S	probably damaging	Het
Trdn	C	A	10: 33,274,410 (GRCm39)	S461*	probably null	Het
Trip4	G	A	9: 65,764,727 (GRCm39)	P413S	probably benign	Het
Wdr17	A	G	8: 55,149,302 (GRCm39)		probably null	Het
Wnt9a	T	C	11: 59,221,855 (GRCm39)	L251P	probably damaging	Het
Xrcc1	A	T	7: 24,272,719 (GRCm39)	K618*	probably null	Het
Zfp759	T	C	13: 67,286,728 (GRCm39)	L93P	probably damaging	Het

Other mutations in Ifi209

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00422:Ifi209	APN	1	173,466,529 (GRCm39)	missense	possibly damaging	0.88
IGL02598:Ifi209	APN	1	173,472,281 (GRCm39)	missense	probably damaging	0.99
IGL02712:Ifi209	APN	1	173,470,267 (GRCm39)	missense	possibly damaging	0.68
IGL03368:Ifi209	APN	1	173,470,057 (GRCm39)	missense	possibly damaging	0.91
R0880:Ifi209	UTSW	1	173,472,379 (GRCm39)	missense	probably damaging	1.00
R1317:Ifi209	UTSW	1	173,465,029 (GRCm39)	missense	possibly damaging	0.96
R1640:Ifi209	UTSW	1	173,464,931 (GRCm39)	missense	probably damaging	0.98
R1769:Ifi209	UTSW	1	173,468,728 (GRCm39)	missense	probably benign	0.11
R2349:Ifi209	UTSW	1	173,470,122 (GRCm39)	missense	probably damaging	1.00
R5096:Ifi209	UTSW	1	173,472,300 (GRCm39)	missense	probably benign	0.17
R5369:Ifi209	UTSW	1	173,464,873 (GRCm39)	start codon destroyed	probably null	1.00
R5484:Ifi209	UTSW	1	173,468,640 (GRCm39)	missense	probably benign	0.18
R5532:Ifi209	UTSW	1	173,466,542 (GRCm39)	missense	probably damaging	0.99
R5551:Ifi209	UTSW	1	173,468,763 (GRCm39)	missense	probably benign	0.01
R5554:Ifi209	UTSW	1	173,468,763 (GRCm39)	missense	probably benign	0.01
R5749:Ifi209	UTSW	1	173,464,893 (GRCm39)	missense	probably damaging	1.00
R5960:Ifi209	UTSW	1	173,466,382 (GRCm39)	splice site	probably null
R6401:Ifi209	UTSW	1	173,472,269 (GRCm39)	missense	probably damaging	0.99
R7042:Ifi209	UTSW	1	173,470,236 (GRCm39)	missense	probably benign	0.34
R7304:Ifi209	UTSW	1	173,470,156 (GRCm39)	missense	possibly damaging	0.88
R7521:Ifi209	UTSW	1	173,470,261 (GRCm39)	missense	probably damaging	0.97
R7742:Ifi209	UTSW	1	173,470,198 (GRCm39)	missense	probably damaging	1.00
R7763:Ifi209	UTSW	1	173,470,445 (GRCm39)	missense	probably damaging	1.00
R7975:Ifi209	UTSW	1	173,468,722 (GRCm39)	missense	probably benign	0.24
R8498:Ifi209	UTSW	1	173,470,069 (GRCm39)	missense	probably benign	0.05
R8873:Ifi209	UTSW	1	173,470,156 (GRCm39)	missense	probably damaging	1.00
R9178:Ifi209	UTSW	1	173,464,969 (GRCm39)	missense	probably damaging	1.00
R9673:Ifi209	UTSW	1	173,470,332 (GRCm39)	missense	probably damaging	1.00
R9752:Ifi209	UTSW	1	173,472,235 (GRCm39)	missense	probably damaging	0.99
Z1088:Ifi209	UTSW	1	173,468,712 (GRCm39)	missense	probably benign	0.00
Z1088:Ifi209	UTSW	1	173,464,973 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02