Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03111:Zfp455'

419201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp455

Ensembl Gene

ENSMUSG00000051037

Gene Name

zinc finger protein 455

Synonyms

Rslcan-10, 3732412P20Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.356) question?

Stock #

IGL03111

Quality Score

Status

Chromosome

Chromosomal Location

67342570-67357362 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 67356063 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 444 (S444P)

Ref Sequence

ENSEMBL: ENSMUSP00000112546 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117110] [ENSMUST00000120861]

AlphaFold

Q7M6X9

Predicted Effect

probably benign
Transcript: ENSMUST00000117110
AA Change: S379P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
AA Change: S379P

Domain	Start	End	E-Value	Type
ZnF_C2H2	44	66	7.15e-2	SMART
ZnF_C2H2	72	94	1.6e-4	SMART
ZnF_C2H2	100	122	2.12e-4	SMART
ZnF_C2H2	128	150	6.23e-2	SMART
ZnF_C2H2	184	206	1.01e-1	SMART
ZnF_C2H2	212	234	3.11e-2	SMART
ZnF_C2H2	240	262	1.1e-2	SMART
ZnF_C2H2	268	290	1.38e-3	SMART
ZnF_C2H2	296	318	3.58e-2	SMART
ZnF_C2H2	324	346	2.24e-3	SMART
ZnF_C2H2	352	374	7.9e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000120861
AA Change: S444P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: S444P

Domain	Start	End	E-Value	Type
KRAB	5	65	1.92e-34	SMART
ZnF_C2H2	109	131	7.15e-2	SMART
ZnF_C2H2	137	159	1.6e-4	SMART
ZnF_C2H2	165	187	2.12e-4	SMART
ZnF_C2H2	193	215	6.23e-2	SMART
ZnF_C2H2	249	271	1.01e-1	SMART
ZnF_C2H2	277	299	3.11e-2	SMART
ZnF_C2H2	305	327	1.1e-2	SMART
ZnF_C2H2	333	355	1.38e-3	SMART
ZnF_C2H2	361	383	3.58e-2	SMART
ZnF_C2H2	389	411	2.24e-3	SMART
ZnF_C2H2	417	439	7.9e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aftph	T	C	11: 20,676,040 (GRCm39)	D523G	probably benign	Het
Alkbh1	A	C	12: 87,480,907 (GRCm39)	H176Q	probably damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Arid4a	G	A	12: 71,086,740 (GRCm39)	A193T	probably damaging	Het
Cdkal1	A	G	13: 29,538,684 (GRCm39)	S492P	possibly damaging	Het
Cep170b	C	T	12: 112,701,613 (GRCm39)	T164I	probably damaging	Het
Chst1	T	C	2: 92,443,692 (GRCm39)	Y55H	possibly damaging	Het
Clybl	C	T	14: 122,639,395 (GRCm39)	P320S	probably damaging	Het
Cpne9	T	C	6: 113,277,571 (GRCm39)	I430T	possibly damaging	Het
Cyc1	T	G	15: 76,229,072 (GRCm39)	S113A	probably benign	Het
Cyp4b1	C	T	4: 115,493,066 (GRCm39)		probably benign	Het
Dpysl3	T	C	18: 43,462,910 (GRCm39)	D489G	probably damaging	Het
Epha3	T	C	16: 63,473,809 (GRCm39)	D15G	probably damaging	Het
Ephb4	C	A	5: 137,370,767 (GRCm39)	F933L	probably benign	Het
Fan1	A	T	7: 63,999,816 (GRCm39)	D856E	possibly damaging	Het
Gabra6	T	A	11: 42,207,844 (GRCm39)	D208V	probably damaging	Het
Kif3b	T	A	2: 153,171,988 (GRCm39)	S719R	probably benign	Het
Ldhd	A	C	8: 112,353,797 (GRCm39)	C439G	probably damaging	Het
Lipo3	C	T	19: 33,559,637 (GRCm39)	V78I	probably damaging	Het
Mterf2	A	T	10: 84,955,786 (GRCm39)	Y279*	probably null	Het
Myo9a	G	T	9: 59,734,526 (GRCm39)	A703S	probably benign	Het
Ndst3	T	A	3: 123,465,745 (GRCm39)	T76S	possibly damaging	Het
Nlrp4f	A	T	13: 65,330,816 (GRCm39)	L859Q	probably damaging	Het
Nlrp4g	T	A	9: 124,353,978 (GRCm38)		noncoding transcript	Het
Or1s2	T	A	19: 13,758,343 (GRCm39)	Y122*	probably null	Het
Or51g2	G	A	7: 102,622,738 (GRCm39)	R154C	probably damaging	Het
Or6c215	G	A	10: 129,637,947 (GRCm39)	T149I	probably benign	Het
Osgin1	A	T	8: 120,169,788 (GRCm39)	K113M	probably damaging	Het
Plcb4	T	A	2: 135,818,202 (GRCm39)	Y823N	probably damaging	Het
Prg4	T	C	1: 150,327,653 (GRCm39)	I856V	probably benign	Het
Pxdn	T	A	12: 30,032,755 (GRCm39)	S180T	probably damaging	Het
Skint9	T	A	4: 112,248,921 (GRCm39)	N169I	probably benign	Het
Slc24a1	T	C	9: 64,833,608 (GRCm39)	T996A	probably damaging	Het
Tbc1d20	T	C	2: 152,149,998 (GRCm39)	Y91H	probably damaging	Het
Tbc1d9b	A	G	11: 50,049,369 (GRCm39)	Y772C	probably damaging	Het
Thbd	T	A	2: 148,248,392 (GRCm39)	E492V	probably benign	Het
Thra	A	G	11: 98,651,855 (GRCm39)		probably benign	Het
Tmem131	A	G	1: 36,867,225 (GRCm39)	S403P	probably damaging	Het
Zfp946	A	G	17: 22,673,537 (GRCm39)	H97R	possibly damaging	Het

Other mutations in Zfp455

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00743:Zfp455	APN	13	67,355,962 (GRCm39)	missense	probably benign	0.33
IGL03210:Zfp455	APN	13	67,355,113 (GRCm39)	missense	possibly damaging	0.93
IGL03371:Zfp455	APN	13	67,355,066 (GRCm39)	nonsense	probably null
PIT4504001:Zfp455	UTSW	13	67,346,685 (GRCm39)	missense	probably damaging	0.98
R0245:Zfp455	UTSW	13	67,355,899 (GRCm39)	missense	probably damaging	1.00
R0277:Zfp455	UTSW	13	67,346,728 (GRCm39)	splice site	probably null
R1141:Zfp455	UTSW	13	67,346,655 (GRCm39)	missense	probably damaging	1.00
R1266:Zfp455	UTSW	13	67,355,028 (GRCm39)	nonsense	probably null
R1657:Zfp455	UTSW	13	67,346,703 (GRCm39)	missense	possibly damaging	0.83
R1749:Zfp455	UTSW	13	67,355,073 (GRCm39)	missense	probably damaging	1.00
R1757:Zfp455	UTSW	13	67,355,601 (GRCm39)	missense	probably damaging	1.00
R1854:Zfp455	UTSW	13	67,355,881 (GRCm39)	missense	probably damaging	1.00
R1867:Zfp455	UTSW	13	67,355,509 (GRCm39)	missense	probably benign	0.33
R4411:Zfp455	UTSW	13	67,355,389 (GRCm39)	missense	probably damaging	0.96
R6060:Zfp455	UTSW	13	67,355,257 (GRCm39)	missense	probably damaging	1.00
R6544:Zfp455	UTSW	13	67,355,121 (GRCm39)	missense	probably benign	0.33
R7132:Zfp455	UTSW	13	67,347,230 (GRCm39)	missense	probably damaging	1.00
R7524:Zfp455	UTSW	13	67,355,688 (GRCm39)	missense	possibly damaging	0.73
R7966:Zfp455	UTSW	13	67,347,302 (GRCm39)	missense	probably benign
R8848:Zfp455	UTSW	13	67,356,089 (GRCm39)	missense	possibly damaging	0.70
R8994:Zfp455	UTSW	13	67,355,478 (GRCm39)	missense	probably damaging	1.00
Z1176:Zfp455	UTSW	13	67,355,107 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02