Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01155:Trap1'

52988

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trap1

Ensembl Gene

ENSMUSG00000005981

Gene Name

TNF receptor-associated protein 1

Synonyms

HSP75, 2410002K23Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01155

Quality Score

Status

Chromosome

Chromosomal Location

4039971-4077827 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 4043978 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 641 (Q641*)

Ref Sequence

ENSEMBL: ENSMUSP00000006137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006136] [ENSMUST00000006137] [ENSMUST00000120009] [ENSMUST00000137748] [ENSMUST00000175755] [ENSMUST00000177337]

Predicted Effect

probably benign
Transcript: ENSMUST00000006136

SMART Domains

Protein: ENSMUSP00000006136
Gene: ENSMUSG00000005980

Domain	Start	End	E-Value	Type
DNaseIc	6	282	5.04e-220	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000006137
AA Change: Q641*

SMART Domains

Protein: ENSMUSP00000006137
Gene: ENSMUSG00000005981
AA Change: Q641*

Domain	Start	End	E-Value	Type
HATPase_c	110	263	3.68e-3	SMART
Pfam:HSP90	290	706	2.6e-98	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120009

SMART Domains

Protein: ENSMUSP00000113119
Gene: ENSMUSG00000005980

Domain	Start	End	E-Value	Type
DNaseIc	6	282	5.04e-220	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125961

Predicted Effect

probably benign
Transcript: ENSMUST00000137748

SMART Domains

Protein: ENSMUSP00000119934
Gene: ENSMUSG00000005980

Domain	Start	End	E-Value	Type
DNaseIc	6	225	7.51e-146	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137945

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144792

Predicted Effect

probably benign
Transcript: ENSMUST00000175755

SMART Domains

Protein: ENSMUSP00000135060
Gene: ENSMUSG00000005980

Domain	Start	End	E-Value	Type
SCOP:d2dnja_	1	52	3e-9	SMART
Blast:DNaseIc	1	61	2e-31	BLAST
PDB:3W3D\|B	1	61	5e-27	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176642

Predicted Effect

probably benign
Transcript: ENSMUST00000177337

SMART Domains

Protein: ENSMUSP00000135442
Gene: ENSMUSG00000005980

Domain	Start	End	E-Value	Type
DNaseIc	6	200	6.86e-67	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Adgrl3	T	A	5: 81,560,893	I409N	probably benign	Het
Akap13	A	G	7: 75,569,936	D29G	probably damaging	Het
Ap4e1	C	A	2: 127,043,445	T322K	probably damaging	Het
Arfgef1	G	A	1: 10,198,982		probably benign	Het
Asic5	A	G	3: 82,008,588	T282A	probably benign	Het
Bptf	T	C	11: 107,080,727	T985A	probably damaging	Het
Btnl9	A	G	11: 49,175,691	F349L	probably damaging	Het
Bves	T	A	10: 45,353,859	I253K	probably damaging	Het
Cars	T	A	7: 143,569,849	Y455F	probably benign	Het
Cfap206	C	T	4: 34,721,562	S162N	probably damaging	Het
Cuedc2	C	A	19: 46,332,649	V15F	probably damaging	Het
Defa22	T	A	8: 21,163,037		probably null	Het
Fat1	G	A	8: 45,023,949	A2011T	probably damaging	Het
Fyb2	C	T	4: 104,999,386	T533I	probably benign	Het
Gm1043	T	C	5: 37,187,089	L182P	probably damaging	Het
Ice1	A	T	13: 70,604,082	V1295E	possibly damaging	Het
Il12b	T	A	11: 44,404,088	S18T	probably benign	Het
Iqcg	A	G	16: 33,040,875	V157A	probably damaging	Het
Itgax	T	A	7: 128,145,035	M937K	probably benign	Het
Large1	T	C	8: 73,131,989	S84G	probably benign	Het
Lrp1b	T	C	2: 41,770,935	T54A	probably benign	Het
Mfn1	A	G	3: 32,542,836	M148V	probably damaging	Het
Mobp	C	A	9: 120,168,234	T73K	probably benign	Het
Ms4a3	T	C	19: 11,629,655		probably benign	Het
Muc5ac	C	T	7: 141,806,943		probably benign	Het
Mzt2	A	C	16: 15,862,410	S104A	possibly damaging	Het
Naa16	T	A	14: 79,384,715	K27N	probably damaging	Het
Nos1	T	A	5: 117,945,926	I1267N	probably damaging	Het
Olfr16	T	A	1: 172,956,924	I43N	probably benign	Het
Rara	A	G	11: 98,968,184	E153G	possibly damaging	Het
Scn2a	T	G	2: 65,717,748	S66A	probably damaging	Het
Slc6a1	A	T	6: 114,314,465		probably null	Het
Sorbs3	A	G	14: 70,199,341	V136A	probably damaging	Het
Spink5	T	A	18: 43,981,147	H143Q	probably benign	Het
Susd2	G	A	10: 75,640,892	T99I	possibly damaging	Het
T	C	T	17: 8,441,745		probably null	Het
Tac2	G	A	10: 127,726,134		probably null	Het
Tfap4	G	T	16: 4,547,359	P180T	probably damaging	Het
Unc119	A	G	11: 78,348,609	N252S	probably damaging	Het

Other mutations in Trap1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03087:Trap1	APN	16	4044701	splice site	probably null
E0354:Trap1	UTSW	16	4065288	missense	probably benign	0.01
R0034:Trap1	UTSW	16	4069030	splice site	probably benign
R0034:Trap1	UTSW	16	4069030	splice site	probably benign
R0316:Trap1	UTSW	16	4045560	missense	probably benign
R0336:Trap1	UTSW	16	4044626	missense	probably damaging	0.99
R0614:Trap1	UTSW	16	4060751	splice site	probably benign
R2069:Trap1	UTSW	16	4068336	missense	probably benign
R2089:Trap1	UTSW	16	4046039	nonsense	probably null
R2091:Trap1	UTSW	16	4046039	nonsense	probably null
R2091:Trap1	UTSW	16	4046039	nonsense	probably null
R2148:Trap1	UTSW	16	4060760	missense	probably damaging	0.97
R2419:Trap1	UTSW	16	4068330	missense	probably benign	0.23
R3853:Trap1	UTSW	16	4054822	missense	possibly damaging	0.69
R4926:Trap1	UTSW	16	4045488	missense	probably benign	0.27
R5120:Trap1	UTSW	16	4044088	missense	probably damaging	1.00
R5261:Trap1	UTSW	16	4056422	missense	probably damaging	1.00
R5434:Trap1	UTSW	16	4044665	missense	probably benign	0.00
R6194:Trap1	UTSW	16	4054800	missense	possibly damaging	0.94
R6284:Trap1	UTSW	16	4060809	missense	probably benign	0.07
R6415:Trap1	UTSW	16	4043992	missense	possibly damaging	0.92
R7132:Trap1	UTSW	16	4055829	missense	probably benign	0.17
R7167:Trap1	UTSW	16	4052928	missense	probably damaging	1.00

Posted On

2013-06-21