Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03092:Rnf157'

418436

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf157

Ensembl Gene

ENSMUSG00000052949

Gene Name

ring finger protein 157

Synonyms

A130073L17Rik, 2610036E23Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03092

Quality Score

Status

Chromosome

Chromosomal Location

116227179-116303858 bp(-) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

T to A at 116238795 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100202] [ENSMUST00000100202] [ENSMUST00000100202] [ENSMUST00000100202] [ENSMUST00000106398] [ENSMUST00000106398] [ENSMUST00000106398] [ENSMUST00000106398]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000100202

SMART Domains

Protein: ENSMUSP00000097776
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000100202

SMART Domains

Protein: ENSMUSP00000097776
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000100202

SMART Domains

Protein: ENSMUSP00000097776
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000100202

SMART Domains

Protein: ENSMUSP00000097776
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106398

SMART Domains

Protein: ENSMUSP00000102006
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC
low complexity region	563	574	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106398

SMART Domains

Protein: ENSMUSP00000102006
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC
low complexity region	563	574	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106398

SMART Domains

Protein: ENSMUSP00000102006
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC
low complexity region	563	574	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106398

SMART Domains

Protein: ENSMUSP00000102006
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	277	315	5.64e-4	SMART
low complexity region	345	358	N/A	INTRINSIC
low complexity region	427	444	N/A	INTRINSIC
low complexity region	446	457	N/A	INTRINSIC
low complexity region	552	562	N/A	INTRINSIC
low complexity region	563	574	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137264

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141229

Predicted Effect

probably null
Transcript: ENSMUST00000149147

SMART Domains

Protein: ENSMUSP00000122483
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	102	140	5.64e-4	SMART
low complexity region	170	183	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	271	282	N/A	INTRINSIC
low complexity region	377	387	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000149147

SMART Domains

Protein: ENSMUSP00000122483
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	102	140	5.64e-4	SMART
low complexity region	170	183	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	271	282	N/A	INTRINSIC
low complexity region	377	387	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000149147

SMART Domains

Protein: ENSMUSP00000122483
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	102	140	5.64e-4	SMART
low complexity region	170	183	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	271	282	N/A	INTRINSIC
low complexity region	377	387	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000149147

SMART Domains

Protein: ENSMUSP00000122483
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
RING	102	140	5.64e-4	SMART
low complexity region	170	183	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	271	282	N/A	INTRINSIC
low complexity region	377	387	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000150775

SMART Domains

Protein: ENSMUSP00000123289
Gene: ENSMUSG00000052949

Domain	Start	End	E-Value	Type
low complexity region	65	75	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: The gene supports neuronal survival and dendrite growth and maintenance and knockdown with siRNA induces apoptosis in neuronal tissues. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,200,119 (GRCm39)	L491P	probably damaging	Het
Abcc6	T	A	7: 45,635,894 (GRCm39)	D1051V	probably damaging	Het
Actmap	T	C	7: 26,900,561 (GRCm39)	M180T	probably damaging	Het
Aqr	T	A	2: 113,989,424 (GRCm39)	E133V	probably benign	Het
Bag6	A	G	17: 35,364,603 (GRCm39)	N911D	probably damaging	Het
Cdcp3	G	T	7: 130,803,527 (GRCm39)		probably null	Het
Ces4a	C	T	8: 105,874,836 (GRCm39)		probably benign	Het
Clec3b	A	T	9: 122,980,100 (GRCm39)		probably benign	Het
Cnot1	T	C	8: 96,496,243 (GRCm39)		probably benign	Het
Ctsg	T	A	14: 56,337,417 (GRCm39)	*262L	probably null	Het
Cyp17a1	T	A	19: 46,661,050 (GRCm39)	H78L	possibly damaging	Het
Dcaf13	C	A	15: 38,991,371 (GRCm39)		probably benign	Het
Dcun1d1	G	T	3: 35,975,141 (GRCm39)	Q52K	possibly damaging	Het
Ddb1	C	T	19: 10,590,309 (GRCm39)	R279W	probably damaging	Het
Dock1	A	G	7: 134,366,945 (GRCm39)		probably benign	Het
Dsel	A	G	1: 111,787,793 (GRCm39)	L914P	probably damaging	Het
Fbxo31	A	G	8: 122,286,757 (GRCm39)	F174L	probably benign	Het
Gm9116	A	G	3: 93,817,513 (GRCm39)		noncoding transcript	Het
Gspt1	C	T	16: 11,056,763 (GRCm39)	V211I	probably benign	Het
Hmgb1	A	T	5: 148,987,508 (GRCm39)	S14T	probably benign	Het
Igsf8	A	G	1: 172,140,096 (GRCm39)		probably benign	Het
Klf13	A	G	7: 63,541,417 (GRCm39)	F237L	probably damaging	Het
Mon2	A	T	10: 122,854,005 (GRCm39)	I962N	probably damaging	Het
Nfx1	A	G	4: 41,024,851 (GRCm39)	D1108G	probably damaging	Het
Nr2e1	T	C	10: 42,447,478 (GRCm39)	Y178C	probably damaging	Het
Or4d10c	C	A	19: 12,065,230 (GRCm39)	E309*	probably null	Het
Or52d1	A	T	7: 103,755,854 (GRCm39)	I123F	probably damaging	Het
Pde3b	A	T	7: 114,122,583 (GRCm39)	H717L	probably damaging	Het
Polr1b	T	C	2: 128,965,049 (GRCm39)	Y712H	probably damaging	Het
Pramel16	C	A	4: 143,676,767 (GRCm39)	K112N	probably damaging	Het
Ros1	T	C	10: 51,974,902 (GRCm39)	E1561G	probably damaging	Het
Serpina6	A	G	12: 103,620,154 (GRCm39)		probably null	Het
St18	A	G	1: 6,839,118 (GRCm39)		probably benign	Het
Ugp2	A	G	11: 21,279,722 (GRCm39)		probably benign	Het
Vmn1r70	T	C	7: 10,368,186 (GRCm39)	S225P	probably benign	Het
Zfp641	T	C	15: 98,188,397 (GRCm39)	D161G	probably damaging	Het

Other mutations in Rnf157

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Rnf157	APN	11	116,253,181 (GRCm39)	missense	probably benign	0.20
IGL01146:Rnf157	APN	11	116,240,912 (GRCm39)	missense	probably benign	0.00
IGL01955:Rnf157	APN	11	116,250,722 (GRCm39)	missense	probably damaging	0.96
IGL02010:Rnf157	APN	11	116,287,052 (GRCm39)	missense	probably damaging	1.00
IGL02194:Rnf157	APN	11	116,237,858 (GRCm39)	critical splice donor site	probably null
PIT4362001:Rnf157	UTSW	11	116,251,143 (GRCm39)	missense	probably damaging	1.00
R0022:Rnf157	UTSW	11	116,240,276 (GRCm39)	unclassified	probably benign
R0022:Rnf157	UTSW	11	116,240,276 (GRCm39)	unclassified	probably benign
R0036:Rnf157	UTSW	11	116,287,128 (GRCm39)	missense	probably damaging	1.00
R0164:Rnf157	UTSW	11	116,245,636 (GRCm39)	splice site	probably benign
R1476:Rnf157	UTSW	11	116,245,585 (GRCm39)	missense	probably damaging	1.00
R1509:Rnf157	UTSW	11	116,237,921 (GRCm39)	missense	probably benign
R1544:Rnf157	UTSW	11	116,245,188 (GRCm39)	splice site	probably null
R1654:Rnf157	UTSW	11	116,249,541 (GRCm39)	missense	probably damaging	1.00
R1820:Rnf157	UTSW	11	116,245,477 (GRCm39)	missense	probably damaging	1.00
R2133:Rnf157	UTSW	11	116,249,520 (GRCm39)	missense	possibly damaging	0.93
R4017:Rnf157	UTSW	11	116,250,067 (GRCm39)	critical splice donor site	probably null
R4590:Rnf157	UTSW	11	116,250,098 (GRCm39)	missense	probably damaging	1.00
R4872:Rnf157	UTSW	11	116,246,298 (GRCm39)	missense	possibly damaging	0.93
R4891:Rnf157	UTSW	11	116,249,496 (GRCm39)	missense	probably damaging	1.00
R5608:Rnf157	UTSW	11	116,287,146 (GRCm39)	splice site	probably null
R5870:Rnf157	UTSW	11	116,237,900 (GRCm39)	missense	probably benign
R7171:Rnf157	UTSW	11	116,253,199 (GRCm39)	missense	possibly damaging	0.83
R7376:Rnf157	UTSW	11	116,251,192 (GRCm39)	missense	probably benign	0.35
R8178:Rnf157	UTSW	11	116,238,307 (GRCm39)	missense	possibly damaging	0.71
R8356:Rnf157	UTSW	11	116,240,246 (GRCm39)	missense	probably benign	0.11
R8456:Rnf157	UTSW	11	116,240,246 (GRCm39)	missense	probably benign	0.11
R8714:Rnf157	UTSW	11	116,237,891 (GRCm39)	missense	probably benign	0.00
R9312:Rnf157	UTSW	11	116,240,158 (GRCm39)	critical splice donor site	probably null
R9313:Rnf157	UTSW	11	116,250,718 (GRCm39)	missense	probably damaging	0.99
R9579:Rnf157	UTSW	11	116,240,822 (GRCm39)	missense	probably benign
R9641:Rnf157	UTSW	11	116,303,576 (GRCm39)	missense	probably benign	0.12
X0020:Rnf157	UTSW	11	116,251,134 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02