Incidental Mutation 'IGL03275:Tas2r110'
ID415383
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r110
Ensembl Gene ENSMUSG00000062952
Gene Nametaste receptor, type 2, member 110
SynonymsSTC 9-1, Tas2r10, T2R10, mt2r57
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL03275
Quality Score
Status
Chromosome6
Chromosomal Location132868008-132869009 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 132868098 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 31 (F31L)
Ref Sequence ENSEMBL: ENSMUSP00000080674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082014]
Predicted Effect probably damaging
Transcript: ENSMUST00000082014
AA Change: F31L

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000080674
Gene: ENSMUSG00000062952
AA Change: F31L

DomainStartEndE-ValueType
Pfam:TAS2R 6 322 3.1e-82 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T A 8: 72,445,124 L125H probably damaging Het
2210408I21Rik A T 13: 77,298,555 T816S possibly damaging Het
Aspm T A 1: 139,487,295 I1438N probably damaging Het
BC005561 T A 5: 104,518,277 C222S probably benign Het
Bicdl1 A G 5: 115,731,160 Y134H probably damaging Het
Btnl1 A T 17: 34,385,512 K422N probably damaging Het
Ccdc158 T A 5: 92,629,632 I941F probably benign Het
Crnn A G 3: 93,149,418 K504E possibly damaging Het
Csmd1 T A 8: 16,157,092 I1308L probably benign Het
Cwf19l1 T C 19: 44,123,257 M246V probably benign Het
Desi1 T A 15: 82,003,762 I36F probably damaging Het
Foxf2 A G 13: 31,626,531 N151S probably damaging Het
Fryl A G 5: 73,148,033 V35A possibly damaging Het
Gabrg3 T C 7: 56,773,347 Y201C probably damaging Het
Gm11487 T A 4: 73,403,416 R127S possibly damaging Het
Gm813 T C 16: 58,615,756 Y68C probably damaging Het
Grb10 T A 11: 11,933,591 T500S possibly damaging Het
Hsdl2 A G 4: 59,617,747 *371W probably null Het
Irf7 C A 7: 141,265,146 R49L probably damaging Het
Itpr2 T C 6: 146,158,877 probably benign Het
Jam3 T C 9: 27,101,249 T201A probably damaging Het
Mst1 T C 9: 108,084,388 S606P possibly damaging Het
Olfr483 T A 7: 108,103,608 C100S probably damaging Het
Otog A G 7: 46,306,230 E2800G probably damaging Het
Ptpro C T 6: 137,450,006 P292S probably damaging Het
Rab10 A T 12: 3,256,959 Y79N probably damaging Het
Rc3h1 T C 1: 160,959,555 probably null Het
Slc2a3 C T 6: 122,736,742 probably null Het
Sptbn2 T C 19: 4,732,661 Y542H possibly damaging Het
Ttn A G 2: 76,945,107 S1864P probably damaging Het
Ttn A G 2: 76,717,344 S32161P probably damaging Het
Vmn1r228 A G 17: 20,776,842 I138T probably damaging Het
Vmn2r10 T A 5: 109,003,377 T124S probably benign Het
Other mutations in Tas2r110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03103:Tas2r110 APN 6 132868480 missense probably benign 0.09
R0111:Tas2r110 UTSW 6 132868203 missense probably benign 0.00
R0539:Tas2r110 UTSW 6 132868371 missense possibly damaging 0.63
R1432:Tas2r110 UTSW 6 132868368 missense probably damaging 1.00
R1672:Tas2r110 UTSW 6 132868066 missense probably damaging 1.00
R2483:Tas2r110 UTSW 6 132868470 missense probably benign 0.00
R3110:Tas2r110 UTSW 6 132868024 missense unknown
R3112:Tas2r110 UTSW 6 132868024 missense unknown
R3623:Tas2r110 UTSW 6 132868470 missense probably benign 0.00
R3847:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R3849:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R3850:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R4871:Tas2r110 UTSW 6 132868128 missense probably benign 0.09
R5010:Tas2r110 UTSW 6 132868475 nonsense probably null
R5108:Tas2r110 UTSW 6 132868705 missense probably damaging 1.00
R5289:Tas2r110 UTSW 6 132868009 start codon destroyed probably null
R5938:Tas2r110 UTSW 6 132868053 missense probably benign 0.39
R6262:Tas2r110 UTSW 6 132868675 missense probably damaging 0.96
R6286:Tas2r110 UTSW 6 132868527 missense probably benign 0.01
R6582:Tas2r110 UTSW 6 132868285 missense possibly damaging 0.94
R7236:Tas2r110 UTSW 6 132868704 missense possibly damaging 0.76
X0024:Tas2r110 UTSW 6 132868633 missense probably damaging 1.00
Z1176:Tas2r110 UTSW 6 132868611 missense probably benign 0.37
Posted On2016-08-02