Incidental Mutation 'R6827:Gm3573'
ID 534221
Institutional Source Beutler Lab
Gene Symbol Gm3573
Ensembl Gene ENSMUSG00000091792
Gene Name predicted gene 3573
MMRRC Submission 044938-MU
Accession Numbers
Essential gene? Not available question?
Stock # R6827 (G1)
Quality Score 105.008
Status Not validated
Chromosome 14
Chromosomal Location 42007348-42012748 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42010429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 59 (T59S)
Ref Sequence ENSEMBL: ENSMUSP00000127488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168673]
AlphaFold L7N292
Predicted Effect probably benign
Transcript: ENSMUST00000168673
AA Change: T59S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000127488
Gene: ENSMUSG00000091792
AA Change: T59S

Pfam:Takusan 10 88 1.4e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef26 C A 3: 62,330,919 (GRCm39) probably null Het
Asb3 A G 11: 31,051,211 (GRCm39) N555S probably benign Het
Bcr T C 10: 74,966,896 (GRCm39) V501A probably damaging Het
Cchcr1 A G 17: 35,841,302 (GRCm39) T773A possibly damaging Het
Dmxl1 C T 18: 50,054,091 (GRCm39) P2566S probably damaging Het
Dscam T A 16: 96,840,191 (GRCm39) N139Y probably damaging Het
Ephx1 A G 1: 180,817,453 (GRCm39) L406P probably damaging Het
Fbxl13 T A 5: 21,727,176 (GRCm39) I607F probably damaging Het
Gm572 T C 4: 148,742,543 (GRCm39) L94P possibly damaging Het
Gypa A T 8: 81,231,417 (GRCm39) M109L probably benign Het
Hk3 C A 13: 55,159,165 (GRCm39) V409L probably damaging Het
Kcnh6 A G 11: 105,899,925 (GRCm39) T65A probably benign Het
Kdr G T 5: 76,105,205 (GRCm39) P1055Q probably damaging Het
Lef1 T C 3: 130,994,053 (GRCm39) probably null Het
Lrrc10 A G 10: 116,881,545 (GRCm39) Q73R possibly damaging Het
Moxd1 C T 10: 24,155,748 (GRCm39) T284I probably benign Het
Naf1 A T 8: 67,330,343 (GRCm39) T290S possibly damaging Het
Naip5 C A 13: 100,382,437 (GRCm39) V91L possibly damaging Het
Ncaph2 T C 15: 89,255,530 (GRCm39) V568A probably damaging Het
Ntrk2 T C 13: 59,274,382 (GRCm39) W753R probably damaging Het
Or51v15-ps1 C A 7: 103,279,032 (GRCm39) C45F possibly damaging Het
Pbld1 C A 10: 62,903,212 (GRCm39) N96K probably damaging Het
Pcdhac2 G A 18: 37,277,706 (GRCm39) V229M probably benign Het
Prrc2b G T 2: 32,090,963 (GRCm39) R445L probably benign Het
Scyl2 T C 10: 89,505,666 (GRCm39) probably null Het
Sdf2l1 C G 16: 16,950,158 (GRCm39) R6P probably benign Het
Slc22a5 A T 11: 53,762,442 (GRCm39) I21N possibly damaging Het
Tex51 C T 18: 32,591,713 (GRCm39) W186* probably null Het
Tmem168 A T 6: 13,582,837 (GRCm39) F297L probably damaging Het
Trpm4 T C 7: 44,968,052 (GRCm39) E293G possibly damaging Het
Trps1 T A 15: 50,685,959 (GRCm39) T69S probably benign Het
Ubxn4 T C 1: 128,204,714 (GRCm39) M468T probably benign Het
Unc5b C A 10: 60,616,011 (GRCm39) R104L probably benign Het
Wfdc3 C T 2: 164,576,178 (GRCm39) G38R possibly damaging Het
Wnt2b A G 3: 104,854,408 (GRCm39) V350A probably benign Het
Zfp518b T C 5: 38,828,882 (GRCm39) Q1041R probably damaging Het
Zranb1 T C 7: 132,551,474 (GRCm39) F68L probably benign Het
Other mutations in Gm3573
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Gm3573 APN 14 42,009,523 (GRCm39) missense probably benign 0.08
IGL02548:Gm3573 APN 14 42,009,452 (GRCm39) critical splice donor site probably null
R6774:Gm3573 UTSW 14 42,009,472 (GRCm39) missense possibly damaging 0.86
R7607:Gm3573 UTSW 14 42,011,707 (GRCm39) missense probably benign 0.18
R9625:Gm3573 UTSW 14 42,011,605 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-09-12