Incidental Mutation 'IGL03237:Zfp128'
ID414095
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp128
Ensembl Gene ENSMUSG00000060397
Gene Namezinc finger protein 128
SynonymsmZnf8, 9630016P15Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.103) question?
Stock #IGL03237
Quality Score
Status
Chromosome7
Chromosomal Location12881177-12893422 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 12891026 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 440 (E440D)
Ref Sequence ENSEMBL: ENSMUSP00000115378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000144578]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000081891
Predicted Effect probably benign
Transcript: ENSMUST00000144578
AA Change: E440D

PolyPhen 2 Score 0.278 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000115378
Gene: ENSMUSG00000060397
AA Change: E440D

DomainStartEndE-ValueType
KRAB 25 85 2.51e-38 SMART
ZnF_C2H2 254 276 8.47e-4 SMART
ZnF_C2H2 282 304 5.21e-4 SMART
ZnF_C2H2 310 332 4.17e-3 SMART
ZnF_C2H2 338 360 3.89e-3 SMART
ZnF_C2H2 366 388 1.47e-3 SMART
ZnF_C2H2 394 416 8.47e-4 SMART
ZnF_C2H2 464 486 3.39e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 A G 13: 91,781,269 Y405C probably benign Het
Adam19 A G 11: 46,137,556 K672R probably benign Het
Adamts7 C A 9: 90,188,664 P613T probably damaging Het
Adgrl1 G T 8: 83,929,683 probably null Het
Adrb1 A T 19: 56,723,368 N333Y probably damaging Het
AI314180 A T 4: 58,810,668 M1563K probably benign Het
Aqp7 C T 4: 41,034,884 V190M possibly damaging Het
Atg101 T C 15: 101,287,173 F59L probably damaging Het
Capn12 T C 7: 28,890,941 S638P probably damaging Het
Ccm2l T C 2: 153,066,002 probably benign Het
Cdc14a A T 3: 116,404,626 probably benign Het
Cdh7 A T 1: 110,138,307 K770N possibly damaging Het
Col23a1 A C 11: 51,567,919 E294D possibly damaging Het
Cped1 A T 6: 22,233,596 Y679F probably damaging Het
Ctu2 A G 8: 122,479,053 E180G probably benign Het
Cyp11b2 C T 15: 74,851,065 V495I probably benign Het
Efcab1 A G 16: 14,920,788 D161G probably damaging Het
Gabrg3 A T 7: 56,982,712 probably null Het
Hsd17b11 A G 5: 104,003,170 *233Q probably null Het
Klhl41 T C 2: 69,670,558 V121A possibly damaging Het
Kptn A T 7: 16,120,125 D56V probably damaging Het
L3mbtl4 T A 17: 68,777,861 I589N probably damaging Het
Lpl A T 8: 68,894,726 N177Y possibly damaging Het
Manba G A 3: 135,544,751 V380M probably damaging Het
Mecom A T 3: 29,956,499 probably benign Het
Mertk A G 2: 128,790,272 E707G probably damaging Het
Myo5a A T 9: 75,129,994 I160F probably damaging Het
Myo7a A T 7: 98,102,593 I81N probably damaging Het
Nelfcd G A 2: 174,426,832 A559T possibly damaging Het
Nipal1 C T 5: 72,666,807 R76C probably damaging Het
Noc3l C T 19: 38,814,681 probably null Het
Nt5e A G 9: 88,355,734 D239G probably damaging Het
Olr1 A C 6: 129,502,154 W34G probably damaging Het
Plekhf1 A T 7: 38,221,375 N256K probably benign Het
Psen2 T C 1: 180,240,849 T80A possibly damaging Het
Psg27 A G 7: 18,560,492 I330T probably benign Het
Ranbp2 T C 10: 58,492,961 V2894A probably damaging Het
Sgcz A T 8: 37,563,178 D170E probably benign Het
Snrnp200 C T 2: 127,233,313 A1573V probably damaging Het
Steap3 C T 1: 120,243,790 G195D probably damaging Het
Tmem165 T A 5: 76,199,509 Y5* probably null Het
Tnpo1 C T 13: 98,863,840 E340K probably damaging Het
Vmn2r67 A T 7: 85,149,910 C530S probably damaging Het
Wdfy3 T A 5: 101,844,599 D3389V probably damaging Het
Other mutations in Zfp128
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Zfp128 APN 7 12891022 missense probably benign 0.00
IGL01293:Zfp128 APN 7 12891424 makesense probably null
IGL02067:Zfp128 APN 7 12885050 missense possibly damaging 0.86
IGL02146:Zfp128 APN 7 12890032 missense possibly damaging 0.72
IGL02654:Zfp128 APN 7 12884679 missense possibly damaging 0.95
IGL03066:Zfp128 APN 7 12890117 missense probably benign 0.00
IGL03076:Zfp128 APN 7 12884709 missense possibly damaging 0.95
IGL03113:Zfp128 APN 7 12890387 missense probably benign 0.00
R1686_Zfp128_342 UTSW 7 12890636 nonsense probably null
R0783:Zfp128 UTSW 7 12890272 missense probably damaging 1.00
R1686:Zfp128 UTSW 7 12890636 nonsense probably null
R1806:Zfp128 UTSW 7 12891022 missense probably benign 0.00
R2021:Zfp128 UTSW 7 12890029 missense possibly damaging 0.96
R3792:Zfp128 UTSW 7 12884732 missense probably damaging 0.98
R4105:Zfp128 UTSW 7 12884740 missense probably damaging 0.99
R4167:Zfp128 UTSW 7 12890362 missense probably benign 0.28
R4168:Zfp128 UTSW 7 12890362 missense probably benign 0.28
R5743:Zfp128 UTSW 7 12884727 missense probably damaging 1.00
R6266:Zfp128 UTSW 7 12890970 missense possibly damaging 0.80
R6799:Zfp128 UTSW 7 12890899 missense possibly damaging 0.93
R7102:Zfp128 UTSW 7 12890472 missense probably damaging 1.00
R7313:Zfp128 UTSW 7 12890534 missense possibly damaging 0.94
R7428:Zfp128 UTSW 7 12890362 missense probably benign 0.28
R7504:Zfp128 UTSW 7 12890478 missense probably damaging 0.99
R7539:Zfp128 UTSW 7 12890552 nonsense probably null
R7636:Zfp128 UTSW 7 12890112 missense probably benign
R7755:Zfp128 UTSW 7 12890313 nonsense probably null
R7820:Zfp128 UTSW 7 12891022 missense probably benign 0.00
R8269:Zfp128 UTSW 7 12890736 missense probably damaging 1.00
Posted On2016-08-02