Incidental Mutation 'IGL03350:Wee2'
ID419678
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wee2
Ensembl Gene ENSMUSG00000037159
Gene NameWEE1 homolog 2 (S. pombe)
SynonymsLOC381759, Wee1b
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03350
Quality Score
Status
Chromosome6
Chromosomal Location40439088-40466813 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 40449731 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 145 (S145P)
Ref Sequence ENSEMBL: ENSMUSP00000144628 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038907] [ENSMUST00000202464]
Predicted Effect probably benign
Transcript: ENSMUST00000038907
AA Change: S145P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000038754
Gene: ENSMUSG00000037159
AA Change: S145P

DomainStartEndE-ValueType
low complexity region 117 128 N/A INTRINSIC
Pfam:Pkinase 208 481 3.6e-51 PFAM
Pfam:Pkinase_Tyr 209 478 9.6e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000202464
AA Change: S145P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000144628
Gene: ENSMUSG00000037159
AA Change: S145P

DomainStartEndE-ValueType
low complexity region 117 128 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4922502D21Rik C A 6: 129,331,023 V28L probably benign Het
Adam26a A T 8: 43,569,552 Y300* probably null Het
Adgre1 T A 17: 57,401,908 V33E probably benign Het
AI987944 A G 7: 41,393,237 probably benign Het
Atp4a T C 7: 30,720,867 L813P probably damaging Het
Blmh A G 11: 76,971,948 N396D probably damaging Het
Brat1 T C 5: 140,705,995 L9P probably damaging Het
Ccdc171 T C 4: 83,681,378 I810T possibly damaging Het
Cyp2a22 T C 7: 26,934,854 T292A possibly damaging Het
Ecm2 C T 13: 49,520,944 T280I probably benign Het
Fa2h C T 8: 111,349,296 V232I probably benign Het
Fbxw24 T C 9: 109,607,013 D317G probably damaging Het
Flt4 C A 11: 49,634,793 S722* probably null Het
Fryl T C 5: 73,133,306 Q85R probably damaging Het
Gm3239 A G 14: 4,667,115 R188G possibly damaging Het
Hspa13 A T 16: 75,757,829 S456R probably damaging Het
Htr1b T C 9: 81,632,122 Y144C probably damaging Het
Hydin A G 8: 110,312,224 H198R possibly damaging Het
Krt78 A T 15: 101,946,517 M953K probably benign Het
Lgr5 G T 10: 115,471,988 T255K probably damaging Het
Lrp2 T A 2: 69,438,453 D4162V probably damaging Het
Map3k2 A G 18: 32,212,148 D342G probably damaging Het
Miip A G 4: 147,862,522 V258A probably benign Het
Muc6 T C 7: 141,652,059 H52R probably damaging Het
Nfs1 T C 2: 156,127,740 E329G probably benign Het
Npsr1 T C 9: 24,098,309 V37A probably benign Het
Olfr1107 A C 2: 87,071,560 D191E probably damaging Het
Olfr23 A T 11: 73,940,838 L197F probably damaging Het
Olfr356 T C 2: 36,937,583 Y155H probably damaging Het
Pex16 T A 2: 92,377,497 M98K probably damaging Het
Pla2r1 C T 2: 60,455,173 C699Y probably damaging Het
Plcd4 A T 1: 74,549,301 D103V probably damaging Het
Pnpla1 A G 17: 28,876,992 D129G probably damaging Het
Rad23a T C 8: 84,837,479 E265G possibly damaging Het
Rbm11 C T 16: 75,600,808 P209S probably benign Het
Ribc2 T A 15: 85,135,502 W162R probably damaging Het
Rnf4 A G 5: 34,346,860 E32G possibly damaging Het
Rpe65 A T 3: 159,614,517 S269C possibly damaging Het
Slc7a14 T A 3: 31,237,409 Y240F probably benign Het
Sorbs2 C T 8: 45,805,807 P1047L probably damaging Het
Ttn T C 2: 76,749,822 I23576V probably damaging Het
Usp24 T G 4: 106,371,079 Y780* probably null Het
Zcchc7 A G 4: 44,931,188 T126A probably benign Het
Zpld1 A G 16: 55,241,329 probably benign Het
Zufsp G A 10: 33,928,111 R456C probably benign Het
Other mutations in Wee2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Wee2 APN 6 40462061 missense probably damaging 1.00
IGL01096:Wee2 APN 6 40463253 missense probably benign 0.00
IGL01978:Wee2 APN 6 40455153 missense probably damaging 1.00
IGL03026:Wee2 APN 6 40461981 missense probably benign 0.00
IGL03091:Wee2 APN 6 40462034 missense probably benign 0.02
IGL03352:Wee2 APN 6 40452655 critical splice donor site probably null
R0420:Wee2 UTSW 6 40456995 missense probably benign 0.04
R0506:Wee2 UTSW 6 40463253 missense probably benign 0.04
R1205:Wee2 UTSW 6 40443941 start gained probably benign
R1702:Wee2 UTSW 6 40464201 missense probably benign 0.04
R3982:Wee2 UTSW 6 40455241 missense possibly damaging 0.86
R3983:Wee2 UTSW 6 40455241 missense possibly damaging 0.86
R5946:Wee2 UTSW 6 40463212 missense probably null 1.00
R6020:Wee2 UTSW 6 40449620 splice site probably null
R6127:Wee2 UTSW 6 40449767 missense probably damaging 1.00
R6189:Wee2 UTSW 6 40449683 missense probably damaging 1.00
R6342:Wee2 UTSW 6 40444255 missense probably benign 0.05
R6347:Wee2 UTSW 6 40455105 missense probably damaging 1.00
R6350:Wee2 UTSW 6 40455105 missense probably damaging 1.00
R6513:Wee2 UTSW 6 40452619 missense probably benign 0.00
R7091:Wee2 UTSW 6 40462002 missense probably benign 0.00
R8258:Wee2 UTSW 6 40444180 missense probably benign 0.00
R8259:Wee2 UTSW 6 40444180 missense probably benign 0.00
Posted On2016-08-02