Incidental Mutation 'IGL01069:Lmf2'
ID 52764
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lmf2
Ensembl Gene ENSMUSG00000022614
Gene Name lipase maturation factor 2
Synonyms Tmem112b, Tmem153
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL01069
Quality Score
Status
Chromosome 15
Chromosomal Location 89235207-89239862 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 89237091 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 408 (A408S)
Ref Sequence ENSEMBL: ENSMUSP00000023283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023283] [ENSMUST00000036987] [ENSMUST00000074552] [ENSMUST00000088717] [ENSMUST00000229111] [ENSMUST00000145259]
AlphaFold Q8C3X8
Predicted Effect probably benign
Transcript: ENSMUST00000023283
AA Change: A408S

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000023283
Gene: ENSMUSG00000022614
AA Change: A408S

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
transmembrane domain 87 109 N/A INTRINSIC
Pfam:LMF1 122 589 5.6e-164 PFAM
low complexity region 679 693 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000036987
SMART Domains Protein: ENSMUSP00000036900
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:DUF1032 20 576 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074552
SMART Domains Protein: ENSMUSP00000074139
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:DUF1032 51 607 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000088717
SMART Domains Protein: ENSMUSP00000086095
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:CNDH2_N 11 123 1.2e-48 PFAM
Pfam:CNDH2_M 147 285 2.1e-20 PFAM
Pfam:CNDH2_C 308 598 1.9e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123889
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141643
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145793
Predicted Effect probably benign
Transcript: ENSMUST00000229111
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230112
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229291
Predicted Effect probably benign
Transcript: ENSMUST00000145259
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229436
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230523
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229308
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231067
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231107
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
1700123K08Rik C T 5: 138,560,751 (GRCm39) A215T probably benign Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Apc2 G A 10: 80,147,820 (GRCm39) C929Y probably damaging Het
Arap2 T C 5: 62,807,199 (GRCm39) H1156R probably benign Het
Arhgap9 A G 10: 127,164,821 (GRCm39) T582A probably damaging Het
Ccdc57 T A 11: 120,752,085 (GRCm39) H832L probably benign Het
Ces3b T C 8: 105,818,206 (GRCm39) S92P probably benign Het
Ces5a A G 8: 94,252,172 (GRCm39) probably null Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cpb2 T A 14: 75,508,215 (GRCm39) D225E probably damaging Het
Cpne8 C T 15: 90,499,313 (GRCm39) probably null Het
Cux2 G A 5: 122,005,414 (GRCm39) T924M possibly damaging Het
Dtl T A 1: 191,293,651 (GRCm39) probably null Het
Dysf T A 6: 84,176,767 (GRCm39) I1912N possibly damaging Het
Edc4 T A 8: 106,613,766 (GRCm39) F369I probably benign Het
Fibcd1 T C 2: 31,711,531 (GRCm39) E298G probably benign Het
Focad C A 4: 88,244,383 (GRCm39) H788N unknown Het
Frem1 C T 4: 82,932,104 (GRCm39) R199H probably benign Het
Gadl1 T C 9: 115,783,907 (GRCm39) probably null Het
Hipk1 G A 3: 103,685,015 (GRCm39) T200I possibly damaging Het
Ighv14-2 C T 12: 113,958,379 (GRCm39) V21I possibly damaging Het
Kank4 A T 4: 98,666,632 (GRCm39) I605N probably damaging Het
Krt88 T G 15: 101,351,508 (GRCm39) *172G probably null Het
Lsm12 T C 11: 102,054,896 (GRCm39) probably benign Het
Myo3b A G 2: 70,075,735 (GRCm39) I580V probably benign Het
Myt1 T C 2: 181,467,749 (GRCm39) M1061T probably damaging Het
Nup133 G A 8: 124,657,721 (GRCm39) R405* probably null Het
Or1ad1 A T 11: 50,875,830 (GRCm39) I101F possibly damaging Het
Or5m3 A G 2: 85,838,891 (GRCm39) Y257C probably damaging Het
Or8g2 A T 9: 39,821,902 (GRCm39) M268L possibly damaging Het
Pcnx1 A G 12: 81,964,918 (GRCm39) R362G probably benign Het
Pomt2 G T 12: 87,157,078 (GRCm39) T747K probably damaging Het
Rgma G A 7: 73,067,239 (GRCm39) A165T probably damaging Het
Rhbdf2 T C 11: 116,492,577 (GRCm39) D437G possibly damaging Het
Rpl5 T C 5: 108,055,145 (GRCm39) probably null Het
Rtkn2 A G 10: 67,877,494 (GRCm39) D518G probably benign Het
Sclt1 T C 3: 41,696,426 (GRCm39) probably benign Het
Sidt2 C T 9: 45,854,375 (GRCm39) V616I possibly damaging Het
Ska2 A G 11: 87,000,091 (GRCm39) probably benign Het
Slc13a4 C A 6: 35,245,817 (GRCm39) L609F probably damaging Het
Sorbs3 T C 14: 70,428,604 (GRCm39) E390G probably damaging Het
Syt15 T C 14: 33,946,881 (GRCm39) V220A possibly damaging Het
Tob1 T C 11: 94,104,881 (GRCm39) F139S probably damaging Het
Yars2 C T 16: 16,124,406 (GRCm39) R338* probably null Het
Other mutations in Lmf2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Lmf2 APN 15 89,237,539 (GRCm39) missense probably benign 0.00
IGL00953:Lmf2 APN 15 89,238,102 (GRCm39) missense probably damaging 1.00
IGL00987:Lmf2 APN 15 89,238,771 (GRCm39) missense probably benign
IGL01340:Lmf2 APN 15 89,237,075 (GRCm39) missense probably damaging 0.98
IGL01878:Lmf2 APN 15 89,236,621 (GRCm39) missense probably damaging 1.00
IGL02588:Lmf2 APN 15 89,239,609 (GRCm39) splice site probably null
IGL02698:Lmf2 APN 15 89,238,357 (GRCm39) missense probably damaging 1.00
BB003:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
BB013:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
PIT4651001:Lmf2 UTSW 15 89,236,272 (GRCm39) missense possibly damaging 0.58
R1761:Lmf2 UTSW 15 89,236,916 (GRCm39) missense possibly damaging 0.61
R2355:Lmf2 UTSW 15 89,235,966 (GRCm39) missense possibly damaging 0.65
R2880:Lmf2 UTSW 15 89,235,856 (GRCm39) missense possibly damaging 0.59
R4896:Lmf2 UTSW 15 89,236,003 (GRCm39) missense probably benign 0.16
R5141:Lmf2 UTSW 15 89,235,810 (GRCm39) splice site probably null
R6785:Lmf2 UTSW 15 89,236,236 (GRCm39) missense probably benign 0.43
R7301:Lmf2 UTSW 15 89,239,733 (GRCm39) start gained probably benign
R7926:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
R8110:Lmf2 UTSW 15 89,236,561 (GRCm39) critical splice donor site probably null
R8274:Lmf2 UTSW 15 89,236,866 (GRCm39) missense probably damaging 1.00
R8472:Lmf2 UTSW 15 89,239,005 (GRCm39) missense possibly damaging 0.80
R9127:Lmf2 UTSW 15 89,239,771 (GRCm39) start gained probably benign
R9332:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9333:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9334:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9710:Lmf2 UTSW 15 89,237,419 (GRCm39) missense probably benign 0.09
Posted On 2013-06-21