Incidental Mutation 'R2903:Trav17'
ID 477232
Institutional Source Beutler Lab
Gene Symbol Trav17
Ensembl Gene ENSMUSG00000096397
Gene Name T cell receptor alpha variable 17
Synonyms OTTMUSG00000015028
MMRRC Submission 040490-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.247) question?
Stock # R2903 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 54044096-54044572 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 54044123 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 10 (S10R)
Ref Sequence ENSEMBL: ENSMUSP00000140087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103672] [ENSMUST00000186545]
AlphaFold A0A087WQ87
Predicted Effect probably benign
Transcript: ENSMUST00000103672
AA Change: S10R

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000100449
Gene: ENSMUSG00000096397
AA Change: S10R

DomainStartEndE-ValueType
Pfam:V-set 20 113 2.2e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186545
AA Change: S10R

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000140087
Gene: ENSMUSG00000096397
AA Change: S10R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG_like 36 111 4.9e-6 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230112D13Rik A T 14: 34,233,898 (GRCm39) V131E unknown Het
Ccnk T C 12: 108,168,647 (GRCm39) probably benign Het
Cd276 A G 9: 58,444,603 (GRCm39) F123L probably benign Het
Ddr2 T A 1: 169,825,730 (GRCm39) N290I probably damaging Het
Ecpas A G 4: 58,828,622 (GRCm39) V937A possibly damaging Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gpt A G 15: 76,582,666 (GRCm39) D37G probably damaging Het
Grik3 T A 4: 125,564,437 (GRCm39) L473Q probably damaging Het
Hsp90b1 A C 10: 86,539,349 (GRCm39) I90S probably damaging Het
Ift56 T C 6: 38,378,037 (GRCm39) V283A possibly damaging Het
Ing5 G A 1: 93,731,710 (GRCm39) probably benign Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Kdr T C 5: 76,127,069 (GRCm39) Y307C probably damaging Het
Or51t4 A T 7: 102,598,661 (GRCm39) M320L probably benign Het
Rapgef5 A G 12: 117,677,854 (GRCm39) K161R probably damaging Het
Rassf10 A T 7: 112,553,756 (GRCm39) D119V possibly damaging Het
Samhd1 A T 2: 156,965,335 (GRCm39) F160Y possibly damaging Het
Sh3bp2 T A 5: 34,700,900 (GRCm39) C34* probably null Het
Six3 A G 17: 85,931,283 (GRCm39) E313G probably damaging Het
Tas2r118 A G 6: 23,969,801 (GRCm39) F87L possibly damaging Het
Tmem131 A G 1: 36,864,378 (GRCm39) L591P probably damaging Het
Ttll3 T C 6: 113,384,284 (GRCm39) F534S probably damaging Het
Umodl1 T A 17: 31,211,147 (GRCm39) V890E probably damaging Het
Uso1 G A 5: 92,343,294 (GRCm39) probably null Het
Utrn A G 10: 12,519,172 (GRCm39) I2260T probably damaging Het
Vav1 A G 17: 57,613,187 (GRCm39) N620D probably benign Het
Other mutations in Trav17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03124:Trav17 APN 14 54,044,106 (GRCm39) missense probably benign 0.01
R2867:Trav17 UTSW 14 54,044,383 (GRCm39) missense probably benign 0.03
R2867:Trav17 UTSW 14 54,044,383 (GRCm39) missense probably benign 0.03
R4776:Trav17 UTSW 14 54,044,097 (GRCm39) start codon destroyed probably null 1.00
R7308:Trav17 UTSW 14 54,044,436 (GRCm39) missense probably benign 0.38
R7451:Trav17 UTSW 14 54,044,096 (GRCm39) start codon destroyed probably damaging 0.98
R7588:Trav17 UTSW 14 54,044,302 (GRCm39) missense probably benign 0.00
R9055:Trav17 UTSW 14 54,044,320 (GRCm39) missense probably damaging 0.98
Predicted Primers
Posted On 2017-05-15