Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01155:Cuedc2'

53310

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cuedc2

Ensembl Gene

ENSMUSG00000036748

Gene Name

CUE domain containing 2

Synonyms

3010002G01Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.300) question?

Stock #

IGL01155

Quality Score

Status

Chromosome

Chromosomal Location

46318251-46327141 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 46321088 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 15 (V15F)

Ref Sequence

ENSEMBL: ENSMUSP00000129589 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026256] [ENSMUST00000051234] [ENSMUST00000167861] [ENSMUST00000177667]

AlphaFold

Q9CXX9

Predicted Effect

probably benign
Transcript: ENSMUST00000026256

SMART Domains

Protein: ENSMUSP00000026256
Gene: ENSMUSG00000025226

Domain	Start	End	E-Value	Type
Pfam:F-box	18	63	1.9e-6	PFAM
low complexity region	76	84	N/A	INTRINSIC
LRR	113	138	1.01e1	SMART
LRR	139	164	1.89e-1	SMART
LRR	165	190	2.27e-4	SMART
LRR	192	217	3.47e0	SMART
LRR	218	243	2.57e-3	SMART
LRR	244	269	2.05e1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000051234
AA Change: V15F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000053469
Gene: ENSMUSG00000036748
AA Change: V15F

Domain	Start	End	E-Value	Type
Pfam:CUE	144	183	4.6e-7	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000167861
AA Change: V15F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000129589
Gene: ENSMUSG00000036748
AA Change: V15F

Domain	Start	End	E-Value	Type
Pfam:CUE	144	183	5.7e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000177667

SMART Domains

Protein: ENSMUSP00000137489
Gene: ENSMUSG00000025226

Domain	Start	End	E-Value	Type
Pfam:F-box	18	63	2.1e-6	PFAM
low complexity region	76	84	N/A	INTRINSIC
LRR	113	138	1.01e1	SMART
LRR	139	164	1.89e-1	SMART
LRR	165	190	2.27e-4	SMART
LRR	192	217	3.47e0	SMART
LRR	218	243	2.57e-3	SMART
LRR	244	269	2.05e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180538

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
Adgrl3	T	A	5: 81,708,740 (GRCm39)	I409N	probably benign	Het
Akap13	A	G	7: 75,219,684 (GRCm39)	D29G	probably damaging	Het
Ap4e1	C	A	2: 126,885,365 (GRCm39)	T322K	probably damaging	Het
Arfgef1	G	A	1: 10,269,207 (GRCm39)		probably benign	Het
Asic5	A	G	3: 81,915,895 (GRCm39)	T282A	probably benign	Het
Bptf	T	C	11: 106,971,553 (GRCm39)	T985A	probably damaging	Het
Btnl9	A	G	11: 49,066,518 (GRCm39)	F349L	probably damaging	Het
Bves	T	A	10: 45,229,955 (GRCm39)	I253K	probably damaging	Het
Cars1	T	A	7: 143,123,586 (GRCm39)	Y455F	probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Defa22	T	A	8: 21,653,053 (GRCm39)		probably null	Het
Fat1	G	A	8: 45,476,986 (GRCm39)	A2011T	probably damaging	Het
Fyb2	C	T	4: 104,856,583 (GRCm39)	T533I	probably benign	Het
Gm1043	T	C	5: 37,344,433 (GRCm39)	L182P	probably damaging	Het
Ice1	A	T	13: 70,752,201 (GRCm39)	V1295E	possibly damaging	Het
Il12b	T	A	11: 44,294,915 (GRCm39)	S18T	probably benign	Het
Iqcg	A	G	16: 32,861,245 (GRCm39)	V157A	probably damaging	Het
Itgax	T	A	7: 127,744,207 (GRCm39)	M937K	probably benign	Het
Large1	T	C	8: 73,858,617 (GRCm39)	S84G	probably benign	Het
Lrp1b	T	C	2: 41,660,947 (GRCm39)	T54A	probably benign	Het
Mfn1	A	G	3: 32,596,985 (GRCm39)	M148V	probably damaging	Het
Mobp	C	A	9: 119,997,300 (GRCm39)	T73K	probably benign	Het
Ms4a3	T	C	19: 11,607,019 (GRCm39)		probably benign	Het
Muc5ac	C	T	7: 141,360,680 (GRCm39)		probably benign	Het
Mzt2	A	C	16: 15,680,274 (GRCm39)	S104A	possibly damaging	Het
Naa16	T	A	14: 79,622,155 (GRCm39)	K27N	probably damaging	Het
Nos1	T	A	5: 118,083,991 (GRCm39)	I1267N	probably damaging	Het
Or10j5	T	A	1: 172,784,491 (GRCm39)	I43N	probably benign	Het
Rara	A	G	11: 98,859,010 (GRCm39)	E153G	possibly damaging	Het
Scn2a	T	G	2: 65,548,092 (GRCm39)	S66A	probably damaging	Het
Slc6a1	A	T	6: 114,291,426 (GRCm39)		probably null	Het
Sorbs3	A	G	14: 70,436,790 (GRCm39)	V136A	probably damaging	Het
Spink5	T	A	18: 44,114,214 (GRCm39)	H143Q	probably benign	Het
Susd2	G	A	10: 75,476,726 (GRCm39)	T99I	possibly damaging	Het
T	C	T	17: 8,660,577 (GRCm39)		probably null	Het
Tac2	G	A	10: 127,562,003 (GRCm39)		probably null	Het
Tfap4	G	T	16: 4,365,223 (GRCm39)	P180T	probably damaging	Het
Trap1	G	A	16: 3,861,842 (GRCm39)	Q641*	probably null	Het
Unc119	A	G	11: 78,239,435 (GRCm39)	N252S	probably damaging	Het

Other mutations in Cuedc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00164:Cuedc2	APN	19	46,320,359 (GRCm39)	missense	probably damaging	1.00
IGL01733:Cuedc2	APN	19	46,321,112 (GRCm39)	missense	probably damaging	1.00
R1656:Cuedc2	UTSW	19	46,320,427 (GRCm39)	missense	probably damaging	0.99
R1778:Cuedc2	UTSW	19	46,320,079 (GRCm39)	missense	probably benign	0.00
R2905:Cuedc2	UTSW	19	46,321,088 (GRCm39)	missense	probably benign	0.16
R5801:Cuedc2	UTSW	19	46,319,796 (GRCm39)	missense	probably damaging	0.99
R5874:Cuedc2	UTSW	19	46,319,824 (GRCm39)	missense	possibly damaging	0.71
R8511:Cuedc2	UTSW	19	46,319,358 (GRCm39)	critical splice donor site	probably null
R9483:Cuedc2	UTSW	19	46,319,399 (GRCm39)	missense	probably benign	0.10
R9742:Cuedc2	UTSW	19	46,319,727 (GRCm39)	critical splice donor site	probably null

Posted On

2013-06-21