Incidental Mutation 'R6037:Cdhr18'
ID 479275
Institutional Source Beutler Lab
Gene Symbol Cdhr18
Ensembl Gene ENSMUSG00000084902
Gene Name cadherin related family member 18
Synonyms Gm281, LOC238939
MMRRC Submission 043258-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R6037 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 8555242-8646046 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13864282 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 348 (N348S)
Ref Sequence ENSEMBL: ENSMUSP00000121887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000144914]
AlphaFold D3Z1Y0
Predicted Effect probably damaging
Transcript: ENSMUST00000144914
AA Change: N348S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121887
Gene: ENSMUSG00000084902
AA Change: N348S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
CA 32 127 3.45e-2 SMART
CA 156 230 7.87e-9 SMART
CA 274 352 1.36e-3 SMART
CA 376 470 6.99e-3 SMART
CA 492 563 8.69e-11 SMART
CA 589 683 2.09e-1 SMART
transmembrane domain 705 727 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157171
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.0%
  • 10x: 92.4%
  • 20x: 72.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
Abi2 C A 1: 60,503,738 (GRCm39) P212T probably damaging Het
Ano4 A G 10: 89,153,108 (GRCm39) F68S possibly damaging Het
Art5 C A 7: 101,747,591 (GRCm39) A63S probably benign Het
Asgr1 T A 11: 69,947,247 (GRCm39) S96R probably benign Het
Bdp1 A T 13: 100,163,957 (GRCm39) V2248D possibly damaging Het
Cacna1s C T 1: 135,998,705 (GRCm39) A200V possibly damaging Het
Cacna2d2 A G 9: 107,390,738 (GRCm39) K357E probably damaging Het
Cfap52 C T 11: 67,837,126 (GRCm39) G212R probably benign Het
Dcun1d3 A G 7: 119,456,965 (GRCm39) F249S probably damaging Het
Ece2 A G 16: 20,449,112 (GRCm39) Y17C probably damaging Het
Efemp1 C T 11: 28,871,760 (GRCm39) T425I probably damaging Het
Eprs1 A G 1: 185,128,306 (GRCm39) E562G probably damaging Het
Fbn2 T C 18: 58,177,295 (GRCm39) T2001A probably benign Het
Flt4 G A 11: 49,527,867 (GRCm39) R940H probably damaging Het
Fry T A 5: 150,351,644 (GRCm39) M1716K probably benign Het
Gm10684 T A 9: 45,019,039 (GRCm39) probably benign Het
Hivep1 G A 13: 42,311,416 (GRCm39) V1219I probably damaging Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Il23r C T 6: 67,455,938 (GRCm39) V177M probably damaging Het
Klf12 T C 14: 100,137,650 (GRCm39) S299G probably benign Het
Lama5 G A 2: 179,848,806 (GRCm39) R265C probably damaging Het
Lifr A G 15: 7,216,424 (GRCm39) T800A probably damaging Het
Megf8 T C 7: 25,063,831 (GRCm39) L2729P probably damaging Het
Mki67 A C 7: 135,298,532 (GRCm39) S2167R possibly damaging Het
Mus81 T C 19: 5,534,032 (GRCm39) K400E probably damaging Het
Nomo1 T A 7: 45,712,423 (GRCm39) I656N possibly damaging Het
Oas3 T C 5: 120,907,384 (GRCm39) T418A probably benign Het
Olr1 A G 6: 129,470,504 (GRCm39) L221P probably damaging Het
Or14c44 C T 7: 86,062,478 (GRCm39) L303F probably benign Het
Or5m9 T C 2: 85,876,928 (GRCm39) M34T probably benign Het
Or8b3 T A 9: 38,314,601 (GRCm39) C144S probably benign Het
Or8g22 A G 9: 38,958,403 (GRCm39) V104A probably damaging Het
Or8k28 T A 2: 86,286,133 (GRCm39) I161L probably benign Het
Pih1d1 C T 7: 44,805,738 (GRCm39) A69V probably damaging Het
Pkdrej A C 15: 85,703,967 (GRCm39) S656R probably damaging Het
Polr3f A G 2: 144,377,943 (GRCm39) D171G probably damaging Het
Rasal1 T C 5: 120,787,566 (GRCm39) V11A possibly damaging Het
Rsf1 G GACGGCGGCT 7: 97,229,116 (GRCm39) probably benign Het
Sptbn4 T A 7: 27,063,595 (GRCm39) Y2277F probably damaging Het
St6galnac6 A G 2: 32,502,240 (GRCm39) Q7R probably damaging Het
Thrsp T G 7: 97,066,499 (GRCm39) D71A possibly damaging Het
Vmn2r1 C A 3: 63,989,150 (GRCm39) Q30K probably benign Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Wipf2 C T 11: 98,787,005 (GRCm39) P345S probably benign Het
Zeb2 G T 2: 44,878,652 (GRCm39) S1170* probably null Het
Zfp947 A G 17: 22,366,415 (GRCm39) Y38H probably damaging Het
Other mutations in Cdhr18
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0115:Cdhr18 UTSW 14 13,899,571 (GRCm38) missense probably damaging 0.99
R0842:Cdhr18 UTSW 14 13,856,686 (GRCm38) missense probably benign 0.16
R1252:Cdhr18 UTSW 14 13,862,444 (GRCm38) missense probably benign 0.00
R1275:Cdhr18 UTSW 14 13,896,949 (GRCm38) missense probably damaging 1.00
R1631:Cdhr18 UTSW 14 13,829,796 (GRCm38) missense probably damaging 0.99
R1831:Cdhr18 UTSW 14 13,899,619 (GRCm38) missense probably damaging 1.00
R1885:Cdhr18 UTSW 14 13,828,607 (GRCm38) missense probably damaging 1.00
R1886:Cdhr18 UTSW 14 13,828,607 (GRCm38) missense probably damaging 1.00
R1887:Cdhr18 UTSW 14 13,828,607 (GRCm38) missense probably damaging 1.00
R1903:Cdhr18 UTSW 14 13,829,657 (GRCm38) missense possibly damaging 0.94
R1940:Cdhr18 UTSW 14 13,828,582 (GRCm38) missense probably null 0.95
R2324:Cdhr18 UTSW 14 13,868,077 (GRCm38) missense probably damaging 1.00
R3923:Cdhr18 UTSW 14 13,865,990 (GRCm38) nonsense probably null
R4193:Cdhr18 UTSW 14 13,914,416 (GRCm38) missense probably benign 0.02
R4195:Cdhr18 UTSW 14 13,829,772 (GRCm38) missense probably benign 0.05
R4370:Cdhr18 UTSW 14 13,862,375 (GRCm38) missense probably benign 0.03
R4675:Cdhr18 UTSW 14 13,856,724 (GRCm38) missense probably benign 0.32
R4734:Cdhr18 UTSW 14 13,845,292 (GRCm38) missense probably benign 0.13
R5387:Cdhr18 UTSW 14 13,914,438 (GRCm38) start codon destroyed probably null 0.82
R6037:Cdhr18 UTSW 14 13,864,282 (GRCm38) missense probably damaging 1.00
R6177:Cdhr18 UTSW 14 13,868,002 (GRCm38) missense probably benign 0.08
R7051:Cdhr18 UTSW 14 13,828,486 (GRCm38) missense
R7205:Cdhr18 UTSW 14 13,866,032 (GRCm38) missense
R7258:Cdhr18 UTSW 14 13,899,648 (GRCm38) missense
R7833:Cdhr18 UTSW 14 13,896,968 (GRCm38) splice site probably null
R8309:Cdhr18 UTSW 14 13,814,954 (GRCm38) nonsense probably null
R8911:Cdhr18 UTSW 14 13,823,796 (GRCm38) critical splice acceptor site probably null
R9124:Cdhr18 UTSW 14 13,864,354 (GRCm38) missense
R9458:Cdhr18 UTSW 14 13,856,709 (GRCm38) missense
R9594:Cdhr18 UTSW 14 13,814,959 (GRCm38) missense unknown
Z1177:Cdhr18 UTSW 14 13,845,421 (GRCm38) missense
Z1177:Cdhr18 UTSW 14 13,823,754 (GRCm38) missense
Predicted Primers
Posted On 2017-06-26