Incidental Mutation 'R0536:AW209491'
ID |
49467 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
AW209491
|
Ensembl Gene |
ENSMUSG00000039182 |
Gene Name |
expressed sequence AW209491 |
Synonyms |
|
MMRRC Submission |
038728-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.242)
|
Stock # |
R0536 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
14804830-14812787 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 14811558 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 137
(Y137C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136376
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038690]
[ENSMUST00000178289]
[ENSMUST00000221168]
[ENSMUST00000222052]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000038690
AA Change: Y137C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000041523 Gene: ENSMUSG00000039182 AA Change: Y137C
Domain | Start | End | E-Value | Type |
Pfam:DUF1308
|
38 |
401 |
2.2e-115 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000178289
AA Change: Y137C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000136376 Gene: ENSMUSG00000039182 AA Change: Y137C
Domain | Start | End | E-Value | Type |
Pfam:DUF1308
|
37 |
401 |
1.1e-121 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000221168
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000222052
|
Meta Mutation Damage Score |
0.8475 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 95.1%
|
Validation Efficiency |
100% (29/29) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acaca |
T |
C |
11: 84,171,342 (GRCm39) |
|
probably benign |
Het |
Agrn |
A |
T |
4: 156,264,010 (GRCm39) |
D84E |
probably benign |
Het |
Akap11 |
A |
G |
14: 78,751,464 (GRCm39) |
S308P |
probably damaging |
Het |
Atp6v1c2 |
A |
T |
12: 17,357,509 (GRCm39) |
|
probably null |
Het |
Chst9 |
G |
A |
18: 15,628,387 (GRCm39) |
|
probably benign |
Het |
Dok7 |
A |
G |
5: 35,223,826 (GRCm39) |
T122A |
probably damaging |
Het |
Hoxb5 |
T |
C |
11: 96,194,854 (GRCm39) |
S139P |
possibly damaging |
Het |
Ikzf4 |
T |
A |
10: 128,477,118 (GRCm39) |
E64D |
probably benign |
Het |
Kif21a |
C |
A |
15: 90,843,886 (GRCm39) |
|
probably benign |
Het |
Klhl41 |
G |
A |
2: 69,500,554 (GRCm39) |
R5Q |
probably benign |
Het |
Lama3 |
C |
T |
18: 12,658,951 (GRCm39) |
R2036C |
probably damaging |
Het |
Lrba |
T |
A |
3: 86,622,839 (GRCm39) |
V311D |
probably damaging |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Mylk |
T |
C |
16: 34,820,757 (GRCm39) |
V1903A |
possibly damaging |
Het |
Naa30 |
C |
T |
14: 49,410,534 (GRCm39) |
A154V |
possibly damaging |
Het |
Or2ag1 |
T |
A |
7: 106,313,528 (GRCm39) |
Y120F |
probably damaging |
Het |
Or52z12 |
T |
C |
7: 103,233,468 (GRCm39) |
S80P |
probably damaging |
Het |
Or8g24 |
G |
T |
9: 38,989,625 (GRCm39) |
Q139K |
probably benign |
Het |
Pgm3 |
C |
T |
9: 86,449,589 (GRCm39) |
V144M |
possibly damaging |
Het |
Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
Rgsl1 |
T |
A |
1: 153,701,927 (GRCm39) |
S211C |
probably damaging |
Het |
Setx |
T |
C |
2: 29,048,260 (GRCm39) |
Y1954H |
possibly damaging |
Het |
Sorcs3 |
C |
T |
19: 48,791,137 (GRCm39) |
Q1162* |
probably null |
Het |
Sptbn2 |
T |
A |
19: 4,776,718 (GRCm39) |
D255E |
probably damaging |
Het |
Ttc39b |
T |
C |
4: 83,145,435 (GRCm39) |
E597G |
probably damaging |
Het |
Vldlr |
G |
A |
19: 27,217,364 (GRCm39) |
A436T |
probably damaging |
Het |
Wdr72 |
G |
A |
9: 74,064,690 (GRCm39) |
G574D |
probably damaging |
Het |
Zzz3 |
T |
G |
3: 152,154,465 (GRCm39) |
I572S |
probably damaging |
Het |
|
Other mutations in AW209491 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00924:AW209491
|
APN |
13 |
14,811,660 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02634:AW209491
|
APN |
13 |
14,812,268 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02635:AW209491
|
APN |
13 |
14,811,852 (GRCm39) |
missense |
possibly damaging |
0.46 |
IGL03401:AW209491
|
APN |
13 |
14,812,041 (GRCm39) |
missense |
probably benign |
|
R0067:AW209491
|
UTSW |
13 |
14,812,328 (GRCm39) |
missense |
probably benign |
0.24 |
R0067:AW209491
|
UTSW |
13 |
14,812,328 (GRCm39) |
missense |
probably benign |
0.24 |
R0539:AW209491
|
UTSW |
13 |
14,812,317 (GRCm39) |
missense |
probably damaging |
1.00 |
R0845:AW209491
|
UTSW |
13 |
14,811,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R1851:AW209491
|
UTSW |
13 |
14,811,318 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4110:AW209491
|
UTSW |
13 |
14,812,158 (GRCm39) |
missense |
probably damaging |
1.00 |
R4379:AW209491
|
UTSW |
13 |
14,812,412 (GRCm39) |
makesense |
probably null |
|
R5153:AW209491
|
UTSW |
13 |
14,811,764 (GRCm39) |
missense |
probably benign |
|
R5987:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R5988:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R5990:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R6019:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R6021:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R6022:AW209491
|
UTSW |
13 |
14,812,365 (GRCm39) |
missense |
probably benign |
0.00 |
R6160:AW209491
|
UTSW |
13 |
14,811,306 (GRCm39) |
missense |
probably damaging |
0.99 |
R6179:AW209491
|
UTSW |
13 |
14,811,668 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6194:AW209491
|
UTSW |
13 |
14,811,705 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7594:AW209491
|
UTSW |
13 |
14,811,831 (GRCm39) |
missense |
probably benign |
|
R7947:AW209491
|
UTSW |
13 |
14,811,447 (GRCm39) |
missense |
probably benign |
|
R8316:AW209491
|
UTSW |
13 |
14,812,349 (GRCm39) |
missense |
probably damaging |
0.99 |
R8425:AW209491
|
UTSW |
13 |
14,811,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R9016:AW209491
|
UTSW |
13 |
14,812,193 (GRCm39) |
missense |
probably damaging |
0.98 |
R9635:AW209491
|
UTSW |
13 |
14,811,957 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- AAAGCCATCGTGGAATCGGCAG -3'
(R):5'- CAGAAGTTCTTGGCCCTCGTCATC -3'
Sequencing Primer
(F):5'- TCGTGGAATCGGCAGAGAAC -3'
(R):5'- AGAGTTGACGGCTACAATGTCTC -3'
|
Posted On |
2013-06-12 |