Incidental Mutation 'IGL01155:Trap1'
ID52988
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trap1
Ensembl Gene ENSMUSG00000005981
Gene NameTNF receptor-associated protein 1
SynonymsHSP75, 2410002K23Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01155
Quality Score
Status
Chromosome16
Chromosomal Location4039971-4077827 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 4043978 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 641 (Q641*)
Ref Sequence ENSEMBL: ENSMUSP00000006137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006136] [ENSMUST00000006137] [ENSMUST00000120009] [ENSMUST00000137748] [ENSMUST00000175755] [ENSMUST00000177337]
Predicted Effect probably benign
Transcript: ENSMUST00000006136
SMART Domains Protein: ENSMUSP00000006136
Gene: ENSMUSG00000005980

DomainStartEndE-ValueType
DNaseIc 6 282 5.04e-220 SMART
Predicted Effect probably null
Transcript: ENSMUST00000006137
AA Change: Q641*
SMART Domains Protein: ENSMUSP00000006137
Gene: ENSMUSG00000005981
AA Change: Q641*

DomainStartEndE-ValueType
HATPase_c 110 263 3.68e-3 SMART
Pfam:HSP90 290 706 2.6e-98 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120009
SMART Domains Protein: ENSMUSP00000113119
Gene: ENSMUSG00000005980

DomainStartEndE-ValueType
DNaseIc 6 282 5.04e-220 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125961
Predicted Effect probably benign
Transcript: ENSMUST00000137748
SMART Domains Protein: ENSMUSP00000119934
Gene: ENSMUSG00000005980

DomainStartEndE-ValueType
DNaseIc 6 225 7.51e-146 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137945
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144792
Predicted Effect probably benign
Transcript: ENSMUST00000175755
SMART Domains Protein: ENSMUSP00000135060
Gene: ENSMUSG00000005980

DomainStartEndE-ValueType
SCOP:d2dnja_ 1 52 3e-9 SMART
Blast:DNaseIc 1 61 2e-31 BLAST
PDB:3W3D|B 1 61 5e-27 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176642
Predicted Effect probably benign
Transcript: ENSMUST00000177337
SMART Domains Protein: ENSMUSP00000135442
Gene: ENSMUSG00000005980

DomainStartEndE-ValueType
DNaseIc 6 200 6.86e-67 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Adgrl3 T A 5: 81,560,893 I409N probably benign Het
Akap13 A G 7: 75,569,936 D29G probably damaging Het
Ap4e1 C A 2: 127,043,445 T322K probably damaging Het
Arfgef1 G A 1: 10,198,982 probably benign Het
Asic5 A G 3: 82,008,588 T282A probably benign Het
Bptf T C 11: 107,080,727 T985A probably damaging Het
Btnl9 A G 11: 49,175,691 F349L probably damaging Het
Bves T A 10: 45,353,859 I253K probably damaging Het
Cars T A 7: 143,569,849 Y455F probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Cuedc2 C A 19: 46,332,649 V15F probably damaging Het
Defa22 T A 8: 21,163,037 probably null Het
Fat1 G A 8: 45,023,949 A2011T probably damaging Het
Fyb2 C T 4: 104,999,386 T533I probably benign Het
Gm1043 T C 5: 37,187,089 L182P probably damaging Het
Ice1 A T 13: 70,604,082 V1295E possibly damaging Het
Il12b T A 11: 44,404,088 S18T probably benign Het
Iqcg A G 16: 33,040,875 V157A probably damaging Het
Itgax T A 7: 128,145,035 M937K probably benign Het
Large1 T C 8: 73,131,989 S84G probably benign Het
Lrp1b T C 2: 41,770,935 T54A probably benign Het
Mfn1 A G 3: 32,542,836 M148V probably damaging Het
Mobp C A 9: 120,168,234 T73K probably benign Het
Ms4a3 T C 19: 11,629,655 probably benign Het
Muc5ac C T 7: 141,806,943 probably benign Het
Mzt2 A C 16: 15,862,410 S104A possibly damaging Het
Naa16 T A 14: 79,384,715 K27N probably damaging Het
Nos1 T A 5: 117,945,926 I1267N probably damaging Het
Olfr16 T A 1: 172,956,924 I43N probably benign Het
Rara A G 11: 98,968,184 E153G possibly damaging Het
Scn2a T G 2: 65,717,748 S66A probably damaging Het
Slc6a1 A T 6: 114,314,465 probably null Het
Sorbs3 A G 14: 70,199,341 V136A probably damaging Het
Spink5 T A 18: 43,981,147 H143Q probably benign Het
Susd2 G A 10: 75,640,892 T99I possibly damaging Het
T C T 17: 8,441,745 probably null Het
Tac2 G A 10: 127,726,134 probably null Het
Tfap4 G T 16: 4,547,359 P180T probably damaging Het
Unc119 A G 11: 78,348,609 N252S probably damaging Het
Other mutations in Trap1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03087:Trap1 APN 16 4044701 splice site probably null
E0354:Trap1 UTSW 16 4065288 missense probably benign 0.01
R0034:Trap1 UTSW 16 4069030 splice site probably benign
R0034:Trap1 UTSW 16 4069030 splice site probably benign
R0316:Trap1 UTSW 16 4045560 missense probably benign
R0336:Trap1 UTSW 16 4044626 missense probably damaging 0.99
R0614:Trap1 UTSW 16 4060751 splice site probably benign
R2069:Trap1 UTSW 16 4068336 missense probably benign
R2089:Trap1 UTSW 16 4046039 nonsense probably null
R2091:Trap1 UTSW 16 4046039 nonsense probably null
R2091:Trap1 UTSW 16 4046039 nonsense probably null
R2148:Trap1 UTSW 16 4060760 missense probably damaging 0.97
R2419:Trap1 UTSW 16 4068330 missense probably benign 0.23
R3853:Trap1 UTSW 16 4054822 missense possibly damaging 0.69
R4926:Trap1 UTSW 16 4045488 missense probably benign 0.27
R5120:Trap1 UTSW 16 4044088 missense probably damaging 1.00
R5261:Trap1 UTSW 16 4056422 missense probably damaging 1.00
R5434:Trap1 UTSW 16 4044665 missense probably benign 0.00
R6194:Trap1 UTSW 16 4054800 missense possibly damaging 0.94
R6284:Trap1 UTSW 16 4060809 missense probably benign 0.07
R6415:Trap1 UTSW 16 4043992 missense possibly damaging 0.92
R7132:Trap1 UTSW 16 4055829 missense probably benign 0.17
R7167:Trap1 UTSW 16 4052928 missense probably damaging 1.00
Posted On2013-06-21