Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03275:Vmn2r10'

415384

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

VR16, V2r16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL03275

Quality Score

Status

Chromosome

Chromosomal Location

109141278-109154337 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109151243 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 124 (T124S)

Ref Sequence

ENSEMBL: ENSMUSP00000078162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

AlphaFold

K7N621

Predicted Effect

probably benign
Transcript: ENSMUST00000079163
AA Change: T124S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: T124S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176594

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	T	A	8: 73,198,968 (GRCm39)	L125H	probably damaging	Het
2210408I21Rik	A	T	13: 77,446,674 (GRCm39)	T816S	possibly damaging	Het
Aspm	T	A	1: 139,415,033 (GRCm39)	I1438N	probably damaging	Het
Bicdl1	A	G	5: 115,869,219 (GRCm39)	Y134H	probably damaging	Het
Btnl1	A	T	17: 34,604,486 (GRCm39)	K422N	probably damaging	Het
Ccdc158	T	A	5: 92,777,491 (GRCm39)	I941F	probably benign	Het
Crnn	A	G	3: 93,056,725 (GRCm39)	K504E	possibly damaging	Het
Csmd1	T	A	8: 16,207,106 (GRCm39)	I1308L	probably benign	Het
Cwf19l1	T	C	19: 44,111,696 (GRCm39)	M246V	probably benign	Het
Desi1	T	A	15: 81,887,963 (GRCm39)	I36F	probably damaging	Het
Foxf2	A	G	13: 31,810,514 (GRCm39)	N151S	probably damaging	Het
Fryl	A	G	5: 73,305,376 (GRCm39)	V35A	possibly damaging	Het
Ftdc1	T	C	16: 58,436,119 (GRCm39)	Y68C	probably damaging	Het
Gabrg3	T	C	7: 56,423,095 (GRCm39)	Y201C	probably damaging	Het
Grb10	T	A	11: 11,883,591 (GRCm39)	T500S	possibly damaging	Het
Hsdl2	A	G	4: 59,617,747 (GRCm39)	*371W	probably null	Het
Irf7	C	A	7: 140,845,059 (GRCm39)	R49L	probably damaging	Het
Itpr2	T	C	6: 146,060,375 (GRCm39)		probably benign	Het
Jam3	T	C	9: 27,012,545 (GRCm39)	T201A	probably damaging	Het
Msantd5f6	T	A	4: 73,321,653 (GRCm39)	R127S	possibly damaging	Het
Mst1	T	C	9: 107,961,587 (GRCm39)	S606P	possibly damaging	Het
Or5p59	T	A	7: 107,702,815 (GRCm39)	C100S	probably damaging	Het
Otog	A	G	7: 45,955,654 (GRCm39)	E2800G	probably damaging	Het
Ptpro	C	T	6: 137,427,004 (GRCm39)	P292S	probably damaging	Het
Rab10	A	T	12: 3,306,959 (GRCm39)	Y79N	probably damaging	Het
Rc3h1	T	C	1: 160,787,125 (GRCm39)		probably null	Het
Slc2a3	C	T	6: 122,713,701 (GRCm39)		probably null	Het
Sptbn2	T	C	19: 4,782,689 (GRCm39)	Y542H	possibly damaging	Het
Tas2r110	T	C	6: 132,845,061 (GRCm39)	F31L	probably damaging	Het
Thoc2l	T	A	5: 104,666,143 (GRCm39)	C222S	probably benign	Het
Ttn	A	G	2: 76,547,688 (GRCm39)	S32161P	probably damaging	Het
Ttn	A	G	2: 76,775,451 (GRCm39)	S1864P	probably damaging	Het
Vmn1r228	A	G	17: 20,997,104 (GRCm39)	I138T	probably damaging	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Vmn2r10	APN	5	109,150,451 (GRCm39)	missense	possibly damaging	0.75
IGL01618:Vmn2r10	APN	5	109,150,345 (GRCm39)	missense	probably damaging	1.00
IGL01624:Vmn2r10	APN	5	109,154,112 (GRCm39)	missense	possibly damaging	0.83
IGL01941:Vmn2r10	APN	5	109,143,820 (GRCm39)	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	109,145,571 (GRCm39)	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	109,143,543 (GRCm39)	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109,154,125 (GRCm39)	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	109,143,788 (GRCm39)	nonsense	probably null
IGL02503:Vmn2r10	APN	5	109,151,341 (GRCm39)	missense	probably damaging	1.00
R0035:Vmn2r10	UTSW	5	109,145,467 (GRCm39)	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109,149,859 (GRCm39)	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109,151,327 (GRCm39)	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	109,143,782 (GRCm39)	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	109,143,890 (GRCm39)	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109,154,117 (GRCm39)	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109,149,861 (GRCm39)	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109,154,120 (GRCm39)	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109,151,410 (GRCm39)	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	109,143,961 (GRCm39)	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R3933:Vmn2r10	UTSW	5	109,150,088 (GRCm39)	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109,151,324 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	109,145,592 (GRCm39)	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109,154,286 (GRCm39)	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	109,143,761 (GRCm39)	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	109,143,466 (GRCm39)	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	109,143,586 (GRCm39)	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109,154,121 (GRCm39)	missense	probably damaging	1.00
R5321:Vmn2r10	UTSW	5	109,143,505 (GRCm39)	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5670:Vmn2r10	UTSW	5	109,146,910 (GRCm39)	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109,151,377 (GRCm39)	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	109,146,944 (GRCm39)	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	109,143,667 (GRCm39)	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109,151,328 (GRCm39)	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	109,143,944 (GRCm39)	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	109,143,488 (GRCm39)	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109,149,845 (GRCm39)	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109,149,894 (GRCm39)	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109,151,200 (GRCm39)	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	109,144,306 (GRCm39)	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109,149,955 (GRCm39)	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	109,143,636 (GRCm39)	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	109,145,572 (GRCm39)	missense	possibly damaging	0.51
R8698:Vmn2r10	UTSW	5	109,151,390 (GRCm39)	missense	probably benign	0.00
R8796:Vmn2r10	UTSW	5	109,143,917 (GRCm39)	missense	possibly damaging	0.74
R8854:Vmn2r10	UTSW	5	109,144,126 (GRCm39)	missense	probably benign	0.20
R8871:Vmn2r10	UTSW	5	109,146,899 (GRCm39)	missense	possibly damaging	0.67
R8893:Vmn2r10	UTSW	5	109,143,677 (GRCm39)	missense	probably benign	0.09
R8907:Vmn2r10	UTSW	5	109,149,791 (GRCm39)	missense	probably benign
R8957:Vmn2r10	UTSW	5	109,149,780 (GRCm39)	missense	possibly damaging	0.60
R8976:Vmn2r10	UTSW	5	109,145,479 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r10	UTSW	5	109,144,212 (GRCm39)	missense	probably benign	0.10
R9308:Vmn2r10	UTSW	5	109,145,476 (GRCm39)	nonsense	probably null
R9800:Vmn2r10	UTSW	5	109,150,404 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r10	UTSW	5	109,143,979 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109,149,854 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02